Metabolic Determinants of Cerebellar Circuit Formation and Maintenance
Cerebellum. 2023 Dec 20. doi: 10.1007/s12311-023-01641-2. Online ahead of print.ABSTRACTCells configure their metabolism in a synchronized and timely manner to meet their energy demands throughout development and adulthood. Transitions of developmental stages are coupled to metabolic shifts, such that glycolysis is highly active during cell proliferation, whereas oxidative phosphorylation prevails in postmitotic states. In the cerebellum, metabolic transitions are remarkable given its protracted developmental timelines. Such distinctive feature, along with its high neuronal density and metabolic demands, make the cerebellu...
Source: Cerebellum - December 20, 2023 Category: Neuroscience Authors: Manuel Gonzalez-Rodriguez Isaac Marin-Valencia Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia
Cerebellum. 2023 Dec 8. doi: 10.1007/s12311-023-01633-2. Online ahead of print.ABSTRACTRecent findings in animals have challenged the traditional view of the cerebellum solely as the site of motor control, suggesting that the cerebellum may also be important for learning to predict reward from trial-and-error feedback. Yet, evidence for the role of the cerebellum in reward learning in humans is lacking. Moreover, open questions remain about which specific aspects of reward learning the cerebellum may contribute to. Here we address this gap through an investigation of multiple forms of reward learning in individuals with ce...
Source: Cerebellum - December 8, 2023 Category: Neuroscience Authors: Jonathan Nicholas Christian Amlang Chi-Ying R Lin Leila Montaser-Kouhsari Natasha Desai Ming-Kai Pan Sheng-Han Kuo Daphna Shohamy Source Type: research
Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases
We report on two PAPT cases without evidence of anti-IgLON5 antibodies in both CSF and serum. Despite common clinical and pathological characteristics, PAPT and IgLON5 disease are two distinct entities.PMID:38060151 | DOI:10.1007/s12311-023-01647-w (Source: Cerebellum)
Source: Cerebellum - December 7, 2023 Category: Neuroscience Authors: Andrea Mastrangelo Maria Pia Giannoccaro Vincenzo Donadio Fortuna Ricciardiello Felice Di Laudo Flavia Palombo Rocco Liguori Giovanni Rizzo Source Type: research
Progressive Ataxia and Palatal Tremor Is Not Associated with IgLON5 Antibodies: Results From Two Cases
We report on two PAPT cases without evidence of anti-IgLON5 antibodies in both CSF and serum. Despite common clinical and pathological characteristics, PAPT and IgLON5 disease are two distinct entities.PMID:38060151 | DOI:10.1007/s12311-023-01647-w (Source: Cerebellum)
Source: Cerebellum - December 7, 2023 Category: Neuroscience Authors: Andrea Mastrangelo Maria Pia Giannoccaro Vincenzo Donadio Fortuna Ricciardiello Felice Di Laudo Flavia Palombo Rocco Liguori Giovanni Rizzo Source Type: research
Amyotrophic Lateral Sclerosis with SOD1 Mutation Presenting with Progressive Cerebellar Ataxia
We describe a patient with a homozygous pathogenic mutation in SOD1 gene that presented with a progressive cerebellar ataxia and ultimately developed a complex phenotype of cerebellar ataxia and motor neuron disease. The linkage between the cerebellum and ALS is shortly discussed.PMID:38049694 | DOI:10.1007/s12311-023-01643-0 (Source: Cerebellum)
Source: Cerebellum - December 4, 2023 Category: Neuroscience Authors: Marta Sequeira Filipe Godinho Jo ão Lourenço Source Type: research
Amyotrophic Lateral Sclerosis with SOD1 Mutation Presenting with Progressive Cerebellar Ataxia
We describe a patient with a homozygous pathogenic mutation in SOD1 gene that presented with a progressive cerebellar ataxia and ultimately developed a complex phenotype of cerebellar ataxia and motor neuron disease. The linkage between the cerebellum and ALS is shortly discussed.PMID:38049694 | DOI:10.1007/s12311-023-01643-0 (Source: Cerebellum)
Source: Cerebellum - December 4, 2023 Category: Neuroscience Authors: Marta Sequeira Filipe Godinho Jo ão Lourenço Source Type: research
Amyotrophic Lateral Sclerosis with SOD1 Mutation Presenting with Progressive Cerebellar Ataxia
We describe a patient with a homozygous pathogenic mutation in SOD1 gene that presented with a progressive cerebellar ataxia and ultimately developed a complex phenotype of cerebellar ataxia and motor neuron disease. The linkage between the cerebellum and ALS is shortly discussed.PMID:38049694 | DOI:10.1007/s12311-023-01643-0 (Source: Cerebellum)
Source: Cerebellum - December 4, 2023 Category: Neuroscience Authors: Marta Sequeira Filipe Godinho Jo ão Lourenço Source Type: research
