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Changes in the peripheral blood and bone marrow from untreated advanced breast cancer patients that are associated with the establishment of bone metastases.
ng NA Abstract Bone metastasis is an incurable complication of breast cancer affecting 70-80 % of advanced patients. It is a multistep process that includes tumour cell mobilisation, intravasation, survival in the circulation, extravasation, migration and proliferation in the bone marrow/bone. Although novel findings demonstrate the bone marrow microenvironment significance in bone metastatic progression, a majority of studies have focused on end-stage disease and little is known about how the pre-metastatic niche arises in the bone marrow/bone tissues. We demonstrated a significant increase in patients' peri...
Source: Clinical Breast Cancer - October 31, 2013 Category: Cancer & Oncology Authors: Martinez LM, Vallone VB, Labovsky V, Choi H, Hofer EL, Feldman L, Bordenave RH, Batagelj E, Dimase F, Villafañe AR, Chasseing NA Tags: Clin Exp Metastasis Source Type: research

The biomarker-based validity of a food frequency questionnaire to assess the intake status of folate, pyridoxine and cobalamin among Iranian primary breast cancer patients.
Abstract Background/Objectives:Folate, pyridoxine and cobalamin are coenzymatically essential in one-carbon methyl metabolism, and their deficiencies could explain some alterations during breast carcinogenesis. We aimed to evaluate the validity of folate, pyridoxine and cobalamin estimates from a food frequency questionnaire (FFQ) on the basis of their corresponding fasting plasma biomarkers, in breast cancer (BC) patients.Subjects/Methods:In a prospective, consecutive case series, 149 women with primary BC aged between 30 and 69 years as a representative sample of Iranian women with BC were recruited. The 136-ite...
Source: Clinical Breast Cancer - October 30, 2013 Category: Cancer & Oncology Authors: Pirouzpanah S, Taleban FA, Mehdipour P, Atri M, Hooshyareh-Rad A, Sabour S Tags: Eur J Clin Nutr Source Type: research

Multicenter trials using 18F-fluorodeoxyglucose (FDG) PET to predict chemotherapy response: Effects of differential measurement error and bias on power calculations for unselected and enrichment designs.
CONCLUSION: Even moderate additional measurement error substantially reduced study power under both unselected and enrichment designs. PMID: 24169628 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 29, 2013 Category: Cancer & Oncology Authors: Kurland BF, Doot RK, Linden HM, Mankoff DA, Kinahan PE Tags: Clin Trials Source Type: research

PIASγ expression in relation to clinicopathological, tumour factors and survival in indigenous black breast cancer women.
CONCLUSIONS: PIASγ appears to be important in breast cancer behaviour arising from Nigerian women. PIASγ may therefore be useful for the screening of basal-like and TNBC. Also, development of novel therapies towards targeting PIASγ functional pathways may enhance the BC management among this ethnic nationality. PMID: 24170211 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 29, 2013 Category: Cancer & Oncology Authors: Agboola A, Musa A, Banjo A, Ayoade B, Deji-Agboola M, Nolan C, Rakha E, Ellis I, Green A Tags: J Clin Pathol Source Type: research

The value of archival tissue blocks in understanding breast cancer biology.
Abstract Pathological reporting of breast cancer has evolved alongside scientific advances. Such advances have led to recognition of different molecular classes of breast cancer resulting in improved disease management. The aim of this study was to establish whether these advances could be applied to archival breast cancer cases dating from the 1940s to assess historical trends. Important observations included the marked differences in pathological reporting, size of tumour and in ERα expression throughout the decades. PMID: 24170212 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 29, 2013 Category: Cancer & Oncology Authors: Dowsett T, Verghese E, Pollock S, Pollard J, Heads J, Hanby A, Speirs V Tags: J Clin Pathol Source Type: research

Cost Effectiveness of Primary Pegfilgrastim Prophylaxis in Patients With Breast Cancer at Risk of Febrile Neutropenia.
CONCLUSION: We conclude that G-CSF prophylaxis throughout all chemotherapy cycles is more effective, but more costly, compared with prophylaxis limited to the first two cycles. Whether G-CSF prophylaxis throughout all chemotherapy cycles is considered cost effective depends on the willingness to pay per patient with episodes of FN prevented. PMID: 24166522 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 28, 2013 Category: Cancer & Oncology Authors: Aarts MJ, Grutters JP, Peters FP, Mandigers CM, Dercksen MW, Stouthard JM, Nortier HJ, van Laarhoven HW, van Warmerdam LJ, van de Wouw AJ, Jacobs EM, Mattijssen V, van der Rijt CC, Smilde TJ, van der Velden AW, Temizkan M, Batman E, Muller EW, van Gastel Tags: J Clin Oncol Source Type: research

Ultrasonography-Guided Breast-Conserving Surgery Is Superior to Palpation-Guided Surgery for Palpable Breast Cancer.
Abstract INTRODUCTION: The aim of this study was to determine the efficacy of ultrasonography (US)-guided excision of palpable breast cancer and to compare it with the standard palpation-guided breast-conserving surgery (BCS). METHODS: For this purpose, 335 women with palpable breast cancer who underwent BCS were retrospectively studied. The positive surgical margins and re-excision rates were investigated. RESULTS: Of the total cohort, 137 patients were treated with palpation-guided BCS and 198 underwent US-guided tumor excision. The tumor and patient characteristics were similar in both groups. Patient...
Source: Clinical Breast Cancer - October 26, 2013 Category: Cancer & Oncology Authors: Eggemann H, Ignatov T, Beni A, Costa SD, Ignatov A Tags: Clin Breast Cancer Source Type: research

Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2.
ardisson D, Mayor F, Penela P Abstract Tumor vessel dysfunction is a pivotal event in cancer progression. Using an in vivo neovascularization model, we identified G protein-coupled receptor kinase 2 (GRK2) as a key angiogenesis regulator. An impaired angiogenic response involving immature vessels was observed in mice hemizygous for Grk2 or in animals with endothelium-specific Grk2 silencing. ECs isolated from these animals displayed intrinsic alterations in migration, TGF-β signaling, and formation of tubular networks. Remarkably, an altered pattern of vessel growth and maturation was detected in postnatal re...
Source: Clinical Breast Cancer - October 23, 2013 Category: Cancer & Oncology Authors: Rivas V, Carmona R, Muñoz-Chápuli R, Mendiola M, Nogués L, Reglero C, Miguel-Martín M, García-Escudero R, Dorn GW, Hardisson D, Mayor F, Penela P Tags: J Clin Invest Source Type: research

Clinical significance of NOB1 expression in breast infiltrating ductal carcinoma.
CONCLUSIONS: In summary, our present study clarify that the aberrant expression of NOB1 in breast infiltrating ductal carcinoma is possibly involved with tumorigenesis and development, and the NOB1 protein could act as a potential biomarker for prognosis assessment of breast infiltrating ductal carcinoma. Related mechanism is worthy of further investigation. PMID: 24133592 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 18, 2013 Category: Cancer & Oncology Authors: Li XY, Luo QF, Li J, Wei CK, Kong XJ, Zhang JF, Fang L Tags: Int J Clin Exp Pathol Source Type: research

Experience of BRCA1/2 mutation-negative young women from families with hereditary breast and ovarian cancer: a qualitative study.
CONCLUSIONS: By eliciting detailed patient narratives we have begun to show that this generation of BRCA mutation-negative young women is likely still affected by the degree of cancer history in their family, even with their understanding of the genetic contribution to disease. Larger studies with tightened participant characteristics, as well as studies involving women from different cultural backgrounds, are needed to further define the experience and needs of true negative young women from HBOC families. PMID: 24131499 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 16, 2013 Category: Cancer & Oncology Authors: Macrae L, de Souza AN, Loiselle CG, Wong N Tags: Hered Cancer Clin Pract Source Type: research

Prognostic Significance of Metastasis-Related microRNAs in Early Breast Cancer Patients with a Long Follow-up.
CONCLUSIONS: Our results clearly indicate that deregulation of metastasis-associated miRNAs in primary tumors is associated with clinical outcome in patients with early breast cancer and can differentiate patients with higher risk in well-characterized subgroups. PMID: 24132943 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 16, 2013 Category: Cancer & Oncology Authors: Markou A, Yousef GM, Stathopoulos E, Georgoulias V, Lianidou E Tags: Clin Chem Source Type: research

Genomic signatures of BRCA1 but not BRCA2 associated high-grade serous carcinoma resembles basal-like breast cancer.
PMID: 24127632 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 15, 2013 Category: Cancer & Oncology Authors: Patankar JV Tags: Clin Genet Source Type: research

Breast cancer: Differential response of TNBC to neoadjuvant chemotherapy.
Authors: PMID: 24129346 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 15, 2013 Category: Cancer & Oncology Tags: Nat Rev Clin Oncol Source Type: research

Appraising iniparib, the PARP inhibitor that never was-what must we learn?
Abstract Several drugs targeting poly(ADP-ribose) polymerase (PARP) enzymes are under development. Responses have been observed in patients with germline mutations in BRCA1 and BRCA2, with further data supporting antitumour activity of PARP inhibitors in sporadic ovarian cancer. Strategies to identify other predictive biomarkers remain under investigation. Iniparib was purported to be a PARP inhibitor that showed promising results in randomized phase II trials in patients with triple-negative breast cancer. Negative results from a phase III study in this disease setting, however, tempered enthusiasm for this agent...
Source: Clinical Breast Cancer - October 15, 2013 Category: Cancer & Oncology Authors: Mateo J, Ong M, Tan DS, Gonzalez MA, de Bono JS Tags: Nat Rev Clin Oncol Source Type: research

From ECC2013-breast cancer: T-DM1 shows promise in heavily pretreated patients.
Authors: PMID: 24129353 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 15, 2013 Category: Cancer & Oncology Tags: Nat Rev Clin Oncol Source Type: research

Adherence in tamoxifen therapy after conversion to a rebate pharmaceutical in breast cancer patients in Germany.
Abstract Background: The aim of this study was to investigate the risk of therapy discontinuation in breast cancer patients treated with tamoxifen with and without conversion to a rebate pharmaceutical (tamoxifen) and to analyze the negative consequences of rebate contracts on the compliance of breast cancer patients among gynecologist and general practitioner practices in Germany. Methods: This retrospective analysis was performed using the IMS Disease Analyzer® database. Women with a diagnosis of breast cancer and first time prescription of tamoxifen in the time from January 2008 until December 2011 were sel...
Source: Clinical Breast Cancer - October 14, 2013 Category: Cancer & Oncology Authors: Kostev K, May U, Hog D, Eisel J, Kremmers T, Kosteic M, Waehlert L, Hadji P Tags: Int J Clin Pharmacol Ther Source Type: research

Trastuzumab-Related Cardiotoxicity Among Older Patients With Breast Cancer.
CONCLUSION: In this large cohort of older breast cancer patients, the rates of trastuzumb-related CHF are higher than those reported in clinical trials. Among patients treated with trastuzumab, those with cardiac comorbidities and older age may be at higher risk. Further studies need to confirm the role that the frequency of administration plays in the development of trastuzumab-related CHF. PMID: 24127446 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 14, 2013 Category: Cancer & Oncology Authors: Chavez-Macgregor M, Zhang N, Buchholz TA, Zhang Y, Niu J, Elting L, Smith BD, Hortobagyi GN, Giordano SH Tags: J Clin Oncol Source Type: research

Lapatinib Versus Placebo Added to Paclitaxel in First-Line Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer: Ethical Lessons Not Learned From Africa.
PMID: 24127451 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 14, 2013 Category: Cancer & Oncology Authors: Ades F Tags: J Clin Oncol Source Type: research

Changing frequency of equivocal HER-2/neu scores and factors predictive of negative HER 2/neu fluorescent in situ hybridisation in invasive carcinomas of the breast.
CONCLUSIONS: In countries where resources are strained, oncologists need to think of measures to minimise the increasing financial burden of cancer care. Our study serves to highlight a few clinicopathological characteristics that might eliminate the need for further testing through FISH. PMID: 24108431 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 9, 2013 Category: Cancer & Oncology Authors: Boulos F, Farra CG, Saad Aldin EM, Masaad C, Hassoun Y, Fedda F, Doumiati H, Tawil AN, Nasser Z, Nahleh Z, Tfayli A Tags: J Clin Pathol Source Type: research

Dietary patterns and breast cancer risk in the California Teachers Study cohort.
CONCLUSION: The finding that greater consumption of a plant-based dietary pattern is associated with a reduced breast cancer risk, particularly for ER-PR- tumors, offers a potential avenue for prevention. PMID: 24108781 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 9, 2013 Category: Cancer & Oncology Authors: Link LB, Canchola AJ, Bernstein L, Clarke CA, Stram DO, Ursin G, Horn-Ross PL Tags: Am J Clin Nutr Source Type: research

Shikonin Inhibits Thyroid Cancer Cell Growth and Invasiveness through Targeting Major Signaling Pathways.
Conclusion:We for the first time demonstrated that shikonin is a potentially effective antitumor agent for thyroid cancers. PMID: 24106286 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 8, 2013 Category: Cancer & Oncology Authors: Yang Q, Ji M, Guan H, Shi B, Hou P Tags: J Clin Endocrinol Metab Source Type: research

Clinical Implications of CSN6 Protein Expression and Correlation with Mutant-type P53 Protein in Breast Cancer.
We examined mastectomy specimens from 92 invasive breast cancers and matched with 20 adjacent non-cancerous tissues using immunohistochemistry. RESULTS: The positive expressions of constitutive photomorphogenesis 9 subunit 6 protein in invasive breast cancer and adjacent non-cancerous tissue were 32.61% (30 of 92) and 10% (2 of 20), respectively. The positive expression of constitutive photomorphogenesis 9 subunit 6 protein was related to tumor size, histological type and lymph node metastasis (P = 0.015, 0.009 and 0.009, respectively). After univariate analysis, constitutive photomorphogenesis 9 subunit 6-positive ex...
Source: Clinical Breast Cancer - October 8, 2013 Category: Cancer & Oncology Authors: Wang W, Tang M, Zhang L, Xu X, Qi X, Yang Y, Jin F, Chen B Tags: Jpn J Clin Oncol Source Type: research

Introductory pictorial atlas of 3D tomosynthesis.
This article will highlight the utility of DBT as a tool for the detection of breast pathology; it will demonstrate normal findings as well as breast pathology on DBT and two-dimensional conventional mammography. DBT is a very promising modality, which may decrease the false-positive rate of mammography and find additional abnormalities not seen on two-dimensional mammography. PMID: 24113063 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 7, 2013 Category: Cancer & Oncology Authors: Cohen SL, Margolies LR, Szabo JR, Patel NS, Hermann G Tags: Clin Imaging Source Type: research

Comparative analysis of differential network modularity in tissue specific normal and cancer protein interaction networks.
CONCLUSION: The study predicts some major molecular complexes that might act as the important regulators in cancer progression. The crucial nodes identified in this study can be potential drug targets to combat cancer. PMID: 24093757 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 6, 2013 Category: Cancer & Oncology Authors: Islam MF, Hoque MM, Banik RS, Roy S, Sumi SS, Hassan FN, Tomal MT, Ullah A, Rahman KT Tags: J Clin Bioinforma Source Type: research

RhoA and RhoC differentially modulate estrogen receptor α recruitment, transcriptional activities, and expression in breast cancer cells (MCF-7).
CONCLUSIONS: Taken together, our results strongly suggest that RhoA and RhoC play different, but clear, roles in ERα signaling. These GTPases are definitely involved, along with RhoB, in ERα recruitment and, to some extent, ERα cofactor balance. We hypothesize a differential role of RhoA in breast cancer tumors that depend on hormone status. PMID: 24096540 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 6, 2013 Category: Cancer & Oncology Authors: Malissein E, Meunier E, Lajoie-Mazenc I, Médale-Giamarchi C, Dalenc F, Doisneau-Sixou SF Tags: J Cancer Res Clin Oncol Source Type: research

Adapted physical activity and diet (APAD) during adjuvant breast cancer therapy: Design and implementation of a prospective randomized controlled trial.
not G Abstract Exercise practice and appropriate nutrition have been advanced as non pharmacological supportive care to reduce side effects related to cancer and its treatment, but large sample-sized randomized controlled trials are needed to confirm such results. The Adapted Physical Activity and Diet counseling (APAD) study is a prospective randomized controlled trial designed to evaluate the effectiveness of a 26-week hospital- and home-based lifestyle intervention on cancer-related fatigue in women receiving breast cancer adjuvant treatment (chemotherapy and radiotherapy). The aim of this paper is to describe ...
Source: Clinical Breast Cancer - October 3, 2013 Category: Cancer & Oncology Authors: Carayol M, Romieu G, Bleuse JP, Senesse P, Gourgou-Bourgade S, Sari C, Jacot W, Sancho-Garnier H, Janiszewski C, Launay S, Cousson-Gélie F, Ninot G Tags: Contemp Clin Trials Source Type: research

Solitary Breast Metastasis From Recurrent Gallbladder Carcinoma Simulating a Second Primary on 18F-FDG PET/CT.
We present a case of solitary breast metastasis from recurrent gallbladder carcinoma mimicking a primary breast cancer in F-FDG PET/CT. PMID: 24096996 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 3, 2013 Category: Cancer & Oncology Authors: Khangembam BC, Sharma P, Naswa N, Sahoo MK, Kumar R Tags: Clin Nucl Med Source Type: research

Incidental Finding of Anterior Cranial Fossa Meningioma on 18F-Fluoride PET/CT.
We report a case of anterior cranial fossa meningioma in a woman with breast cancer detected by F-fluoride PET/CT. The whole-body F-fluoride PET images demonstrate an intense intracranial focal radiotracer accumulation in the skull base. Simultaneous CT showed a corresponding calcified space-occupying lesion consistent with meningioma. Follow-up CT image obtained 8 months later demonstrated the persistence and stable appearance of the lesion. PMID: 24096998 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 3, 2013 Category: Cancer & Oncology Authors: Zacchi SR, Duarte PS, Coura Filho GB, Sapienza MT, Buchpiguel CA Tags: Clin Nucl Med Source Type: research

Breast cancer management in the elderly.
cía-Estévez L, Fernández Y Abstract The increase in life expectancy in the western world means that we are faced with patients diagnosed with breast cancer in old age with increasing frequency. The management of these cases is a challenge for the oncologist, who must take into account the conditions associated with advanced age and the lack of trials in this population. In this review, we addressed the incorporation of geriatric assessment methods that may be useful in making decisions, the particular biological characteristics of breast cancer in elderly patients and their treatment in both l...
Source: Clinical Breast Cancer - October 2, 2013 Category: Cancer & Oncology Authors: Luque M, Arranz F, Cueva JF, de Juan A, García-Teijido P, Calvo L, Peláez I, García-Palomo A, García-Mata J, Antolín S, García-Estévez L, Fernández Y Tags: Clin Transl Oncol Source Type: research

Tumor histological subtyping determined by hormone receptors and HER2 status defines different pathological complete response and outcome to dose-dense neoadjuvant chemotherapy in breast cancer patients.
ascual J, Alba E, Sánchez-Rovira P Abstract PURPOSE: To assess the impact in pathological complete response (pCR) and outcome of two dose-dense neoadjuvant chemotherapy (DDNC) regimens among different histological subtypes determined by hormonal receptor (HR) and HER2 status in breast cancer patients. METHODS: A total of 127 breast cancer patients were treated with DDNC in two prospective studies. A: adriamycin 40 mg/m(2) on day (d) 1 plus paclitaxel 150 mg/m(2) and gemcitabine 2,000 mg/m(2) on d2 for six cycles (n = 54). B: epirubicin 90 mg/m(2), cyclophosphamide 600 ...
Source: Clinical Breast Cancer - October 2, 2013 Category: Cancer & Oncology Authors: Sánchez-Muñoz A, Plata-Fernández Y, Fernández M, Jaén-Morago A, Fernández-Navarro M, de la Torre-Cabrera C, Ramirez-Tortosa C, Pascual J, Alba E, Sánchez-Rovira P Tags: Clin Transl Oncol Source Type: research

Changes in Breast Radiotherapy: Prone Positioning and Hypofractionation.
This article attempts to summarize some of those changes for nurses caring for patients with breast cancer during radiation therapy. PMID: 24080055 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 1, 2013 Category: Cancer & Oncology Authors: Fenton-Kerimian M, Maisonet O, Formenti SC Tags: Clin J Oncol Nurs Source Type: research

Nursing Perspectives on Trastuzumab Emtansine for the Treatment of Metastatic Breast Cancer.
This article reviews the clinical development of T-DM1 and its usage, with a focus on the nurse's role in preventing and managing adverse events associated with T-DM1 therapy. PMID: 24080060 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 1, 2013 Category: Cancer & Oncology Authors: Bourdeanu L, Luu T Tags: Clin J Oncol Nurs Source Type: research

Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates.
Abstract Cancer risk reduction using pharmacological means is an attractive modern preventive approach that supplements the classical behavioural prevention recommendations. Medications that are commonly used by large populations to treat a variety of common, non-cancer-related, medical situations are an attractive candidate pool. This Review discusses three pharmacological agents with the most evidence for their potential as cancer chemopreventive agents: anti-hypercholesterolaemia medications (statins), an antidiabetic agent (metformin) and antiosteoporosis drugs (bisphosphonates). Data are accumulating to suppo...
Source: Clinical Breast Cancer - October 1, 2013 Category: Cancer & Oncology Authors: Gronich N, Rennert G Tags: Nat Rev Clin Oncol Source Type: research

Can Regional Anesthesia and Analgesia Prolong Cancer Survival After Orthopaedic Oncologic Surgery?
CONCLUSIONS: Although basic science studies suggest a potential benefit of regional anesthesia and stress response reduction in cancer formation, we found little clinical evidence to support the theory that regional anesthesia and analgesia improve overall patient survival after oncologic surgery. PMID: 24081665 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - October 1, 2013 Category: Cancer & Oncology Authors: Cata JP, Hernandez M, Lewis VO, Kurz A Tags: Clin Orthop Relat Res Source Type: research

Advances in molecular and clinical subtyping of breast cancer and their implications for therapy.
This article reviews the intrinsic classification system and the clinically defined subtypes of breast cancer. We review the molecular drivers of each subtype and discuss implications for prognosis, clinical management, and future directions. PMID: 24012401 [PubMed - in process] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - September 11, 2013 Category: Cancer & Oncology Authors: Cadoo KA, Traina TA, King TA Tags: Surg Oncol Clin N Am Source Type: research

The prognostic role of cancer stem cells in breast tumors.
PMID: 23976904 [PubMed] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 28, 2013 Category: Cancer & Oncology Authors: Bonito MD, Cantile M, Malzone G, Liguori G, Botti G Tags: J Clin Med Res Source Type: research

Relaxins enhance growth of spontaneous murine breast cancers as well as metastatic colonization of the brain.
Abstract Relaxins are known for their tissue remodeling capacity which is also a hallmark of cancer progression. However, their role in the latter context is still unclear, particularly in breast cancer. In a mouse model with spontaneously arising breast cancer due to erbB2-overexpression we show that exposure to porcine relaxin results in significantly enhanced tumour growth as compared to control animals. This is accompanied by increased serum concentrations of progesterone and estradiol as well as elevated expression of the respective receptors and the relaxin receptor RXFP1 in the tumour tissue. It is also ass...
Source: Clinical Breast Cancer - August 21, 2013 Category: Cancer & Oncology Authors: Binder C, Chuang E, Habla C, Bleckmann A, Schulz M, Bathgate R, Einspanier A Tags: Clin Exp Metastasis Source Type: research

Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model.
Abstract Current spontaneous metastasis models require a long period of observation after establishment of primary tumors to see significant metastatic progression. The degree of metastasis is not consistent among animals: this is problematic since it requires the use of a large number of animals to obtain reliable statistics. Here we report that pre-treatment of animals with tumor-conditioned media (TCM) consistently accelerates spontaneous metastasis in breast cancer. An inguinal breast tumor model facilitated by TCM showed robust anterior metastasis to the axillary and brachial lymph nodes (LN), and the lungs c...
Source: Clinical Breast Cancer - August 21, 2013 Category: Cancer & Oncology Authors: Lee E, Pandey NB, Popel AS Tags: Clin Exp Metastasis Source Type: research

Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer.
CONCLUSIONS: Our results suggest that SphK1 may be a predictive factor for pCR after neoadjuvant treatment in luminal type breast cancers and warrants further investigation. PMID: 23955546 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 18, 2013 Category: Cancer & Oncology Authors: Ruckhäberle E, Karn T, Denkert C, Loibl S, Ataseven B, Reimer T, Becker S, Holtrich U, Rody A, Darb-Esfahani S, Nekljudova V, von Minckwitz G Tags: J Cancer Res Clin Oncol Source Type: research

Late radiation injury to peripheral nerves.
Abstract Although the peripheral nerve has often been considered as radioresistant, clinical practice demonstrates the occurrence of radiation-induced peripheral neuropathies. Because these complications appear late, usually several years after the course of radiotherapy, their occurrence is explained by improvement in the prognosis of several cancers. Their physiopathology is not fully understood. Compression by radio-induced fibrosis probably plays a central role but direct injury to nerves and blood vessels is probably also involved. The most frequent and best known form of postradiation neuropathy is brachial ...
Source: Clinical Breast Cancer - August 18, 2013 Category: Cancer & Oncology Authors: Pradat PF, Delanian S Tags: Handb Clin Neurol Source Type: research

PALB2 and breast cancer: ready for clinical translation!
Abstract For almost two decades, breast cancer clinical genetics has operated in an environment where a heritable cause of breast cancer susceptibility is identified in the vast minority of women seeking advice about their personal and/or family history of breast and/or ovarian cancer. A new wave of genetic information is upon us that promises to provide an explanation for the greater proportion of current missing heritability of breast cancer. Whilst researchers refine bioinformatic and analytic methodology necessary to interpret the new genetic data, attention needs to be paid to defining appropriate and coordin...
Source: Clinical Breast Cancer - August 18, 2013 Category: Cancer & Oncology Authors: Southey MC, Teo ZL, Winship I Tags: Appl Clin Genet Source Type: research

Breastfeeding and the prevention of breast cancer: a retrospective review of clinical histories.
In this study, we analysed 504 medical records of female patients, 19-91 years of age, who had been diagnosed and treated for breast cancer from 2004-2009 at the San Cecilio University Hospital in Granada (Spain). Relevant data (age of diagnosis, period of lactation, family history of cancer, obesity, alcohol consumption and smoking habits) were collected from the clinical histories of each patient and analysed. A conditional inference tree was used to relate the age of diagnosis to smoking habits and the length of the lactation period. RESULTS: The conditional inference tree identified significant differences be...
Source: Clinical Breast Cancer - August 13, 2013 Category: Cancer & Oncology Authors: González-Jiménez E, García PA, Aguilar MJ, Padilla CA, Alvarez J Tags: J Clin Nurs Source Type: research

Breast cancer: Mutations in breast cancer stem cells correlate with metastases.
PMID: 23939549 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 13, 2013 Category: Cancer & Oncology Authors: Marchesi V Tags: Nat Rev Clin Oncol Source Type: research

RABEX-5 plays an oncogenic role in breast cancer by activating MMP-9 pathway.
CONCLUSIONS: Our results indicate that RABEX-5 plays an oncogenic role in breast cancer by modulating the proliferation and metastasis potential of breast cancer cells. Thus, RABEX-5 is a promising prognostic indicator for patients with breast cancer. PMID: 23941575 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 13, 2013 Category: Cancer & Oncology Authors: Zhang X, Min J, Wang Y, Li Y, Li H, Liu Q, Liang X, Mu P, Li H Tags: J Exp Clin Cancer Res Source Type: research

Striking life events associated with primary breast cancer susceptibility in women: a meta-analysis study.
CONCLUSIONS: The current meta-analysis showed significant evidence for a positive association between striking life events and primary breast cancer incidence in women. PMID: 23941600 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 13, 2013 Category: Cancer & Oncology Authors: Lin Y, Wang C, Zhong Y, Huang X, Peng L, Shan G, Wang K, Sun Q Tags: J Exp Clin Cancer Res Source Type: research

Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment. J Clin Invest. 2013 Aug 8; Authors: Hanks BA, Holtzhausen A, Evans KS, Jamieson R, Gimpel P, Campbell OM, Hector-Greene M, Sun L, Tewari A, George A, Starr M, Nixon A, Augustine C, Beasley G, Tyler DS, Osada T, Morse MA, Ling L, Lyerly HK, Blobe GC Abstract Cancers subvert the host immune system to facilitate disease progression. These evolved immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic strategies. Emerging data indicate that local tumor-associated DC populations exhibit t...
Source: Clinical Breast Cancer - August 8, 2013 Category: Cancer & Oncology Authors: Hanks BA, Holtzhausen A, Evans KS, Jamieson R, Gimpel P, Campbell OM, Hector-Greene M, Sun L, Tewari A, George A, Starr M, Nixon A, Augustine C, Beasley G, Tyler DS, Osada T, Morse MA, Ling L, Lyerly HK, Blobe GC Tags: J Clin Invest Source Type: research

Bacterial flora and biofilm of malignant wounds of breast cancers.
Conclusion:this study provides a dynamic description of the bacterial flora of tumoral wounds. This underlines the absolute need for news therapeutics options, active on circulating bacteria as well as on bacteria organized in biofilm. PMID: 23926169 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 7, 2013 Category: Cancer & Oncology Authors: Fromantin I, Seyer D, Watson S, Rollot F, Elard J, Escande MC, De Rycke Y, Kriegel I, Larreta Garde V Tags: J Clin Microbiol Source Type: research

Tamoxifen and Risk of Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers.
CONCLUSIONThis study provides evidence that tamoxifen use is associated with a reduction in CBC risk for BRCA1 and BRCA2 mutation carriers. Further follow-up of these cohorts will provide increased statistical power for future prospective analyses. PMID: 23918944 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 5, 2013 Category: Cancer & Oncology Authors: Phillips KA, Milne RL, Rookus MA, Daly MB, Antoniou AC, Peock S, Frost D, Easton DF, Ellis S, Friedlander ML, Buys SS, Andrieu N, Noguès C, Stoppa-Lyonnet D, Bonadona V, Pujol P, McLachlan SA, John EM, Hooning MJ, Seynaeve C, Tollenaar RA, Goldgar DE, Te Tags: J Clin Oncol Source Type: research

Randomized Controlled Trial of Mindfulness-Based Cancer Recovery Versus Supportive Expressive Group Therapy for Distressed Survivors of Breast Cancer (MINDSET).
CONCLUSIONIn the largest trial to date, MBCR was superior for improving a range of psychological outcomes for distressed survivors of breast cancer. Both SET and MBCR also resulted in more normative diurnal cortisol profiles than the control condition. The clinical implications of this finding require further investigation. PMID: 23918953 [PubMed - as supplied by publisher] (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - August 5, 2013 Category: Cancer & Oncology Authors: Carlson LE, Doll R, Stephen J, Faris P, Tamagawa R, Drysdale E, Speca M Tags: J Clin Oncol Source Type: research

Assignment of tumor subtype by genomic testing and pathologic-based approximations: implications on patient's management and therapy selection.
erou CM, Cladés T, Martín M Abstract BACKGROUND: Breast cancer subtypes can be identified by genomic testing or pathology-based approximations. However, these classifications are not equivalent and the clinical relevance of both classifications needs to be fully explored. METHODS: Ninety-four patients were randomized to neoadjuvant single agent doxorubicin or docetaxel. Tumor subtype was assessed by pathology-based classification and by gene expression using the PAM50 plus the claudin-low predictor (CLP). Kappa Cohen's coefficient (κ) was used to test the agreement between methods. Multiva...
Source: Clinical Breast Cancer - August 2, 2013 Category: Cancer & Oncology Authors: Romero A, Prat A, García-Sáenz JA, Del Prado N, Pelayo A, Furió V, Román JM, de la Hoya M, Díaz-Rubio E, Perou CM, Cladés T, Martín M Tags: Clin Transl Oncol Source Type: research