Clinical and Translational Oncology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

A nomogram based on 4-lncRNAs signature for improving prognostic prediction of hepatocellular carcinoma
ConclusionsA prognostic nomogram on the base of 4-lncRNAs markers was built, which is capable to accurately predict the 1-year, 3-year, and 5-year survival of HCC patients after the construction of the 4-lncRNAs signature linked with prognosis of HCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

Surface guided radiation therapy with an innovative open-face mask and mouth bite: patient motion management in brain stereotactic radiotherapy
ConclusionsThe application of the SGRT with an innovative open-face mask and mouth bite device could achieve precision positioning accuracy and stability, and the accuracy of the AlignRT system exhibits excellent constancy with the CBCT gold standard. The non-coplanar radiation field monitoring can provide reliable support for motion management in fractional treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

Glioblastoma research on zebrafish xenograft models: a systematic review
AbstractGlioblastoma (GBM) constitutes the most common primary brain tumor in adults. The challenges in GBM therapeutics have shed light on zebrafish used as a promising animal model for preclinical GBM xenograft studies without a standardized methodology. This systematic review aims to summarize the advances in zebrafish GBM xenografting, compare research protocols to pinpoint advantages and underlying limitations, and designate the predominant xenografting parameters. Based on the PRISMA checklist, we systematically searched PubMed, Scopus, and ZFIN using the keywords “glioblastoma,” “xenotransplantation,” and �...
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

Correction: SEOM-GEICAM-SOLTI clinical guidelines for early-stage breast cancer (2022)
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

Correction to: Sensitivity analysis of EGFR L861Q mutation to six tyrosine kinase inhibitors
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 25, 2024 Category: Cancer & Oncology Source Type: research

CAR-T cell therapy: a game-changer in cancer treatment and beyond
AbstractIn recent years, cancer has become one of the primary causes of mortality, approximately 10 million deaths worldwide each year. The most advanced, chimeric antigen receptor (CAR) T cell immunotherapy has turned out as a promising treatment for cancer. CAR-T cell therapy involves the genetic modification of T cells obtained from the patient's blood, and infusion back to the patients. CAR-T cell immunotherapy has led to a significant improvement in the remission rates of hematological cancers. CAR-T cell therapy presently limited to hematological cancers, there are ongoing efforts to develop additional CAR constructs...
Source: Clinical and Translational Oncology - January 20, 2024 Category: Cancer & Oncology Source Type: research

Radiation-induced changes in gene expression in rectal cancer specimens
ConclusionFuture studies would benefit from standardised prospective approaches to sampling to enable the inclusion of timepoints relevant to the tumour and immune response. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 19, 2024 Category: Cancer & Oncology Source Type: research

Exosomal noncoding RNAs as noninvasive biomarkers in bladder cancer: a diagnostic meta-analysis
ConclusionExosomal ncRNAs in blood and urine may play a vital role in diagnosing bladder cancer as prospective noninvasive biomarkers; nonetheless, their clinical performance needs to be confirmed by further massive proactive researches. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 16, 2024 Category: Cancer & Oncology Source Type: research

Changes in the fecal microbiota of breast cancer patients based on 16S rRNA gene sequencing: a systematic review and meta-analysis
ConclusionsThis observational meta-analysis revealed that the changes in gut microbiota were correlated with BC, and the changes in some primary fecal microbiota might affect the beginning of breast cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 13, 2024 Category: Cancer & Oncology Source Type: research

Surgical margins and prognosis of borderline and malignant phyllodes tumors
ConclusionsA negative surgical margin of at least 1 cm (with secondary resection if necessary) should be achieved for borderline and malignant PTs. Tumor size ≥ 5 cm and age < 45 years were predictive of recurrence, suggesting multiple therapy modalities may be considered for these high-risk patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 13, 2024 Category: Cancer & Oncology Source Type: research