Construction of a prognostic model for lung adenocarcinoma based on heat shock protein-related genes and immune analysis
Cell Stress Chaperones. 2023 Sep 11. doi: 10.1007/s12192-023-01374-5. Online ahead of print.ABSTRACTLung adenocarcinoma (LUAD) represents a prevalent form of cancer, with low early diagnosis rates and high mortality rates, posing a global health challenge. Heat shock proteins (HSPs) assume a crucial role within the tumor immune microenvironment (TME) of LUAD. Here, a collection of 97 HSP-related genes (HSPGs) was assembled based on prior literature reports, of which 36 HSPGs were differentially expressed in LUAD. In The Cancer Genome Atlas (TCGA) cohort, we constructed a prognostic model for risk stratification and prognos...
Source: Cell Stress and Chaperones - September 10, 2023 Category: Cytology Authors: Wangyan Zhou Wei Zeng Dayang Zheng Xu Yang Yongcheng Qing Chunxiang Zhou Xiang Liu Source Type: research
Construction of a prognostic model for lung adenocarcinoma based on heat shock protein-related genes and immune analysis
Cell Stress Chaperones. 2023 Sep 11. doi: 10.1007/s12192-023-01374-5. Online ahead of print.ABSTRACTLung adenocarcinoma (LUAD) represents a prevalent form of cancer, with low early diagnosis rates and high mortality rates, posing a global health challenge. Heat shock proteins (HSPs) assume a crucial role within the tumor immune microenvironment (TME) of LUAD. Here, a collection of 97 HSP-related genes (HSPGs) was assembled based on prior literature reports, of which 36 HSPGs were differentially expressed in LUAD. In The Cancer Genome Atlas (TCGA) cohort, we constructed a prognostic model for risk stratification and prognos...
Source: Cell Stress and Chaperones - September 10, 2023 Category: Cytology Authors: Wangyan Zhou Wei Zeng Dayang Zheng Xu Yang Yongcheng Qing Chunxiang Zhou Xiang Liu Source Type: research
Construction of a prognostic model for lung adenocarcinoma based on heat shock protein-related genes and immune analysis
Cell Stress Chaperones. 2023 Sep 11. doi: 10.1007/s12192-023-01374-5. Online ahead of print.ABSTRACTLung adenocarcinoma (LUAD) represents a prevalent form of cancer, with low early diagnosis rates and high mortality rates, posing a global health challenge. Heat shock proteins (HSPs) assume a crucial role within the tumor immune microenvironment (TME) of LUAD. Here, a collection of 97 HSP-related genes (HSPGs) was assembled based on prior literature reports, of which 36 HSPGs were differentially expressed in LUAD. In The Cancer Genome Atlas (TCGA) cohort, we constructed a prognostic model for risk stratification and prognos...
Source: Cell Stress and Chaperones - September 10, 2023 Category: Cytology Authors: Wangyan Zhou Wei Zeng Dayang Zheng Xu Yang Yongcheng Qing Chunxiang Zhou Xiang Liu Source Type: research
circABCA3 knockdown relieves hypoxia-induced human cardiac microvascular endothelial cell dysfunction by targeting the miR-671-5p/PCSK9 axis
Cell Stress Chaperones. 2023 Sep 7. doi: 10.1007/s12192-023-01377-2. Online ahead of print.ABSTRACTEndothelial cell dysfunction is one of the important stages in the development of acute myocardial infarction (AMI). However, whether circABCA3 (hsa_circ_0037516) mediates AMI development by regulating endothelial cell dysfunction remains unclear. The GEO database (GSE169594 and GSE160717) was used to screen the differentially expressed circRNAs. Hypoxia-induced human cardiac microvascular endothelial cells (HCMECs) were used to mimic AMI cell model. The expression of circABCA3, microRNA (miR)-671-5p, and proprotein convertas...
Source: Cell Stress and Chaperones - September 7, 2023 Category: Cytology Authors: Hui Hui Gaowa Zhao Mingliang Du Qin Yu Source Type: research
circABCA3 knockdown relieves hypoxia-induced human cardiac microvascular endothelial cell dysfunction by targeting the miR-671-5p/PCSK9 axis
Cell Stress Chaperones. 2023 Sep 7. doi: 10.1007/s12192-023-01377-2. Online ahead of print.ABSTRACTEndothelial cell dysfunction is one of the important stages in the development of acute myocardial infarction (AMI). However, whether circABCA3 (hsa_circ_0037516) mediates AMI development by regulating endothelial cell dysfunction remains unclear. The GEO database (GSE169594 and GSE160717) was used to screen the differentially expressed circRNAs. Hypoxia-induced human cardiac microvascular endothelial cells (HCMECs) were used to mimic AMI cell model. The expression of circABCA3, microRNA (miR)-671-5p, and proprotein convertas...
Source: Cell Stress and Chaperones - September 7, 2023 Category: Cytology Authors: Hui Hui Gaowa Zhao Mingliang Du Qin Yu Source Type: research
circABCA3 knockdown relieves hypoxia-induced human cardiac microvascular endothelial cell dysfunction by targeting the miR-671-5p/PCSK9 axis
Cell Stress Chaperones. 2023 Sep 7. doi: 10.1007/s12192-023-01377-2. Online ahead of print.ABSTRACTEndothelial cell dysfunction is one of the important stages in the development of acute myocardial infarction (AMI). However, whether circABCA3 (hsa_circ_0037516) mediates AMI development by regulating endothelial cell dysfunction remains unclear. The GEO database (GSE169594 and GSE160717) was used to screen the differentially expressed circRNAs. Hypoxia-induced human cardiac microvascular endothelial cells (HCMECs) were used to mimic AMI cell model. The expression of circABCA3, microRNA (miR)-671-5p, and proprotein convertas...
Source: Cell Stress and Chaperones - September 7, 2023 Category: Cytology Authors: Hui Hui Gaowa Zhao Mingliang Du Qin Yu Source Type: research
N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury
This study aimed to evaluate whether N-acetylcysteine (NAC) has hepatoprotective effects against ADR-induced hepatotoxicity in rats. In addition, it was aimed to determine how Meteorin-Like (MtrnL), which has pleiotropic effects on immunology, inflammation, and metabolism, is affected by ADR and/or NAC applications in liver tissue. 28 rats were randomly assigned to one of four equal groups in the study: control (no treatment), NAC (150 mg/kg/day of NAC intraperitoneally (i.p), ADR (15 mg/kg only on the first day of the experiment), and ADR + NAC (ADR 15 mg/kg on the first day of the experiment + 150 mg/kg/day NAC i.p). Aft...
Source: Cell Stress and Chaperones - September 5, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Ahmet Tektemur Tuncay Kulo ğlu Source Type: research
N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury
This study aimed to evaluate whether N-acetylcysteine (NAC) has hepatoprotective effects against ADR-induced hepatotoxicity in rats. In addition, it was aimed to determine how Meteorin-Like (MtrnL), which has pleiotropic effects on immunology, inflammation, and metabolism, is affected by ADR and/or NAC applications in liver tissue. 28 rats were randomly assigned to one of four equal groups in the study: control (no treatment), NAC (150 mg/kg/day of NAC intraperitoneally (i.p), ADR (15 mg/kg only on the first day of the experiment), and ADR + NAC (ADR 15 mg/kg on the first day of the experiment + 150 mg/kg/day NAC i.p). Aft...
Source: Cell Stress and Chaperones - September 5, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Ahmet Tektemur Tuncay Kulo ğlu Source Type: research
In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics
This study was carried out to determine whether L-Arg pre-intervention has protective effects on heart tissue in the experimental MI model. The 28 rats used in the study were randomly divided into 4 equal groups: control, L-Arg, ISO, and L-Arg+ISO. Upon completion of all applications, cardiac markers in serum and biochemical, histopathological, and immunohistochemical examinations in cardiac tissues were performed. Cardiac markers, histopathological changes, oxidative stress, inflammation, and apoptosis were increased in the experimental MI model. In addition, administration of ISO deregulated OTULIN levels and mitochondri...
Source: Cell Stress and Chaperones - August 29, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Source Type: research
In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics
This study was carried out to determine whether L-Arg pre-intervention has protective effects on heart tissue in the experimental MI model. The 28 rats used in the study were randomly divided into 4 equal groups: control, L-Arg, ISO, and L-Arg+ISO. Upon completion of all applications, cardiac markers in serum and biochemical, histopathological, and immunohistochemical examinations in cardiac tissues were performed. Cardiac markers, histopathological changes, oxidative stress, inflammation, and apoptosis were increased in the experimental MI model. In addition, administration of ISO deregulated OTULIN levels and mitochondri...
Source: Cell Stress and Chaperones - August 29, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Source Type: research
In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics
This study was carried out to determine whether L-Arg pre-intervention has protective effects on heart tissue in the experimental MI model. The 28 rats used in the study were randomly divided into 4 equal groups: control, L-Arg, ISO, and L-Arg+ISO. Upon completion of all applications, cardiac markers in serum and biochemical, histopathological, and immunohistochemical examinations in cardiac tissues were performed. Cardiac markers, histopathological changes, oxidative stress, inflammation, and apoptosis were increased in the experimental MI model. In addition, administration of ISO deregulated OTULIN levels and mitochondri...
Source: Cell Stress and Chaperones - August 29, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Source Type: research
In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics
This study was carried out to determine whether L-Arg pre-intervention has protective effects on heart tissue in the experimental MI model. The 28 rats used in the study were randomly divided into 4 equal groups: control, L-Arg, ISO, and L-Arg+ISO. Upon completion of all applications, cardiac markers in serum and biochemical, histopathological, and immunohistochemical examinations in cardiac tissues were performed. Cardiac markers, histopathological changes, oxidative stress, inflammation, and apoptosis were increased in the experimental MI model. In addition, administration of ISO deregulated OTULIN levels and mitochondri...
Source: Cell Stress and Chaperones - August 29, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Source Type: research
In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics
This study was carried out to determine whether L-Arg pre-intervention has protective effects on heart tissue in the experimental MI model. The 28 rats used in the study were randomly divided into 4 equal groups: control, L-Arg, ISO, and L-Arg+ISO. Upon completion of all applications, cardiac markers in serum and biochemical, histopathological, and immunohistochemical examinations in cardiac tissues were performed. Cardiac markers, histopathological changes, oxidative stress, inflammation, and apoptosis were increased in the experimental MI model. In addition, administration of ISO deregulated OTULIN levels and mitochondri...
Source: Cell Stress and Chaperones - August 29, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Source Type: research
In an experimental myocardial infarction model, L-arginine pre-intervention may exert cardioprotective effects by regulating OTULIN levels and mitochondrial dynamics
This study was carried out to determine whether L-Arg pre-intervention has protective effects on heart tissue in the experimental MI model. The 28 rats used in the study were randomly divided into 4 equal groups: control, L-Arg, ISO, and L-Arg+ISO. Upon completion of all applications, cardiac markers in serum and biochemical, histopathological, and immunohistochemical examinations in cardiac tissues were performed. Cardiac markers, histopathological changes, oxidative stress, inflammation, and apoptosis were increased in the experimental MI model. In addition, administration of ISO deregulated OTULIN levels and mitochondri...
Source: Cell Stress and Chaperones - August 29, 2023 Category: Cytology Authors: Sercan Kaya Tuba Yalc ın Source Type: research
A subfamily of the small heat shock proteins of the marine red alga Neopyropia yezoensis localizes in the chloroplast
This study provides insights into the evolution and function of the sHSP gene family of the marine red alga N. yezoensis and how it adapts to the stressful intertidal zone.PMID:37632625 | DOI:10.1007/s12192-023-01375-4 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - August 26, 2023 Category: Cytology Authors: Jiwong Wi Eun-Jeong Park Mi-Sook Hwang Dong-Woog Choi Source Type: research
