Second international symposium on the chaperone code, 2023
Cell Stress Chaperones. 2024 Feb 3;29(1):88-96. doi: 10.1016/j.cstres.2024.01.003. Online ahead of print.NO ABSTRACTPMID:38316354 | DOI:10.1016/j.cstres.2024.01.003 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - February 5, 2024 Category: Cytology Authors: Johannes Buchner Milad J Alasady Sarah J Backe Brian S J Blagg Richard L Carpenter Giorgio Colombo Ioannis Gelis Daniel T Gewirth Lila M Gierasch Walid A Houry Jill L Johnson Byoung Heon Kang Aimee W Kao Paul LaPointe Seema Mattoo Amie J McClellan Leonard Source Type: research
Stress Biology: Complexity and Multifariousness in Health and Disease
Cell Stress Chaperones. 2024 Feb 2:S1355-8145(24)00046-4. doi: 10.1016/j.cstres.2024.01.006. Online ahead of print.ABSTRACTPreserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response (HSR), unfolded protein response (UPR) and integrated stress response (ISR), that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous re...
Source: Cell Stress and Chaperones - February 4, 2024 Category: Cytology Authors: Matthias P Mayer Laura Blair Gregory L Blatch Thiago J Borges Ahmed Chadli Gabriela Chiosis Aur élie de Thonel Albena Dinkova-Kostova Heath Ecroyd Adrienne L Edkins Takanori Eguchi Monika Fleshner Kevin P Foley Sotirios Fragkostefanakis Jason Gestwicki P Source Type: research
Novel insights into the post-translational modifications of Ydj1/DNAJA1 co-chaperones
Cell Stress Chaperones. 2023 Nov 17;29(1):1-9. doi: 10.1016/j.cstres.2023.11.001. Online ahead of print.ABSTRACTThe activity of the Hsp70 molecular chaperone is regulated by a suite of helper co-chaperones that include J-proteins. Studies on J-proteins have historically focused on their expression, localization, and activation of Hsp70. There is growing evidence that the post-translational modifications (PTMs) of chaperones (the chaperone code) fine-tune chaperone function. This mini-review summarizes the current understanding of the role and regulation of PTMs on the major J-proteins Ydj1 and DNAJA1. Understanding these P...
Source: Cell Stress and Chaperones - February 3, 2024 Category: Cytology Authors: Megan M Mitchem Courtney Shrader Elizabeth Abedi Andrew W Truman Source Type: research
Introduction of Dimitra Bourboulia as the new Editor-in-Chief of Cell Stress & amp; Chaperones
Cell Stress Chaperones. 2024 Feb 1;29(1):49-50. doi: 10.1016/j.cstres.2024.01.008. Online ahead of print.NO ABSTRACTPMID:38309686 | DOI:10.1016/j.cstres.2024.01.008 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - February 3, 2024 Category: Cytology Authors: Lawrence E Hightower Source Type: research
Editorial: A new chapter for Cell Stress and Chaperones
Cell Stress Chaperones. 2024 Feb 1;29(1):113-115. doi: 10.1016/j.cstres.2024.01.007. Online ahead of print.NO ABSTRACTPMID:38309687 | DOI:10.1016/j.cstres.2024.01.007 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - February 3, 2024 Category: Cytology Authors: Dimitra Bourboulia Laura J Blair Melody S Clark Adrienne L Edkins Lawrence E Hightower Mehdi Mollapour Veena Prahlad Elizabeth A Repasky Manuela Truebano Andrew W Truman Matthias C Truttmann Patricija van Oosten-Hawle Mark R Woodford Source Type: research
Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR)
Cell Stress Chaperones. 2024 Feb 1;29(1):66-87. doi: 10.1016/j.cstres.2024.01.005. Online ahead of print.ABSTRACTEffective resolution of inflammation via the heat shock response (HSR) is pivotal in averting the transition to chronic inflammatory states. This transition characterizes a spectrum of debilitating conditions, including insulin resistance, obesity, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments. This manuscript explores a range of physiological, pharmacological, and nutraceutical interventions aimed at reinstating the HSR in the context of chronic low-grade inflammation, as well a...
Source: Cell Stress and Chaperones - February 3, 2024 Category: Cytology Authors: Helena Trevisan Schroeder Carlos Henrique De Lemos Muller Thiago Gomes Heck Mauricio Krause Paulo Ivo Homem de Bittencourt Source Type: research
Endoplasmic reticulum stress-mediated cell death in cardiovascular disease
Cell Stress Chaperones. 2024 Jan 29:S1355-8145(23)02245-9. doi: 10.1016/j.cstres.2023.12.003. Online ahead of print.ABSTRACTThe endoplasmic reticulum (ER) plays a vital function in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) can trigger various modes of cell death by activating the unfolded protein response (UPR) signaling pathway. Cell death plays a crucial role in the occurrence and development of diseases such as cancer, liver diseases, neurological diseases, and cardiovascular diseases. Several cardiovascular diseases including hypertension, atherosclerosis, and heart failure (HF) are associate...
Source: Cell Stress and Chaperones - January 31, 2024 Category: Cytology Authors: Yajuan An Xinshuang Wang Xiuju Guan Peng Yuan Yue Liu Liping Wei Fei Wang Xin Qi Source Type: research
Expansion of the HSP70 gene family in Tegillarca granosa and expression profiles in response to zinc toxicity
Cell Stress Chaperones. 2024 Jan 24;29(1):97-112. doi: 10.1016/j.cstres.2024.01.004. Online ahead of print.ABSTRACTZinc (Zn) is an essential micronutrient in organisms and an abundant element in the Earth's crust. Trace amounts of Zn released from natural sources can enter aquatic ecosystems through weathering and erosion. Zn accumulates in organisms, and when its intracellular concentration exceeds a certain level, it can induce oxidative stress and trigger oxidative stress-mediated heat shock protein (HSP) modulation. HSP70 is the most evolutionarily conserved among the HSP families. Despite extensive research on HSP70 g...
Source: Cell Stress and Chaperones - January 25, 2024 Category: Cytology Authors: Jinmu Kim Hyeon Jin Kim Eunkyung Choi Minjoo Cho Soyun Choi Mi Ae Jeon Jung Sick Lee Hyun Park Source Type: research
Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases
Cell Stress Chaperones. 2024 Jan 18:S1355-8145(24)00042-7. doi: 10.1016/j.cstres.2024.01.002. Online ahead of print.ABSTRACTThe heat shock response (HSR) is a crucial biochemical pathway that orchestrates the resolution of inflammation, primarily under proteotoxic stress conditions. This process hinges on the upregulation of heat shock proteins (HSPs) and other chaperones, notably the 70kDa family of HSPs (HSP70s), under the command of the heat shock transcription factor-1 (HSF1). However, in the context of chronic degenerative disorders characterized by persistent low-grade inflammation - such as insulin resistance, obesi...
Source: Cell Stress and Chaperones - January 20, 2024 Category: Cytology Authors: Helena Trevisan Schroeder Carlos Henrique de Lemos Muller Thiago Gomes Heck Mauricio Krause Paulo Ivo Homem de Bittencourt Source Type: research
Neuroprotective effects of cordycepin inhibit glutamate-induced apoptosis in hippocampal neurons
This study suggests that cordycepin can protect against glutamate-induced neuronal injury in cell models, and this effect was inhibited by adenosine A1 receptor blockers, indicating that its neuroprotective effect is achieved through activation of the adenosine A1 receptor.PMID:38219840 | DOI:10.1016/j.cstres.2024.01.001 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - January 14, 2024 Category: Cytology Authors: Huizhen Sun Shanshan Wei Yanchun Gong Kaizhi Ding Shan Tang Wei Sun Chunhua Yuan Liping Huang Zhibing Liu Chong Chen Lihua Yao Source Type: research
Identification and functional characterization of a novel TRPA1 gene from sea cucumber Apostichopus japonicus and interaction with miR-2013 in response to salt stress
This study aimed to identify and functional study of a novel transient receptor potential cation channel subfamily A member 1 (TRPA1) involved in salinity stress through interaction with miR-2013 in the sea cucumber. The full-length cDNA sequence was 1369 bp in length and encoded 138 amino acids. The TRPA1 homolog protein was a hydrophilic protein without a signal peptide and was predicted to a spatial structure of seven helices and eight random coils and two major ANK functional domains. Bioinformatic analysis and luciferase reporter assays confirmed TRPA1 as a target gene of miR-2013. Quantitative PCR revealed that miR-2...
Source: Cell Stress and Chaperones - December 18, 2023 Category: Cytology Authors: Xin Wei Haoran Pan Dan Liu Xinyan Zhao Yuqing Gou Ran Guo Yi Tian Source Type: research
Retraction Note: Carvedilol protection against endogenous A β-induced neurotoxicity in N2a cells
Cell Stress Chaperones. 2023 Nov;28(6):1071. doi: 10.1007/s12192-023-01399-w.NO ABSTRACTPMID:38108990 | PMC:PMC10746621 | DOI:10.1007/s12192-023-01399-w (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - December 18, 2023 Category: Cytology Authors: Jia Liu Min Wang Source Type: research
Identification and functional characterization of a novel TRPA1 gene from sea cucumber Apostichopus japonicus and interaction with miR-2013 in response to salt stress
This study aimed to identify and functional study of a novel transient receptor potential cation channel subfamily A member 1 (TRPA1) involved in salinity stress through interaction with miR-2013 in the sea cucumber. The full-length cDNA sequence was 1369 bp in length and encoded 138 amino acids. The TRPA1 homolog protein was a hydrophilic protein without a signal peptide and was predicted to a spatial structure of seven helices and eight random coils and two major ANK functional domains. Bioinformatic analysis and luciferase reporter assays confirmed TRPA1 as a target gene of miR-2013. Quantitative PCR revealed that miR-2...
Source: Cell Stress and Chaperones - December 18, 2023 Category: Cytology Authors: Xin Wei Haoran Pan Dan Liu Xinyan Zhao Yuqing Gou Ran Guo Yi Tian Source Type: research
Retraction Note: Carvedilol protection against endogenous A β-induced neurotoxicity in N2a cells
Cell Stress Chaperones. 2023 Nov;28(6):1071. doi: 10.1007/s12192-023-01399-w.NO ABSTRACTPMID:38108990 | PMC:PMC10746621 | DOI:10.1007/s12192-023-01399-w (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - December 18, 2023 Category: Cytology Authors: Jia Liu Min Wang Source Type: research
Identification and functional characterization of a novel TRPA1 gene from sea cucumber Apostichopus japonicus and interaction with miR-2013 in response to salt stress
This study aimed to identify and functional study of a novel transient receptor potential cation channel subfamily A member 1 (TRPA1) involved in salinity stress through interaction with miR-2013 in the sea cucumber. The full-length cDNA sequence was 1369 bp in length and encoded 138 amino acids. The TRPA1 homolog protein was a hydrophilic protein without a signal peptide and was predicted to a spatial structure of seven helices and eight random coils and two major ANK functional domains. Bioinformatic analysis and luciferase reporter assays confirmed TRPA1 as a target gene of miR-2013. Quantitative PCR revealed that miR-2...
Source: Cell Stress and Chaperones - December 18, 2023 Category: Cytology Authors: Xin Wei Haoran Pan Dan Liu Xinyan Zhao Yuqing Gou Ran Guo Yi Tian Source Type: research
