The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample
Cerebellum. 2023 Dec 27. doi: 10.1007/s12311-023-01645-y. Online ahead of print.ABSTRACTMultiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar structure is missing. We analyzed structural neuroimaging data from the Healthy Brain Network (HBN). Cerebellar parcellation was performed with a validated automated segmentation pipeline (CERES) and stringent visual quality check (n = 662 subjects retained from initial n = 1452). Canonica...
Source: Cerebellum - December 27, 2023 Category: Neuroscience Authors: Indrit B ègue Yannis Elandaloussi Farnaz Delavari Hengyi Cao Alexandra Moussa-Tooks Mathilde Roser Pierrick Coup é Marion Leboyer Stefan Kaiser Josselin Houenou Roscoe Brady Charles Laidi Source Type: research
The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample
Cerebellum. 2023 Dec 27. doi: 10.1007/s12311-023-01645-y. Online ahead of print.ABSTRACTMultiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar structure is missing. We analyzed structural neuroimaging data from the Healthy Brain Network (HBN). Cerebellar parcellation was performed with a validated automated segmentation pipeline (CERES) and stringent visual quality check (n = 662 subjects retained from initial n = 1452). Canonica...
Source: Cerebellum - December 27, 2023 Category: Neuroscience Authors: Indrit B ègue Yannis Elandaloussi Farnaz Delavari Hengyi Cao Alexandra Moussa-Tooks Mathilde Roser Pierrick Coup é Marion Leboyer Stefan Kaiser Josselin Houenou Roscoe Brady Charles Laidi Source Type: research
The Cerebellum and Cognitive Function: Anatomical Evidence from a Transdiagnostic Sample
Cerebellum. 2023 Dec 27. doi: 10.1007/s12311-023-01645-y. Online ahead of print.ABSTRACTMultiple lines of evidence across human functional, lesion, and animal data point to a cerebellar role, in particular of crus I, crus II, and lobule VIIB, in cognitive function. However, a mapping of distinct facets of cognitive function to cerebellar structure is missing. We analyzed structural neuroimaging data from the Healthy Brain Network (HBN). Cerebellar parcellation was performed with a validated automated segmentation pipeline (CERES) and stringent visual quality check (n = 662 subjects retained from initial n = 1452). Canonica...
Source: Cerebellum - December 27, 2023 Category: Neuroscience Authors: Indrit B ègue Yannis Elandaloussi Farnaz Delavari Hengyi Cao Alexandra Moussa-Tooks Mathilde Roser Pierrick Coup é Marion Leboyer Stefan Kaiser Josselin Houenou Roscoe Brady Charles Laidi Source Type: research
Cerebellar Direct Current Stimulation Reveals the Causal Role of the Cerebellum in Temporal Prediction
Cerebellum. 2023 Dec 26. doi: 10.1007/s12311-023-01649-8. Online ahead of print.ABSTRACTTemporal prediction (TP) influences our perception and cognition. The cerebellum could mediate this multi-level ability in a context-dependent manner. We tested whether a modulation of the cerebellar neural activity, induced by transcranial Direct Current Stimulation (tDCS), changed the TP ability according to the temporal features of the context and the duration of target interval. Fifteen healthy participants received anodal, cathodal, and sham tDCS (15 min × 2 mA intensity) over the right cerebellar hemisphere during a TP task. We r...
Source: Cerebellum - December 26, 2023 Category: Neuroscience Authors: Sara Terranova Alessandro Botta Martina Putzolu Gaia Bonassi Carola Cosentino Susanna Mezzarobba Elisa Ravizzotti Elisa Pelosin Laura Avanzino Source Type: research
Cerebellar Direct Current Stimulation Reveals the Causal Role of the Cerebellum in Temporal Prediction
Cerebellum. 2023 Dec 26. doi: 10.1007/s12311-023-01649-8. Online ahead of print.ABSTRACTTemporal prediction (TP) influences our perception and cognition. The cerebellum could mediate this multi-level ability in a context-dependent manner. We tested whether a modulation of the cerebellar neural activity, induced by transcranial Direct Current Stimulation (tDCS), changed the TP ability according to the temporal features of the context and the duration of target interval. Fifteen healthy participants received anodal, cathodal, and sham tDCS (15 min × 2 mA intensity) over the right cerebellar hemisphere during a TP task. We r...
Source: Cerebellum - December 26, 2023 Category: Neuroscience Authors: Sara Terranova Alessandro Botta Martina Putzolu Gaia Bonassi Carola Cosentino Susanna Mezzarobba Elisa Ravizzotti Elisa Pelosin Laura Avanzino Source Type: research
Toward a Better Understanding of Walking Speed in Ataxia of Charlevoix-Saguenay: a Factor Exploratory Study
The objective of the study was to identify the factors influencing the self-selected walking speed in adults with ARSACS. The dependent variable of this cross-sectional study was the self-selected speed and the factors (independent variables) were age, sex, balance, balance confidence, knee flexion and extension cocontraction indexes, lower limb coordination, passive range of motion of ankle dorsiflexion, knee and hip extension, and global spasticity. Multiple regression models were used to assess the relationships between walking speed and each factor individually. Six factors were significantly associated with walking sp...
Source: Cerebellum - December 22, 2023 Category: Neuroscience Authors: Isabelle Lessard Luc J H ébert Rapha ël St-Gelais Isabelle C ôté Jean Mathieu Bernard Brais Cynthia Gagnon Source Type: research
Toward a Better Understanding of Walking Speed in Ataxia of Charlevoix-Saguenay: a Factor Exploratory Study
The objective of the study was to identify the factors influencing the self-selected walking speed in adults with ARSACS. The dependent variable of this cross-sectional study was the self-selected speed and the factors (independent variables) were age, sex, balance, balance confidence, knee flexion and extension cocontraction indexes, lower limb coordination, passive range of motion of ankle dorsiflexion, knee and hip extension, and global spasticity. Multiple regression models were used to assess the relationships between walking speed and each factor individually. Six factors were significantly associated with walking sp...
Source: Cerebellum - December 22, 2023 Category: Neuroscience Authors: Isabelle Lessard Luc J H ébert Rapha ël St-Gelais Isabelle C ôté Jean Mathieu Bernard Brais Cynthia Gagnon Source Type: research
Toward a Better Understanding of Walking Speed in Ataxia of Charlevoix-Saguenay: a Factor Exploratory Study
The objective of the study was to identify the factors influencing the self-selected walking speed in adults with ARSACS. The dependent variable of this cross-sectional study was the self-selected speed and the factors (independent variables) were age, sex, balance, balance confidence, knee flexion and extension cocontraction indexes, lower limb coordination, passive range of motion of ankle dorsiflexion, knee and hip extension, and global spasticity. Multiple regression models were used to assess the relationships between walking speed and each factor individually. Six factors were significantly associated with walking sp...
Source: Cerebellum - December 22, 2023 Category: Neuroscience Authors: Isabelle Lessard Luc J H ébert Rapha ël St-Gelais Isabelle C ôté Jean Mathieu Bernard Brais Cynthia Gagnon Source Type: research
Toward a Better Understanding of Walking Speed in Ataxia of Charlevoix-Saguenay: a Factor Exploratory Study
The objective of the study was to identify the factors influencing the self-selected walking speed in adults with ARSACS. The dependent variable of this cross-sectional study was the self-selected speed and the factors (independent variables) were age, sex, balance, balance confidence, knee flexion and extension cocontraction indexes, lower limb coordination, passive range of motion of ankle dorsiflexion, knee and hip extension, and global spasticity. Multiple regression models were used to assess the relationships between walking speed and each factor individually. Six factors were significantly associated with walking sp...
Source: Cerebellum - December 22, 2023 Category: Neuroscience Authors: Isabelle Lessard Luc J H ébert Rapha ël St-Gelais Isabelle C ôté Jean Mathieu Bernard Brais Cynthia Gagnon Source Type: research
Short-Term Efficacy of Cerebello-spinal tDCS and Body Weight-Supported Treadmill Training in the Hypertrophic Olivary Degeneration: a Rare Case Report
Cerebellum. 2023 Dec 20. doi: 10.1007/s12311-023-01650-1. Online ahead of print.ABSTRACTThe present case study reported a patient diagnosed with hypertrophic olivary degeneration, a rare condition characterized by a trans-neuronal degeneration and signal enhancement in T2-weighted images on magnetic resonance imaging, usually caused by cerebral hemorrhage, cerebral infarction, and trauma. Furthermore, the relevant literature review was performed. The existing pharmacological treatment has limited clinical benefits on the patient. Since spontaneous remission hardly occurs in the disease, there are no other effective treatme...
Source: Cerebellum - December 20, 2023 Category: Neuroscience Authors: Xi-Chen Wang Nai-Qing Cai Xiao-Ping Cheng Lin Zhang Wen-Zong Wang Jun Ni Xin-Yuan Chen Source Type: research
Scale for Ocular Motor Disorders in Ataxia (SODA) in Patients with Multiple System Atrophy
Cerebellum. 2023 Dec 20. doi: 10.1007/s12311-023-01653-y. Online ahead of print.ABSTRACTA clinical scale fully dedicated to evaluating ocular motor abnormalities is required for now. We investigated the utility of a recently developed Scale for Ocular motor Disorders in Ataxia (SODA) in patients with multiple system atrophy (MSA). We prospectively assessed SODA in consecutive patients with MSA between August 2021 and August 2023 at the Korea University Medical Center. The results of the clinical exam-based SODA were compared with those measured using video-oculography (VOG-guided SODA). We also compared the findings with o...
Source: Cerebellum - December 20, 2023 Category: Neuroscience Authors: Hojin Yoon Hanim Kwon Sun-Uk Lee Euyhyun Park Chan-Nyoung Lee Byung-Jo Kim Ji-Soo Kim Kun-Woo Park Source Type: research
Metabolic Determinants of Cerebellar Circuit Formation and Maintenance
Cerebellum. 2023 Dec 20. doi: 10.1007/s12311-023-01641-2. Online ahead of print.ABSTRACTCells configure their metabolism in a synchronized and timely manner to meet their energy demands throughout development and adulthood. Transitions of developmental stages are coupled to metabolic shifts, such that glycolysis is highly active during cell proliferation, whereas oxidative phosphorylation prevails in postmitotic states. In the cerebellum, metabolic transitions are remarkable given its protracted developmental timelines. Such distinctive feature, along with its high neuronal density and metabolic demands, make the cerebellu...
Source: Cerebellum - December 20, 2023 Category: Neuroscience Authors: Manuel Gonzalez-Rodriguez Isaac Marin-Valencia Source Type: research
Short-Term Efficacy of Cerebello-spinal tDCS and Body Weight-Supported Treadmill Training in the Hypertrophic Olivary Degeneration: a Rare Case Report
Cerebellum. 2023 Dec 20. doi: 10.1007/s12311-023-01650-1. Online ahead of print.ABSTRACTThe present case study reported a patient diagnosed with hypertrophic olivary degeneration, a rare condition characterized by a trans-neuronal degeneration and signal enhancement in T2-weighted images on magnetic resonance imaging, usually caused by cerebral hemorrhage, cerebral infarction, and trauma. Furthermore, the relevant literature review was performed. The existing pharmacological treatment has limited clinical benefits on the patient. Since spontaneous remission hardly occurs in the disease, there are no other effective treatme...
Source: Cerebellum - December 20, 2023 Category: Neuroscience Authors: Xi-Chen Wang Nai-Qing Cai Xiao-Ping Cheng Lin Zhang Wen-Zong Wang Jun Ni Xin-Yuan Chen Source Type: research
Scale for Ocular Motor Disorders in Ataxia (SODA) in Patients with Multiple System Atrophy
Cerebellum. 2023 Dec 20. doi: 10.1007/s12311-023-01653-y. Online ahead of print.ABSTRACTA clinical scale fully dedicated to evaluating ocular motor abnormalities is required for now. We investigated the utility of a recently developed Scale for Ocular motor Disorders in Ataxia (SODA) in patients with multiple system atrophy (MSA). We prospectively assessed SODA in consecutive patients with MSA between August 2021 and August 2023 at the Korea University Medical Center. The results of the clinical exam-based SODA were compared with those measured using video-oculography (VOG-guided SODA). We also compared the findings with o...
Source: Cerebellum - December 20, 2023 Category: Neuroscience Authors: Hojin Yoon Hanim Kwon Sun-Uk Lee Euyhyun Park Chan-Nyoung Lee Byung-Jo Kim Ji-Soo Kim Kun-Woo Park Source Type: research
Metabolic Determinants of Cerebellar Circuit Formation and Maintenance
Cerebellum. 2023 Dec 20. doi: 10.1007/s12311-023-01641-2. Online ahead of print.ABSTRACTCells configure their metabolism in a synchronized and timely manner to meet their energy demands throughout development and adulthood. Transitions of developmental stages are coupled to metabolic shifts, such that glycolysis is highly active during cell proliferation, whereas oxidative phosphorylation prevails in postmitotic states. In the cerebellum, metabolic transitions are remarkable given its protracted developmental timelines. Such distinctive feature, along with its high neuronal density and metabolic demands, make the cerebellu...
Source: Cerebellum - December 20, 2023 Category: Neuroscience Authors: Manuel Gonzalez-Rodriguez Isaac Marin-Valencia Source Type: research
