Role of miR-424 in the carcinogenesis
AbstractRecent studies have revealed the impact of microRNAs (miRNAs) in the carcinogenic process. miR-424 is a miRNA whose role in this process is being to be identified. Experiments in the ovarian cancer, cervical cancer, hepatocellular carcinoma, neuroblastoma, breast cancer, osteosarcoma, intrahepatic cholangiocarcinoma, prostate cancer, endometrial cancer, non-small cell lung cancer, hemangioma and gastric cancer have reported down-regulation of miR-424. On the other hand, this miRNA has been found to be up-regulated in melanoma, laryngeal and esophageal squamous cell carcinomas, glioma, multiple myeloma and thyroid c...
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Measurable residual disease study through three different methods can anticipate relapse and guide early interventions in childhood acute lymphoblastic leukemia
ConclusionMFC, FISH and RT-PCR are complementary methods for MRD monitoring in pediatric ALL. Although, our data clearly show that MDR positive detection is associated with relapse, continuation of standard treatment, intensification or other early interventions were able to halt relapse in patients with different risks and genetic background. More sensitive and specific methods are warranted to enhance this approach. However, whether early treatment of MRD can improve overall survival in patients with childhood ALL needs to be evaluated in adequately controlled clinical trials. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Transarterial embolization followed by staged hepatectomy versus emergency hepatectomy for ruptured HCC: a meta-analysis
ConclusionCompared with EH, TAE  + SH could reduce perioperative operating time, blood loss, blood transfusion, mortality rate and increase the long-term survival rate of the rHCC patients, which may be a better treatment for resectable rHCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Correction: Update on the management of elderly patients with colorectal cancer
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Update on the management of elderly patients with colorectal cancer
AbstractColorectal cancer (CRC) is one of the most common tumours worldwide, and 70% of CRC patients are over 65  years of age. However, the scientific evidence available for these patients is poor, as they are underrepresented in clinical trials. Therefore, a group of experts from the Oncogeriatrics Section of the Spanish Society of Medical Oncology (SEOM), the Spanish Cooperative Group for the Treatment of Digestive Tumours, (TTD) and the Multidisciplinary Spanish Group of Digestive Cancer (GEMCAD) have reviewed the scientific evidence available in older patients with CRC. This group of experts recommends a multidiscipl...
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Delivery of SIRT1 by cancer-associated adipocyte-derived extracellular vesicles regulates immune response and tumorigenesis of ovarian cancer cells
ConclusionCAA-EVs-mediated transfer of SIRT1 regulates the CD24/Siglec-10 axis to curb immune response and promote tumorigenesis of ovarian cancer cells. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Comparative analysis of upper aerodigestive tract and non-upper aerodigestive tract in NK/T-cell lymphoma
ConclusionIt was difficult to distinguish between UAT and NUAT-NKTCL from histopathology. NUAT-NKTCL patients did have advanced stage and poor outcome. The prognostic value of PINK score and bone marrow involvement was proposed. We aimed to improve initial CR rates, as well as to find new predictive models to predict the whole population. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Validation of the CoVID-TE model as a tool to predict thrombosis, bleeding, and mortality in the oncology patient with Sars-Cov-2 infection: a study by the SEOM cancer and thrombosis group
ConclusionsThe data from our series does not validate of the CoVID-TE as a model to predict thrombosis, hemorrhage, or mortality in cancer patients with Sars-Cov-2 infection. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Which is the appropriate surgical procedure for appendiceal adenocarcinoma: appendectomy, partial colectomy or right hemicolectomy?
ConclusionsRight hemicolectomy may not always be necessary for appendiceal adenocarcinoma patients. An appendectomy could be sufficient for therapeutic effect of stage I patients, but limited for stage II patients. Right hemicolectomy was not superior to partial colectomy for advanced stage patients, suggesting omission of standard hemicolectomy might be feasible. However, adequate lymphadenectomy should be strongly recommended. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Cost-effectiveness of the addition of CDK4/6 inhibitors to standard endocrine therapy in first-line treatment of women with advanced HR+/HER2 − breast cancer in Mexico
ConclusionPalbociclib, ribociclib, and abemaciclib demonstrated a significant increase in effectiveness in postmenopausal patients, and ribociclib in premenopausal patients, when added to standard endocrine therapy for patients with advanced HR+/HER2 − breast cancer. At the national stablished willingness to pay, only the addition of abemaciclib to standard endocrine therapy in postmenopausal women would be considered cost-effective. However, differences on results between therapies for postmenopausal patients were not statistically significan t. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Assessing the methodological strengths and limitations of the Spanish Society of Medical Oncology (SEOM) guidelines: a critical appraisal using AGREE II and AGREE-REX tool
ConclusionsAlthough developed with acceptable methodological rigor, SEOM guidelines could be improved in the future, particularly in terms of clinical applicability and patient perspectives. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
AbstractMicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational repression. The aberrant expression of various miRNAs has been associated with a number of human cancer. Oncogenic or tumor-suppressor miRNAs regulate a variety of pathways involved in the development of breast cancer (BC), including cell proliferation, apoptosis, metastasis, cancer recurrence, and chemoresistance. Variations in miRNA-encoding genes and their target genes lead to dysregulated gene expression resulting in the development and progression of BC. The various ther...
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Impact of breath hold on regional nodal irradiation and heart volume in field in left breast cancer adjuvant irradiation
ConclusionWhen compared to free breathing scans, DIBH procedures result in considerably reduced dosage to the OAR and no appreciable changes in dose exposure to regional lymph node stations in patients with left-sided breast cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

Synthesis of the scFv fragment of anti-Frizzled-7 antibody and evaluation of its effects on triple-negative breast cancer in vitro study
ConclusionThe recombinantly developed anti-Fzd7 scFv of this study could exhibit significant antiproliferative and antimigratory properties, along with a high apoptosis-inducing potential, making it suitable for the immunotherapy of triple negative breast cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research

The expression of corticotropin-releasing hormone family peptides in premalignant and malignant vulvar lesions
ConclusionsStress response system and CRH family peptides seem to have a role in inflammation maintenance and progression of vulvar premalignant lesions to malignancy. It seems that stress peptides may locally modulate the stroma through Fas/FasL upregulation, possibly contributing to vulvar cancer development. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research