Clinical and Translational Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

CircRNA-regulated glucose metabolism in ovarian cancer: an emerging landscape for therapeutic intervention
AbstractOvarian cancer (OC) has the highest mortality rate among female reproductive system tumours, with limited efficacy of traditional treatments and 5-year survival rates that rarely exceed 40%. Circular RNA (circRNA) is a stable endogenous circular RNA that typically regulates protein expression by binding to downstream miRNA. It has been demonstrated that circRNAs play an important role in the proliferation, migration, and glucose metabolism (such as the Warburg effect) of OC and can regulate the expression of glucose metabolism-related proteins such as GLUT1 and HK2, promoting anaerobic glycolysis of cancer cells, i...
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Palliative care for children with central nervous system tumors: results of a Spanish multicenter study
ConclusionChildren dying from CNS tumors have specific needs during palliative phase. The optimal indication of PS depended on the center experience although, in our series, it was also influenced by the place of death. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Clinical significance of CD166 and HER-2 in different types of gastric cancer
ConclusionOur results confirmed that increased membranous and cytoplasmic expression of CD166 showed clinical significance in the SRC type and is associated with the progression of the disease and more aggressive tumor behaviors. These findings can be used to assist in designating subgroups of patients that require different follow-up strategies, and also, they might be utilized as the prognostic or diagnostic biomarkers in these types of GC for prospective clinical application. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

The relationship between brain metastasis and HER2 expression status in gastric cancer
ConclusionThe incidence of BM in patients with HER2-positive gastric cancer is 4.08 times higher than that in general patients. The median overall survival time from BM is shorter for HER2-positive patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Development of fatty acid metabolism score based on gene signature for predicting prognosis and immunotherapy response in colon cancer
ConclusionsOur study provided a comprehensive analysis of the heterogeneity of fatty acid metabolism in colon cancer. We highlighted the potential clinical utility of fatty acid metabolism-related genes to be biomarkers of colon cancer prognosis and targets to improve the effect of immunotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

LncRNA XXYLT1-AS2 promotes tumor progression via autophagy inhibition through ubiquitinated degradation of TFEB in hepatocellular carcinoma
ConclusionXXYLT1-AS2 plays an oncogenic role in HCC progression through inhibition of autophagy via promoting the degradation of TFEB, and thus could be a novel target for HCC treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Hype or hope? A review of challenges in balancing tumor control and treatment toxicity in breast cancer from the perspective of the radiation oncologist
AbstractThe aim of this article is to discuss the challenges and new strategies in managing breast cancer patients, with a specific focus on radiation oncology and the importance of balancing oncologic outcomes with quality of life and post-treatment morbidity. A comprehensive literature review was conducted to identify advances in the management of breast cancer, exploring de-escalation strategies, hypofractionation schemes, predictors and tools for reducing toxicity (radiation-induced lymphocyte apoptosis, deep inspiration breath-hold, adaptive radiotherapy), enhancer treatments (hyperthermia, immunotherapy) and innovati...
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Difficulties on the access to innovative targeted therapies for lung cancer in Spain
ConclusionSLCG considers imperative to improve the access in Spain to innovative treatments for NSCLC to reduce inequity across European countries. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

A deep learning model for accurately predicting cancer-specific survival in patients with primary bone sarcoma of the extremity: a population-based study
ConclusionA deep learning model for predicting the survival probability of patients with long bone sarcoma was constructed and validated. It is more accurate and flexible in predicting prognosis than the classical CoxPH model. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

MMP11 and MMP17 are potential biomarkers for uterine corpus endometrial carcinoma prognosis
ConclusionMMP11 and MMP17 may affect UCEC prognosis by influencing immune cell infiltration and may be potential UCEC biomarkers. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Impact of bone metastasis on the prognosis of non-small cell lung cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
ConclusionThe presence of bone metastasis is a predictor of poor OS in NSCLC treated with ICIs. However, PFS does not seem to be influenced by the presence of bone metastasis. Clinicians should prioritize the management of NSCLC patients with bone metastasis and explore the use of combination therapies to achieve optimal results. Further studies taking into account different combination therapies for such patients would strengthen the evidence. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Capecitabine/cisplatin combined with concurrent intensity-modulated radiation therapy: a feasible therapeutic strategy for anal squamous cell carcinoma
ConclusionThe XP regimen was as effective as the MF regimen in non-metastatic ASCC. Compared with the standard MF regimen, XP combined with IMRT showed higher treatment completion and lower toxicities. It could be considered a feasible alternative for patients with non-metastatic ASCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2024 Category: Cancer & Oncology Source Type: research

Relationship between hemoglobin and lung cancer: evidence from Mendelian randomization and National Health and Nutrition Examination Survey
ConclusionsOur study provides further evidence for the relationship between Hb levels and lung cancer, highlighting the potential significance of Hb as a biomarker for predicting the risk and prognosis of lung cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research

Analysis of the prognostic value of uric acid on the efficacy of immunotherapy in patients with primary liver cancer
ConclusionsThe serum UA level is a reliable biomarker for predicting the prognosis of patients undergoing immunotherapy for PLC, and might provide a basis for the individualized treatment of these patients. Dynamic monitoring of the serum UA level may compensate for the deficiency of the current liver cancer staging system. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research

Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas
ConclusionsThe study indicated that low T3 syndrome may be a good candidate for predicting prognosis of peripheral T-cell lymphomas. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research