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Partial-accelerated irradiation with stereotactic radiotherapy at a dose of 30  Gy in 5 fractions in early breast cancer
ConclusionAPBI with SBRT 30  Gy in 5 fractions in early-stage breast cancer is a feasible technique, very-well tolerated and has excellent oncologic and cosmetic outcome during our follow-up period. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 20, 2024 Category: Cancer & Oncology Source Type: research

Circulating serum exosomes i-tRF-AspGTC and tRF-1-SerCGA as diagnostic indicators for non-small cell lung cancer
ConclusionThe expression of serum exosomes i-tRF-AspGTC and tRF-1-SerCGA was significantly downregulated in NSCLC patients. These exosomes could be used as predictive indicators for diagnosis or early diagnosis of NSCLC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 19, 2024 Category: Cancer & Oncology Source Type: research

Contouring aid tools in radiotherapy. Smoothing: the false friend
ConclusionSmoothing is a good tool to reduce artifacts due to the manual delineation of radiotherapy volumes. The resulting volumes must be always carefully reviewed. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 17, 2024 Category: Cancer & Oncology Source Type: research

Correction: Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 16, 2024 Category: Cancer & Oncology Source Type: research

Association between thyroid disorders and extra-thyroidal cancers, a review
AbstractThyroid hormone has been shown to have both tumor-promoting and tumor-suppressing actions, which has led to significant debate over its involvement in the development of cancer. Proliferation, apoptosis, invasiveness, and angiogenesis are all aspects of cancer that are affected by the thyroid hormones T3 and T4, according to research conducted in animal models and in vitro experiments. The effects of thyroid hormones on cancer cells are mediated by many non-genomic mechanisms, one of which involves the activation of the plasma membrane receptor integrin αvβ3. Typically, abnormal amounts of thyroid hormones are li...
Source: Clinical and Translational Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research

Enhanced outcomes in residual or recurrent craniopharyngioma: evaluating combined gamma knife and phosphorus-32 brachytherapy
ConclusionThe combination of gamma knife and phosphorus-32 brachytherapy presents a viable, minimally invasive alternative for treating residual and recurrent craniopharyngioma. It offers high tumor control and functional improvement rates, suggesting its potential as a preferred strategy in some instances. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research

The diagnostic and prognostic value of exosomal microRNAs in lung cancer: a systematic review
ConclusionsExosomal miRNAs are valuable biomarkers in lung cancer patients. Exosomal miR-486-5p and miR-451a can be used as new diagnostic biomarkers for lung cancer. Dysregulated exosomal miRNAs could serve as indicators of survival outcomes in lung cancer patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research

Bevacizumab improved prognosis for advanced EGFR-mutant lung adenocarcinoma with brain metastasis receiving cerebral radiotherapy
ConclusionIn patients with BM from EGFR-mutated NSCLC, cerebral radiotherapy with bevacizumab markedly improved OS. This improvement was more evident after cerebral radiotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 13, 2024 Category: Cancer & Oncology Source Type: research

Clinical risk prediction model and external validation of positive surgical margin in laparoscopic radical prostatectomy based on MRI lesion location
ConclusionThe positive rate of surgical margin in middle PZ was significantly lower than that in other regions, and MRI lesion location was an independent risk factor for PSM. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 13, 2024 Category: Cancer & Oncology Source Type: research

Assessment of TUFT1 and Rac1-GTP levels in triple-negative breast cancer patients: clinical and pathological correlations
ConclusionA significant correlation was identified between the levels of TUFT1 and Rac1-GTP expressions in the cancerous tissues of patients with TNBC, suggesting a close association with the progression of TNBC. The two molecules play significant roles in facilitating an early diagnosis and treatment of TNBC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 13, 2024 Category: Cancer & Oncology Source Type: research

A signature of circulating miRNAs predicts the prognosis and therapeutic outcome of taxane/platinum regimen in advanced ovarian carcinoma patients
ConclusionOur findings indicate that circulating miRNAs might be a potential minimally invasive diagnostic marker for treatment outcome and recurrence in ovarian carcinoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 12, 2024 Category: Cancer & Oncology Source Type: research

Integrated analysis reveals an aspartate metabolism-related gene signature for predicting the overall survival in patients with hepatocellular carcinoma
ConclusionsThe AMGS represents a promising prognostic value for HCC patients, providing a perspective for finding novel biomarkers and therapeutic targets for HCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 12, 2024 Category: Cancer & Oncology Source Type: research

Bladder-sparing treatment using tislelizumab combined with gemcitabine/cisplatin in selected patients with muscle-invasive bladder cancer: a real-world study
ConclusionsOur retrospective study of patients with MIBC suggests that tislelizumab-based neoadjuvant therapy was a safe and effective bladder-sparing treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 12, 2024 Category: Cancer & Oncology Source Type: research

Sarcopenia among treated cancer patients before and after neoadjuvant chemotherapy: a systematic review and meta ‐analysis of high-quality studies
ConclusionThe risk of muscle reduction significantly increases in cancer patients after neoadjuvant chemotherapy and digestive system cancers tend to have a higher risk of developing sarcopenia post-treatment compared to non-digestive system cancers. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 12, 2024 Category: Cancer & Oncology Source Type: research