"The Red Flags" in Clinical Approach to Acute Ataxia-the Experience in Cohort of 76 Children
Cerebellum. 2023 Nov 27. doi: 10.1007/s12311-023-01639-w. Online ahead of print.ABSTRACTThe aim of our study is to define the most frequent etiology, clinical presentation, and predictive factors of outcome in children with acute ataxia (AA) and to determine "the red flags" in the diagnostic approach to children with AA. The retrospective study included the patients with AA treated in the institute from 2015 to 2021. The inclusion criteria were children aged 1-18 years, evolution time of ataxia within 72 h, and diagnosis made by a physician. The exclusion criteria were anamnestic data about ataxia without confirmation by a...
Source: Cerebellum - November 26, 2023 Category: Neuroscience Authors: R Kravljanac A Golubovic B Vucetic Tadic S Ostojic I Cerovic J Savkic Source Type: research
"The Red Flags" in Clinical Approach to Acute Ataxia-the Experience in Cohort of 76 Children
Cerebellum. 2023 Nov 27. doi: 10.1007/s12311-023-01639-w. Online ahead of print.ABSTRACTThe aim of our study is to define the most frequent etiology, clinical presentation, and predictive factors of outcome in children with acute ataxia (AA) and to determine "the red flags" in the diagnostic approach to children with AA. The retrospective study included the patients with AA treated in the institute from 2015 to 2021. The inclusion criteria were children aged 1-18 years, evolution time of ataxia within 72 h, and diagnosis made by a physician. The exclusion criteria were anamnestic data about ataxia without confirmation by a...
Source: Cerebellum - November 26, 2023 Category: Neuroscience Authors: R Kravljanac A Golubovic B Vucetic Tadic S Ostojic I Cerovic J Savkic Source Type: research
Favorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy
We present a case of acute cerebellar ataxia and nystagmus with detected anti-DNER antibody. Brain magnetic resonance imaging (MRI) showed cerebellar atrophy. High titer of anti-DNER antibody was detected in CSF and serum. Positron emission tomography (PET) scanning was unremarkable at a 10-month follow up. The patient improved significantly after immunosuppressive therapy with intravenous steroids, immunoglobulin followed by rituximab. Our study suggest that the presence of such anti-neuronal antibodies might not come along with malignancy and that early onset non-tumor patients are more likely to have a better outcome af...
Source: Cerebellum - November 22, 2023 Category: Neuroscience Authors: Ruo-Nan Duan Wei-Yue Si Li-Li Cao Source Type: research
Transcranial Alternating Current Stimulation in a Patient with Ataxia-Ocular Apraxia 2: a Case Report
In this study, we present the case of a patient diagnosed with AOA2, who experienced walking instability and uncoordinated movement. The patient underwent transcranial alternating current stimulation (tACS) treatment for 4 weeks with follow-up after 1 month. The effectiveness of the treatment was evaluated using the International Cooperative Ataxia Rating Scale (ICARS), the Scale for the Assessment and Rating of Ataxia (SARA), the 9-Hole Peg Test (9HPT), and functional near-infrared spectroscopy (fNIRS). Following treatment, the patient's ataxia symptoms showed significant improvement and continued to be alleviated during ...
Source: Cerebellum - November 22, 2023 Category: Neuroscience Authors: Xiao-Ping Cheng Wen-Hui Yu Xia Liu Wei Lin Zhao-Di Wang Xi-Chen Wang Jun Ni Nai-Qing Cai Xin-Yuan Chen Source Type: research
Favorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy
We present a case of acute cerebellar ataxia and nystagmus with detected anti-DNER antibody. Brain magnetic resonance imaging (MRI) showed cerebellar atrophy. High titer of anti-DNER antibody was detected in CSF and serum. Positron emission tomography (PET) scanning was unremarkable at a 10-month follow up. The patient improved significantly after immunosuppressive therapy with intravenous steroids, immunoglobulin followed by rituximab. Our study suggest that the presence of such anti-neuronal antibodies might not come along with malignancy and that early onset non-tumor patients are more likely to have a better outcome af...
Source: Cerebellum - November 22, 2023 Category: Neuroscience Authors: Ruo-Nan Duan Wei-Yue Si Li-Li Cao Source Type: research
Transcranial Alternating Current Stimulation in a Patient with Ataxia-Ocular Apraxia 2: a Case Report
In this study, we present the case of a patient diagnosed with AOA2, who experienced walking instability and uncoordinated movement. The patient underwent transcranial alternating current stimulation (tACS) treatment for 4 weeks with follow-up after 1 month. The effectiveness of the treatment was evaluated using the International Cooperative Ataxia Rating Scale (ICARS), the Scale for the Assessment and Rating of Ataxia (SARA), the 9-Hole Peg Test (9HPT), and functional near-infrared spectroscopy (fNIRS). Following treatment, the patient's ataxia symptoms showed significant improvement and continued to be alleviated during ...
Source: Cerebellum - November 22, 2023 Category: Neuroscience Authors: Xiao-Ping Cheng Wen-Hui Yu Xia Liu Wei Lin Zhao-Di Wang Xi-Chen Wang Jun Ni Nai-Qing Cai Xin-Yuan Chen Source Type: research
Favorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy
We present a case of acute cerebellar ataxia and nystagmus with detected anti-DNER antibody. Brain magnetic resonance imaging (MRI) showed cerebellar atrophy. High titer of anti-DNER antibody was detected in CSF and serum. Positron emission tomography (PET) scanning was unremarkable at a 10-month follow up. The patient improved significantly after immunosuppressive therapy with intravenous steroids, immunoglobulin followed by rituximab. Our study suggest that the presence of such anti-neuronal antibodies might not come along with malignancy and that early onset non-tumor patients are more likely to have a better outcome af...
Source: Cerebellum - November 22, 2023 Category: Neuroscience Authors: Ruo-Nan Duan Wei-Yue Si Li-Li Cao Source Type: research
Transcranial Alternating Current Stimulation in a Patient with Ataxia-Ocular Apraxia 2: a Case Report
In this study, we present the case of a patient diagnosed with AOA2, who experienced walking instability and uncoordinated movement. The patient underwent transcranial alternating current stimulation (tACS) treatment for 4 weeks with follow-up after 1 month. The effectiveness of the treatment was evaluated using the International Cooperative Ataxia Rating Scale (ICARS), the Scale for the Assessment and Rating of Ataxia (SARA), the 9-Hole Peg Test (9HPT), and functional near-infrared spectroscopy (fNIRS). Following treatment, the patient's ataxia symptoms showed significant improvement and continued to be alleviated during ...
Source: Cerebellum - November 22, 2023 Category: Neuroscience Authors: Xiao-Ping Cheng Wen-Hui Yu Xia Liu Wei Lin Zhao-Di Wang Xi-Chen Wang Jun Ni Nai-Qing Cai Xin-Yuan Chen Source Type: research
Favorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy
We present a case of acute cerebellar ataxia and nystagmus with detected anti-DNER antibody. Brain magnetic resonance imaging (MRI) showed cerebellar atrophy. High titer of anti-DNER antibody was detected in CSF and serum. Positron emission tomography (PET) scanning was unremarkable at a 10-month follow up. The patient improved significantly after immunosuppressive therapy with intravenous steroids, immunoglobulin followed by rituximab. Our study suggest that the presence of such anti-neuronal antibodies might not come along with malignancy and that early onset non-tumor patients are more likely to have a better outcome af...
Source: Cerebellum - November 22, 2023 Category: Neuroscience Authors: Ruo-Nan Duan Wei-Yue Si Li-Li Cao Source Type: research
Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in Spinocerebellar Ataxia Type 3: a Systematic Review and Meta ‑analysis of Randomized Controlled Trials
Cerebellum. 2023 Nov 17. doi: 10.1007/s12311-023-01628-z. Online ahead of print.ABSTRACTTherapeutic alternatives for spinocerebellar ataxia type 3 (SCA3) are limited. Repetitive transcranial magnetic stimulation (rTMS) as a potential intervention has drawn heightened interest because of its ease of implementation, cost-effectiveness, and safety profile. We conducted a systematic review and meta-analysis to evaluate the efficacy of rTMS in the treatment of SCA3. We systematically searched databases-PubMed, Embase, the Cochrane Library, and Springer-for randomized controlled trials (RCTs) investigating the use of rTMS in the...
Source: Cerebellum - November 17, 2023 Category: Neuroscience Authors: Mengqiu Qiu Rui Wang Yusha Shen Zhenggang Hu Yanbin Zhang Source Type: research
Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in Spinocerebellar Ataxia Type 3: a Systematic Review and Meta ‑analysis of Randomized Controlled Trials
Cerebellum. 2023 Nov 17. doi: 10.1007/s12311-023-01628-z. Online ahead of print.ABSTRACTTherapeutic alternatives for spinocerebellar ataxia type 3 (SCA3) are limited. Repetitive transcranial magnetic stimulation (rTMS) as a potential intervention has drawn heightened interest because of its ease of implementation, cost-effectiveness, and safety profile. We conducted a systematic review and meta-analysis to evaluate the efficacy of rTMS in the treatment of SCA3. We systematically searched databases-PubMed, Embase, the Cochrane Library, and Springer-for randomized controlled trials (RCTs) investigating the use of rTMS in the...
Source: Cerebellum - November 17, 2023 Category: Neuroscience Authors: Mengqiu Qiu Rui Wang Yusha Shen Zhenggang Hu Yanbin Zhang Source Type: research
Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in Spinocerebellar Ataxia Type 3: a Systematic Review and Meta ‑analysis of Randomized Controlled Trials
Cerebellum. 2023 Nov 17. doi: 10.1007/s12311-023-01628-z. Online ahead of print.ABSTRACTTherapeutic alternatives for spinocerebellar ataxia type 3 (SCA3) are limited. Repetitive transcranial magnetic stimulation (rTMS) as a potential intervention has drawn heightened interest because of its ease of implementation, cost-effectiveness, and safety profile. We conducted a systematic review and meta-analysis to evaluate the efficacy of rTMS in the treatment of SCA3. We systematically searched databases-PubMed, Embase, the Cochrane Library, and Springer-for randomized controlled trials (RCTs) investigating the use of rTMS in the...
Source: Cerebellum - November 17, 2023 Category: Neuroscience Authors: Mengqiu Qiu Rui Wang Yusha Shen Zhenggang Hu Yanbin Zhang Source Type: research
Exploring the Therapeutic Effects and Mechanisms of Transcranial Alternating Current Stimulation on Improving Walking Ability in Stroke Patients via Modulating Cerebellar Gamma Frequency Band-a Narrative Review
Cerebellum. 2023 Nov 14. doi: 10.1007/s12311-023-01632-3. Online ahead of print.ABSTRACTThe cerebellum plays an important role in maintaining balance, posture control, muscle tone, and lower limb coordination in healthy individuals and stroke patients. At the same time, the relationship between cerebellum and motor learning has been widely concerned in recent years. Due to the relatively intact structure preservation and high plasticity after supratentorial stroke, non-invasive neuromodulation targeting the cerebellum is increasingly used to treat abnormal gait in stroke patients. The gamma frequency of transcranial altern...
Source: Cerebellum - November 14, 2023 Category: Neuroscience Authors: Tingyi Feng Lichao Zhang Yuwei Wu Lin Tang Xixi Chen Yuanli Li Chunlei Shan Source Type: research
Exploring the Therapeutic Effects and Mechanisms of Transcranial Alternating Current Stimulation on Improving Walking Ability in Stroke Patients via Modulating Cerebellar Gamma Frequency Band-a Narrative Review
Cerebellum. 2023 Nov 14. doi: 10.1007/s12311-023-01632-3. Online ahead of print.ABSTRACTThe cerebellum plays an important role in maintaining balance, posture control, muscle tone, and lower limb coordination in healthy individuals and stroke patients. At the same time, the relationship between cerebellum and motor learning has been widely concerned in recent years. Due to the relatively intact structure preservation and high plasticity after supratentorial stroke, non-invasive neuromodulation targeting the cerebellum is increasingly used to treat abnormal gait in stroke patients. The gamma frequency of transcranial altern...
Source: Cerebellum - November 14, 2023 Category: Neuroscience Authors: Tingyi Feng Lichao Zhang Yuwei Wu Lin Tang Xixi Chen Yuanli Li Chunlei Shan Source Type: research
Exploring the Therapeutic Effects and Mechanisms of Transcranial Alternating Current Stimulation on Improving Walking Ability in Stroke Patients via Modulating Cerebellar Gamma Frequency Band-a Narrative Review
Cerebellum. 2023 Nov 14. doi: 10.1007/s12311-023-01632-3. Online ahead of print.ABSTRACTThe cerebellum plays an important role in maintaining balance, posture control, muscle tone, and lower limb coordination in healthy individuals and stroke patients. At the same time, the relationship between cerebellum and motor learning has been widely concerned in recent years. Due to the relatively intact structure preservation and high plasticity after supratentorial stroke, non-invasive neuromodulation targeting the cerebellum is increasingly used to treat abnormal gait in stroke patients. The gamma frequency of transcranial altern...
Source: Cerebellum - November 14, 2023 Category: Neuroscience Authors: Tingyi Feng Lichao Zhang Yuwei Wu Lin Tang Xixi Chen Yuanli Li Chunlei Shan Source Type: research
