Association of imaging and pathological findings of breast cancer in very young women: Report of a twenty-year retrospective study
CONCLUSION: Our study shows the most common subtype to be Luminal A cancer, with 74 % of the tumors being larger than 2 cm at the time of diagnosis. Irregular masses with non-circumscribed margins were the most common imaging findings.PMID:38599926 | DOI:10.1016/j.clinimag.2024.110094 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Sepideh Sefidbakht Zahra Beizavi Fatemeh Kanaani Nejad Parisa Pishdad Nahid Sadighi Masoumeh Ghoddusi Johari Bijan Bijan Sedigheh Tahmasebi Source Type: research
Quantifying radiation-induced breast fibrosis by shear-wave elastography in patients with breast cancer: A 12-months-follow-up data of a prospective study
CONCLUSION: We demonstrated that SWE enables the evaluation of tissue stiffness to provide quantified information for the RIF of breast cancer. Further studies with long-term follow-up should provide more quantitative data.PMID:38590328 | PMC:PMC10999491 | DOI:10.1016/j.ctro.2024.100773 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Wonguen Jung Jin Chung Jihae Lee Kyubo Kim Source Type: research
Improving resource utilization: Axillary lymph node core biopsy triaging for lymphoma
CONCLUSIONS: Our enterprise overused hematopathology resources in the evaluation of AxLNCB performed in the study period. Our process could improve from the application of a simple tool generated from this cohort to predict percent risk of the specimen containing hematologic malignancy using patient characteristics easily found via routine chart review.PMID:38591770 | DOI:10.1093/ajcp/aqae032 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Carl Dernell John Astle Abraham Bogachkov Shelly Reimer Anubha Wadhwa Shadie S Majidi Bethany Canales Julie M Jorns Source Type: research
Can neoadjuvant systemic therapy provide additional benefits for T1 HER2+ breast cancer patients: a subgroup analysis based on different high-risk signatures
CONCLUSION: Our findings suggest that NAST does not provide additional benefit to patients with T1 HER2+ breast cancer, even in the presence of lymph node metastasis, T1c, or hormone receptor negativity. This study facilitates the implementation of individualized management strategies.PMID:38592638 | DOI:10.1007/s12094-024-03472-x (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Lidan Chang Dandan Liu Xuyan Zhao Luyao Dai Xueting Ren Qian Hao Peinan Liu Hao Wu Xiaobin Ma Huafeng Kang Source Type: research
Neoadjuvant Chemotherapy and Immunotherapy for Estrogen Receptor-Positive Human Epidermal Growth Factor 2-Negative Breast Cancer
J Clin Oncol. 2024 Apr 9:JCO2302614. doi: 10.1200/JCO.23.02614. Online ahead of print.NO ABSTRACTPMID:38593393 | DOI:10.1200/JCO.23.02614 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Alejandro R íos-Hoyo Erin Cobain Laura A Huppert Peter D Beitsch Thomas A Buchholz Laura Esserman Laura J van 't Veer Hope S Rugo Lajos Pusztai Source Type: research
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
CONCLUSIONS: BET inhibitors specifically target p60AmotL2-expressing invasive cancer cells, likely by exploiting differences in chromatin accessibility, leading to cell death. Additionally, our findings support the use of this phenotypic strategy to discover novel compounds that can exploit vulnerabilities and specifically target invasive cancer cells.PMID:38594748 | PMC:PMC11003180 | DOI:10.1186/s13046-024-03031-w (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Pedro Fonseca Weiyingqi Cui Nona Struyf Le Tong Ayushi Chaurasiya Felipe Casagrande Honglei Zhao Dinura Fernando Xinsong Chen Nicholas P Tobin Brinton Seashore-Ludlow Andreas Lundqvist Johan Hartman Anita G öndör P äivi Östling Lars Holmgren Source Type: research
Quantifying radiation-induced breast fibrosis by shear-wave elastography in patients with breast cancer: A 12-months-follow-up data of a prospective study
CONCLUSION: We demonstrated that SWE enables the evaluation of tissue stiffness to provide quantified information for the RIF of breast cancer. Further studies with long-term follow-up should provide more quantitative data.PMID:38590328 | PMC:PMC10999491 | DOI:10.1016/j.ctro.2024.100773 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Wonguen Jung Jin Chung Jihae Lee Kyubo Kim Source Type: research
Improving resource utilization: Axillary lymph node core biopsy triaging for lymphoma
CONCLUSIONS: Our enterprise overused hematopathology resources in the evaluation of AxLNCB performed in the study period. Our process could improve from the application of a simple tool generated from this cohort to predict percent risk of the specimen containing hematologic malignancy using patient characteristics easily found via routine chart review.PMID:38591770 | DOI:10.1093/ajcp/aqae032 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Carl Dernell John Astle Abraham Bogachkov Shelly Reimer Anubha Wadhwa Shadie S Majidi Bethany Canales Julie M Jorns Source Type: research
Can neoadjuvant systemic therapy provide additional benefits for T1 HER2+ breast cancer patients: a subgroup analysis based on different high-risk signatures
CONCLUSION: Our findings suggest that NAST does not provide additional benefit to patients with T1 HER2+ breast cancer, even in the presence of lymph node metastasis, T1c, or hormone receptor negativity. This study facilitates the implementation of individualized management strategies.PMID:38592638 | DOI:10.1007/s12094-024-03472-x (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Lidan Chang Dandan Liu Xuyan Zhao Luyao Dai Xueting Ren Qian Hao Peinan Liu Hao Wu Xiaobin Ma Huafeng Kang Source Type: research
Postmastectomy radiation therapy in breast cancer patients with micrometastatic disease in sentinel node dissection: A cohort study and meta-analysis
CONCLUSION: PMRT does not seem to impact survival in patients with T1 or T2 breast cancer with micrometastatic disease in SLND. Considering the low level of evidence and the relatively short follow-up of included studies, caution in interpreting the results into clinical practice is suggested.PMID:38586080 | PMC:PMC10998037 | DOI:10.1016/j.ctro.2024.100770 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Fatema Jafer Stilda Malki Mariam Akram Tamana Gulwarisdotter Andreas Karakatsanis Antonis Valachis Source Type: research
Efficacy and safety of a combination treatment of immune checkpoint inhibitors in metastatic breast cancer: a systematic review and meta-analysis
CONCLUSION: Pooled therapy had improved PFS in mTNBC patients, especially in patients with PD-L1-positive tumors, and it was less likely to cause grade ≥ 3 AEs.PMID:38587602 | DOI:10.1007/s12094-024-03396-6 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Ying Wang Yalan Sun Fang Lu Xianghong Zhao Zhenlin Nie Feng Zhu Bangshun He Source Type: research
Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients
CONCLUSIONS: Women with stage I cancer, no chemotherapy, higher comorbidity burden, and history of chronic non-cancer medication use were less likely to adhere to AET. Taking steps to promote adherence in these groups of women may reduce their risk of recurrence.PMID:38589932 | DOI:10.1186/s13058-024-01819-4 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Kirsten M Woolpert Julie A Schmidt Thomas P Ahern Cathrine F Hjorth D óra K Farkas Bent Ejlertsen Lindsay J Collin Timothy L Lash Deirdre P Cronin-Fenton Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Breast Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis
In this study, we hypothesized that soluble lung-derived factors secreted in the presence of a primary TNBC tumor can influence stemness/plasticity of breast cancer cells. Using an ex vivo pulmonary metastasis assay (PuMA), we observed that the lung microenvironment supports colonization and growth of ALDHhiCD44+ TNBC cells, potentially via interactions with lung-derived FGF2. Exposure of TNBC cells to lung-conditioned media (LCM) generated from mice bearing TNBC primary tumors (tbLCM) significantly enhanced the proportion of ALDHhiCD44+ cells compared to control or LCM from tumor-naïve mice (tnLCM). Further analysis usin...
Source: Clinical Breast Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Vasudeva Bhat Matthew Piaseczny David Goodale Urvi Patel Ashkan Sadri Alison L Allan Source Type: research
Is Immediate Breast Reconstruction With a Latissimus Dorsi Myocutaneous Flap Safe for Starting Adjuvant Chemotherapy in Patients With Breast Cancer?
CONCLUSION: Major postoperative complications significantly delayed initiation of adjuvant chemotherapy in oncological patients who underwent radical breast surgery followed by immediate reconstruction with a latissimus dorsi myocutaneous flap and silicone implants.PMID:38582616 | DOI:10.1016/j.clbc.2024.03.003 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Gabriel Salum D'Alessandro Alexandre Mendon ça Munhoz Fabiana Midori Takeuchi Alejandro Povedano Jo ão Carlos Sampaio Goes Source Type: research
