The dance of proteostasis and metabolism: Unveiling the caloristatic controlling switch
Cell Stress Chaperones. 2024 Feb 6;29(1):175-200. doi: 10.1016/j.cstres.2024.02.002. Online ahead of print.ABSTRACTThe heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis and energy regulation is rooted in the fundamental need for ATP to fuel protein synthesis and repair, making the HSR an essential component of cellular energy management. Recent findings suggest that the origins of pr...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Helena Trevisan Schroeder Carlos Henrique De Lemos Muller Thiago Gomes Heck Mauricio Krause Paulo Ivo Homem de Bittencourt Source Type: research
Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway
Cell Stress Chaperones. 2024 Feb 6;29(1):201-215. doi: 10.1016/j.cstres.2024.02.001. Online ahead of print.ABSTRACTChronic stress is a common emotional disorder in cancer patients. Chronic stress promotes progression of gastric cancer (GC) and leads to poor outcomes. However, the underlying mechanisms remain not clear. Herein, we explored the possible mechanisms of chronic stress in GC progression. The Cancer Genome Atlas (TCGA) datasets were analyzed for differentially expressed genes. Clinical data of GC were evaluated for their association with PlexinA1 using TCGA and Kaplan-Meier-plotter databases. Chronic stress of GC...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Yanjie Lu Die Cheng Jiayu Pang Yuqiao Peng Shunkang Jin Xinyu Zhang Yuhong Li Yanzhen Zuo Source Type: research
The major inducible small heat shock protein HSP20-3 in the tardigrade Ramazzottius varieornatus forms filament-like structures and is an active chaperone
In this study, we have characterised two members of the small heat shock protein (sHSP) family in R. varieornatus, HSP20-3 and HSP20-6. These are the most highly upregulated sHSPs in response to a 24 h heat shock at 35 0C of adult tardigrades with HSP20-3 being one of the most highly upregulated gene in the whole transcriptome. Both R. varieornatus sHSPs and the human sHSP, CRYAB (HSPB5), were produced recombinantly for comparative structure-function studies. HSP20-3 exhibited a superior chaperone activity than human CRYAB in a heat-induced protein aggregation assay. Both tardigrade sHSPs also formed larger oligomers than ...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Mohammad Al-Ansari Taylor Fitzsimons Wenbin Wei Martin W Goldberg Takekazu Kunieda Roy A Quinlan Source Type: research
The dance of proteostasis and metabolism: Unveiling the caloristatic controlling switch
Cell Stress Chaperones. 2024 Feb 6;29(1):175-200. doi: 10.1016/j.cstres.2024.02.002. Online ahead of print.ABSTRACTThe heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis and energy regulation is rooted in the fundamental need for ATP to fuel protein synthesis and repair, making the HSR an essential component of cellular energy management. Recent findings suggest that the origins of pr...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Helena Trevisan Schroeder Carlos Henrique De Lemos Muller Thiago Gomes Heck Mauricio Krause Paulo Ivo Homem de Bittencourt Source Type: research
Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway
Cell Stress Chaperones. 2024 Feb 6;29(1):201-215. doi: 10.1016/j.cstres.2024.02.001. Online ahead of print.ABSTRACTChronic stress is a common emotional disorder in cancer patients. Chronic stress promotes progression of gastric cancer (GC) and leads to poor outcomes. However, the underlying mechanisms remain not clear. Herein, we explored the possible mechanisms of chronic stress in GC progression. The Cancer Genome Atlas (TCGA) datasets were analyzed for differentially expressed genes. Clinical data of GC were evaluated for their association with PlexinA1 using TCGA and Kaplan-Meier-plotter databases. Chronic stress of GC...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Yanjie Lu Die Cheng Jiayu Pang Yuqiao Peng Shunkang Jin Xinyu Zhang Yuhong Li Yanzhen Zuo Source Type: research
The major inducible small heat shock protein HSP20-3 in the tardigrade Ramazzottius varieornatus forms filament-like structures and is an active chaperone
In this study, we have characterised two members of the small heat shock protein (sHSP) family in R. varieornatus, HSP20-3 and HSP20-6. These are the most highly upregulated sHSPs in response to a 24 h heat shock at 35 0C of adult tardigrades with HSP20-3 being one of the most highly upregulated gene in the whole transcriptome. Both R. varieornatus sHSPs and the human sHSP, CRYAB (HSPB5), were produced recombinantly for comparative structure-function studies. HSP20-3 exhibited a superior chaperone activity than human CRYAB in a heat-induced protein aggregation assay. Both tardigrade sHSPs also formed larger oligomers than ...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Mohammad Al-Ansari Taylor Fitzsimons Wenbin Wei Martin W Goldberg Takekazu Kunieda Roy A Quinlan Source Type: research
The Dance of Proteostasis and Metabolism: Unveiling the Caloristatic Controlling Switch
Cell Stress Chaperones. 2024 Feb 6:S1355-8145(24)00050-6. doi: 10.1016/j.cstres.2024.02.002. Online ahead of print.ABSTRACTThe heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis and energy regulation is rooted in the fundamental need for ATP to fuel protein synthesis and repair, making the HSR an essential component of cellular energy management. Recent findings suggest that the origi...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Helena Trevisan Schroeder Carlos Henrique de Lemos Muller Thiago Gomes Heck Mauricio Krause Paulo Ivo Homem de Bittencourt Source Type: research
Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway
CONCLUSIONS: Our findings suggest that chronic stress plays an important role in GC progression and there is a potential for blocking the epinephrine-β2AR/PlexinA1 pathway in the treatment of GC.PMID:38331165 | DOI:10.1016/j.cstres.2024.02.001 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Yanjie Lu Die Cheng Jiayu Pang Yuqiao Peng Shunkang Jin Xinyu Zhang Yanzhen Zuo Yuhong Li Source Type: research
The major inducible small heat shock protein HSP20-3 in the tardigrade Ramazzottius varieornatus forms filament-like structures and is an active chaperone
In this study, we have characterised two members of the small heat shock protein (sHSP) family in R. varieornatus, HSP20-3 and HSP20-6. These are the most highly upregulated sHSPs in response to a 24 h heat shock at 35 0C of adult tardigrades with HSP20-3 being one of the most highly upregulated gene in the whole transcriptome. Both R. varieornatus sHSPs and the human sHSP, CRYAB (HSPB5), were produced recombinantly for comparative structure-function studies. HSP20-3 exhibited a superior chaperone activity than human CRYAB in a heat-induced protein aggregation assay. Both tardigrade sHSPs also formed larger oligomers than ...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Mohammad Al-Ansari Taylor Fitzsimons Wenbin Wei Martin W Goldberg Takekazu Kunieda Roy A Quinlan Source Type: research
The Dance of Proteostasis and Metabolism: Unveiling the Caloristatic Controlling Switch
Cell Stress Chaperones. 2024 Feb 6:S1355-8145(24)00050-6. doi: 10.1016/j.cstres.2024.02.002. Online ahead of print.ABSTRACTThe heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis and energy regulation is rooted in the fundamental need for ATP to fuel protein synthesis and repair, making the HSR an essential component of cellular energy management. Recent findings suggest that the origi...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Helena Trevisan Schroeder Carlos Henrique de Lemos Muller Thiago Gomes Heck Mauricio Krause Paulo Ivo Homem de Bittencourt Source Type: research
Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway
CONCLUSIONS: Our findings suggest that chronic stress plays an important role in GC progression and there is a potential for blocking the epinephrine-β2AR/PlexinA1 pathway in the treatment of GC.PMID:38331165 | DOI:10.1016/j.cstres.2024.02.001 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Yanjie Lu Die Cheng Jiayu Pang Yuqiao Peng Shunkang Jin Xinyu Zhang Yanzhen Zuo Yuhong Li Source Type: research
The major inducible small heat shock protein HSP20-3 in the tardigrade Ramazzottius varieornatus forms filament-like structures and is an active chaperone
In this study, we have characterised two members of the small heat shock protein (sHSP) family in R. varieornatus, HSP20-3 and HSP20-6. These are the most highly upregulated sHSPs in response to a 24 h heat shock at 35 0C of adult tardigrades with HSP20-3 being one of the most highly upregulated gene in the whole transcriptome. Both R. varieornatus sHSPs and the human sHSP, CRYAB (HSPB5), were produced recombinantly for comparative structure-function studies. HSP20-3 exhibited a superior chaperone activity than human CRYAB in a heat-induced protein aggregation assay. Both tardigrade sHSPs also formed larger oligomers than ...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Mohammad Al-Ansari Taylor Fitzsimons Wenbin Wei Martin W Goldberg Takekazu Kunieda Roy A Quinlan Source Type: research
The Dance of Proteostasis and Metabolism: Unveiling the Caloristatic Controlling Switch
Cell Stress Chaperones. 2024 Feb 6:S1355-8145(24)00050-6. doi: 10.1016/j.cstres.2024.02.002. Online ahead of print.ABSTRACTThe heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis and energy regulation is rooted in the fundamental need for ATP to fuel protein synthesis and repair, making the HSR an essential component of cellular energy management. Recent findings suggest that the origi...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Helena Trevisan Schroeder Carlos Henrique de Lemos Muller Thiago Gomes Heck Mauricio Krause Paulo Ivo Homem de Bittencourt Source Type: research
Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway
CONCLUSIONS: Our findings suggest that chronic stress plays an important role in GC progression and there is a potential for blocking the epinephrine-β2AR/PlexinA1 pathway in the treatment of GC.PMID:38331165 | DOI:10.1016/j.cstres.2024.02.001 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Yanjie Lu Die Cheng Jiayu Pang Yuqiao Peng Shunkang Jin Xinyu Zhang Yanzhen Zuo Yuhong Li Source Type: research
The major inducible small heat shock protein HSP20-3 in the tardigrade Ramazzottius varieornatus forms filament-like structures and is an active chaperone
In this study, we have characterised two members of the small heat shock protein (sHSP) family in R. varieornatus, HSP20-3 and HSP20-6. These are the most highly upregulated sHSPs in response to a 24 h heat shock at 35 0C of adult tardigrades with HSP20-3 being one of the most highly upregulated gene in the whole transcriptome. Both R. varieornatus sHSPs and the human sHSP, CRYAB (HSPB5), were produced recombinantly for comparative structure-function studies. HSP20-3 exhibited a superior chaperone activity than human CRYAB in a heat-induced protein aggregation assay. Both tardigrade sHSPs also formed larger oligomers than ...
Source: Cell Stress and Chaperones - February 8, 2024 Category: Cytology Authors: Mohammad Al-Ansari Taylor Fitzsimons Wenbin Wei Martin W Goldberg Takekazu Kunieda Roy A Quinlan Source Type: research
