Cytokines, breast cancer stem cells (BCSCs) and chemoresistance.
Abstract Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce adverse prognosis, such as metastasis. In recent years, the progress of research on cytokine-modulated tumor microenvironment and breast cancer stem cells (BCSCs) has shed light on defining the mechanisms of drug resistance gradually. In this review, we have discussed cytokine regulation on breast cancer chemoresistance. Cytokines can affect tumor cell behavior or reprogram tumor niche through specifi...
Source: Clinical Breast Cancer - September 3, 2018 Category: Cancer & Oncology Authors: Chen W, Qin Y, Liu S Tags: Clin Transl Med Source Type: research

ESR1-promoter-methylation status in primary breast cancer and its corresponding metastases.
Abstract The role of ESR1 methylation in breast cancer and its influence on disease progression is not yet fully understood. Healthy breast tissue usually does not show ESR1 promoter methylation, whereas the frequency of ESR1 methylation appears to increase in primary breast cancer and in metastatic disease. Although women with ER positive breast cancer have a good prognosis, some will relapse. We aimed to evaluate the methylation status of ESR1 in primary breast cancer and its corresponding metastases by a methylation-specific real-time PCR and to correlate the methylation status with clinical outcome. Women who ...
Source: Clinical Breast Cancer - September 1, 2018 Category: Cancer & Oncology Authors: Kirn V, Strake L, Thangarajah F, Richters L, Eischeid H, Koitzsch U, Odenthal M, Fries J Tags: Clin Exp Metastasis Source Type: research

5-HT serotonin receptors modulate mitogenic signaling and impact tumor cell viability.
Abstract Symptoms of depression are present in over half of all cancer patients, and selective serotonin reuptake inhibitor (SSRI) anti-depressant medications are prescribed to nearly a quarter of these individuals in order to cope with their disease. Previous studies have provided evidence that elevated serotonin (5-HT) and serotonin receptor levels may contribute to oncogenic progression, yet little is known regarding the mechanism by which this occurs. The data demonstrated that serotonin receptor mRNAs and proteins are expressed across diverse cancer types, and that serotonin stimulation of tumor cells activat...
Source: Clinical Breast Cancer - August 30, 2018 Category: Cancer & Oncology Authors: Ballou Y, Rivas A, Belmont A, Patel L, Amaya CN, Lipson S, Khayou T, Dickerson EB, Nahleh Z, Bryan BA Tags: Mol Clin Oncol Source Type: research

Exemestane and Everolimus combination treatment of hormone receptor positive, HER2 negative metastatic breast cancer: A retrospective study of 9 cancer centers in the Campania Region (Southern Italy) focused on activity, efficacy and safety.
ura M Abstract Exemestane (Exe) in combination with Everolimus (Eve) represents an important treatment option for patients diagnosed with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer (MBC), which was previously treated with non-steroidal aromatase inhibitors (NSAI). Data from unselected populations may be useful for defining the optimal therapeutic algorithm within a clinical setting. Data from 264 HR+, HER2-MBC patients who received Exe-Eve treatment in combination, following the failure of NSAIs was retrospectively analyzed. Different lines o...
Source: Clinical Breast Cancer - August 30, 2018 Category: Cancer & Oncology Authors: Riccardi F, Colantuoni G, Diana A, Mocerino C, Cartenì G, Lauria R, Febbraro A, Nuzzo F, Addeo R, Marano O, Incoronato P, De Placido S, Ciardiello F, Orditura M Tags: Mol Clin Oncol Source Type: research

Abscopal effect following radiation monotherapy in breast cancer: A case report.
Abstract Radiotherapy has been found to be valuable for the control and eradication of local foci in various malignant tumors. The abscopal effect is determined as a systemic antitumor response at a distance from the irradiation site invoked by local irradiation. We herein present an extremely rare case of breast cancer in a 64-year-old woman, in whom the abscopal effect was observed after radiotherapy induced an antitumor response in all metastatic lesions, without any combination therapy. The patient was admitted to our hospital complaining of a breast mass and pain at the left hip, and was diagnosed with breast...
Source: Clinical Breast Cancer - August 30, 2018 Category: Cancer & Oncology Authors: Azami A, Suzuki N, Azami Y, Seto I, Sato A, Takano Y, Abe T, Teranishi Y, Tachibana K, Ohtake T Tags: Mol Clin Oncol Source Type: research

Higher efficacy and complete response with administration of eribulin for recurrent squamous cell breast carcinoma: A case report.
Abstract Squamous cell carcinoma is a rare histological type of breast cancer classified as metaplastic carcinoma. Metaplastic carcinoma involves differentiation of the breast glandular duct cells into mesenchymal tissues. While the chemotherapy regimen for metaplastic carcinoma is often similar to that for invasive ductal carcinoma, recurrence is associated with a poor prognosis due to the inadequate therapeutic efficacy of the regimen. We herein present the case of a 42-year-old female patient who underwent mastectomy of the right breast and right axillary node lymphadenectomy for T4N3aM0 breast cancer stage. Th...
Source: Clinical Breast Cancer - August 30, 2018 Category: Cancer & Oncology Authors: Goto Y, Yoshida T, Kimura M Tags: Mol Clin Oncol Source Type: research

Prognostic value of Ki67 analysed by cytology or histology in primary breast cancer.
CONCLUSIONS: This study shows considerable differences in the prognostic value of Ki67 but not ER in breast cancer depending on the diagnostic method. Furthermore, our findings show that both methods are insufficient in predicting true molecular subtypes. PMID: 29588372 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 29, 2018 Category: Cancer & Oncology Authors: Robertson S, Stålhammar G, Darai-Ramqvist E, Rantalainen M, Tobin NP, Bergh J, Hartman J Tags: J Clin Pathol Source Type: research

FOXO3a expression is associated with lymph node metastasis and poor disease-free survival in triple-negative breast cancer.
CONCLUSION: Among FOXO members, FOXO3a may have a potential role in promoting tumour cell migration and proliferation and may serve as a prognostic biomarker and a potential therapeutic target for TNBC. PMID: 29588373 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 29, 2018 Category: Cancer & Oncology Authors: Rehman A, Kim Y, Kim H, Sim J, Ahn H, Chung MS, Shin SJ, Jang K Tags: J Clin Pathol Source Type: research

Diagnostic concordance of reporting lymphovascular invasion in breast cancer.
CONCLUSIONS: The concordance of reporting LVI is variable. Cases without LVI and those with multiple involved vessels are likely to have the highest concordance and the highest detection rates. PMID: 29599396 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 29, 2018 Category: Cancer & Oncology Authors: Rakha EA, Abbas A, Pinto Ahumada P, ElSayed ME, Colman D, Pinder SE, Ellis IO Tags: J Clin Pathol Source Type: research

The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia.
Abstract Based on the 2010 version, the 2017 World Health Organization (WHO 2017) classification is for pancreatic neuroendocrine neoplasms (PanNEN). The WHO 2017 classification introduces the novel well-differentiated neuroendocrine tumor of high grade (NET G3). A sharp distinction between NET and poorly differentiated neuroendocrine carcinoma (NEC) is emphasized to highlight substantial biological differences. Further changes comprise the definition of mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN), to accommodate all grades of both neoplasm components, and the abolition of preneoplastic lesions given ...
Source: Clinical Breast Cancer - August 14, 2018 Category: Cancer & Oncology Authors: Inzani F, Petrone G, Rindi G Tags: Endocrinol Metab Clin North Am Source Type: research

Effects of Exercise on Sleep in Women with Breast Cancer: A Systematic Review.
This article describes the scope and quality of evidence related to exercise interventions to improve sleep in women with breast cancer. Fifteen studies met the criteria and 12 were judged to be excellent quality. The most frequent intervention was walking, primarily during the time of chemotherapy. Eleven studies reported postintervention improvement in sleep deficiency. Most yoga, qigong, and dance intervention studies reported no differences between groups. Emerging evidence exists for the effectiveness of aerobic exercise to improve various sleep outcomes in women with breast cancer. PMID: 30098755 [PubMed - in pr...
Source: Clinical Breast Cancer - August 14, 2018 Category: Cancer & Oncology Authors: Matthews EE, Janssen DW, Djalilova DM, Berger AM Tags: Sleep Med Clin Source Type: research

Evaluation of the effects of sensorimotor exercise on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy.
t T Abstract INTRODUCTION: Breast cancer is the most common cancer disease of women in industrialized countries. Neurotoxic chemotherapy drugs are known to harm peripheral nerves and cause a chemotherapy-induced peripheral neuropathy (CIPN). CIPN is one of the most common adverse events associated with Paclitaxel chemotherapy and may remain present long after the termination of chemotherapy. Thus, it reduces the patients' quality of life (QoL) both during chemotherapy and onwards, and can impose a danger on breast cancer survivors due to an increased risk of falling and fall-related injuries. METHODS: The aim...
Source: Clinical Breast Cancer - August 7, 2018 Category: Cancer & Oncology Authors: Vollmers PL, Mundhenke C, Maass N, Bauerschlag D, Kratzenstein S, Röcken C, Schmidt T Tags: J Cancer Res Clin Oncol Source Type: research

Novel evaluation scale for QOL (QOL-ACD-BP) in preoperative chemotherapy for breast cancer.
CONCLUSION: Our study shows that QOL after POC may also affect prognosis and supported the importance of maintaining QOL in cancer treatment. In patients with breast cancer treated with POC, QOL-ACD-BP, which is a new QOL evaluation index, was found to be a useful tool for predicting the patients' prognosis. PMID: 29779135 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 1, 2018 Category: Cancer & Oncology Authors: Takada K, Kashiwagi S, Goto W, Asano Y, Takahashi K, Morisaki T, Takashima T, Tomita S, Hirakawa K, Ohira M Tags: J Cancer Res Clin Oncol Source Type: research

TIS21/BTG2 inhibits breast cancer growth and progression by differential regulation of mTORc1 and mTORc2-AKT1-NFAT1-PHLPP2 signaling axis.
CONCLUSIONS: TIS21/BTG2 significantly lost in the infiltrating ductal carcinoma, but it can inhibit cancer growth via the TIS21/BTG2-tsc1/2-mTORc1-p70S6K axis and downregulate cancer progression via the TIS21/BTG2-mTORc2-AKT1-NFAT1-PHLPP2 pathway. PMID: 29808317 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 1, 2018 Category: Cancer & Oncology Authors: Sundaramoorthy S, Devanand P, Ryu MS, Song KY, Noh DY, Lim IK Tags: J Cancer Res Clin Oncol Source Type: research

Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer.
CONCLUSIONS: FRα is overexpressed in high-grade TNBC and post-chemotherapy residual tumors. It participates in cancer cell signaling and presents a promising target for therapeutic strategies such as antibody-drug conjugates, or passive immunotherapy priming Fc-mediated anti-tumor immune cell responses. PMID: 30068707 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 1, 2018 Category: Cancer & Oncology Authors: Cheung A, Opzoomer JW, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, Marlow R, Francesch-Domenech E, Fittall MW, Dominguez Rodriguez D, Clifford A, Badder L, Patel N, Mele S, Pellizzari G, Bax HJ, Crescioli S, Petranyi G, Larcombe-Young D, Josephs DH, Cane Tags: Clin Cancer Res Source Type: research

Interobserver variation in the diagnosis of fibroepithelial lesions of the breast: a multicentre audit by digital pathology.
CONCLUSION: Accurate and reproducible diagnosis of equivocal FELs is difficult, particularly on CNB, resulting in poor interobserver agreement and suboptimal accuracy. Given the diagnostic difficulty, and surgical implications, equivocal FELs should be reported in consultation with experienced breast pathologists as a small number of benign FAs can be selected out from equivocal lesions. PMID: 29440134 [PubMed - indexed for MEDLINE] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 31, 2018 Category: Cancer & Oncology Authors: Dessauvagie BF, Lee AHS, Meehan K, Nijhawan A, Tan PH, Thomas J, Tie B, Treanor D, Umar S, Hanby AM, Millican-Slater R Tags: J Clin Pathol Source Type: research

Experiences of breast cancer related lymphoedema and the use of reflexology for managing swelling: A qualitative study.
CONCLUSION: The main conclusion from this qualitative evaluation was that participants perceived benefit on physical and psychological levels. Participation in the study appeared to help re-engagement with normal life. Further research is needed to quantify the changes in these parameters. PMID: 30057039 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 31, 2018 Category: Cancer & Oncology Authors: Whatley J, Street R, Kay S Tags: Complement Ther Clin Pract Source Type: research

Can yoga have any effect on shoulder and arm pain and quality of life in patients with breast cancer? A randomized, controlled, single-blind trial.
CONCLUSION: Yoga was an effective and safe exercise for alleviating shoulder and arm pain, which is a complication with a high prevalence in patients with breast cancer. PMID: 30057055 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 31, 2018 Category: Cancer & Oncology Authors: Eyigor S, Uslu R, Apaydın S, Caramat I, Yesil H Tags: Complement Ther Clin Pract Source Type: research

Radiation Dermatitis: A Prevention Protocol for Patients With Breast Cancer.
The objectives of this study were to (a) improve clinicians' knowledge of screening, assessment, and prevention of RD in patients with breast cancer and (b) decrease the incidence of RD by 10% at a tertiary care cancer center. METHODS: Center-wide standards of care were created and implemented. A retrospective chart analysis was performed before and after protocol implementation. An education session was used to analyze protocol effectiveness. FINDINGS: Surveys completed by nurses (N = 11) before and after the education session demonstrated a significant increase in overall confidence in assessing RD. Statistical...
Source: Clinical Breast Cancer - July 24, 2018 Category: Cancer & Oncology Authors: Lucas AS, Lacouture M, Schneider SM Tags: Clin J Oncol Nurs Source Type: research

Bibliotherapy: Appraisal of Evidence for Patients Diagnosed With Cancer.
Abstract An appraisal of the evidence on the efficacy of bibliotherapy on anxiety, distress, and coping in patients with cancer is lacking in the literature. Bibliotherapy is a self-help intervention using a variety of tools, such as self-help workbooks, pamphlets, novels, and audiobooks, to improve mental health. This review identified nine original research articles that examined bibliotherapy as an intervention to alleviate the psychological issues associated with a cancer diagnosis. Data synthesis from these studies provides preliminary evidence that bibliotherapy is an acceptable and beneficial adjunct therap...
Source: Clinical Breast Cancer - July 24, 2018 Category: Cancer & Oncology Authors: Malibiran R, Tariman JD, Amer K Tags: Clin J Oncol Nurs Source Type: research

Breast Cancer Genetics and Indications for Prophylactic Mastectomy.
Abstract As more genetic information becomes available to inform breast cancer treatment, screening, and risk-reduction approaches, clinicians must become more knowledgeable about possible genetic testing and prevention strategies, including outcomes, benefits, risks, and limitations. The aim of this article is to define and distinguish high- and moderate-risk breast cancer predisposition genes, summarize the clinical recommendations that may be considered based on the identification of pathogenic variants (mutations) in these genes, and indications for risk-reducing and contralateral prophylactic mastectomy. ...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Krontiras H, Farmer M, Whatley J Tags: Surg Clin North Am Source Type: research

Incorporating Biologic Factors into the American Joint Committee on Cancer Breast Cancer Staging System: Review of the Supporting Evidence.
Abstract The American Joint Committee on Cancer staging system has evolved in response to improved imaging, refined surgical techniques, enhanced pathologic evaluation, and greater understanding of tumor biology. The 8th edition has introduced clinical and pathologic prognostic stages for breast cancer that incorporate biologic variables (grade, estrogen/progesterone receptor status, HER2 status, multigene panels) with TNM categories that define the anatomic stage. The prognostic staging system facilitates more refined stratification than the anatomic stage with respect to survival and is an important advance that...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Weiss A, King TA, Hunt KK, Mittendorf EA Tags: Surg Clin North Am Source Type: research

Impact of Advancing Technology on Diagnosis and Treatment of Breast Cancer.
Abstract New emerging breast imaging techniques have shown great promise in breast cancer screening, evaluation of extent of disease, and response to neoadjuvant therapy. Tomosynthesis, allows 3-dimensional imaging of the breast, and increases breast cancer detection. Fast abbreviated MRI has reduced time and costs associated with traditional breast MRI while maintaining cancer detection. Diffusion-weighted imaging is a functional MRI technique that does not require contrast and has shown potential in screening, lesion characterization and also evaluation of treatment response. New image-guided preoperative locali...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Greenwood HI, Dodelzon K, Katzen JT Tags: Surg Clin North Am Source Type: research

Ductal Carcinoma In Situ.
Abstract Ductal carcinoma in situ has been stable in incidence for a decade and has an excellent prognosis. Breast conservation therapy is safe and effective for most patients. Adjuvant whole breast radiation therapy is recommended to reduce the risk of local recurrence. Accelerated partial breast irradiation is a promising alternative to decrease toxicity and improve cosmetic results. Adjuvant hormonal therapy can reduce local recurrence, but should be used cautiously. Future directions in management include developing predictive tools for guidance for use of adjuvant therapy and selecting low-risk patients ...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Fu F, Gilmore RC, Jacobs LK Tags: Surg Clin North Am Source Type: research

Management of the Axilla in the  Patient with Breast Cancer.
Management of the Axilla in the Patient with Breast Cancer. Surg Clin North Am. 2018 Aug;98(4):747-760 Authors: Park KU, Caudle A Abstract Evaluation of the axillary lymph nodes is critical in the management of breast cancer because it is a key predictor of survival outcome. Surgeons must not only be able to perform sentinel lymph node dissection with high accuracy but also understand the implications of the results. Management of clinically node-negative and node-positive cases can vary significantly, as described in this review. With emerging data, management of the axilla in breast cancer will...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Park KU, Caudle A Tags: Surg Clin North Am Source Type: research

Definition and Management of Positive Margins for Invasive Breast Cancer.
Abstract Breast-conserving surgery (BCS) followed by radiation therapy is the current standard of care for early stage breast cancer. Successful BCS necessitates complete tumor resection with clear margins at the pathologic assessment of the specimen ("no ink on tumor"). The presence of positive margins warrants additional surgery to obtain negative final margins, which has significant physical, psychological, and financial implications for the patient. The challenge lies in developing accurate real-time intraoperative margin assessment techniques to minimize the presence of "ink on tumor" and ...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Nayyar A, Gallagher KK, McGuire KP Tags: Surg Clin North Am Source Type: research

Future Developments in Neoadjuvant Therapy for Triple-Negative Breast Cancer.
Abstract Breast cancer is the 2nd leading cause of cancer-related death in women in the United States. In general, advances in targeted treatment for breast cancer have improved over the last twenty years, except in the triple-negative breast cancer (TNBC) subtype. TNBC is an aggressive breast cancer subtype with limited treatment options as compared to hormone positive breast cancers. Recently, genomic profiling of TNBC shows promise in aiding clinicians to develop personalized targeted agents. Prioritizing novel molecular-based therapies in the neoadjuvant setting may help investigators understand mechanisms of ...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Moore-Smith L, Forero-Torres A, Stringer-Reasor E Tags: Surg Clin North Am Source Type: research

Inflammatory Breast Cancer: What to Know About This Unique, Aggressive Breast Cancer.
Abstract Inflammatory breast cancer (IBC) is a rare form of breast cancer that accounts for only 2% to 4% of all breast cancer cases. Despite its low incidence, IBC contributes to 7% to 10% of breast cancer caused mortality. Despite ongoing international efforts to formulate better diagnosis, treatment, and research, the survival of patients with IBC has not been significantly improved, and there are no therapeutic agents that specifically target IBC to date. The authors present a comprehensive overview that aims to assess the present and new management strategies of IBC. PMID: 30005774 [PubMed - in process] ...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Menta A, Fouad TM, Lucci A, Le-Petross H, Stauder MC, Woodward WA, Ueno NT, Lim B Tags: Surg Clin North Am Source Type: research

The Evolving Role of Postmastectomy Radiation Therapy.
Abstract Throughout various eras of breast cancer therapy, postmastectomy radiation therapy (PMRT) has played an important role in the treatment of locally advanced breast cancer. PMRT decreases locoregional recurrence and may improve overall survival in patients with tumors over 5 cm or positive lymph nodes. As novel cancer therapies improve survival in breast cancer, the role of radiation therapy is evolving. Individualized recommendations for PMRT dependent on pathologic response after neoadjuvant systemic therapy are under investigation. This review summarizes the role of PMRT during breast cancer therapy...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Everett AS, De Los Santos JF, Boggs DH Tags: Surg Clin North Am Source Type: research

Breast Cancer in the Elderly.
Abstract With increasing life expectancy and growth of the elderly US population, it becomes paramount that breast cancer research focuses more on the prevention, screening, and treatment of these patients. Age is no longer a cutoff for managing breast cancer in the elderly. Studies have shown the current undertreatment of cancer undermines survival, but the tide is turning to provide evidence-based medicine for the elderly. More often, clinicians and surgeons look not only at tumor-specific characteristics of breast cancer but also the functionality, tolerance, comorbidities, and life expectancy of patients to de...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Varghese F, Wong J Tags: Surg Clin North Am Source Type: research

Evolution of Operative Technique for Mastectomy.
Abstract The radical mastectomy was the mainstay of breast cancer treatment through the majority of the twentieth century. However, as the understanding of breast cancer increased, the indications for more extensive surgical intervention decreased. The mastectomy has evolved so that skin-sparing or nipple-sparing mastectomy can be performed in the majority of women who undergo mastectomy currently. Today, nearly 40% of all women undergo mastectomy for breast cancer. The improved cosmetic appearance associated with skin- or nipple-sparing mastectomies does not compromise oncologic outcomes. PMID: 30005777 [Pub...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Jones C, Lancaster R Tags: Surg Clin North Am Source Type: research

Role of Operative Management in Stage IV  Breast Cancer.
Role of Operative Management in Stage IV Breast Cancer. Surg Clin North Am. 2018 Aug;98(4):859-868 Authors: Teshome M Abstract The role of operative therapy in stage IV breast cancer continues to evolve with advances in therapy and improvements in survival among this population. Traditionally surgery was performed with palliative intent to alleviate symptoms related to the intact breast primary. Several retrospective studies have challenged this paradigm, demonstrating survival advantage with surgery in de novo metastatic disease. Prospective studies are ongoing and maturing data. A comprehensive...
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Teshome M Tags: Surg Clin North Am Source Type: research

Management of Breast Cancer.
PMID: 30005782 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 15, 2018 Category: Cancer & Oncology Authors: Parker CC Tags: Surg Clin North Am Source Type: research

Molecular biology as a tool for the treatment of cancer.
Abstract Cancer is a genetic disease characterized by uncontrolled cell growth and metastasis. Cancer can have a number of causes, such the activation of oncogenes, the inactivation of tumor-suppressing genes, mutagenesis provoked by external factors, and epigenetic modifications. The development of diagnostic tools and treatments using a molecular biological approach permits the use of sensitive, low-cost, noninvasive tests for cancer patients. Biomarkers can be used to provide rapid, personalized oncology, in particular the molecular diagnosis of chronic myeloid leukemia, and gastric, colon, and breast cancers. ...
Source: Clinical Breast Cancer - July 13, 2018 Category: Cancer & Oncology Authors: de Castro Sant' Anna C, Junior AGF, Soares P, Tuji F, Paschoal E, Chaves LC, Burbano RR Tags: Clin Exp Med Source Type: research

DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.
Conclusion: Our data demonstrate that both DNA and histone modifications are involved in upregulation of PD-1, CTLA-4, TIM-3, and LAG-3 in breast tumor tissue and these epigenetic modifications could be useful as diagnostic/prognostic biomarkers and/or therapeutic targets in breast cancer. PMID: 29983831 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 11, 2018 Category: Cancer & Oncology Authors: Sasidharan Nair V, El Salhat H, Taha RZ, John A, Ali BR, Elkord E Tags: Clin Epigenetics Source Type: research

Long non-coding RNAs: implications in targeted diagnoses, prognosis, and improved therapeutic strategies in human non- and triple-negative breast cancer.
reno F, Arrieta O Abstract Triple-negative breast cancer (TNBC) has been clinically difficult to manage because of tumor aggressiveness, cellular and histological heterogeneity, and molecular mechanisms' complexity. All this in turn leads us to evaluate that tumor biological behavior is not yet fully understood. Additionally, the heterogeneity of tumor cells represents a great biomedicine challenge in terms of the complex molecular-genetical-transcriptional and epigenetical-mechanisms, which have not been fully elucidated on human solid tumors. Recently, human breast cancer, but specifically TNBC is under basic an...
Source: Clinical Breast Cancer - July 11, 2018 Category: Cancer & Oncology Authors: Rodríguez Bautista R, Ortega Gómez A, Hidalgo Miranda A, Zentella Dehesa A, Villarreal-Garza C, Ávila-Moreno F, Arrieta O Tags: Clin Epigenetics Source Type: research

The Clinical Pharmacology of Cladribine Tablets for the Treatment of Relapsing Multiple Sclerosis.
Abstract Cladribine Tablets (MAVENCLAD®) are used to treat relapsing multiple sclerosis (MS). The recommended dose is 3.5 mg/kg, consisting of 2 annual courses, each comprising 2 treatment weeks 1 month apart. We reviewed the clinical pharmacology of Cladribine Tablets in patients with MS, including pharmacokinetic and pharmacometric data. Cladribine Tablets are rapidly absorbed, with a median time to reach maximum concentration (Tmax) of 0.5 h (range 0.5-1.5 h) in fasted patients. When administered with food, absorption is delayed (median Tmax 1.5 h, range 1-3 h), and maximum con...
Source: Clinical Breast Cancer - July 10, 2018 Category: Cancer & Oncology Authors: Hermann R, Karlsson MO, Novakovic AM, Terranova N, Fluck M, Munafo A Tags: Clin Pharmacokinet Source Type: research

Safety of adipose-derived cell (stromal vascular fraction - SVF) augmentation for surgical breast reconstruction in cancer patients.
CONCLUSIONS: Our study does not produce any data suggesting increased cancer risk following breast reconstruction after a mastectomy or a lumpectomy combined with local radiotherapy. It may be concluded that an autologous transplantation of fat augmented with ASC is a safe and efficient procedure. Longer observation time and the observation of larger numbers of patients would be useful for strengthening the conclusion. PMID: 29989681 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 10, 2018 Category: Cancer & Oncology Authors: Mazur S, Zołocińska A, Siennicka K, Janik-Kosacka K, Chrapusta A, Pojda Z Tags: Adv Clin Exp Med Source Type: research

Association Between Inflammatory Biomarker C-Reactive Protein and Radiotherapy-Induced Early Adverse Skin Reactions in a Multiracial/Ethnic Breast Cancer Population.
Conclusion This large prospective study is the first to our knowledge of hsCRP as an inflammatory biomarker in RT-induced skin toxicities in breast cancer. We demonstrate that nonobese patients with elevated RT-related change in hsCRP levels have a significantly increased risk of grade 4+ skin toxicity. The outcomes may help to predict RT responses and guide decision making. PMID: 29989859 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 10, 2018 Category: Cancer & Oncology Authors: Hu JJ, Urbanic JJ, Case LD, Takita C, Wright JL, Brown DR, Langefeld CD, Lively MO, Mitchell SE, Thakrar A, Bryant D, Baglan K, Strasser J, Baez-Diaz L, Lesser GJ, Shaw EG Tags: J Clin Oncol Source Type: research

Breast tumour resembling tall cell variant of papillary thyroid carcinoma: case presentation (in a patient with Lynch syndrome).
PMID: 29982234 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 7, 2018 Category: Cancer & Oncology Authors: Gai L, Done SJ, Cook D, Denic N, Erivwo P, Voisey K, Kao K Tags: J Clin Pathol Source Type: research

Providing integrative care in the pre-chemotherapy setting: a pragmatic controlled patient-centered trial with implications for supportive cancer care.
CONCLUSION: A patient-tailored CIM program, initiated within a week of the first chemotherapy cycle, may help reduce the severity of fatigue, depression, and impaired well-being among patients with breast and gynecological cancers. PMID: 29980837 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 6, 2018 Category: Cancer & Oncology Authors: Ben-Arye E, Dahly H, Keshet Y, Dagash J, Samuels N Tags: J Cancer Res Clin Oncol Source Type: research

Periodontal disease and susceptibility to breast cancer: a meta-analysis of observational studies.
CONCLUSION: Our results provided evidence of a modest positive association between periodontal disease and breast cancer. Implementation of practical measures to prevent and treat periodontal disease is of great public health significance. Moreover, additional studies are recommended to explore this topic in more detail. This article is protected by copyright. All rights reserved. PMID: 29974484 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 5, 2018 Category: Cancer & Oncology Authors: Shi T, Min M, Sun C, Zhang Y, Liang M, Sun Y Tags: J Clin Periodontol Source Type: research

Correction to: Reply to the letter "Cardiac autonomic evaluation in breast cancer patients: role of cytokines and heart rate recovery".
Correction to: Reply to the letter "Cardiac autonomic evaluation in breast cancer patients: role of cytokines and heart rate recovery". Clin Res Cardiol. 2018 Jul 03;: Authors: Arab C, Vanderlei LCM, Gidron Y, Ferreira C Abstract Unfortunately, errors occurred in the original article. PMID: 29971564 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 3, 2018 Category: Cancer & Oncology Authors: Arab C, Vanderlei LCM, Gidron Y, Ferreira C Tags: Clin Res Cardiol Source Type: research

Drug-Drug Interaction Study of Apixaban with Cyclosporine and Tacrolimus in Healthy Volunteers.
This article is protected by copyright. All rights reserved. PMID: 29972633 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 3, 2018 Category: Cancer & Oncology Authors: Bashir B, Stickle DF, Chervoneva I, Kraft WK Tags: Clin Transl Sci Source Type: research

Is an indistinct picture "exactly what we need"? Objectivity, accuracy, and harm in imaging for cancer.
Is an indistinct picture "exactly what we need"? Objectivity, accuracy, and harm in imaging for cancer. J Eval Clin Pract. 2018 Jul 02;: Authors: Reid L Abstract Assumptions about the epistemic ideal of objectivity, closely related to ontological assumptions about the nature of disease as pathophysiological abnormality, lead us into oversimplified ways of thinking about medical imaging. This is illustrated by current controversies in the early detection of cancer. Improvements in the technical quality of imaging failed to address the problem of overdiagnosis in breast cancer screening and ex...
Source: Clinical Breast Cancer - July 2, 2018 Category: Cancer & Oncology Authors: Reid L Tags: J Eval Clin Pract Source Type: research

The dark side of granulocyte-colony stimulating factor: a supportive therapy with potential to promote tumour progression.
Abstract Granulocyte-colony stimulating factor (G-CSF) is one of several cytokines that can expand and mobilize haematopoietic precursor cells from bone marrow. In particular, G-CSF mobilizes neutrophils when the host is challenged by infection or tissue damage. Severe neutropenia, or febrile neutropenia is a life-threatening event that can be mitigated by administration of G-CSF. Consequently, G-CSF has been used to support patients undergoing chemotherapy who would otherwise require dose reduction due to neutropenia. Over the past 10-15 years it has become increasingly apparent, in preclinical tumour growth...
Source: Clinical Breast Cancer - July 2, 2018 Category: Cancer & Oncology Authors: Yeo B, Redfern AD, Mouchemore KA, Hamilton JA, Anderson RL Tags: Clin Exp Metastasis Source Type: research

Therapeutic effect of simvastatin on DMBA-induced breast cancer in mice.
This article is protected by copyright. All rights reserved. PMID: 29962034 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - July 1, 2018 Category: Cancer & Oncology Authors: Karimi B, Ashrafi M, Shomali T, Yektaseresht A Tags: Fundam Clin Pharmacol Source Type: research

Breast cancer incidence rates in the world from the Cancer Incidence in Five Continents XI.
PMID: 29931296 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - June 28, 2018 Category: Cancer & Oncology Authors: Katanoda K, Hori M Tags: Jpn J Clin Oncol Source Type: research

Hormonal Management for Transfeminine Individuals.
Abstract Transfeminine individuals are treated with estradiol and anti-androgen agents to transition to a more feminine appearance. The physical changes that occur with estradiol therapy include breast development, body fat redistribution, and decreased muscle mass. Transfeminine treatment regimens require monitoring and dose adjustments to achieve appropriate physiologic targets to enhance feminization and decrease risk of adverse outcomes. Adverse effects associated with estradiol use include thromboembolic disease, macroprolactinoma, breast cancer, coronary artery disease, cerebrovascular disease, cholelithiasi...
Source: Clinical Breast Cancer - June 18, 2018 Category: Cancer & Oncology Authors: Abramowitz J, Tangpricha V Tags: Clin Plast Surg Source Type: research

Primary breast cancer relapse as metastasis to the cervix uteri: A case report.
Abstract Metastasis of non-gynaecological tumours to the cervix is a rare event, and metastasis from breast cancer is even rarer, with only a limited number of such cases reported in the literature to date. We herein report the case of an 86-year-old female patient who had undergone mastectomy and axillary lymphadenectomy for invasive ductal cell breast carcinoma 2 years prior, followed by adjuvant hormonal therapy with letrozole. During hospitalization for anemia associated with an inflammatory syndrome and abdominal pain with menorrhagia, an abdominal ultrasound examination revealed a suspicious uterine mass wit...
Source: Clinical Breast Cancer - June 14, 2018 Category: Cancer & Oncology Authors: Thouvenot A, Bizet Y, Baccar LS, Lamuraglia M Tags: Mol Clin Oncol Source Type: research