Do patients receiving hemodialysis regret starting dialysis? A survey of affected patients 
.
CONCLUSIONS: Most of our patients were optimistic about their health and prognosis. Few regretted the decision to start dialysis.
. PMID: 28128729 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 27, 2017 Category: Urology & Nephrology Authors: Gilman EA, Feely MA, Hildebrandt D, Edakkanambeth Varayil J, Chong EY, Williams AW, Mueller PS Tags: Clin Nephrol Source Type: research

Successful induction of peritoneal dialysis in  a patient with massive hydrothorax due to pleuroperitoneal communication
.
Successful induction of peritoneal dialysis in a patient with massive hydrothorax due to pleuroperitoneal communication
. Clin Nephrol. 2017 Jan 19;: Authors: Uchida T, Yamada Y, Imakiire T, Oshima N, Kumagai H Abstract A 74-year-old woman with liver cirrhosis and chronic kidney disease (CKD) who had complained of chronic abdominal distension due to prominent ascites presented with sudden dyspnea. Chest radiography showed massive right pleural effusion that shifted the mediastinum. Peritoneal scintigraphy using 99mTc-macroaggregated albumin revealed pleuroperitoneal communication (PPC...
Source: Clinical Nephrology - January 19, 2017 Category: Urology & Nephrology Authors: Uchida T, Yamada Y, Imakiire T, Oshima N, Kumagai H Tags: Clin Nephrol Source Type: research

Assessment of the characteristics and quality of life of patients with uremic peripheral neuropathy 
.
This study seeks to examine the characteristics and health-related quality of life (HRQL) of patients with uremic peripheral neuropathy. METHODS: Uremic patients undergoing maintenance hemodialysis (MHD) at our hospital were enrolled in this study. Data collection began in January 2011 and ended in June 2011. The patients were divided into two groups, the lesion group (110 cases) and the non-lesion group (168 cases), based on the presence or absence of peripheral neuropathy. To examine continuous changes in signs and symptoms in the lesion group, electromyography (EMG) was performed to measure sensory nerve conduction...
Source: Clinical Nephrology - January 19, 2017 Category: Urology & Nephrology Authors: Yu XZ, Lu S, Gou W, Wang W, Zou SH, Han YX, Wang WW, Zhang JY Tags: Clin Nephrol Source Type: research

Clinicopathological features, diagnosis, and treatment of IgA nephropathy with minimal change disease related to exposure to mercury-containing cosmetics: a case report 
.
CONCLUSIONS: The unique clinical and pathological features of IgA nephropathy with MCD had raised the controversial question of whether MCD and IgA deposition are separate entities or a common pathophysiology. Repeated renal biopsy and similar cases were helpful and should be carried out as far as possible.
. PMID: 28102816 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 19, 2017 Category: Urology & Nephrology Authors: Niu HX, Li SH, Li HY, Chen YH, Liu WW, Li PL, Long HB Tags: Clin Nephrol Source Type: research

Validating identification of patients with small vessel vasculitis, with or without renal involvement, using administrative healthcare records.
PMID: 28102817 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 19, 2017 Category: Urology & Nephrology Authors: O'Shaughnessy MM, Cheng XS, Montez-Rath ME, Lafayette RA, Winkelmayer WC Tags: Clin Nephrol Source Type: research

ESRD: epidemiology and treatment in developing countries in Southeast Asia.
PMID: 28079514 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 12, 2017 Category: Urology & Nephrology Authors: Tang SC Tags: Clin Nephrol Source Type: research

Low-dose dialysis combined with low protein intake can maintain nitrogen balance in peritoneal dialysis patients in poor economies 
.
CONCLUSIONS: Lower dialysis dose with lower daily protein intake can achieve a lower-level nitrogen balance and does not lead to malnutrition. It may be an effective approach to solve the dialysis problem for the economically week population in China, especially for people with a smaller body size with lower transport membrane.
. PMID: 28074773 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - January 11, 2017 Category: Urology & Nephrology Authors: Su CY, Wang T, Lu XH, Ma S, Tang W, Wang PY Tags: Clin Nephrol Source Type: research

Correlation between pharmacokinetics of tacrolimus and pharmacodynamics on NFAT-regulated gene expression in stable kidney transplant recipients 
.
Correlation between pharmacokinetics of tacrolimus and pharmacodynamics on NFAT-regulated gene expression in stable kidney transplant recipients
. Clin Nephrol. 2016 Dec 27;: Authors: Keller F, Sommerer C, Giese T, Zeier M, Schröppel B Abstract Gene expression regulated by the transcription factor NFAT (nuclear factor of activated T-cells) has been proposed for monitoring the pharmacodynamic effect of calcineurin inhibitors. We aimed to correlate the pharmacokinetics of tacrolimus with the suppression of NFAT-regulated gene expression. Tacrolimus trough (Ctrough) and peak concentrations (Cpeak)...
Source: Clinical Nephrology - December 27, 2016 Category: Urology & Nephrology Authors: Keller F, Sommerer C, Giese T, Zeier M, Schröppel B Tags: Clin Nephrol Source Type: research

Localization of ectopic fibroblast growth factor 23 production in tumor-induced osteomalacia using selective venous samplings.
ard M PMID: 28025958 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 27, 2016 Category: Urology & Nephrology Authors: Pelletier K, Troyanov S, Guité JF, Sainte-Marie LG, Roberge D, Lessard M Tags: Clin Nephrol Source Type: research

Hypokalemia associated with acute colonic pseudo-obstruction in an ESRD patient.
We report an anuric, end-stage renal disease (ESRD) patient undergoing peritoneal dialysis (PD) who developed acute colonic pseudo-obstruction causing a prolonged hospitalization. He also developed severe hypokalemia with a serum potassium (K+) as low as 2.4 mEq/L and required 180 - 240 mEq of potassium chloride per day for more than a month to correct it. While PD K+ losses often contribute to hypokalemia, the PD K+ loss was estimated to be only 39 mEq/day. Therefore, PD could only contribute modestly to the recalcitrant hypokalemia observed during the episode of pseudo-obstruction. It has been shown, however, that patien...
Source: Clinical Nephrology - December 27, 2016 Category: Urology & Nephrology Authors: Boobés K, Rosa RM, Batlle D Tags: Clin Nephrol Source Type: research

Factors effective on peritoneal phosphorus transport and clearance in peritoneal dialysis patients 
.
Factors effective on peritoneal phosphorus transport and clearance in peritoneal dialysis patients
. Clin Nephrol. 2016 Dec 12; Authors: Cebeci E, Gursu M, Uzun S, Karadag S, Kazancioglu R, Ozturk S Abstract AIMS: Transport characteristics of phosphorus are different from other small solutes that are evaluated in routine peritoneal equilibration test (PET) in peritoneal dialysis (PD) patients. We aimed to evaluate peritoneal phosphorus clearance and permeability, and their relationship with peritoneal membrane transport type and creatinine clearance as well as factors affecting peritoneal phosphorus...
Source: Clinical Nephrology - December 12, 2016 Category: Urology & Nephrology Authors: Cebeci E, Gursu M, Uzun S, Karadag S, Kazancioglu R, Ozturk S Tags: Clin Nephrol Source Type: research

Perioperative and long-term outcomes in octogenarians after kidney transplantation: the  US perspective
.
Perioperative and long-term outcomes in octogenarians after kidney transplantation: the US perspective
. Clin Nephrol. 2016 Dec 12; Authors: Ravinuthala A, Mei X, Daily M, Shah M, Castellanos A, Berger J, Gedaly R Abstract BACKGROUND: We aimed to study outcomes on octogenarian patients undergoing kidney transplantation in the US. METHODS: We queried the UNOS dataset from 1988 through 2013 and found 471 octogenarians transplanted during the study period. RESULTS: 86 (18.3%) were female and 385 (81.7%) were male with a mean age of 81.58 years. The octogenarians had a significantly highe...
Source: Clinical Nephrology - December 12, 2016 Category: Urology & Nephrology Authors: Ravinuthala A, Mei X, Daily M, Shah M, Castellanos A, Berger J, Gedaly R Tags: Clin Nephrol Source Type: research

Thrombotic microangiopathy associated with cetuximab, an epidermal growth factor receptor inhibitor 
.
Thrombotic microangiopathy associated with cetuximab, an epidermal growth factor receptor inhibitor
. Clin Nephrol. 2016 Dec 07; Authors: Koizumi M, Takahashi M, Murata M, Kikuchi Y, Seta K, Yahata K Abstract Cetuximab is a chimeric human-murine monoclonal antibody that binds competitively and with high affinity to the epidermal growth factor receptor (EGFR) and is used to treat advanced squamous cell carcinoma of the head and neck. After receiving a total of six doses of cetuximab, a 72-year-old male presented with pretibial edema, acne-like skin rash, and nephrotic syndrome. The renal biopsy findi...
Source: Clinical Nephrology - December 7, 2016 Category: Urology & Nephrology Authors: Koizumi M, Takahashi M, Murata M, Kikuchi Y, Seta K, Yahata K Tags: Clin Nephrol Source Type: research

LAMB2 mutation with different phenotypes in China 
.
CONCLUSIONS: The phenotypes caused by LAMB2 mutation were variable, mainly Pierson syndrome, as well as isolated nephrotic syndrome without ocular involvement. Mutational analysis of LAMB2 should be considered in all steroid-resistant nephrotic syndrome patients, with or without any ocular abnormalities.
. PMID: 27925579 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - December 7, 2016 Category: Urology & Nephrology Authors: Zhang H, Cui J, Wang F, Xiao H, Ding J, Yao Y Tags: Clin Nephrol Source Type: research

Calcitriol in the treatment of IgA nephropathy with non-nephrotic range proteinuria: a meta-analysis of randomized controlled trials 
.
CONCLUSION: These data indicated that calcitriol is a promising treatment to reduce proteinuria in Chinese patients with IgA nephropathy presenting as non-nephrotic range proteinuria, and it has only mild side effects.
. PMID: 27900938 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 30, 2016 Category: Urology & Nephrology Authors: Deng J, Zheng X, Xie H, Chen L Tags: Clin Nephrol Source Type: research

Incidence and implications of silent hydronephrosis following percutaneous nephrolithotomy 
.
CONCLUSIONS: SH following, PCNL was identified in 16% of this screened population, with the majority requiring no intervention. However, SH may be attributed to residual stone or stricture, which may have been otherwise unrecognized in up to 2% of patients undergoing PCNL. Consideration should be given for routine postoperative ultrasound to screen for silent obstruction following PCNL.
. PMID: 27900939 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 30, 2016 Category: Urology & Nephrology Authors: Dagrosa L, Moses R, Pais V Tags: Clin Nephrol Source Type: research

Acute kidney injury in allopurinol-induced DRESS syndrome: a case report of concurrent tubulointerstitial nephritis and kidney-limited necrotizing vasculitis 
.
We report the case of a man who presented with allopurinol-induced DRESS and acute kidney injury (AKI) requiring hemodialysis. Kidney biopsy revealed eosinophilic tubulointerstitial nephritis and necrotizing vasculitis of the intralobular arteries without systemic markers of vasculitis. After cyclophosphamide and glucocorticoids, his symptoms and AKI resolved. To our knowledge, this is the first case of kidney-limited necrotizing vasculitis, questioning whether a biopsy should be routinely performed in patients with DRESS accompanied by severe AKI. It is possible that kidney-limited necrotizing vasculitis is an under-diagn...
Source: Clinical Nephrology - November 30, 2016 Category: Urology & Nephrology Authors: Esposito AJ, Murphy RC, Toukatly MN, Amro OW, Kestenbaum BR, Najafian B Tags: Clin Nephrol Source Type: research

The kidney in sickle hemoglobinopathies 
.
The kidney in sickle hemoglobinopathies
. Clin Nephrol. 2016 Nov 30; Authors: Airy M, Eknoyan G Abstract With improvements in the care of patients with sickle hemoglobinopathies, sickle cell disease (SCD) has evolved from a disease that was fatal in childhood into one in which most survive past their 5th decade and some into old age. As a result, the renal complications of sickle hemoglobinopathies, which are age dependent, have emerged as a common and serious complication of SCD. Approximately 14 - 18% of mortality in SCD is attributed to chronic kidney disease (CKD), which develops in 1/...
Source: Clinical Nephrology - November 30, 2016 Category: Urology & Nephrology Authors: Airy M, Eknoyan G Tags: Clin Nephrol Source Type: research

Association between chronic kidney disease and cancer mortality: A report from the ALLHAT.
This study evaluated CKD as a risk factor for cancer mortality in a large cohort of hypertensive patients. STUDY DESIGN: We did post-hoc analyses of in-trial and post-trial data from participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). SETTING AND PARTICIPANTS: Participants were ≥ 55 years old with hypertension and one other additional risk factor for coronary heart disease. PREDICTOR: Baseline estimated glomerular filtration rate (eGFR). OUTCOMES: Cancer mortality was ascertained by cancer-related deaths reported in national databases during and a...
Source: Clinical Nephrology - November 30, 2016 Category: Urology & Nephrology Authors: Chen DP, Davis BR, Simpson LM, Cushman WC, Cutler JA, Dobre M, Ford CE, Louis GT, Muntner P, Oparil S, Piller LB, Pressel SL, Sarnak MJ, Whelton PK, Wright JT, Rahman M Tags: Clin Nephrol Source Type: research

Collagen type III glomerulopathy: case report and review of the literature.
Abstract To summarize the clinical and pathological features of collagen type III glomerulopathy, the present report describes a case of collagen type III glomerulopathy and reviewed more than 60 cases recorded by other groups in English literature over the last few years. A 24-year-old female patient was admitted because of lower limbs edema, without any other discomforts. The lab examination of the patient reported proteinuria (2.42 g/24 h urine), microscopic hematuria, and the serum creatinine was 71 μmol/L. She received renal biopsy. The immunofluorescence staining results showed that collagen type III expr...
Source: Clinical Nephrology - November 30, 2016 Category: Urology & Nephrology Authors: Chen X, Wang H, Xu W, Zhu J Tags: Clin Nephrol Source Type: research

The Sustainable Kidney Care Foundation's contribution to the improvement of AKI management in developing countries using peritoneal dialysis.
Abstract Professional organizations, such as kidney foundations, have been active for over half a century in the field of nephrology, serving as the basic institutions for advocacy, disease education, prevention, and treatment. These organizations have focused efforts in four areas: supporting the training of clinical specialists, raising awareness about kidney disease, improving patient outcomes, and organizing continuing medical education. These activities, while essential for the success of nephrology organizations, do not usually initiate renal service programs in the neediest of places. To remedy the lack of ...
Source: Clinical Nephrology - November 23, 2016 Category: Urology & Nephrology Authors: Carter M, Levin NW, Carter CS, Callegari J Tags: Clin Nephrol Source Type: research

Gemcitabine-induced hemolytic-uremic syndrome treated with eculizumab or plasmapheresis: two case reports 
.
CONCLUSION: ECU successfully improved kidney function in a patient with GEM-HUS, while conventional treatment did not.
. PMID: 27879189 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 23, 2016 Category: Urology & Nephrology Authors: López Rubio ME, Rodado Martínez R, Illescas ML, Mateo Bosch E, Martínez Díaz M, de la Vara Inesta L, Cabezuelo B, Morales Albuja ME, Lucas Guillén E, Jimeno García L Tags: Clin Nephrol Source Type: research

Transplantation in Africa - an overview.
Abstract Africa is underdeveloped in terms of treatment options for patients with end-stage renal failure. Economic growth and corresponding increases in health expenditures in the African region mean that we can confidently anticipate increased demand for organ transplantation within the region over the next few years. Renal failure in Africa occurs mainly due to glomerular nephropathies, hypertension, diabetes, and HIV. For the subset of the population that might be considered medically suitable for transplantation, demand for transplantation is tightly constrained by the availability of specialist physicians an...
Source: Clinical Nephrology - November 23, 2016 Category: Urology & Nephrology Authors: Muller E Tags: Clin Nephrol Source Type: research

Why would serum phosphorus correlate with cardiovascular risk, and how is the clinician supposed to use this information? 
.
Why would serum phosphorus correlate with cardiovascular risk, and how is the clinician supposed to use this information?
. Clin Nephrol. 2016 Nov 14; Authors: Lederer E Abstract Numerous recent studies have demonstrated an association between serum phosphorus and cardiovascular risk, even in individuals with normal kidney function and with serum phosphorus levels considered within the acceptable range. Whether serum phosphorus serves as a biomarker, as a causative agent, or both remains unclear. Additionally, the impact of other important considerations, such as the time of day when the phosphorus ...
Source: Clinical Nephrology - November 14, 2016 Category: Urology & Nephrology Authors: Lederer E Tags: Clin Nephrol Source Type: research

Calciphylaxis in a nondialysis patient treated with sodium thiosulfate and high dose of oxygen 
.
CONCLUSION: High-dose oxygen and sodium thiosulfate could potentially be effective treatments for calciphylaxis in nondialysis patients.
. PMID: 27841148 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 14, 2016 Category: Urology & Nephrology Authors: Sanguankeo A, Thamcharoen N, Upala S Tags: Clin Nephrol Source Type: research

Acute kidney injury in leptospirosis: the Kidney Disease Improving Global Outcomes (KDIGO) criteria and mortality 
.
Acute kidney injury in leptospirosis: the Kidney Disease Improving Global Outcomes (KDIGO) criteria and mortality
. Clin Nephrol. 2016 Nov 2; Authors: Teles F, de Mendonça Uchôa JV, Barreto Mendonça DM, Pedrosa Costa AF Abstract Acute kidney injury (AKI) is one of the most serious complications of leptospirosis. In recent years, studies have evaluated this complication using the risk, injury, failure, loss, and end-stage kidney disease and the acute kidney injury network classification systems. More recently, the kidney disease improving global outcomes (KDIGO) criteria have been...
Source: Clinical Nephrology - November 2, 2016 Category: Urology & Nephrology Authors: Teles F, de Mendonça Uchôa JV, Barreto Mendonça DM, Pedrosa Costa AF Tags: Clin Nephrol Source Type: research

Computed tomography for the management of  exit-site and tunnel infections in peritoneal dialysis patients
.
CONCLUSIONS: In this retrospective study comprising a small number of cases, increased attenuation of fatty tissue around the Tenckhoff catheter correlated with exit-site or tunnel infections. CT might be an auxiliary tool for diagnosis, although CT costs much more than US and is not always available in general practice. Further prospective studies are needed.
. PMID: 27805563 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 2, 2016 Category: Urology & Nephrology Authors: Nozaki K, Kamijo Y, Nakatsuka M, Azuma T, Nakagawa T, Miyazaki H, Fujimura T, Fukuhara H, Kume H, Ishibashi Y, Homma Y Tags: Clin Nephrol Source Type: research

Coronary artery calcification in CKD-5D 
patients is tied to adverse cardiac function 
and increased mortality
.
This study tested the hypothesis that CAC increases mortality by adversely affecting cardiac function. METHODS: Patients were recruited from 37 regional dialysis centers. 2-D and Doppler echocardiographic analyses were performed, and CAC was measured using 64-slice computed tomography. Relationships between CAC and echocardiographic measures of left ventricular (LV) function were analyzed. Survival was assessed with median follow-up of 37 months. RESULTS: There were 157 patients: 59% male, 46% Caucasian, 48% diabetic. Median age was 55 years, and median duration of CKD-5D was 45 months. Agatston CAC scores> 10...
Source: Clinical Nephrology - November 2, 2016 Category: Urology & Nephrology Authors: Anaya P, Blomquist GA, Davenport DL, Monier-Faugere MC, Sorrell VL, Malluche HH Tags: Clin Nephrol Source Type: research

Low-dose mycophenolate mofetil in tablet form or capsule form combined with tacrolimus in the early period after kidney transplantation: a prospective randomized trial 
.
CONCLUSION: Low-dose MMF in tablet form combined with tacrolimus can be considered as an efficacious and safe immunosuppressive regimen in the early period after kidney transplantation.
. PMID: 27781419 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 26, 2016 Category: Urology & Nephrology Authors: Lee S, Kim CD, Huh K, Cho BH, Ju M, Lee D, Cho H, Park JW, Lee J, Lee S, So B, Oh CK, Kim Y Tags: Clin Nephrol Source Type: research

IgG4-related disease and idiopathic membranous nephropathy: 
"The clothes do not make the man"
.
IgG4-related disease and idiopathic membranous nephropathy: 
"The clothes do not make the man"
. Clin Nephrol. 2016 Oct 14; Authors: Acevedo Ribó M, Ahijado Hormigos FJ, Díaz F, Romero Molina M, Fernandez Rojo MA, Garcia Rubiales MA, García Diaz E Abstract This case report describes a patient with a previous history of autoimmune pancreatitis secondary to IgG4-related disease, who developed an overt nephrotic syndrome due to membranous nephropathy, surprisingly idiopathic. In all the previously described cases with both concurrent diseases, membranous nephropathy was...
Source: Clinical Nephrology - October 14, 2016 Category: Urology & Nephrology Authors: Acevedo Ribó M, Ahijado Hormigos FJ, Díaz F, Romero Molina M, Fernandez Rojo MA, Garcia Rubiales MA, García Diaz E Tags: Clin Nephrol Source Type: research

A prospective observational study of effectiveness and safety of iron isomaltoside in patients with chronic renal failure and iron deficiency anemia 
.
A prospective observational study of effectiveness and safety of iron isomaltoside in patients with chronic renal failure and iron deficiency anemia
. Clin Nephrol. 2016 Oct 14; Authors: Biggar P, Leistikow F, Walper A Abstract AIMS: The aim of this study was to investigate the effectiveness, safety, and tolerability of iron isomaltoside in routine practical care of iron deficiency anemia (IDA) in patients with chronic renal failure. METHODS: The study included 698 patients with IDA on dialysis or with nondialysis chronic kidney disease (CKD) stages 3 - 5 designated by their physicians for trea...
Source: Clinical Nephrology - October 14, 2016 Category: Urology & Nephrology Authors: Biggar P, Leistikow F, Walper A Tags: Clin Nephrol Source Type: research

Successful return to peritoneal dialysis after a case of relapsing Sphingomonas paucimobilis peritonitis 
.
We report a unique case in which a patient was able to successfully return to PD after relapsing Sphingomonas paucimobilis peritonitis, without apparent effects to dialysis clearance or ultrafiltration.
. PMID: 27730806 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 12, 2016 Category: Urology & Nephrology Authors: Owen J, Washco V, Reisin E Tags: Clin Nephrol Source Type: research

Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients 
.
Association between 1,25-dihydroxyvitamin D and left atrial diameter in pre-dialysis chronic kidney disease patients
. Clin Nephrol. 2016 Oct 12; Authors: Inaguma D, Shinjo H, Tanaka A, Ito E, Kamegai N, Kato A, Mizutani M, Shimogushi H, Otsuka Y, Takeda A, Hasegawa M, Yuzawa Y Abstract OBJECTIVE: To investigate the correlation between serum 1,25-dihydroxyvitamin D (1,25D) levels and left atrial diameter (LAD) using echocardiography in pre-dialysis chronic kidney disease (CKD). SUBJECTS AND METHODS: From an initial population of 487 patients (109 met the exclusion criteria), a total of 378 pati...
Source: Clinical Nephrology - October 12, 2016 Category: Urology & Nephrology Authors: Inaguma D, Shinjo H, Tanaka A, Ito E, Kamegai N, Kato A, Mizutani M, Shimogushi H, Otsuka Y, Takeda A, Hasegawa M, Yuzawa Y Tags: Clin Nephrol Source Type: research

Regression of vascular calcification in a parathyroidectomized patient on dialysis with untreated hypocalcemia over 12-year follow-up 
.
We report a case of severe VC regression in a parathyroidectomized patient on hemodialysis over 12-year follow-up, highlighting the use of calcium-free phosphate binders and a 2.5 mEq/L calcium dialysate for reducing calcium loading, despite persistent asymptomatic hypocalcemia occurrences. This case suggests that phosphate-binder choice and calcium dialysate concentration could be influenced by other components of CKD-MBD besides biochemical parameters, such as the presence of VC, so concluding that asymptomatic hypocalcemia may not be as harmful as once supposed, and conferring greater prognostic weight to the presence o...
Source: Clinical Nephrology - October 10, 2016 Category: Urology & Nephrology Authors: Molina P, Górriz JL, Beltrán S, Vizcaino B, Pallardó LM Tags: Clin Nephrol Source Type: research

The other side of vitamin D therapy: 
a case series of acute kidney injury due to malpractice-related vitamin D intoxication
.
CONCLUSION: This is the largest case series of AKI secondary to vitamin D toxicity ever reported.
. PMID: 27719737 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 10, 2016 Category: Urology & Nephrology Authors: Wani M, Wani I, Banday K, Ashraf M Tags: Clin Nephrol Source Type: research

Bendamustine-induced nephrogenic diabetes insipidus 
.
Bendamustine-induced nephrogenic diabetes insipidus
. Clin Nephrol. 2016 Oct 10;: Authors: Derman B, Jain M, McAninch E, Gashti C Abstract A 59-year-old man presented with polyuria and polydipsia immediately following his sixth cycle of rituximab and bendamustine for chronic lymphocytic leukemia. He initially compensated by increasing his oral fluid intake at home, but later developed septic shock and was admitted with orders to be kept nil per os (NPO). This prompted an episode of acute hypernatremia during which he exhibited continued polyuria with inappropriately dilute urine. Desmopressin challe...
Source: Clinical Nephrology - October 10, 2016 Category: Urology & Nephrology Authors: Derman B, Jain M, McAninch E, Gashti C Tags: Clin Nephrol Source Type: research

Early recognition of gonadal dysgenesis in congenital nephrotic syndrome 
.
We present here three cases of steroid-resistant nephrotic syndrome with WT1 mutation and 46,XY karyotype. Patient 1 and 2 have intron splice site (IVS9+5G> A) mutation. Patient 3 has c.1301G>A (p. R434H) mutation. All cases had normal female external genitalia at birth and eluded the diagnosis of gonadal dysgenesis until later in life. We suggest that chromosomal analysis should be promptly performed in female patients with early-onset steroid-resistant nephrotic syndrome.
. PMID: 27719739 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 10, 2016 Category: Urology & Nephrology Authors: Ukarapong S, Berkovitz G, McElreavey K, Bashamboo A, Bao Y Tags: Clin Nephrol Source Type: research

Second vascular access after failure of the first fistula in the elderly 
.
Second vascular access after failure of the first fistula in the elderly
. Clin Nephrol. 2016 Sep 19; Authors: Hod T, Goldfarb-Rumyantzev AS, Patibandla BK, Narra A, Brown RS Abstract BACKGROUND: In patients with failure of an initial arteriovenous fistula (AVF), a subsequent vascular access is needed before hemodialysis (HD) initiation. METHODS: To assess the optimal access strategy after a failed AVF, we linked data from the US Renal Data System with Medicare claims data identifying 21,436 patients ≥ 67 years old who started HD between January 1, 2005, and December 31, 2008, with an A...
Source: Clinical Nephrology - September 19, 2016 Category: Urology & Nephrology Authors: Hod T, Goldfarb-Rumyantzev AS, Patibandla BK, Narra A, Brown RS Tags: Clin Nephrol Source Type: research

Modulation of circulating endothelial progenitor cells by erythropoiesis-stimulating agents in patients with chronic kidney disease stage G5 and 5D 
.
CONCLUSION: We speculate that the pleiotropic effects of rhEPO and DA beyond their hematopoietic effects may differ between CKD G5 and 5D patients.
. PMID: 27641052 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 19, 2016 Category: Urology & Nephrology Authors: Naito T, Sanaka T, Mikami H, Soga A, Yamatani K, Segawa K, Kawashima M, Yoshikura T, Niwayama J, Nishimura H, Ogawa T, Ando A, Teramoto A, Nitta K Tags: Clin Nephrol Source Type: research

Data completeness as an unmeasured confounder in dialysis facility performance comparison with 1-year follow-up 
.
Data completeness as an unmeasured confounder in dialysis facility performance comparison with 1-year follow-up
. Clin Nephrol. 2016 Sep 19; Authors: Liu J, Krishnan M, Zhou J, Nieman KM, Peng Y, Gilbertson D Abstract AIMS: Standardized mortality and hospitalization ratios (SMRs, SHRs) are used to measure dialysis facility performance in the US, with adjustment for demographics and comorbid conditions derived from the end-stage renal disease (ESRD) Medical Evidence (ME) Report. Sensitivities are low for ME-based comorbidity, and levels of under-reporting may differ among facilities. We aimed to asse...
Source: Clinical Nephrology - September 19, 2016 Category: Urology & Nephrology Authors: Liu J, Krishnan M, Zhou J, Nieman KM, Peng Y, Gilbertson D Tags: Clin Nephrol Source Type: research

30-year follow-up study of IgA nephritis in a Southeast Asian population: an evaluation of the Oxford histological classification 
.
30-year follow-up study of IgA nephritis in a Southeast Asian population: an evaluation of the Oxford histological classification
. Clin Nephrol. 2016 Sep 19; Authors: Woo KT, Lim CC, Foo MW, Loh HL, Jin AZ, Chin YM, Choo JC, Tan PH, Chow KY, Choong LH, Tan HK, Wong KS, Chan CM Abstract BACKGROUND: In 1985 we reported that 11% of a cohort of 151 patients with IgA nephritis (IgAN) had developed end-stage renal disease (ESRD) after a follow-up period of 5 years. 15 years later, 35% had developed ESRD. METHODS: We retrieved 125 stored renal biopsy paraffin blocks of the original cohort. From these...
Source: Clinical Nephrology - September 19, 2016 Category: Urology & Nephrology Authors: Woo KT, Lim CC, Foo MW, Loh HL, Jin AZ, Chin YM, Choo JC, Tan PH, Chow KY, Choong LH, Tan HK, Wong KS, Chan CM Tags: Clin Nephrol Source Type: research

Vitamin D levels, vitamin D supplementation, and prognosis in patients with chronic kidney disease 
.
CONCLUSIONS: Significant Vit D deficiency in CKD can serve as a biological marker indicating patients in whom adverse renal outcomes can be anticipated. Moreover, Vit D3 supplementation and rise of serum 25(OH)D levels may have beneficial influence on hard renal outcomes.
. PMID: 27616756 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 12, 2016 Category: Urology & Nephrology Authors: Namir Y, Cohen MJ, Haviv YS, Slotki I, Shavit L Tags: Clin Nephrol Source Type: research

KDPI score is a strong predictor of future graft function: Moderate KDPI (35  - 85) and high KDPI ( >  85) grafts yield similar graft function and survival
.
KDPI score is a strong predictor of future graft function: Moderate KDPI (35 - 85) and high KDPI (> 85) grafts yield similar graft function and survival
. Clin Nephrol. 2016 Sep 12; Authors: Gupta A, Francos G, Frank AM, Shah AP Abstract BACKGROUND: Efforts have been made to maximize the utility of each organ transplanted. Policy changes to capture unrealized graft years have been implemented utilizing the kidney donor profile index (KDPI). Understanding the impact of KDPI on long-term graft function is critical to an informed organ acceptance decision. METHODS: We reviewed th...
Source: Clinical Nephrology - September 12, 2016 Category: Urology & Nephrology Authors: Gupta A, Francos G, Frank AM, Shah AP Tags: Clin Nephrol Source Type: research

The effect of gender on aminoglycoside-associated nephrotoxicity 
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DISCUSSION: Our meta-analysis contradicts the generally held consensus that female gender is an independent risk factor for the development of AAN. Our findings may have much wider implications insofar as AAN cannot be used as an example to support the conclusion of the KDIGO Clinical Practice Guidelines that female gender is an independent risk factor for AKI.
. PMID: 27616758 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 12, 2016 Category: Urology & Nephrology Authors: Neugarten J, Golestaneh L Tags: Clin Nephrol Source Type: research

IL-1 β promotes tubulointerstitial injury in 
MPO-ANCA-associated glomerulonephritis
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CONCLUSIONS: Sterile inflammation leads to the formation of ANCA-mediated neutrophil extracellular traps (NETs), which may stimulate macrophages and dendritic cells via TLR4 and induce NF-κB-dependent mRNA expression and translation of pro-IL-1β. Simultaneously, damage-associated molecular pattern signals resulting from NETs promote NLRP3 inflammasome-dependent processing and release mature active IL-1β. Sterile inflammation utilizing the NLRP3 inflammasome might be a characteristic reaction limited to the tubulointerstitium. Thus, neutralizing IL-1β may be a promising strategy to suspend the progress ...
Source: Clinical Nephrology - September 12, 2016 Category: Urology & Nephrology Authors: Tashiro M, Sasatomi Y, Watanabe R, Watanabe M, Miyake K, Abe Y, Yasuno T, Ito K, Ueki N, Hamauchi A, Noda R, Hisano S, Nakashima H Tags: Clin Nephrol Source Type: research

Prevention of recurrence of atypical hemolytic uremic syndrome post renal transplant with the use of higher-dose eculizumab 
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We describe a case that highlights the need to monitor the effects of eculizumab on the complement system and in this case alter the dosage. Despite taking the standard recommended dose of eculizumab for an adult, this aHUS patient developed a low-grade thrombotic microangiopathy on biopsy within months of renal transplantation. Complement assays (trough CH50) showed small amounts of residual terminal pathway activity suggesting inadequate complement blockade on 1,200 mg eculizumab every 2 weeks. Following an increase in the dose of eculizumab to 1,500 mg every 2 weeks, lactate dehydrogenase (LDH), proteinuria, a...
Source: Clinical Nephrology - September 12, 2016 Category: Urology & Nephrology Authors: Riddell A, Goodship T, Bingham C Tags: Clin Nephrol Source Type: research

A systematic literature search and review of sodium concentrations of body fluids 
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CONCLUSIONS: This is the first in-depth review of verifiable sodium concentrations of body fluids most commonly lost in hospitalized patients. Sodium concentrations are fluid-specific and consistent. Sodium concentrations for diarrhea are associated with specific mechanisms/causes. These data should be useful to more accurately replace sodium and water content for specific body fluid losses.
. PMID: 27616761 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 12, 2016 Category: Urology & Nephrology Authors: Kaptein EM, Sreeramoju D, Kaptein JS, Kaptein MJ Tags: Clin Nephrol Source Type: research

Icodextrin-induced acute pancreatitis in a peritoneal dialysis patient: a case report and literature review 
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We describe a case of a man with end-stage renal disease (ESRD) on PD who developed acute pancreatitis following icodextrin use. We also provide a novel possible mechanism for understanding how icodextrin causes AP.
. PMID: 27616762 [PubMed - as supplied by publisher] (Source: Clinical Nephrology)
Source: Clinical Nephrology - September 12, 2016 Category: Urology & Nephrology Authors: Rubinstein S, Franjul R, Surana S, Fogel J Tags: Clin Nephrol Source Type: research

Acquired hemophilia A that developed during the induction of hemodialysis: the use of double-filtration plasmapheresis 
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We present a case of AHA that developed during induction of dialysis and treatment with double filtration plasmapheresis (DFPP). An 86-year-old man with chronic kidney disease was admitted to our hospital with multiple subcutaneous hemorrhages. Because of his prolonged activated partial thromboplastin time (aPTT) and high titer of inhibitors to FVIII, he was diagnosed with AHA, and prednisolone treatment was started. After 3 weeks of steroid therapy, his renal function deteriorated, and dialysis was needed. We performed femoral catheter placement under administration of recombinant activated factor VII (rFVIIa) to prevent ...
Source: Clinical Nephrology - August 22, 2016 Category: Urology & Nephrology Authors: Imafuku A, Sawa N, Ubara Y, Takaichi K Tags: Clin Nephrol Source Type: research

The International Society of Nephrology (ISN). Roles and challenges in Africa and other resource-limited communities.
Abstract ISN (the International Society of Nephrology) is a global organization with more than 9,000 members in 130 countries. The ISN's mission is to "advance the diagnosis, treatment, and prevention of kidney diseases in the developing and developed world". ISN delivers this mission in low-resource settings through its five education and training programs available exclusively to low- and middle-income countries. These programs are designed to enable sustainable growth in capacity in nephrology and related disciplines to provide the basis for the improvement of care for kidney patients worldwide. ISN a...
Source: Clinical Nephrology - August 10, 2016 Category: Urology & Nephrology Authors: Feehally J Tags: Clin Nephrol Source Type: research