Efficacy of roxadustat in maintenance hemodialysis patients with erythropoietin-hyporesponsive anemia
CONCLUSION: Roxadustat could effectively improve anemia; the PLR and dialysis age were independent predictors of roxadustat efficacy in dialysis patients with EPO hypo-responsive anemia.PMID:37969110 | DOI:10.5414/CN111109 (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 16, 2023 Category: Urology & Nephrology Authors: Xiaoshuang Wang Hezhou Cai Haifan Xu Liqun Chen Source Type: research

Characteristics of registered research in peritoneal dialysis: Past and present
The objective of this study was to describe the current landscape of PD clinical trials to assess trends and gaps in clinical research. An advanced search was completed through ClinicalTrials.gov, yielding 248 studies. Descriptive statistics and Fisher exact tests were used for statistical analysis. Most studies were completed (197, 79.4%), did not indicate a phase (143, 57.7%), were academically sponsored (156, 62.9%), or conducted in Asia (88, 35.5%). There has been overall growth in PD clinical trials since 1995. The type of phase was related to study location (p = 0.008). The type of study intervention was related to s...
Source: Clinical Nephrology - November 16, 2023 Category: Urology & Nephrology Authors: Martin L Li Ankush Bajaj Uttam Bhetuwal Ankur D Shah Source Type: research

Plasma neutrophil gelatinase-associated lipocalin predicts renal tubulointerstitial injury in patients with IgA nephropathy
CONCLUSION: The pNGAL levels in patients with IgAN are positively correlated with the Lee and Oxford classifications of T scores. The level of pNGAL in IgAN patients is found to be a prominent indicator for identification of renal tubulointerstitial injury and perhaps this feature may make it a non-invasive predictor for progression of IgAN.PMID:37942929 | DOI:10.5414/CN111270 (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 9, 2023 Category: Urology & Nephrology Authors: Wanwan Zhao Jun Jiang Wei Chen Source Type: research

Plasma neutrophil gelatinase-associated lipocalin predicts renal tubulointerstitial injury in patients with IgA nephropathy
CONCLUSION: The pNGAL levels in patients with IgAN are positively correlated with the Lee and Oxford classifications of T scores. The level of pNGAL in IgAN patients is found to be a prominent indicator for identification of renal tubulointerstitial injury and perhaps this feature may make it a non-invasive predictor for progression of IgAN.PMID:37942929 | DOI:10.5414/CN111270 (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 9, 2023 Category: Urology & Nephrology Authors: Wanwan Zhao Jun Jiang Wei Chen Source Type: research

Plasma neutrophil gelatinase-associated lipocalin predicts renal tubulointerstitial injury in patients with IgA nephropathy
CONCLUSION: The pNGAL levels in patients with IgAN are positively correlated with the Lee and Oxford classifications of T scores. The level of pNGAL in IgAN patients is found to be a prominent indicator for identification of renal tubulointerstitial injury and perhaps this feature may make it a non-invasive predictor for progression of IgAN.PMID:37942929 | DOI:10.5414/CN111270 (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 9, 2023 Category: Urology & Nephrology Authors: Wanwan Zhao Jun Jiang Wei Chen Source Type: research

Plasma neutrophil gelatinase-associated lipocalin predicts renal tubulointerstitial injury in patients with IgA nephropathy
CONCLUSION: The pNGAL levels in patients with IgAN are positively correlated with the Lee and Oxford classifications of T scores. The level of pNGAL in IgAN patients is found to be a prominent indicator for identification of renal tubulointerstitial injury and perhaps this feature may make it a non-invasive predictor for progression of IgAN.PMID:37942929 | DOI:10.5414/CN111270 (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 9, 2023 Category: Urology & Nephrology Authors: Wanwan Zhao Jun Jiang Wei Chen Source Type: research

Plasma neutrophil gelatinase-associated lipocalin predicts renal tubulointerstitial injury in patients with IgA nephropathy
CONCLUSION: The pNGAL levels in patients with IgAN are positively correlated with the Lee and Oxford classifications of T scores. The level of pNGAL in IgAN patients is found to be a prominent indicator for identification of renal tubulointerstitial injury and perhaps this feature may make it a non-invasive predictor for progression of IgAN.PMID:37942929 | DOI:10.5414/CN111270 (Source: Clinical Nephrology)
Source: Clinical Nephrology - November 9, 2023 Category: Urology & Nephrology Authors: Wanwan Zhao Jun Jiang Wei Chen Source Type: research

Comparative analysis of roxadustat efficacy between maintenance hemodialysis and peritoneal dialysis patients
CONCLUSION: Roxadustat can effectively increase the hemoglobin level of maintenance dialysis patients, even in those with low erythropoietin response or erythropoietin resistance, and, more importantly, its efficacy in PD patients was more significant.PMID:37877297 | DOI:10.5414/CN111144 (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 25, 2023 Category: Urology & Nephrology Authors: Liling Zhang Yan Huang Defeng Yin Tingting Zhu Qi Liu Ying Li Linwang Gan Source Type: research

Pitfalls in anticoagulant-related nephropathy
Clin Nephrol. 2023 Oct 25. doi: 10.5414/CN111156. Online ahead of print.ABSTRACTAnticoagulant-related nephropathy (ARN) is a rare but important disease and often misdiagnosed. The hallmark of the diagnosis is acute kidney injury (AKI) superimposed on preexisting kidney disease due to anticoagulation-induced glomerular hemorrhage with histologic features of widespread tubular obstruction by red blood cells and red cell casts. As ARN is a diagnosis of exclusion only proven by renal biopsy, the diagnosis is often unlikely to be confirmed histologically because of fear of biopsy-related bleeding during anticoagulant therapy. G...
Source: Clinical Nephrology - October 25, 2023 Category: Urology & Nephrology Authors: Romeo V Kock Kenrick Berend Sandrine Florquin Hugo Ten Cate Source Type: research

Higher serum trimethylamine N-oxide (TMAO) levels are associated with increased visceral fat in hemodialysis patients
CONCLUSION: Our results showed that there was a significant positive correlation between serum TMAO levels and visceral fat in HD patients, which suggested that TMAO may predict cardiovascular risk through increased visceral fat.PMID:37877299 | DOI:10.5414/CN111163 (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 25, 2023 Category: Urology & Nephrology Authors: Shu-Hong Bi Chunyan Su Ping Yang Xianhua Zhang Yue Wang Wen Tang Wenling Yang Lian He Source Type: research

The reasons for comparative effectiveness clinical trials of arteriovenous fistula versus graft strategy in older adults on hemodialysis with a catheter
Clin Nephrol. 2023 Oct 25. doi: 10.5414/CN111227. Online ahead of print.ABSTRACTClinicians and patients are guided by observational studies to make one of the most consequential decisions for patients with advanced kidney disease: the selection of the "right" hemodialysis vascular access. More than a decade ago, a call for randomized clinical trials was made to equitably compare clinical outcomes between arteriovenous (AV) fistulas (AVFs) and AV grafts (AVGs). Mounting evidence suggests that trade-offs between AVF- and AVGrelated outcomes are context dependent. In this article, we summarize four streams of evidence that co...
Source: Clinical Nephrology - October 25, 2023 Category: Urology & Nephrology Authors: Mariana Murea Michael Allon Source Type: research

Comparative analysis of roxadustat efficacy between maintenance hemodialysis and peritoneal dialysis patients
CONCLUSION: Roxadustat can effectively increase the hemoglobin level of maintenance dialysis patients, even in those with low erythropoietin response or erythropoietin resistance, and, more importantly, its efficacy in PD patients was more significant.PMID:37877297 | DOI:10.5414/CN111144 (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 25, 2023 Category: Urology & Nephrology Authors: Liling Zhang Yan Huang Defeng Yin Tingting Zhu Qi Liu Ying Li Linwang Gan Source Type: research

Pitfalls in anticoagulant-related nephropathy
Clin Nephrol. 2023 Oct 25. doi: 10.5414/CN111156. Online ahead of print.ABSTRACTAnticoagulant-related nephropathy (ARN) is a rare but important disease and often misdiagnosed. The hallmark of the diagnosis is acute kidney injury (AKI) superimposed on preexisting kidney disease due to anticoagulation-induced glomerular hemorrhage with histologic features of widespread tubular obstruction by red blood cells and red cell casts. As ARN is a diagnosis of exclusion only proven by renal biopsy, the diagnosis is often unlikely to be confirmed histologically because of fear of biopsy-related bleeding during anticoagulant therapy. G...
Source: Clinical Nephrology - October 25, 2023 Category: Urology & Nephrology Authors: Romeo V Kock Kenrick Berend Sandrine Florquin Hugo Ten Cate Source Type: research

Higher serum trimethylamine N-oxide (TMAO) levels are associated with increased visceral fat in hemodialysis patients
CONCLUSION: Our results showed that there was a significant positive correlation between serum TMAO levels and visceral fat in HD patients, which suggested that TMAO may predict cardiovascular risk through increased visceral fat.PMID:37877299 | DOI:10.5414/CN111163 (Source: Clinical Nephrology)
Source: Clinical Nephrology - October 25, 2023 Category: Urology & Nephrology Authors: Shu-Hong Bi Chunyan Su Ping Yang Xianhua Zhang Yue Wang Wen Tang Wenling Yang Lian He Source Type: research

The reasons for comparative effectiveness clinical trials of arteriovenous fistula versus graft strategy in older adults on hemodialysis with a catheter
Clin Nephrol. 2023 Oct 25. doi: 10.5414/CN111227. Online ahead of print.ABSTRACTClinicians and patients are guided by observational studies to make one of the most consequential decisions for patients with advanced kidney disease: the selection of the "right" hemodialysis vascular access. More than a decade ago, a call for randomized clinical trials was made to equitably compare clinical outcomes between arteriovenous (AV) fistulas (AVFs) and AV grafts (AVGs). Mounting evidence suggests that trade-offs between AVF- and AVGrelated outcomes are context dependent. In this article, we summarize four streams of evidence that co...
Source: Clinical Nephrology - October 25, 2023 Category: Urology & Nephrology Authors: Mariana Murea Michael Allon Source Type: research