Chemotherapy-elicited extracellular vesicle CXCL1 from dying cells promotes triple-negative breast cancer metastasis by activating TAM/PD-L1 signaling
CONCLUSIONS: Our results highlight CXCL1EV-dead as a novel dying cell-released signal and provide TPCA-1 as a targeting candidate to improve TNBC prognosis.PMID:38654356 | DOI:10.1186/s13046-024-03050-7 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Shengqi Wang Jing Li Shicui Hong Neng Wang Shang Xu Bowen Yang Yifeng Zheng Juping Zhang Bo Pan Yudie Hu Zhiyu Wang Source Type: research
Potential utility of pretreatment serum miRNAs for optimal treatment selection in advanced high-grade serous ovarian cancer
CONCLUSIONS: Pretreatment microRNA profiles could be used to select subgroups of patients who benefited more from primary debulking surgery or neoadjuvant chemotherapy and might contribute to selecting the optimal primary treatment modality in advanced high-grade serous ovarian cancer patients.PMID:38651188 | DOI:10.1093/jjco/hyae051 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Takashi Uehara Juntaro Matsuzaki Hiroshi Yoshida Yuto Ogawa Junichiro Miura Hitoshi Fujimiya Yusuke Yamamoto Junpei Kawauchi Satoko Takizawa Kan Yonemori Hiromi Sakamoto Ken Kato Mitsuya Ishikawa Takahiro Ochiya Source Type: research
Increased prevalence of germline pathogenic CHEK2 variants in individuals with pituitary adenomas
CONCLUSIONS: This is the first study to suggest a role for the breast cancer predisposition gene, CHEK2, in pituitary tumorigenesis, with pathogenic/likely pathogenic variants found in 3% of patients with pituitary adenomas. As pituitary adenomas are relatively common and typically lack classical autosomal dominant family histories, risk alleles - such as these variants found in CHEK2 - might be a significant contributor to pituitary adenoma risk in the general population.PMID:38651569 | DOI:10.1210/clinem/dgae268 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Sunita M C De Sousa Ann McCormack Andreas Orsmond Angeline Shen Christopher J Yates Roderick Clifton-Bligh Stephen Santoreneos James King Jinghua Feng John Toubia David J Torpy Hamish S Scott Source Type: research
Fulfilling the Role of a Parent While Undergoing Treatment for Cancer: A Review of the Literature and the Potential Impact of Childcare Support on Cancer Outcomes
Am J Clin Oncol. 2024 Apr 23. doi: 10.1097/COC.0000000000001102. Online ahead of print.ABSTRACTBreast cancer is the most prevalent malignancy among adolescents and young adults (AYAs). Despite the efficacy of chemotherapy, AYA patients contend with psychosocial challenges, including psychological distress and financial toxicity, exacerbated further by those with dependent children. Parenting responsibilities intersect with cancer care, impacting both family dynamics and treatment adherence. Despite recognized needs, however, the impact of parenting concerns or even parenting status and the presence of dependents has not be...
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Kang Woo Kim Mary Lopresti Stephanie L Graff Sabrina Witherby Don S Dizon Mary Anne Fenton Source Type: research
DNA damage, obesity and obesity-related health complications: what are new data telling us?
This article surveys new data that support these contentions.RECENT FINDINGS: Whole exome sequencing analyses have identified rare variants linked to high BMI and adiposity. Two of the identified genes are linked to DNA damage and DNA repair, suggesting that DNA damage itself may play a role in the cause of obesity. It has also been recognized that obesity increases DNA damage in breast tissue of carriers of BRCA mutations and rates of tumour formation in BRCA1+ mice, indicating effect of obesity on cancer development in high-risk populations. In addition, obesity promotes cancer cell chemoresistance by decreasing fatty ac...
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Marta W łodarczyk Gra żyna Nowicka Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Datopotamab Deruxtecan in Advanced or Metastatic HR+/HER2- and Triple-Negative Breast Cancer: Results From the Phase I TROPION-PanTumor01 Study
CONCLUSION: In patients with heavily pretreated advanced HR+/HER2- BC and TNBC, Dato-DXd demonstrated promising clinical activity and a manageable safety profile. Dato-DXd is currently being evaluated in phase III studies.PMID:38652877 | DOI:10.1200/JCO.23.01909 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Aditya Bardia Ian E Krop Takahiro Kogawa Dejan Juric Anthony W Tolcher Erika P Hamilton Toru Mukohara Aaron Lisberg Toshio Shimizu Alexander I Spira Junji Tsurutani Senthil Damodaran Kyriakos P Papadopoulos Jonathan Greenberg Fumiaki Kobayashi Hong Zebger Source Type: research
Stepwise analysis of thyroid diagnostic modalities with genomic imprinting detection
CONCLUSIONS: Our study demonstrated the significant stepwise diagnostic contributions of standard clinical assessments in the malignancy risk stratification of thyroid nodules. However, the addition of molecular imprinting detection further enabled a more accurate and definitive preoperative evaluation especially for morphologically indeterminate thyroid nodules and cases with potentially discordant results among standard modalities.PMID:38644545 | DOI:10.21037/cco-23-89 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Wanting Yang Ming Yin Jiehong Zhou Yun Zhu Beibei Ye Hui Shi Bingjie Zhang Can Yue Yifeng Zhang Hongxun Wu Haohao Li Xuliang Xia Shufang Yang Buyun Ma Source Type: research
Social characteristics and social benefit use among premenopausal breast cancer survivors in Denmark: a population-based cohort study
CONCLUSIONS: Use of social benefits reflecting lost ability to work was highest in less educated women and in women living alone.IMPLICATIONS FOR CANCER SURVIVORS: Awareness of these groups is crucial when tailoring efforts to support work participation in cancer survivors.PMID:38647591 | DOI:10.1007/s11764-024-01598-z (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Cathrine F Hjorth Julie A Schmidt D óra K Farkas Deirdre Cronin-Fenton Source Type: research
Breast density quantification in dual-energy mammography using virtual anthropomorphic phantoms
CONCLUSIONS: Our results in virtual phantoms indicate that the material decomposition method can produce accurate VBD measurements if the presence of a third material (skin) is considered. The results from our proof of concept showed agreement between MRI and dual-energy mammography VBD. Assessment of VBD using dual-energy images could provide complementary information in dual-energy mammography and tomosynthesis examinations.PMID:38648734 | DOI:10.1002/acm2.14360 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Gustavo Pacheco Jorge Patricio Castillo-Lopez Yolanda Villase ñor-Navarro Mar ía-Ester Brandan Source Type: research
Comparison between a single dose of PEG G-CSF and multiple doses of non-PEG G-CSF: a systematic review and meta-analysis from Clinical Practice Guidelines for the use of G-CSF 2022
CONCLUSIONS: A single dose of PEG G-CSF is strongly recommended over multiple-dose non-PEG G-CSF therapy for the primary prophylaxis of FN.PMID:38649648 | DOI:10.1007/s10147-024-02504-4 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Tetsuhiro Yoshinami Kazuki Nozawa Takamichi Yokoe Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Yuji Miura Makoto Endo Shingo Yano Dai Maruyama Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito Eishi Baba Nobuaki Ochi Toshio K Source Type: research
CyTOF analysis revealed platelet heterogeneity in breast cancer patients received T-DM1 treatment
Clin Immunol. 2024 Apr 19:110227. doi: 10.1016/j.clim.2024.110227. Online ahead of print.ABSTRACTT-DM1 (Trastuzumab Emtansine) belongs to class of Antibody-Drug Conjugates (ADC), where cytotoxic drugs are conjugated with the antibody Trastuzumab to specifically target HER2-positive cancer cells. Platelets, as vital components of the blood system, intricately influence the immune response to tumors through complex mechanisms. In our study, we examined platelet surface proteins in the plasma of patients before and after T-DM1 treatment, categorizing them based on treatment response. We identified a subgroup of platelets with...
Source: Clinical Breast Cancer - April 21, 2024 Category: Cancer & Oncology Authors: Jianli Ma Yuheng Pang Yuefeng Shang Chufei Xie Xiaoxue Xu Liujia Chan Zhiren Zhang Wenjing Wang Source Type: research
Neuropsychological assessment, intervention, and best practices for women with non-Central nervous system cancer: A scoping review of current standards
Conclusions: Women are subject to unique treatment-related outcomes due to the impact of hormonal alterations, differences in metabolization of certain chemotherapies, and psychosocial risk factors. Despite the known impact of cancer intervention, chronic illness, and cancer-related sequelae on cognitive outcomes, the current literature does not parsimoniously outline best practices for neuropsychologists to promote the health of women experiencing cancer. The current paper (1) provides an overview of the cognitive implications of cancer treatment with an intentional focus on cancers that are more prevalent in women versus...
Source: Clinical Breast Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Hannah B VanLandingham Rachael L Ellison Nataliya Turchmanovych-Hienkel Demy Alfonso Alison Oh Erin T Kaseda Karen Basurto Phoebe K Y Tse Humza Khan Source Type: research
Automated treatment planning for whole breast irradiation with individualized tangential IMRT fields
CONCLUSIONS: Although our attempt to correlate patient anatomical features with planning strategy using machine learning tools was unsuccessful, the resulting dosimetric outcomes proved satisfactory. Our algorithm consistently produced high-quality plans, offering significant time and efficiency advantages.PMID:38642406 | DOI:10.1002/acm2.14361 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Giulianne Rivelli Rodrigues Zaratim Ricardo Gomes Dos Reis Marcos Ant ônio Dos Santos Nathalya Ala Yagi Luis Felipe Oliveira E Silva Source Type: research
A Cohort Study to Evaluate Genetic Predictors for Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS): Results from ECOG-ACRIN E1Z11
CONCLUSION: We were unable to prospectively validate candidate SNPs previously associated with AI discontinuation due to AIMSS. Future analyses will explore additional genetic markers, PRO predictors of AIMSS, and differences by race.PMID:38640040 | DOI:10.1158/1078-0432.CCR-23-2137 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Vered Stearns Opeyemi A Jegede Victor Tsu-Shih Chang Todd C Skaar Jeffrey L Berenberg Ranveer Nand Atif Shafqat Nisha Lassi Jacobs William Luginbuhl Paul Gilman Al B Benson Judie R Goodman Gary L Buchschacher N Lynn Henry Charles L Loprinzi Patrick J Flyn Source Type: research
