The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study
Conclusions: The Heart-Brain Study investigates relationships between (cardio-)vascular factors, the hemodynamic status of the heart and the brain, and cognitive impairment. By studying the complete heart-brain axis in patient groups that represent components of this axis, we have the opportunity to assess a combination of clinical and subclinical manifestations of disorders of the heart, vascular system and brain, with hemodynamic status as a possible binding factor.Cerebrovasc Dis Extra 2017;7:140 –152 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 25, 2017 Category: Neurology Source Type: research
Improvement and Aggravation of Spontaneous Unruptured Vertebral Artery Dissection
Conclusions: VAD improvement primarily occurs within 6 months after onset, and VAD aggravation within 1 month. It seems that older patients and current smoking are negative predictors of VAD improvement as risk factors, and as image findings, the pearl and string sign is a positive predictor and occlusion a negative predictor.Cerebrovasc Dis Extra 2017;7:153 –164 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 25, 2017 Category: Neurology Source Type: research
Characteristics and Outcomes of Vertebrobasilar Artery Dissection with Accompanied Atherosclerosis
Conclusion: VBD-related PCS with and without accompanied atherosclerosis had different manifestations and should be regarded as distinct arterial diseases.Cerebrovasc Dis Extra 2017;7:165 –172 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 25, 2017 Category: Neurology Source Type: research
Improvement and Aggravation of Spontaneous Unruptured Vertebral Artery Dissection
Conclusions: VAD improvement primarily occurs within 6 months after onset, and VAD aggravation within 1 month. It seems that older patients and current smoking are negative predictors of VAD improvement as risk factors, and as image findings, the pearl and string sign is a positive predictor and occlusion a negative predictor.Cerebrovasc Dis Extra 2017;7:153 –164 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 17, 2017 Category: Neurology Source Type: research
Characteristics and Outcomes of Vertebrobasilar Artery Dissection with Accompanied Atherosclerosis
Conclusion: VBD-related PCS with and without accompanied atherosclerosis had different manifestations and should be regarded as distinct arterial diseases.Cerebrovasc Dis Extra 2017;7:165 –172 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 17, 2017 Category: Neurology Source Type: research
The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study
Conclusions: The Heart-Brain Study investigates relationships between (cardio-)vascular factors, the hemodynamic status of the heart and the brain, and cognitive impairment. By studying the complete heart-brain axis in patient groups that represent components of this axis, we have the opportunity to assess a combination of clinical and subclinical manifestations of disorders of the heart, vascular system and brain, with hemodynamic status as a possible binding factor.Cerebrovasc Dis Extra 2017;7:140 –152 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 10, 2017 Category: Neurology Source Type: research
Pharyngolaryngeal Sensory Deficits in Patients with Middle Cerebral Artery Infarction: Lateralization and Relation to Overall Dysphagia Severity
Conclusions: This study provides evidence that an intact sensory feedback is of utmost importance to perform nonimpaired swallowing and highlights the key role of disturbed pharyngeal and laryngeal afferents in the pathophysiology of PSD.Cerebrovasc Dis Extra 2017;7:130 –139 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 3, 2017 Category: Neurology Source Type: research
Abbreviation of the Follow-Up NIH Stroke Scale Using Factor Analysis
Conclusions: At 24 h following ischemic stroke, aphasia, neglect, and arm weakness are the most prognostically relevant neurologic findings. The aNIHSS appears to have excellent prognostic accuracy with higher reliability and may be clinically useful.Cerebrovasc Dis Extra 2017;7:120 –129 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 2, 2017 Category: Neurology Source Type: research
In Potential Stroke Patients on Warfarin, the International Normalized Ratio Predicts Ischemia
Conclusions: Sub-therapeutic INR and atrial fibrillation are strongly associated with ischemia in patients on warfarin presenting with acute neurologic symptoms. Ischemia is far less likely in patients with an INR of ≥2 and rare in those with an INR ≥3.6. This study shows that the INR value of a patient on warfarin can help stratify patients’ risk for acute ischemic stroke and guide further neurologic imaging and workup.Cerebrovasc Dis Extra 2017;7:111 –119 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - August 11, 2017 Category: Neurology Source Type: research
Dosage Calculation for Intravenous Thrombolysis of Ischemic Stroke: To Weigh or to Estimate
Conclusion: This first prospective study of weight assessment in acute stroke shows that the use of an easily accessible scale makes it feasible to weigh patients with acute stroke without the treatment delay associated with additional patient transfers. Physicians ’ estimates of patients’ weights demonstrated substantial aberrations from measured weights. Avoiding these deviations would improve the accuracy of tPA dosage.Cerebrovasc Dis Extra 2017;7:103 –110 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - June 9, 2017 Category: Neurology Source Type: research
Dosage Calculation for Intravenous Thrombolysis of Ischemic Stroke: To Weigh or to Estimate?
Conclusion: This first prospective study of weight assessment in acute stroke shows that the use of an easily accessible scale makes it feasible to weigh patients with acute stroke without the treatment delay associated with additional patient transfers. Physicians ’ estimates of patients’ weights demonstrated substantial aberrations from measured weights. Avoiding these deviations would improve the accuracy of tPA dosage.Cerebrovasc Dis Extra 2017;7:103 –110 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - May 30, 2017 Category: Neurology Source Type: research
Outcomes of Endovascular Thrombectomy with and without Thrombolysis for Acute Large Artery Ischaemic Stroke at a Tertiary Stroke Centre
Conclusion: Our study highlights the relatively large proportion of patients suitable for EVT who have a contraindication to alteplase and raises the hypothesis that adding alteplase to successful EVT may not be necessary to optimize functional outcome. The results are consistent with observational data from other endovascular centres and support a randomised controlled trial of EVT versus EVT with bridging alteplase.Cerebrovasc Dis Extra 2017;7:95 –102 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - May 2, 2017 Category: Neurology Source Type: research
Factor XII as a Risk Marker for Hemorrhagic Stroke: A Prospective Cohort Study
Conclusion: We found an independent association between FXII levels and the risk of hemorrhagic stroke, but not between FXII levels and ischemic stroke or myocardial infarction.Cerebrovasc Dis Extra 2017;7:84 –94 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 21, 2017 Category: Neurology Source Type: research
Blunt Traumatic Extracranial Cerebrovascular Injury and Ischemic Stroke
Background: Ischemic stroke occurs in a significant subset of patients with blunt traumatic cerebrovascular injury (TCVI). The patients are victims of motor vehicle crashes, assaults or other high-energy collisions, and suffer ischemic stroke due to injury to the extracranial carotid or vertebral arteries.Summary: An increasing number of patients with TCVI are being identified, largely because of the expanding use of computed tomography angiography for screening patients with blunt trauma. Patients with TCVI are particularly challenging to manage because they often suffer polytrauma, that is, numerous additional injuries i...
Source: Cerebrovascular Diseases Extra - April 11, 2017 Category: Neurology Source Type: research
Volume and Characteristics of Intracerebral Hemorrhage with Direct Oral Anticoagulants in Comparison with Warfarin
Conclusions: Based on the results of the present study, in terms of the risks associated with ICHs, the use of DOACs appears to be safer than warfarin for anticoagulation therapy. Further studies are required to validate these findings.
Cerebrovasc Dis Extra 2017;7:62 –71 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 3, 2017 Category: Neurology Source Type: research
