NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse

In this study, we found that motor training could specially upregulate the expression level of NR1a, a splicing form of NR1 subunit. Interestingly, overexpression of this splicing variant in a cerebellar granule cell-specific manner dramatically elevated the NMDAR binding activity. Furthermore, the NR1a transgenic mice did not only show an enhanced motor learning, but also exhibit a higher efficacy for motor training in motor learning. Our results suggested that as a "junior" receptor, NR1a facilitates NMDAR activity as well as motor skill learning.PMID:37880519 | DOI:10.1007/s12311-023-01614-5

Source: Cerebellum - October 25, 2023 Category: Neuroscience Authors: Ting Tan Linyan Jiang Zhengxiao He Xuejiao Ding Xiaoli Xiong Mingxi Tang Yuan Chen Yaping Tang Source Type: research