Clinical and Translational Oncology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Surface guided radiation therapy with an innovative open-face mask and mouth bite: patient motion management in brain stereotactic radiotherapy
ConclusionsThe application of the SGRT with an innovative open-face mask and mouth bite device could achieve precision positioning accuracy and stability, and the accuracy of the AlignRT system exhibits excellent constancy with the CBCT gold standard. The non-coplanar radiation field monitoring can provide reliable support for motion management in fractional treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 1, 2024 Category: Cancer & Oncology Source Type: research
Neoadjuvant chemotherapy with dose-dense MVAC in muscle-invasive bladder cancer: a tertiary center experience
ConclusionsNeoadjuvant chemotherapy with 4 cycles of dd-MVAC is an effective regimen with high rates of pathological complete responses and down-staging along with an acceptable toxicity profile. DD-MVAC should be considered as an alternative to cisplatin and gemcitabine in patients with good clinical performance status. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 1, 2024 Category: Cancer & Oncology Source Type: research
Glioblastoma research on zebrafish xenograft models: a systematic review
AbstractGlioblastoma (GBM) constitutes the most common primary brain tumor in adults. The challenges in GBM therapeutics have shed light on zebrafish used as a promising animal model for preclinical GBM xenograft studies without a standardized methodology. This systematic review aims to summarize the advances in zebrafish GBM xenografting, compare research protocols to pinpoint advantages and underlying limitations, and designate the predominant xenografting parameters. Based on the PRISMA checklist, we systematically searched PubMed, Scopus, and ZFIN using the keywords “glioblastoma,” “xenotransplantation,” and ...
Source: Clinical and Translational Oncology - February 1, 2024 Category: Cancer & Oncology Source Type: research
Correction: SEOM-GEICAM-SOLTI clinical guidelines for early-stage breast cancer (2022)
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 1, 2024 Category: Cancer & Oncology Source Type: research
Correction to: Efficacy and safety of trifluridine/tipiracil (TAS ‑102) in patients with metastatic colorectal cancer: a systematic review and meta‑analysis
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 1, 2024 Category: Cancer & Oncology Source Type: research
Correction to: Sensitivity analysis of EGFR L861Q mutation to six tyrosine kinase inhibitors
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 1, 2024 Category: Cancer & Oncology Source Type: research
Prognostic value of geriatric nutritional risk index in patients with diffuse large B-cell lymphoma: a meta-analysis
ConclusionThe results of our meta-analysis indicate that a lower GNRI significantly associated with poorer prognosis for DLBCL. It is believed that GNRI was a promisingly predictive indicator of survival outcomes in DLBCL patients. However, large multicenter prospective studies are necessary to verify the results. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity
ConclusionWe identified 14 MRP genes as HCC diagnostic markers. We investigated FRG and m6A modification-related gene expression profiles and immune features in patients with HCC, and developed and validated a model incorporating MRP and FRG expression that accurately and reliably predicts HCC prognosis and may predict disease progression and treatment response. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
Prognostic model of ER-positive, HER2-negative breast cancer predicted by clinically relevant indicators
ConclusionTo generate nomograms that predicted DFS and OS, independent predictors of DFS in ER-positive/HER2-negative breast cancer patients were chosen. The nomograms successfully stratified patients into prognostic categories and worked well in both internal validation and external validation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
Mechanism of action and treatment of type I interferon in hepatocellular carcinoma
AbstractHepatocellular carcinoma (HCC) caused by HBV, HCV infection, and other factors is one of the most common malignancies in the world. Although, percutaneous treatments such as surgery, ethanol injection, radiofrequency ablation, and transcatheter treatments such as arterial chemoembolization are useful for local tumor control, they are not sufficient to improve the prognosis of patients with HCC. External interferon agents that induce interferon-related genes or type I interferon in combination with other drugs can reduce the recurrence rate and improve survival in HCC patients after surgery. Therefore, in this revie...
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
Energy metabolism: a new target for gastric cancer treatment
AbstractGastric cancer is the fifth most common malignancy worldwide having the fourth highest mortality rate. Energy metabolism is key and closely linked to tumour development. Most important in the reprogramming of cancer metabolism is the Warburg effect, which suggests that tumour cells will utilise glycolysis even with normal oxygen levels. Various molecules exert their effects by acting on enzymes in the glycolytic pathway, integral to glycolysis. Second, mitochondrial abnormalities in the reprogramming of energy metabolism, with consequences for glutamine metabolism, the tricarboxylic acid cycle and oxidative phospho...
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
LINC00844 suppresses tumor progression and predicts survival outcomes through inhibiting miR-19a-5p in cholangiocarcinoma
ConclusionThe expression levels of LINC00844 were decreased in both CCA tissues and cells, and high LINC00844 inhibited CCA cell proliferation, migration and invasion through sponging miR-19a-5p. Low LINC00844 and high miR-19a-5p expression were associated with worse overall survival in CCA patients. All the data suggested that the LINC00844/miR-19a-5p axis may provide novel therapeutic targets and prognostic biomarkers for CCA patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
Efficacy and safety of trifluridine/tipiracil (TAS-102) in patients with metastatic colorectal cancer: a systematic review and meta-analysis
ConclusionTAS-102 can enhance the prognosis of mCRC patients whose standard therapy has failed, regardless of KRAS mutation status, and its safety is acceptable. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
Characteristics and prognosis of EGFR mutations in small cell lung cancer patients in the NGS era
ConclusionEGFR-mutated SCLCs occurred more frequently in non-smoking females and were linked to prolonged survival, implying a positive prognostic impact. These SCLCs shared immunohistochemical similarities with conventional SCLCs, and both types had prevalent RB1 and TP53 mutations. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
A nomogram based on 4-lncRNAs signature for improving prognostic prediction of hepatocellular carcinoma
ConclusionsA prognostic nomogram on the base of 4-lncRNAs markers was built, which is capable to accurately predict the 1-year, 3-year, and 5-year survival of HCC patients after the construction of the 4-lncRNAs signature linked with prognosis of HCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research
