Determining Stroke Onset Time Using Quantitative MRI: High Accuracy, Sensitivity and Specificity Obtained from Magnetic Resonance Relaxation Times
Many ischaemic stroke patients are ineligible for thrombolytic therapy due to unknown onset time. Quantitative MRI (qMRI) is a potential surrogate for stroke timing. Rats were subjected to permanent middle cerebral artery occlusion and qMRI parameters including hemispheric differences in apparent diffusion coefficient, T2-weighted signal intensities, T1 and T2 relaxation times (qT1, qT2) andf1,f2 andVoverlap were measured at hourly intervals at 4.7 or 9.4 T. Accuracy and sensitivity for identifying strokes scanned within and beyond 3 h of onset was determined. Accuracy forVoverlap,f2 and qT2 (>90%) was significantly higher...
Source: Cerebrovascular Diseases Extra - August 25, 2016 Category: Neurology Source Type: research
Increased Plasma Matrix Metalloproteinase-9 Levels Contribute to Intracerebral Hemorrhage during Thrombolysis after Concomitant Stroke and Influenza Infection
Conclusion: Preexisting influenza A virus infection led to increased plasma MMP-9 and TIMP-1 levels in mice undergoing thrombolysis after induced stroke. MMP-9 levels closely correlated with intracerebral bleeding after thrombolysis during concomitant infection and stroke. Thus, our data indicate that thrombolysis may be dangerous during influenza infection. MMP-9 inhibitors might be considered to reduce the side effects of thrombolysis during concomitant infection and stroke.Cerebrovasc Dis Extra 2016;6:50-59 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - August 24, 2016 Category: Neurology Source Type: research
Temporal Trends in Incidence and Case Fatality of Intracerebral Hemorrhage: The Troms ø Study 1995-2012
Background: The aim of this study was to explore temporal trends in incidence and case fatality rates of intracerebral hemorrhage (ICH) over the last two decades in a Norwegian municipality.Methods: Incident cases of primary ICH were registered in the period from 1995 through 2012 in 32,530 participants of the longitudinal population-based Troms ø Study. Poisson regression models were used to obtain incidence rates over time in age- and sex-adjusted and age- and sex-specific models. Case fatality rates were calculated and age- and sex-adjusted trends over time were estimated using logistic regression.Results: A total of 2...
Source: Cerebrovascular Diseases Extra - August 12, 2016 Category: Neurology Source Type: research
Difference in Transcranial Doppler Velocity and Patient Age between Proximal and Distal Middle Cerebral Artery Vasospasms after Aneurysmal Subarachnoid Hemorrhage
Conclusions: In patients with cerebral vasospasm localized at the distal part of the MCA, flow velocity at the horizontal segment of the MCA did not increase to the level we defined as positive. To avoid such false negatives, a slight increase in velocity on TCD should be considered as positive in distal vasospasm cases, especially in older patients.Cerebrovasc Dis Extra 2016;6:32-39 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - July 6, 2016 Category: Neurology Source Type: research
Screening for Language Disorders in Stroke: German Validation of the Language Screening Test (LAST)
Conclusion: The German version of the LAST, available in two parallel versions, is a new and valid language screening test in stroke.Cerebrovasc Dis Extra 2016;6:27-31 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - April 19, 2016 Category: Neurology Source Type: research
International Survey on the Management of Wake-Up Stroke
Conclusions: In this study, most stroke experts recommended a recanalization treatment for wake-up stroke. However, there was considerable disagreement among experts regarding the best brain imaging method and the best recanalization treatment. The results of ongoing randomized trials on wake-up stroke are urgently needed.Cerebrovasc Dis Extra 2016;6:22-26 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - March 30, 2016 Category: Neurology Source Type: research
Variability in Motor and Language Recovery during the Acute Stroke Period
Conclusions: Over the first week after stroke onset, recovery of upper extremity hemiparesis and aphasia were not predictable on the basis of initial impairment, lesion volume, or age. In addition, patients only achieved about 1/3 of their remaining possible recovery based on the anticipated 70% proportion found at 90 days. These findings suggest that the complex interaction between poststroke structural repair, regeneration, and functional reorganization during the first week after stroke has yet to be elucidated.Cerebrovasc Dis Extra 2016;6:12-21 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - March 22, 2016 Category: Neurology Source Type: research
Higher Levels of Cystatin C Are Associated with Extracranial Carotid Artery Steno-Occlusive Disease in Patients with Noncardioembolic Ischemic Stroke
Conclusions: This preliminary study suggests that higher levels of CysC were independently associated with symptomatic extracranial ICA stenosis, but not with intracranial ICA/MCA stenosis in patients with noncardioembolic stroke. Our findings provide new insights into the link between serum CysC and carotid atherosclerosis.Cerebrovasc Dis Extra 2016;6:1-11 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - January 19, 2016 Category: Neurology Source Type: research
Subarachnoid Haemorrhage and Sports
Conclusions: Our findings indicate that SAH precipitated by sports is not very frequent and is uncommonly related to trauma. Patients who suffered SAH associated with sports were younger and apparently had a milder clinical presentation.Cerebrovasc Dis Extra 2015;5:146-151 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - November 4, 2015 Category: Neurology Source Type: research
DWI Lesion Patterns in Cancer-Related Stroke - Specifying the Phenotype
Conclusion: When excluding competing embolic and nonembolic stroke etiologies, the pattern of scattered DWI lesions in multiple vascular supply territories strongly dominates the phenotype of cancer-related stroke. Additionally, evidence of recurrent infarction is frequent in this cohort of patients. This is not only important for the diagnosis of cancer-related stroke itself but may prove helpful for the identification of cancer-related stroke patients with unknown malignancy at the time of stroke manifestation and evaluation of strategies for secondary prevention.Cerebrovasc Dis Extra 2015;5:139-145 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 30, 2015 Category: Neurology Source Type: research
Improving Outcomes Achieved by a New Stroke Program in Hungary
Conclusions: Our thrombolysis rate is higher than the national average, but still low compared to the rates of Western European countries. We are continuously working to enhance our stroke program. Here, we discuss those components that need to be further refined in order to improve stroke intervention and outcome.Cerebrovasc Dis Extra 2015;5:132-138 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 30, 2015 Category: Neurology Source Type: research
The CXCR2 Gene Polymorphism Is Associated with Stroke in Patients with Essential Hypertension
Hypertension is the major risk factor for stroke, and genetic factors contribute to its development. Inflammation has been hypothesized to be the key link between blood pressure elevation and stroke. We performed an analysis of the association between inflammatory mediator gene polymorphisms and the incidence of stroke in patients with essential hypertension (EH). The study group consisted of 625 individuals (296 patients with noncomplicated EH, 71 hypertensive patients with ischemic stroke, and 258 control subjects). Both patients and controls were ethnic Tatars originating from the Republic of Bashkortostan (Russian Fede...
Source: Cerebrovascular Diseases Extra - October 28, 2015 Category: Neurology Source Type: research
Clinical, Laboratory, and Imaging Characteristics of Transient Ischemic Attack Caused by Large Artery Lesions: A Comparison between Carotid and Intracranial Arteries
Conclusions: Among our patients with TIA caused by large artery disease, patients with intracranial artery occlusive lesions were more frequent and were at higher risk of early ischemic stroke than those with extracranial carotid artery occlusive lesions. These data highlight the importance of prompt assessment of intracranial artery lesions in patients with TIA.Cerebrovasc Dis Extra 2015;5:115-123 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 17, 2015 Category: Neurology Source Type: research
Erratum
Cerebrovasc Dis Extra 2015;5:114 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 14, 2015 Category: Neurology Source Type: research
Cancer-Associated Stroke: The Bergen NORSTROKE Study
Conclusions: Cancer-associated stroke is rare, and routine investigation for cancer seems unwarranted in acute ischemic stroke. However, in stroke patients with elevated levels of blood coagulation factors, C-reactive protein, higher age and a history of smoking, underlying malignancy should be considered. Our study suggests that an unknown stroke etiology does not predict malignancy.Cerebrovasc Dis Extra 2015;5:107-113 (Source: Cerebrovascular Diseases Extra)
Source: Cerebrovascular Diseases Extra - October 13, 2015 Category: Neurology Source Type: research
