The predictive value of urinary vascular endothelial growth factor (VEGF) on worsening kidney function in proteinuric chronic kidney disease.
CONCLUSIONS: The urinary VEGF/creatinine ratio in 24-hour urine seems to independently predict worsening of chronic kidney disease in patients with glomerular diseases.
. PMID: 28601119 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Avguštin N, Rotar Ž, Pajek J, Kovač D, Osredkar J, Lindič J Tags: Clin Nephrol Source Type: research

Measurement of breath ammonia for detection of patients with chronic kidney disease.
CONCLUSIONS: The results of our pilot study show that breath monitoring of ammonia can be a simple, useful, fast, and noninvasive tool for detection of advanced kidney impairment.
. PMID: 28601120 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Bevc S, Mohorko E, Kolar M, Brglez P, Holobar A, Kniepeiss D, Podbregar M, Piko N, Hojs N, Knehtl M, Ekart R, Hojs R Tags: Clin Nephrol Source Type: research

Relationship between subendocardial viability ratio and hemoglobin in patients with chronic kidney disease.
CONCLUSIONS: Results of our study show that SEVR is independently associated with hemoglobin in nondialysis CKD patients. CKD patients with lower hemoglobin have lower SEVR.
. PMID: 28601121 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Ekart R, Bevc S, Hojs N, Galuf TS, Hren M, Dvoršak B, Knehtl M, Jakopin E, Krajnc I, Hojs R Tags: Clin Nephrol Source Type: research

Subendocardial viability ratio and ejection duration as parameters of early cardiovascular risk in children.
CONCLUSIONS: Our study does not show a significant role of SEVR and ED in early cardiovascular risk determination in children. However, some results do indicate a potential role of both, at least in hypercholesterolemia, and should be further investigated.
. PMID: 28601122 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Marčun-Varda N, Nikolic S, Močnik M Tags: Clin Nephrol Source Type: research

Physical function and 25-hydroxyvitamin D in dialysis patients - lessons learned from the Slovenian DIAGIB study.
jek J Abstract AIMS: Vitamin D stores in dialysis patients may be associated with their muscle function and physical performance. We analyzed associations of 25-hydroxyvitamin D levels with functional test results in prevalent hemodialysis patients and healthy controls. METHODS: Study sample included 54 dialysis patients and 81 healthy controls who performed a 6-minute walk test, sit-to-stand test, handgrip strength measurement, and self-rated habitual adjusted activity score with Human Activity Profile questionnaire. Adjusted general linear models were used to analyze association of 25-hydroxyvitamin D level...
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Pajek MB, Čuk I, Mlinšek G, Osredkar J, Pajek J Tags: Clin Nephrol Source Type: research

Impact of short-term nutritional supplementation on surrogate markers of undernutrition in hemodialysis patients - prospective real-life interventional study.
CONCLUSIONS: In undernourished HD patients after ONS we did not find statistically-significant improvement of NUS evaluating surrogate markers. Nevertheless, in undernourished patients not receiving ONS, serum albumin and HGS showed a trend towards worsening, and even in well-nourished patients, nutritional markers (serum albumin and PhA) declined. We speculate that a certain positive effect of ONS on nutritional status in undernourished HD patients could be observed already after short-term supplementation.
. PMID: 28601124 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Ocepek A, Bevc S, Ekart R Tags: Clin Nephrol Source Type: research

Hyperuricemia and long-term survival in patients with chronic kidney disease undergoing hemodialysis.
Abstract INTRODUCTION: Uric acid (UA), a breakdown product of purines, has been associated with mortality in different populations. Less is known about associations between hyperuricemia and mortality in chronic kidney disease (CKD) patients, later undergoing hemodialysis (HD), during a long observation period. The aim of this study was to determine the impact of elevated UA levels on long-term (19.5 years) survival of CKD patients. METHODS: 120 CKD patients (49 female, 71 male) enrolled in our study were observed from their first visit at the patients' nephrology outpatient clinic (NOC). All patients later s...
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Petreski T, Bevc S, Ekart R, Hojs R Tags: Clin Nephrol Source Type: research

The impact of gene polymorphisms in angiotensin receptor 1 and aldosterone synthase in peritoneal dialysis patients.
CONCLUSIONS: Our findings suggest the possibility of genetic predisposition for development of peritoneal fibrosis that could be important for identification of patients with an "unfavorable" genotype, which could lead to customized prescription of appropriate therapy and personalized patient management.
. PMID: 28601126 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Rupnik AT, Kovač D, Pajek J, Osredkar J, Marc J, Lindič J Tags: Clin Nephrol Source Type: research

Increase in spot urine protein excretion is associated with late kidney graft rejection and predicts rejection phenotype.
var J Abstract AIMS: A noninvasive test that foretells kidney graft rejection before loss of kidney function would be desirable. We hypothesized that an increase in estimated protein excretion rate (ePER) from spot urine samples is associated with graft rejection and predicts rejection phenotype. METHODS: 151 patients who had undergone first-indication kidney biopsy due to graft dysfunction beyond 3 months after transplant were identified from a national cohort of 616 transplant recipients between 2000 and 2012 (25%). ePER were calculated from spot urine protein-to-creatinine ratios at baseline, 3 months befo...
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Arnol M, Oblak M, Mlinšek G, Lindič J, Kandus A, Ferluga D, Kojc N, Buturović-Ponikvar J Tags: Clin Nephrol Source Type: research

Expanded valganciclovir prophylaxis in kidney transplant recipients is associated with lower incidence of cytomegalovirus infection.
CONCLUSIONS: The results show a significant reduction of CMV viremia in D+/R+ and D-/R+ KTRs after introduction of 3-month prophylaxis with valganciclovir. Extension of CMV prophylaxis to 6 months in D+/R- was not associated with reduction in CMV viremia at 12 months after transplant.
. PMID: 28601128 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Večerić-Haler Ž, Bizjak B, Romozi K, Arnol M Tags: Clin Nephrol Source Type: research

Fabry disease: diagnostic methods in nephrology practice.
Abstract Fabry disease (FD; OMIM 301500) is a rare X-linked systemic disease caused by a mutation of the GLA gene. Consequently, there is very low, or even absent, activity of the lysosomal enzyme α-galactosidase A (α-Gal A), resulting in the progressive accumulation of glycosphingolipids (predominantly, globotriaosylceramide (GL-3)) in various cells of different organs. Chronic progressive proteinuric kidney disease is one of the hallmarks of this disease, and it constitutes an important component of this condition's clinical picture. Many patients with FD develop advanced chronic kidney disease, and ...
Source: Clinical Nephrology - June 9, 2017 Category: Urology & Nephrology Authors: Vujkovac B Tags: Clin Nephrol Source Type: research

Predictors and generation of risk equations for albuminuria progression in type 2 diabetes 
.
CONCLUSIONS: We have identified baseline characteristics associated with progression of renal disease in type 2 diabetic subjects and generated equations to estimate the risk of progression. If validated in other populations, these equations might be useful in predicting risk of progression in clinical practice. 
. PMID: 28593836 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 8, 2017 Category: Urology & Nephrology Authors: Imbroll MG, Lauretta DA, Tabone T, Fava S Tags: Clin Nephrol Source Type: research

Real-world effectiveness of sucroferric oxyhydroxide in patients on chronic hemodialysis: A retrospective analysis of pharmacy data 
.
Real-world effectiveness of sucroferric oxyhydroxide in patients on chronic hemodialysis: A retrospective analysis of pharmacy data
. Clin Nephrol. 2017 Jun 07;: Authors: Coyne DW, Ficociello LH, Parameswaran V, Anderson L, Vemula S, Ofsthun NJ, Mullon C, Maddux FW, Kossmann RJ, Sprague SM Abstract AIMS: Hyperphosphatemia has been associated with an increased risk of mortality in patients with end-stage renal disease. We sought to assess the real-world effectiveness of sucroferric oxyhydroxide (SO), an iron-based phosphate binder (PB), in control of serum phosphorus levels, and to determine the asso...
Source: Clinical Nephrology - June 7, 2017 Category: Urology & Nephrology Authors: Coyne DW, Ficociello LH, Parameswaran V, Anderson L, Vemula S, Ofsthun NJ, Mullon C, Maddux FW, Kossmann RJ, Sprague SM Tags: Clin Nephrol Source Type: research

Secondary peritonitis associated with infective endocarditis and vertebral osteomyelitis in a peritoneal dialysis patient.
PMID: 28589875 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - June 7, 2017 Category: Urology & Nephrology Authors: Wen YK Tags: Clin Nephrol Source Type: research

Ferric citrate controls serum phosphorus in dialysis patients: retrospective data 
.
Ferric citrate controls serum phosphorus in dialysis patients: retrospective data
. Clin Nephrol. 2017 May 31;: Authors: Hain DJ, Marinaro M, Koeper DW, Rosenthal MA, Chillemi S, Huffman JM, Gerbeling T, Pritsiolas JM, Loram LC, Pergola PE Abstract Ferric citrate is an approved phosphate binder for use in patients with chronic kidney disease on dialysis. Clinical trials demonstrated that ferric citrate controlled serum phosphorus levels and increased iron stores. The aim of this retrospective chart review was to evaluate real-world bone mineral and anemia parameter data from patients treated with fe...
Source: Clinical Nephrology - May 31, 2017 Category: Urology & Nephrology Authors: Hain DJ, Marinaro M, Koeper DW, Rosenthal MA, Chillemi S, Huffman JM, Gerbeling T, Pritsiolas JM, Loram LC, Pergola PE Tags: Clin Nephrol Source Type: research

High prevalence of elevated molybdenum levels in pediatric CKD patients. A cross-sectional and longitudinal study 
.
High prevalence of elevated molybdenum levels in pediatric CKD patients. A cross-sectional and longitudinal study
. Clin Nephrol. 2017 May 15;: Authors: Yang G, Belostotsky V, Kobrzynski M, Huang SS, Yang L Abstract AIMS: Many of the secondary effects of high levels of molybdenum (Mo) overlap with symptoms commonly seen in pediatric patients with chronic kidney disease (CKD). We measured plasma Mo levels and examined the relationship between Mo levels and kidney function. MATERIALS AND METHODS: The study was carried out at the London Health Sciences Centre in London, Ontario, Canada with 36 chi...
Source: Clinical Nephrology - May 15, 2017 Category: Urology & Nephrology Authors: Yang G, Belostotsky V, Kobrzynski M, Huang SS, Yang L Tags: Clin Nephrol Source Type: research

A case report on the exceptional coincidence of two inherited renal disorders: ADPKD and Alport syndrome 
.
A case report on the exceptional coincidence of two inherited renal disorders: ADPKD and Alport syndrome
. Clin Nephrol. 2017 May 15;: Authors: Ebner K, Reintjes N, Feldkötter M, Körber F, Nagel M, Dötsch J, Hoppe B, Weber L, Beck B, Liebau M Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of dialysis-requiring end-stage renal disease in adults and is characterized by the slowly progressing replacement of renal tissue by focal macrocysts. Alport syndrome (AS; hereditary nephritis) is a rare, inherited disorder of the basement membrane ass...
Source: Clinical Nephrology - May 15, 2017 Category: Urology & Nephrology Authors: Ebner K, Reintjes N, Feldkötter M, Körber F, Nagel M, Dötsch J, Hoppe B, Weber L, Beck B, Liebau M Tags: Clin Nephrol Source Type: research

Favorable long-term outcomes of isolated liver  transplantation in a child with atypical hemolytic uremic syndrome caused by a novel complement factor H mutation
.
We describe a case of neonatal onset aHUS caused by a novel mutation of CFH and treated with an isolated liver transplantation at the age of 24 months. Nearly 5 years post-transplant, the patient's health has been generally good without evidence of aHUS. This case report suggests that isolated liver transplantation in aHUS patients with CFH mutations and preserved eGFR could be a curative therapeutic option in contrast to long-term eculizumab therapy.
. PMID: 28502324 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - May 15, 2017 Category: Urology & Nephrology Authors: Cho H, Lee Y Tags: Clin Nephrol Source Type: research

Acute hypocalcemia following kidney transplantation may depend on the type of remote parathyroidectomy: a retrospective cohort study 
.
Acute hypocalcemia following kidney transplantation may depend on the type of remote parathyroidectomy: a retrospective cohort study
. Clin Nephrol. 2017 May 10;: Authors: Simons M, Bautista J, Occhiogrosso R, Scott-Sheldon L, Gohh R Abstract BACKGROUND: Secondary hyperparathyroidism is a common complication of chronic kidney disease. When medical management fails, parathyroidectomy (PTX) is a treatment option. The two most common types are subtotal PTX and total PTX with autotransplantation (AT). To date, there is no consensus as to which procedure is preferable, especially in patients who are cand...
Source: Clinical Nephrology - May 10, 2017 Category: Urology & Nephrology Authors: Simons M, Bautista J, Occhiogrosso R, Scott-Sheldon L, Gohh R Tags: Clin Nephrol Source Type: research

A strategy based on patient preference improves the adherence and outcomes of phosphate binders in hemodialysis 
.
A strategy based on patient preference improves the adherence and outcomes of phosphate binders in hemodialysis
. Clin Nephrol. 2017 Apr 25;: Authors: Arenas Jiménez MD, Parra Moncasi E, Álvarez-Ude Cotera F Abstract PURPOSE: Phosphate binders (PB) have to be taken with food, their interference with an individual's lifestyle and social habits influences treatment adherence. Several PBs are available, and patient preferences should not be ignored when prescribing. The purpose was to know the extent of intentional and unintentional nonadherence to PB in hemodialysis (HD) patients, and to...
Source: Clinical Nephrology - April 25, 2017 Category: Urology & Nephrology Authors: Arenas Jiménez MD, Parra Moncasi E, Álvarez-Ude Cotera F Tags: Clin Nephrol Source Type: research

Clinical profile and outcome of patients with biopsy-proven acute interstitial nephritis in Cape Town: a 10-year review 
.
CONCLUSIONS: AIN is common in patients with HIV or those on treatment for tuberculosis. Drug-related AIN is often associated with improved outcomes. This is particularly reassuring in the SSA region where the use of potentially-inciting medications is rife from a high burden of HIV and tuberculosis.
. PMID: 28438256 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 25, 2017 Category: Urology & Nephrology Authors: Effa EE, Ekrikpo UE, Borkum M, Rayner BL, Heering P, Okpechi IG Tags: Clin Nephrol Source Type: research

Mortality risk factors in intensive care unit patients with acute kidney injury requiring renal replacement therapy: a retrospective cohort study 
.
CONCLUSION: Critically-ill patients with AKI requiring RRT continue to have a high mortality. Age and APACHE II score showed an impact on mortality whereas traditional cardiovascular risk factors did not. Higher BUN and creatinine levels do not have a negative impact on mortality. Our findings support the current practice that RRT initiation should primarily be guided by clinical decision.
. PMID: 28427496 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 21, 2017 Category: Urology & Nephrology Authors: Schmitz M, Tillmann FP, Paluckaite A, Laufer EA, Rayner B, Rump LC, Heering PJ Tags: Clin Nephrol Source Type: research

Ambulatory arterial stiffness index, blood pressure variability, and nocturnal blood pressure dip in children with IgA and Henoch-Sch önlein nephropathy
.
CONCLUSIONS: 1. Children with IgAN have higher arterial stiffness compared to healthy peers. 2. In children with IgAN/HSN, proteinuria and hyperlipidemia are risk factors for elevated diastolic blood pressure, while obesity is a risk factor for increased blood pressure variability and pulse pressure. 3. Pediatric patients with IgAN/HSN require regular ABPM evaluation to allow for early detection of poor pharmacological control of hypertension.
. PMID: 28406083 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 13, 2017 Category: Urology & Nephrology Authors: Skrzypczyk P, Mizerska-Wasiak M, Jerszow B, Ruszczykowski P, Pańczyk-Tomaszewska M Tags: Clin Nephrol Source Type: research

Evidence that TmP/GFR can be estimated with the Walton-Bijvoet nomogram in chronic kidney disease 
.
CONCLUSIONS: TRP/Ccr was a hyperbolic function of EP/Ccr over a wide range of GFR. Like the Walton-Bijvoet nomogram, this function projected a near-constant TRP/Ccr - i.e., a TmP/GFR - at FEP> 20%. The nomogram depicts TmP/GFR accurately in CKD.
. PMID: 28406084 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 13, 2017 Category: Urology & Nephrology Authors: Phelps KR, Mason DL Tags: Clin Nephrol Source Type: research

A single center kidney transplant experience among ten Caucasian females with end-stage renal disease due to scleroderma 
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A single center kidney transplant experience among ten Caucasian females with end-stage renal disease due to scleroderma
. Clin Nephrol. 2017 Apr 13;: Authors: Saxena N, Djamali A, Astor BC, Mohamed M, Mandelbrot D, Parajuli S Abstract There is limited information on kidney transplant recipients with end-stage renal disease (ESRD) due to scleroderma. We conducted an observational study on kidney transplant recipients with ESRD due to scleroderma who received kidney transplant at our center between 01/1994 and 06/2013. During the study period, there were 10 kidney transplant recipients, all of whom w...
Source: Clinical Nephrology - April 13, 2017 Category: Urology & Nephrology Authors: Saxena N, Djamali A, Astor BC, Mohamed M, Mandelbrot D, Parajuli S Tags: Clin Nephrol Source Type: research

Postprandial serum C-peptide level is associated with increased urinary albumin-to-creatinine ratio in patients with type 2 diabetes mellitus.
PMID: 28406086 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 13, 2017 Category: Urology & Nephrology Authors: Yamada E, Saito T, Niijima Y, Okada S, Yamada M Tags: Clin Nephrol Source Type: research

A case of Crimean-Congo hemorrhagic fever in a chronic hemodialysis patient.
Ü PMID: 28406087 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - April 13, 2017 Category: Urology & Nephrology Authors: Barut HS, Güneş F, Gemici Ü Tags: Clin Nephrol Source Type: research

Renal compensatory adaptation for water handling in a patient with adipsic diabetes insipidus after clipping of a ruptured aneurysm of the anterior communicating artery 
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Renal compensatory adaptation for water handling in a patient with adipsic diabetes insipidus after clipping of a ruptured aneurysm of the anterior communicating artery
. Clin Nephrol. 2017 Apr 04;: Authors: Imai E, Kaneko S, Tsukamoto Y Abstract A 38-year-old Japanese man who had undergone clipping surgery for a ruptured aneurysm of the anterior communicating artery 2 days prior, suddenly developed refractory hypernatremia (serum sodium (Na) 156 - 162 mmol/L). Symptoms included low plasma vasopressin, fluctuating urine osmolality (120 - 710 mOsm/kg) and lack of thirst,...
Source: Clinical Nephrology - April 4, 2017 Category: Urology & Nephrology Authors: Imai E, Kaneko S, Tsukamoto Y Tags: Clin Nephrol Source Type: research

Correlation analysis of renal ultrasound elastography and clinical and pathological changes in patients with chronic kidney disease 
.
Correlation analysis of renal ultrasound elastography and clinical and pathological changes in patients with chronic kidney disease
. Clin Nephrol. 2017 Mar 23;: Authors: Peng L, Zhong T, Fan Q, Liu Y, Wang X, Wang L Abstract OBJECTIVE: To analyze the correlations of renal tissue elastography with clinical biochemical indicators and pathological changes in patients with chronic kidney disease (CKD) as well as to explore the potential for renal tissue elastography as a new, noninvasive method for the dynamic monitoring of renal disease progression, efficacy assessment, and prognosis evaluation. ...
Source: Clinical Nephrology - March 23, 2017 Category: Urology & Nephrology Authors: Peng L, Zhong T, Fan Q, Liu Y, Wang X, Wang L Tags: Clin Nephrol Source Type: research

Brain swelling during dialysis: A randomized trial comparing low-flux hemodialysis with pre-dilution hemodiafiltration 
.
This study showed that HD and pre-HDF caused equal acute cerebral swelling of the grey matter. This appeared to be driven by small solute change in plasma interacting linearly with gray matter volume regardless of additional removal of larger molecules or ultrafiltration.
. PMID: 28332474 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 23, 2017 Category: Urology & Nephrology Authors: Johansen N, Kjaergaard KD, Peters CD, Pedersen M, Jespersen B, Jensen JD Tags: Clin Nephrol Source Type: research

Association of urinary uromodulin with kidney  function decline and mortality: the health ABC study
.
CONCLUSION: Higher levels of uUMOD are associated with lower risk of incident CKD and rapid kidney function decline. Additional studies are needed in the general population and in persons with advanced CKD to confirm these findings.
. PMID: 28332475 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 23, 2017 Category: Urology & Nephrology Authors: Garimella PS, Katz R, Ix JH, Fried LF, Kritchevsky SB, Devarajan P, Bennett MR, Parikh CR, Shlipak MG, Harris TB, Gutiérrez OM, Sarnak MJ Tags: Clin Nephrol Source Type: research

New-onset hepatitis C virus-associated glomerulonephritis following sustained virologic response with direct-acting antiviral therapy 
.
This report presents two cases of new-onset HCV-associated GN that occurred after sustained virologic response was achieved with direct-acting antiviral (DAA) therapy.
. PMID: 28332476 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 23, 2017 Category: Urology & Nephrology Authors: Ghosn M, Palmer MB, Najem CE, Haddad D, Merkel PA, Hogan JJ Tags: Clin Nephrol Source Type: research

Hepcidin clearance is associated with erythropoietin requirement in stable hemodialysis patients 
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Hepcidin clearance is associated with erythropoietin requirement in stable hemodialysis patients
. Clin Nephrol. 2017 Mar 14;: Authors: Ashby D, Busbridge M, Hildebrand S, Clarke C, Aldous G, Palan M, Murphy K, Duncan N, Choi P Abstract BACKGROUND: The discovery of hepcidin, the hormone regulating iron absorption and transport, has improved the understanding of anemia and erythropoietin treatment. Excessive hepcidin signaling causes anemia in chronic inflammatory conditions by restricting iron delivery to the bone marrow. Hepcidin is normally eliminated in the urine, and the high levels seen in rena...
Source: Clinical Nephrology - March 14, 2017 Category: Urology & Nephrology Authors: Ashby D, Busbridge M, Hildebrand S, Clarke C, Aldous G, Palan M, Murphy K, Duncan N, Choi P Tags: Clin Nephrol Source Type: research

The high prevalence of reversible subclinical hypothyroidism with elevated serum thyroglobulin levels in chronic kidney disease patients 
.
We examined the thyroid function of non-dialysis-dependent chronic kidney disease (CKD) patients in Japan. METHODS: Serum-free thyroxine, free triiodothyronine, thyroid-stimulating hormone (TSH), and thyroglobulin (Tg) levels were evaluated in 37 CKD patients. CKD was defined as sustained kidney damage for more than 3 months and was classified as CKD 1+2 (n = 11), 3+4 (n = 10), or 5 (n = 16), which were defined by glomerular filtration rates of ≥ 60, 15 - 59, or
Source: Clinical Nephrology - March 14, 2017 Category: Urology & Nephrology Authors: Sanai T, Okamura K, Rikitake S, Fukuda M, Onozawa K, Sanematsu M, Takashima T, Miyazono M, Ikeda Y Tags: Clin Nephrol Source Type: research

Immunotactoid glomerulopathy leading to the discovery of POEMS syndrome 
.
We report the case of a 32-year-old female patient who underwent renal biopsy on account of an impure nephrotic syndrome associated with immunoglobulin (Ig)G κ monoclonal gammopathy. Histological analysis revealed membranoproliferative glomerulonephritis with IgG, IgM, κ, λ, and C3 deposits. Due to an unfavorable progression, a second renal biopsy was performed. Electron microscopy analysis revealed an immunotactoid glomerulopathy. At the same time, a POEMS syndrome diagnosis (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin abnormalities) was confirmed in light of the follow...
Source: Clinical Nephrology - March 14, 2017 Category: Urology & Nephrology Authors: Philipponnet C, Kemeny JL, Garrouste C, Soubrier M, Heng AE Tags: Clin Nephrol Source Type: research

World Kidney Day 2017: Obesity and kidney disease: hidden consequences of the epidemic.
PMID: 28266910 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 7, 2017 Category: Urology & Nephrology Authors: Kovesdy CP, Furth SL, Zoccali C Tags: Clin Nephrol Source Type: research

WT1 mutation-associated nephropathy: a  single-center experience
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In conclusion, a high WT1 mutation rate was observed in this group of SRNS patients. Patients with splice-site mutations experienced a rapid disease progression, and patients harboring nonsense mutations showed a prominent glomerular developmental delay. CNI therapy was effective in patients with WT1 missense mutations and nonsense mutations.
. PMID: 28257282 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - March 3, 2017 Category: Urology & Nephrology Authors: Yue Z, Wang H, Lin H, Yang J, Liu T, Liu Y, Chen H, Sun L Tags: Clin Nephrol Source Type: research

Transition from lupus podocytopathy to diffuse proliferative lupus nephritis without proteinuria in childhood-onset systemic lupus erythematosus.
PMID: 28244367 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 28, 2017 Category: Urology & Nephrology Authors: Fujinaga S, Nishino T, Mizutani A, Sakuraya K, Sakurai S Tags: Clin Nephrol Source Type: research

Sieving and extraction of peptides and proteins during hemofiltration: a systematic review 
.
Sieving and extraction of peptides and proteins during hemofiltration: a systematic review
. Clin Nephrol. 2017 Feb 17;: Authors: Baird JS Abstract The relationship between the sieving coefficient (SC) or extraction ratio (ER) and the molecular weight (MW) of peptide and protein solutes during hemofiltration has not been investigated; it is possible that the SC and ER correlate with MW, permitting an estimate of peptide and protein clearance by hemofiltration in the absence of empiric data. A search for studies of the SC and/or ER for peptide and protein solutes during hemofiltration identified data...
Source: Clinical Nephrology - February 17, 2017 Category: Urology & Nephrology Authors: Baird JS Tags: Clin Nephrol Source Type: research

Clinical factors influencing the decision to order red blood cell transfusions for a sample of US dialysis patients 
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CONCLUSIONS: The decision to transfuse dialysis patients is influenced by multiple patient factors and medical conditions, of which low Hb is the main contributor to this decision about half of the time.
. PMID: 28211787 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 17, 2017 Category: Urology & Nephrology Authors: Stephens JM, Caloyeras JP, Holmen J, Kumar VA, Tzivelekis S, Pollock A Tags: Clin Nephrol Source Type: research

Hemolytic uremic syndrome complicated by Clostridium septicum bacteremia and new-onset type 1 diabetes mellitus. Report of a case 
.
We report the unusual case of a 5-year-old male hospitalized for management of diabetic ketoacidosis (DKA) and new-onset type 1 diabetes mellitus (T1DM) who developed acute renal injury secondary to hemolytic uremic syndrome (HUS). He was diagnosed with Shiga toxin-producing entero-hemorrhagic Escherichia coli (EHEC) 0157:H7-positive HUS 48 hours after being diagnosed with new-onset T1DM/DKA. His hospital course was complicated by Clostridium septicum sepsis with colonic perforation. This patient's diagnosis of new-onset T1DM just prior to HUS is novel. Furthermore, some cases of HUS and concurrent atraumatic C. septicum i...
Source: Clinical Nephrology - February 17, 2017 Category: Urology & Nephrology Authors: Iddings AC, Shenoi AN, Morales Pozzo A, Kiessling SG Tags: Clin Nephrol Source Type: research

Does spontaneous remission occur in polyarteritis nodosa? 
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CONCLUSION: This case illustrates the importance of considering PAN in the differential diagnosis of renal infarction with inflammatory syndrome and shows that spontaneous remission of renal PAN can occur.
. PMID: 28177278 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 8, 2017 Category: Urology & Nephrology Authors: Beyaert S, Pruijm M, Qanadli SD, Vollenweider P, Halfon M Tags: Clin Nephrol Source Type: research

Sodium glucose co-transporter 2 inhibitors and their nephroprotective potential 
.
Sodium glucose co-transporter 2 inhibitors and their nephroprotective potential
. Clin Nephrol. 2017 Feb 08;: Authors: Vallianou NG, Trigkidis K, Kazazis C Abstract Chronic kidney disease among patients with diabetes is on the rise. The sodium glucose co-transporters 2 inhibitors are a new class of glucose-lowering agents, which act through a novel mechanism by producing a decline in glucose reabsorption in the kidney, thereby increasing glucosuria and decreasing serum glucose levels. Data suggest that they possess nephroprotective properties. It is noteworthy that the efferent glomerular arteriole ...
Source: Clinical Nephrology - February 8, 2017 Category: Urology & Nephrology Authors: Vallianou NG, Trigkidis K, Kazazis C Tags: Clin Nephrol Source Type: research

Orlistat and acute kidney injury: a case report.
PMID: 28177280 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 8, 2017 Category: Urology & Nephrology Authors: Erken E, Altunoren O, Gungor O Tags: Clin Nephrol Source Type: research

Serum klotho levels in acute kidney injury 
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Serum klotho levels in acute kidney injury
. Clin Nephrol. 2017 Feb 03;: Authors: Seibert E, Radler D, Ulrich C, Hanika S, Fiedler R, Girndt M Abstract AIMS: Klotho is a co-receptor for FGF-23 and key regulator of phosphate excretion. Soluble klotho modulates ion-channel expression and growth factor sensitivity. In chronic kidney disease (CKD), impaired klotho expression has been demonstrated. Likewise, reduced soluble klotho levels in serum and urine have been established in rodents in experimental acute kidney injury (AKI). In contrast, no data on soluble serum klotho levels in human AKI has been ...
Source: Clinical Nephrology - February 3, 2017 Category: Urology & Nephrology Authors: Seibert E, Radler D, Ulrich C, Hanika S, Fiedler R, Girndt M Tags: Clin Nephrol Source Type: research

Clinical and pathological characteristics of Fabry disease combined with IgA nephropathy in Chinese patients 
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CONCLUSIONS: The clinical and pathological features of Fabry disease combined with IgA nephropathy are diverse. Therefore, it is important to combine family history, clinical manifestations, α-galactosidase A activity and pathological features, especially ultrastructural changes, to improve the diagnosis and treatment of the disease.
. PMID: 28157068 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - February 3, 2017 Category: Urology & Nephrology Authors: Yang N, Wang X, Xu F, Zeng C, Wang J, Liu Z Tags: Clin Nephrol Source Type: research

The safety of achieved iron stores and their effect on IV iron and ESA use: post-hoc results from a randomized trial of ferric citrate as a phosphate binder in dialysis 
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The safety of achieved iron stores and their effect on IV iron and ESA use: post-hoc results from a randomized trial of ferric citrate as a phosphate binder in dialysis
. Clin Nephrol. 2017 Jan 27;: Authors: Umanath K, Greco B, Jalal DI, McFadden M, Sika M, Koury MJ, Niecestro R, Hunsicker LG, Greene T, Lewis JB, Dwyer JP Abstract Iron stores assuring optimal efficacy/safety for erythropoiesis are unknown in the dialysis population. Using multicenter trial data, we related safety profiles, erythropoiesis-stimulating agent (ESA), and intravenous iron dosing to achieved iron stores in 441 subjects ran...
Source: Clinical Nephrology - January 27, 2017 Category: Urology & Nephrology Authors: Umanath K, Greco B, Jalal DI, McFadden M, Sika M, Koury MJ, Niecestro R, Hunsicker LG, Greene T, Lewis JB, Dwyer JP Tags: Clin Nephrol Source Type: research

Membranous nephropathy occurring with type  2 diabetes mellitus
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CONCLUSIONS: Diabetic MN usually presents in ageing and clinically hypertensive patients and is associated with severe global glomerulosclerosis, IFTA, and afferent arterial lesions histologically. Patients with pure MN with DM can frequently achieve remission. Gender (male), duration of diabetes, and diabetic retinopathy may serve as indicators of DN.
. PMID: 28128727 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 27, 2017 Category: Urology & Nephrology Authors: Qian Y, Zuo K, Li S, Zeng C, Liu Z, Wu Y Tags: Clin Nephrol Source Type: research

Peritoneal dialysis is a reasonable option in patients with cardiovascular disease 
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Peritoneal dialysis is a reasonable option in patients with cardiovascular disease
. Clin Nephrol. 2017 Jan 27;: Authors: Querido S, Quadros Branco P, Silva Sousa H, Adragão T, Araújo Gonçalves P, Gaspar MA, Diogo Barata J Abstract INTRODUCTION: Peritoneal dialysis (PD) has been proposed as a therapeutic option for patients with end-stage renal disease (ESRD) and cardiovascular (CV) disease. The study presented here aimed to compare incident PD patients with and without CV disease at baseline, in order to determine the impact of CV disease in the outcomes of long-term PD patient...
Source: Clinical Nephrology - January 27, 2017 Category: Urology & Nephrology Authors: Querido S, Quadros Branco P, Silva Sousa H, Adragão T, Araújo Gonçalves P, Gaspar MA, Diogo Barata J Tags: Clin Nephrol Source Type: research

Do patients receiving hemodialysis regret starting dialysis? A survey of affected patients 
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CONCLUSIONS: Most of our patients were optimistic about their health and prognosis. Few regretted the decision to start dialysis.
. PMID: 28128729 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 27, 2017 Category: Urology & Nephrology Authors: Gilman EA, Feely MA, Hildebrandt D, Edakkanambeth Varayil J, Chong EY, Williams AW, Mueller PS Tags: Clin Nephrol Source Type: research