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Reducing the Risks of Nuclear War: the Role of Health Professionals
Cerebellum. 2023 Oct 25. doi: 10.1007/s12311-023-01599-1. Online ahead of print.NO ABSTRACTPMID:37878145 | DOI:10.1007/s12311-023-01599-1 (Source: Cerebellum)
Source: Cerebellum - October 25, 2023 Category: Neuroscience Authors: Kamran Abbasi Parveen Ali Virginia Barbour Kirsten Bibbins-Domingo Marcel Gm Olde Rikkert Andy Haines Ira Helfand Richard Horton Bob Mash Arun Mitra Carlos Monteiro Elena N Naumova Eric J Rubin Tilman Ruff Peush Sahni James Tumwine Paul Yonga Chris Zielin Source Type: research

NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse
In this study, we found that motor training could specially upregulate the expression level of NR1a, a splicing form of NR1 subunit. Interestingly, overexpression of this splicing variant in a cerebellar granule cell-specific manner dramatically elevated the NMDAR binding activity. Furthermore, the NR1a transgenic mice did not only show an enhanced motor learning, but also exhibit a higher efficacy for motor training in motor learning. Our results suggested that as a "junior" receptor, NR1a facilitates NMDAR activity as well as motor skill learning.PMID:37880519 | DOI:10.1007/s12311-023-01614-5 (Source: Cerebellum)
Source: Cerebellum - October 25, 2023 Category: Neuroscience Authors: Ting Tan Linyan Jiang Zhengxiao He Xuejiao Ding Xiaoli Xiong Mingxi Tang Yuan Chen Yaping Tang Source Type: research

Bilateral Cerebellar Repetitive Transcranial Magnetic Stimulation for Chronic Ataxia After Hemorrhagic Stroke: a Case Report
We present the case of a patient with chronic cerebellar ataxia following a hemorrhagic stroke who underwent inhibitory rTMS to bilateral cerebellar targets with demonstrated improvement in symptoms.PMID:37864649 | DOI:10.1007/s12311-023-01618-1 (Source: Cerebellum)
Source: Cerebellum - October 21, 2023 Category: Neuroscience Authors: Evan Hy Einstein Juliana Corlier Cole Matthews Doan Ngo Michael K Leuchter Cole Citrenbaum Nikita Vince-Cruz Bhavna Ramesh Aaron Slan Scott A Wilke Nathaniel Ginder Thomas Strouse Andrew F Leuchter Source Type: research

COVID-19 Impacts the Mental Health and Speech Function in Spinocerebellar Ataxia Type 2: Evidences from a Follow-Up Study
The objective of this study is to assess the impact of COVID-19 on the mental health and motor features of SCA2. A follow-up study was carried out in 170 Cuban SCA2 subjects and 87 community controls between 2020 and 2021. All subjects underwent a structured questionnaire to assess the risks of exposure to COVID-19, the confirmation of COVID-19 diagnosis, and the Hospital Anxiety and Depression Scale (HADS). Moreover, 36 subjects underwent the Scale for the Assessment and Rating of ataxia (SARA). The risk of exposure to SARS-CoV-2 and the frequency of COVID-19 were similar between the ataxia cohort and the community contro...
Source: Cerebellum - October 20, 2023 Category: Neuroscience Authors: Luis Vel ázquez-Pérez Roberto Rodr íguez-Labrada Yasmany Gonzalez-Garc és Nalia Canales-Ochoa Jacqueline Medrano-Montero Yennis Dom ínguez-Barrios Frank J Carrillo-Rodes Mar ía B Ramírez-Bautista Alberto Caballero-Laguna Osiel G ámez-Rodríguez Ma Source Type: research

Parkinsonism in SCA19/22: Dopamine Transporter Imaging in an Italian Family Harboring a Novel Mutation
Cerebellum. 2023 Oct 19. doi: 10.1007/s12311-023-01619-0. Online ahead of print.ABSTRACTSpinocerebellar ataxia (SCA)19/22 is a channelopathy caused by mutations in the KCND3 gene encoding for the voltage-gated potassium channel Kv4.3. In the present work, we report an Italian family harboring a novel KCND3 missense mutation characterized by ataxia and mild parkinsonism. Patients underwent dopamine transporter single-photon emission computed tomography to assess dopaminergic degeneration. Normal findings were observed, and treatment with levodopa did not yield any benefit, thus suggesting the involvement of other mechanisms...
Source: Cerebellum - October 19, 2023 Category: Neuroscience Authors: Elena Contaldi Silvia Gallo Lucia Corrado Sandra D'Alfonso Luca Magistrelli Source Type: research

A Novel TTBK2 Mutation in a Chinese Pedigree with Spinocerebellar Ataxia 11
Cerebellum. 2023 Oct 17. doi: 10.1007/s12311-023-01616-3. Online ahead of print.ABSTRACTSpinocerebellar ataxia type 11 (SCA11) is a rare disease and the tau tubulin kinase 2 (TTBK2) gene was the causative gene. To date, only six SCA11 families have been reported. Here, we reported a Chinese SCA11 pedigree with cerebellar ataxia. Both patients in the family demonstrated typical clinical features of cerebellar ataxia and cerebellar atrophy on brain MRI. A novel heterozygous duplication mutation (c.1211_1217dupAGGAGAA) of the TTBK2 gene was identified in the proband using whole-exome sequencing (WES), which resulted in a fram...
Source: Cerebellum - October 17, 2023 Category: Neuroscience Authors: Yin-Qian Lu Jian-Min Chen Ya-Li Huang Zhang-Yu Zou Source Type: research

A Case of Anti-Ma2 Encephalitis Presenting with Pendular Torsional Nystagmus
Cerebellum. 2023 Oct 18. doi: 10.1007/s12311-023-01601-w. Online ahead of print.ABSTRACTAntibodies against the neuronal protein Ma2 have been reported in a peculiar form of paraneoplastic encephalitis with prominent involvement of the limbic, brainstem, and diencephalic structures and usually associated with germ cell testicular, lung, or breast cancer. The diagnosis is frequently challenged by atypical clinical manifestations including parkinsonism, sleep disturbances, hypothalamic-pituitary dysfunctions, and motor neuron-like syndrome. In recent years, the advent of monoclonal antibodies targeting immune checkpoints has ...
Source: Cerebellum - October 17, 2023 Category: Neuroscience Authors: Gloria Vaghi Elisa Vegezzi Paola Bini Matteo Gastaldi Luca Diamanti Enrico Marchioni Silvia Colnaghi Source Type: research