Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis
We present a detailed neurophysiological and computationally-rendered model of functionally grouped Golgi cells which can infer the density of parallel fibre signals activity and convert it into proportional modulation of inhibition of granule cells. The conversion is unlearned and not actively computed; rather, output is simply the computational effect of cell morphology and network architecture. Unexpectedly, the conversion becomes more precise at low density, suggesting that self-regulation is attracted to sparse code, because it is stable. A computational function of gap junctions may not be confined to the cerebellum....
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Mike Gilbert Anders Rasmussen Source Type: research
Gravity-Dependent Modulation of Downbeat Nystagmus and Subjective Visual Vertical in the Roll Plane
In this study, we investigated static and dynamic graviceptive function in the roll-plane in patients with DBN (patients) and healthy-controls (controls) by assessment of the Subjective Visual Vertical (SVV) and the modulation of slow-phase-velocity (SPV) of DBN. SPV of DBN and SVV were tested at different head-on trunk-tilt positions in the roll-plane (0°,30° clockwise (cw) and 30° counterclockwise (ccw)) in 26 patients suffering from DBN and 13 controls. In patients, SPV of DBN did not show significant modulations at different head-tilt angles in the roll-plane. SVV ratings did not differ significantly between DBN pat...
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Stefan Macher Daniela Dunkler Anuscha Theresa Fiehl Paulus Stefan Rommer Kirsten Platho-Elwischger Felix Konstantin Schwarz Gerald Wiest Source Type: research
Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis
We present a detailed neurophysiological and computationally-rendered model of functionally grouped Golgi cells which can infer the density of parallel fibre signals activity and convert it into proportional modulation of inhibition of granule cells. The conversion is unlearned and not actively computed; rather, output is simply the computational effect of cell morphology and network architecture. Unexpectedly, the conversion becomes more precise at low density, suggesting that self-regulation is attracted to sparse code, because it is stable. A computational function of gap junctions may not be confined to the cerebellum....
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Mike Gilbert Anders Rasmussen Source Type: research
Gravity-Dependent Modulation of Downbeat Nystagmus and Subjective Visual Vertical in the Roll Plane
In this study, we investigated static and dynamic graviceptive function in the roll-plane in patients with DBN (patients) and healthy-controls (controls) by assessment of the Subjective Visual Vertical (SVV) and the modulation of slow-phase-velocity (SPV) of DBN. SPV of DBN and SVV were tested at different head-on trunk-tilt positions in the roll-plane (0°,30° clockwise (cw) and 30° counterclockwise (ccw)) in 26 patients suffering from DBN and 13 controls. In patients, SPV of DBN did not show significant modulations at different head-tilt angles in the roll-plane. SVV ratings did not differ significantly between DBN pat...
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Stefan Macher Daniela Dunkler Anuscha Theresa Fiehl Paulus Stefan Rommer Kirsten Platho-Elwischger Felix Konstantin Schwarz Gerald Wiest Source Type: research
Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis
We present a detailed neurophysiological and computationally-rendered model of functionally grouped Golgi cells which can infer the density of parallel fibre signals activity and convert it into proportional modulation of inhibition of granule cells. The conversion is unlearned and not actively computed; rather, output is simply the computational effect of cell morphology and network architecture. Unexpectedly, the conversion becomes more precise at low density, suggesting that self-regulation is attracted to sparse code, because it is stable. A computational function of gap junctions may not be confined to the cerebellum....
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Mike Gilbert Anders Rasmussen Source Type: research
Gravity-Dependent Modulation of Downbeat Nystagmus and Subjective Visual Vertical in the Roll Plane
In this study, we investigated static and dynamic graviceptive function in the roll-plane in patients with DBN (patients) and healthy-controls (controls) by assessment of the Subjective Visual Vertical (SVV) and the modulation of slow-phase-velocity (SPV) of DBN. SPV of DBN and SVV were tested at different head-on trunk-tilt positions in the roll-plane (0°,30° clockwise (cw) and 30° counterclockwise (ccw)) in 26 patients suffering from DBN and 13 controls. In patients, SPV of DBN did not show significant modulations at different head-tilt angles in the roll-plane. SVV ratings did not differ significantly between DBN pat...
Source: Cerebellum - March 19, 2024 Category: Neuroscience Authors: Stefan Macher Daniela Dunkler Anuscha Theresa Fiehl Paulus Stefan Rommer Kirsten Platho-Elwischger Felix Konstantin Schwarz Gerald Wiest Source Type: research
Effects of Baclofen on Central Paroxysmal Positional Downbeat Nystagmus
This study aims to elucidate the mechanism of central positional nystagmus (CPN) by determining the effects of baclofen on the intensity of paroxysmal positional downbeat nystagmus due to central lesions. Fifteen patients with paroxysmal downbeat CPN were subjected to manual straight head-hanging before administration of baclofen, while taking baclofen 30 mg per day for at least one week, and two weeks after discontinuation of baclofen. The maximum slow phase velocity (SPV) and time constant (TC) of the induced paroxysmal downbeat CPN were analyzed. The positional vertigo was evaluated using an 11-point numerical rating sc...
Source: Cerebellum - March 18, 2024 Category: Neuroscience Authors: So-Yeon Yun Jong-Hee Lee Hyo-Jung Kim Jeong-Yoon Choi Ji-Soo Kim Source Type: research
Quantitative Evaluation of Stance as a Sensitive Biomarker of Postural Ataxia Development in Preclinical SCA1 Mutation Carriers
Cerebellum. 2024 Mar 16. doi: 10.1007/s12311-024-01679-w. Online ahead of print.ABSTRACTThe aim of this study was to determine the time between the first detection of postural control impairments and the evident manifestation of ataxia in preclinical SCA1 individuals. Twenty five preclinical SCA1 mutation carriers: 13 with estimated disease onset ≤ 6 years (SCA1 +) aged 27.8 ± 8.1 years; 12 with expected disease onset > 6 years (SCA1-) aged 26.6 ± 3.1 years and 26 age and sex matched healthy controls (HCs) underwent static posturography during 5 years of observation. The movements of the centre of feet pressure (COP...
Source: Cerebellum - March 16, 2024 Category: Neuroscience Authors: Anna Sobanska Leszek Czerwosz Anna Sulek Rafal Rola Iwona Stepniak Maria Rakowicz Source Type: research
Quantitative Evaluation of Stance as a Sensitive Biomarker of Postural Ataxia Development in Preclinical SCA1 Mutation Carriers
Cerebellum. 2024 Mar 16. doi: 10.1007/s12311-024-01679-w. Online ahead of print.ABSTRACTThe aim of this study was to determine the time between the first detection of postural control impairments and the evident manifestation of ataxia in preclinical SCA1 individuals. Twenty five preclinical SCA1 mutation carriers: 13 with estimated disease onset ≤ 6 years (SCA1 +) aged 27.8 ± 8.1 years; 12 with expected disease onset > 6 years (SCA1-) aged 26.6 ± 3.1 years and 26 age and sex matched healthy controls (HCs) underwent static posturography during 5 years of observation. The movements of the centre of feet pressure (COP...
Source: Cerebellum - March 16, 2024 Category: Neuroscience Authors: Anna Sobanska Leszek Czerwosz Anna Sulek Rafal Rola Iwona Stepniak Maria Rakowicz Source Type: research
Quantitative Evaluation of Stance as a Sensitive Biomarker of Postural Ataxia Development in Preclinical SCA1 Mutation Carriers
Cerebellum. 2024 Mar 16. doi: 10.1007/s12311-024-01679-w. Online ahead of print.ABSTRACTThe aim of this study was to determine the time between the first detection of postural control impairments and the evident manifestation of ataxia in preclinical SCA1 individuals. Twenty five preclinical SCA1 mutation carriers: 13 with estimated disease onset ≤ 6 years (SCA1 +) aged 27.8 ± 8.1 years; 12 with expected disease onset > 6 years (SCA1-) aged 26.6 ± 3.1 years and 26 age and sex matched healthy controls (HCs) underwent static posturography during 5 years of observation. The movements of the centre of feet pressure (COP...
Source: Cerebellum - March 16, 2024 Category: Neuroscience Authors: Anna Sobanska Leszek Czerwosz Anna Sulek Rafal Rola Iwona Stepniak Maria Rakowicz Source Type: research
Neuronal Nitric Oxide Synthase Regulates Cerebellar Parallel Fiber Slow EPSC in Purkinje Neurons by Modulating STIM1-Gated TRPC3-Containing Channels
This study investigated the role of nNOS/NO in regulating EPSCSlow. Electrophysiological analyses showed that EPSCSlow in cerebellar slices of nNOS knockout (nNOS-/-) mice was significantly larger than that in wildtype (WT) mice. Activation of mGluR1 in cultured PNs from nNOS-/- mice evoked larger TRPC3-channel mediated currents and intracellular Ca2+ rise than that in PNs from WT mice. In addition, nNOS inhibitor and NO-donor increased and decreased, respectively, the TRPC3-current and Ca2+ rise in PNs. Moreover, the NO-donor effectively decreased TRPC3 currents in HEK293 cells expressing WT STIM1, but not cells expressin...
Source: Cerebellum - March 13, 2024 Category: Neuroscience Authors: Le Gui Vasiliki Tellios Yun-Yan Xiang Qingping Feng Wataru Inoue Wei-Yang Lu Source Type: research
Neuronal Nitric Oxide Synthase Regulates Cerebellar Parallel Fiber Slow EPSC in Purkinje Neurons by Modulating STIM1-Gated TRPC3-Containing Channels
This study investigated the role of nNOS/NO in regulating EPSCSlow. Electrophysiological analyses showed that EPSCSlow in cerebellar slices of nNOS knockout (nNOS-/-) mice was significantly larger than that in wildtype (WT) mice. Activation of mGluR1 in cultured PNs from nNOS-/- mice evoked larger TRPC3-channel mediated currents and intracellular Ca2+ rise than that in PNs from WT mice. In addition, nNOS inhibitor and NO-donor increased and decreased, respectively, the TRPC3-current and Ca2+ rise in PNs. Moreover, the NO-donor effectively decreased TRPC3 currents in HEK293 cells expressing WT STIM1, but not cells expressin...
Source: Cerebellum - March 13, 2024 Category: Neuroscience Authors: Le Gui Vasiliki Tellios Yun-Yan Xiang Qingping Feng Wataru Inoue Wei-Yang Lu Source Type: research
Neuronal Nitric Oxide Synthase Regulates Cerebellar Parallel Fiber Slow EPSC in Purkinje Neurons by Modulating STIM1-Gated TRPC3-Containing Channels
This study investigated the role of nNOS/NO in regulating EPSCSlow. Electrophysiological analyses showed that EPSCSlow in cerebellar slices of nNOS knockout (nNOS-/-) mice was significantly larger than that in wildtype (WT) mice. Activation of mGluR1 in cultured PNs from nNOS-/- mice evoked larger TRPC3-channel mediated currents and intracellular Ca2+ rise than that in PNs from WT mice. In addition, nNOS inhibitor and NO-donor increased and decreased, respectively, the TRPC3-current and Ca2+ rise in PNs. Moreover, the NO-donor effectively decreased TRPC3 currents in HEK293 cells expressing WT STIM1, but not cells expressin...
Source: Cerebellum - March 13, 2024 Category: Neuroscience Authors: Le Gui Vasiliki Tellios Yun-Yan Xiang Qingping Feng Wataru Inoue Wei-Yang Lu Source Type: research
The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells
Cerebellum. 2024 Mar 11. doi: 10.1007/s12311-024-01682-1. Online ahead of print.ABSTRACTClimbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber resp...
Source: Cerebellum - March 12, 2024 Category: Neuroscience Authors: Josefine Öhman Elias Sj ölin Maurizio Cundari Fredrik Johansson Mike Gilbert Henk-Jan Boele P är Svensson Anders Rasmussen Source Type: research
The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells
Cerebellum. 2024 Mar 11. doi: 10.1007/s12311-024-01682-1. Online ahead of print.ABSTRACTClimbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber resp...
Source: Cerebellum - March 12, 2024 Category: Neuroscience Authors: Josefine Öhman Elias Sj ölin Maurizio Cundari Fredrik Johansson Mike Gilbert Henk-Jan Boele P är Svensson Anders Rasmussen Source Type: research
