Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Extra and intra cellular HSP70 levels in adults with and without metabolic disorders: a systematic review and meta-analysis
Cell Stress Chaperones. 2023 Jul 26. doi: 10.1007/s12192-023-01368-3. Online ahead of print.ABSTRACTMetabolic disorders, such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) are related to chronic pro-inflammatory conditions. Evidence suggests that heat shock proteins are linked to metabolic disorders. Intracellular HSP70 (iHSP70) is mandatory for normal insulin signalling, and proteostasis, and exerts a powerful anti-inflammatory role. On the other hand, the extracellular (eHSP72) is linked with a pro-inflammatory state and induces insulin resistance in humans. Then, we conducted a systematic revi...
Source: Cell Stress and Chaperones - July 26, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Helena Trevisan Schroeder Josianne Rodrigues-Krause Maur ício Krause Source Type: research
Quantitative proteomic analyses uncover regulatory roles of Nrf2 in human endothelial cells
Cell Stress Chaperones. 2023 Jul 25. doi: 10.1007/s12192-023-01366-5. Online ahead of print.ABSTRACTNuclear factor erythroid 2-related factor 2 (Nrf2), a transcriptional regulator, is the predominant factor in modulating oxidative stress and other cellular signaling responses. Studies from our lab and others highlighted that activation of the Nrf2 pathway by small molecules improves endothelial function by suppressing oxidative and endoplasmic reticulum (ER) stress. However, the exact mechanisms by which Nrf2 elicits these effects are unknown. In the present study, we developed CRISPR/Cas9-mediated Nrf2 knocked-out human e...
Source: Cell Stress and Chaperones - July 24, 2023 Category: Cytology Authors: Karan Naresh Amin Palanichamy Rajaguru Takayoshi Suzuki Koustav Sarkar Kumar Ganesan Kunka Mohanram Ramkumar Source Type: research
Quantitative proteomic analyses uncover regulatory roles of Nrf2 in human endothelial cells
Cell Stress Chaperones. 2023 Jul 25. doi: 10.1007/s12192-023-01366-5. Online ahead of print.ABSTRACTNuclear factor erythroid 2-related factor 2 (Nrf2), a transcriptional regulator, is the predominant factor in modulating oxidative stress and other cellular signaling responses. Studies from our lab and others highlighted that activation of the Nrf2 pathway by small molecules improves endothelial function by suppressing oxidative and endoplasmic reticulum (ER) stress. However, the exact mechanisms by which Nrf2 elicits these effects are unknown. In the present study, we developed CRISPR/Cas9-mediated Nrf2 knocked-out human e...
Source: Cell Stress and Chaperones - July 24, 2023 Category: Cytology Authors: Karan Naresh Amin Palanichamy Rajaguru Takayoshi Suzuki Koustav Sarkar Kumar Ganesan Kunka Mohanram Ramkumar Source Type: research
The beauty and complexity of the small heat shock proteins: a report on the proceedings of the fourth workshop on small heat shock proteins
Cell Stress Chaperones. 2023 Jul 18. doi: 10.1007/s12192-023-01360-x. Online ahead of print.ABSTRACTThe Fourth Cell Stress Society International workshop on small heat shock proteins (sHSPs), a follow-up to successful workshops held in 2014, 2016 and 2018, took place as a virtual meeting on the 17-18 November 2022. The meeting was designed to provide an opportunity for those working on sHSPs to reconnect and discuss their latest work. The diversity of research in the sHSP field is reflected in the breadth of topics covered in the talks presented at this meeting. Here we summarise the presentations at this meeting and provi...
Source: Cell Stress and Chaperones - July 18, 2023 Category: Cytology Authors: Heath Ecroyd Britta Bartelt-Kirbach Anat Ben-Zvi Raffaella Bonavita Yevheniia Bushman Elena Casarotto Ciro Cecconi Wilson Chun Yu Lau Jonathan D Hibshman Joep Joosten Virginia Kimonis Rachel Klevit Krzysztof Liberek Kathryn A McMenimen Tsukumi Miwa Axel M Source Type: research
Influence of body composition and cardiorespiratory fitness on plasma HSP72, norepinephrine, insulin, and glucose responses to an acute aerobic exercise bout performed in the fed state
Cell Stress Chaperones. 2023 Jul 18. doi: 10.1007/s12192-023-01364-7. Online ahead of print.ABSTRACTBeing overweight is already considered a metabolic risk factor, which can be overcome by increasing cardiorespiratory fitness (CRF). Acute exercise is known to induce changes in plasma hormones and heat shock proteins release. However, there is a lack of studies investigating the impact of body composition and CRF on these variables following acute aerobic exercise. To assess the influence of body composition and cardiorespiratory fitness on plasma heat shock protein 72 kDa (HSP72), norepinephrine (NE), insulin, and glucose ...
Source: Cell Stress and Chaperones - July 18, 2023 Category: Cytology Authors: Carlos Henrique de Lemos Muller Cesar Eduardo Jacintho Moritz Helena Trevisan Schroeder Ana Maria Oliveira Battastini Alvaro Reischak-Oliveira Paulo Ivo Homem de Bittencourt J únior Giuseppe De Vito Maur ício Krause Source Type: research
