Extracellular metallothionein as a therapeutic target in the early progression of Type 1 Diabetes
Cell Stress Chaperones. 2024 Mar 13:S1355-8145(24)00057-9. doi: 10.1016/j.cstres.2024.03.005. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is characterized by lymphocyte infiltration into the pancreatic islets of Langerhans, leading to the destruction of insulin-producing beta cells and uncontrolled hyperglycemia. In the non-obese diabetic (NOD) murine model of T1D, onset of this infiltration starts several weeks before glucose dysregulation and overt diabetes. Recruitment of immune cells to the islets is mediated by several chemotactic cytokines, including CXCL10, while other cytokines, including SDF-1α, can confe...
Source: Cell Stress and Chaperones - March 15, 2024 Category: Cytology Authors: Clare K Melchiorre Matthew D Lynes Sadikshya Bhandari Sheng-Chiang Su Christian M Potts Amy V Thees Carol E Norris Lucy Liaw Yu-Hua Tseng Michael A Lynes Source Type: research
Extracellular metallothionein as a therapeutic target in the early progression of Type 1 Diabetes
Cell Stress Chaperones. 2024 Mar 13:S1355-8145(24)00057-9. doi: 10.1016/j.cstres.2024.03.005. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is characterized by lymphocyte infiltration into the pancreatic islets of Langerhans, leading to the destruction of insulin-producing beta cells and uncontrolled hyperglycemia. In the non-obese diabetic (NOD) murine model of T1D, onset of this infiltration starts several weeks before glucose dysregulation and overt diabetes. Recruitment of immune cells to the islets is mediated by several chemotactic cytokines, including CXCL10, while other cytokines, including SDF-1α, can confe...
Source: Cell Stress and Chaperones - March 15, 2024 Category: Cytology Authors: Clare K Melchiorre Matthew D Lynes Sadikshya Bhandari Sheng-Chiang Su Christian M Potts Amy V Thees Carol E Norris Lucy Liaw Yu-Hua Tseng Michael A Lynes Source Type: research
Extracellular metallothionein as a therapeutic target in the early progression of Type 1 Diabetes
Cell Stress Chaperones. 2024 Mar 13:S1355-8145(24)00057-9. doi: 10.1016/j.cstres.2024.03.005. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is characterized by lymphocyte infiltration into the pancreatic islets of Langerhans, leading to the destruction of insulin-producing beta cells and uncontrolled hyperglycemia. In the non-obese diabetic (NOD) murine model of T1D, onset of this infiltration starts several weeks before glucose dysregulation and overt diabetes. Recruitment of immune cells to the islets is mediated by several chemotactic cytokines, including CXCL10, while other cytokines, including SDF-1α, can confe...
Source: Cell Stress and Chaperones - March 15, 2024 Category: Cytology Authors: Clare K Melchiorre Matthew D Lynes Sadikshya Bhandari Sheng-Chiang Su Christian M Potts Amy V Thees Carol E Norris Lucy Liaw Yu-Hua Tseng Michael A Lynes Source Type: research
Extracellular metallothionein as a therapeutic target in the early progression of Type 1 Diabetes
Cell Stress Chaperones. 2024 Mar 13:S1355-8145(24)00057-9. doi: 10.1016/j.cstres.2024.03.005. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is characterized by lymphocyte infiltration into the pancreatic islets of Langerhans, leading to the destruction of insulin-producing beta cells and uncontrolled hyperglycemia. In the non-obese diabetic (NOD) murine model of T1D, onset of this infiltration starts several weeks before glucose dysregulation and overt diabetes. Recruitment of immune cells to the islets is mediated by several chemotactic cytokines, including CXCL10, while other cytokines, including SDF-1α, can confe...
Source: Cell Stress and Chaperones - March 15, 2024 Category: Cytology Authors: Clare K Melchiorre Matthew D Lynes Sadikshya Bhandari Sheng-Chiang Su Christian M Potts Amy V Thees Carol E Norris Lucy Liaw Yu-Hua Tseng Michael A Lynes Source Type: research
Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies
In conclusion, this review offers valuable insights into the intricate relationship between mitochondrial dysfunction and doxorubicin-mediated cardiotoxicity. It underscores the need for continued research into targeted mitochondrial therapies as a means to improve the cardiac safety profile of doxorubicin, thereby enhancing the overall treatment outcomes for cancer patients.PMID:38485043 | DOI:10.1016/j.cstres.2024.03.003 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - March 14, 2024 Category: Cytology Authors: Tianen Wang Guoli Xing Tong Fu Yanchun Ma Qi Wang Shuxiang Zhang Xing Chang Ying Tong Source Type: research
Roles of heat shock protein A12A in the development of diabetic cardiomyopathy
Cell Stress Chaperones. 2024 Mar 12:S1355-8145(24)00055-5. doi: 10.1016/j.cstres.2024.03.004. Online ahead of print.ABSTRACTLong-term hyperglycemia can lead to diabetic cardiomyopathy (DCM), a main lethal complication of diabetes. However, the mechanisms underlying DCM development have not been fully elucidated. Heat shock protein A12A (HSPA12A) is the atypic member of HSP70 family. In the present study, we found that the expression of HSPA12A was upregulated in hearts of mice with streptozotocin (STZ)-induced diabetes, while ablation of HSPA12A improved cardiac systolic and diastolic dysfunction and increased cumulative s...
Source: Cell Stress and Chaperones - March 14, 2024 Category: Cytology Authors: Yunxiao Jia Yunhao Yu Chenxi Gao Yuehua Li Chuanfu Li Zhengnian Ding Qiuyue Kong Li Liu Source Type: research
Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies
In conclusion, this review offers valuable insights into the intricate relationship between mitochondrial dysfunction and doxorubicin-mediated cardiotoxicity. It underscores the need for continued research into targeted mitochondrial therapies as a means to improve the cardiac safety profile of doxorubicin, thereby enhancing the overall treatment outcomes for cancer patients.PMID:38485043 | DOI:10.1016/j.cstres.2024.03.003 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - March 14, 2024 Category: Cytology Authors: Tianen Wang Guoli Xing Tong Fu Yanchun Ma Qi Wang Shuxiang Zhang Xing Chang Ying Tong Source Type: research
Roles of heat shock protein A12A in the development of diabetic cardiomyopathy
Cell Stress Chaperones. 2024 Mar 12:S1355-8145(24)00055-5. doi: 10.1016/j.cstres.2024.03.004. Online ahead of print.ABSTRACTLong-term hyperglycemia can lead to diabetic cardiomyopathy (DCM), a main lethal complication of diabetes. However, the mechanisms underlying DCM development have not been fully elucidated. Heat shock protein A12A (HSPA12A) is the atypic member of HSP70 family. In the present study, we found that the expression of HSPA12A was upregulated in hearts of mice with streptozotocin (STZ)-induced diabetes, while ablation of HSPA12A improved cardiac systolic and diastolic dysfunction and increased cumulative s...
Source: Cell Stress and Chaperones - March 14, 2024 Category: Cytology Authors: Yunxiao Jia Yunhao Yu Chenxi Gao Yuehua Li Chuanfu Li Zhengnian Ding Qiuyue Kong Li Liu Source Type: research
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2
Cell Stress Chaperones. 2024 Mar 6:S1355-8145(24)00053-1. doi: 10.1016/j.cstres.2024.03.001. Online ahead of print.ABSTRACTHeat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute to a vast variety of human pathologies, ranging from metabolic diseases to cancer and neurodegeneration. Despite their evident role in mitigating cellular perturbations, the functions of HSF1 and HSF2 in physiological proteostasis have remained inconclusive. Here, we analyzed a comprehensive selection of pa...
Source: Cell Stress and Chaperones - March 8, 2024 Category: Cytology Authors: Jenny Joutsen Jenny C Pessa Otto Jokelainen Reijo Sironen Jaana M Hartikainen Lea Sistonen Source Type: research
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2
Cell Stress Chaperones. 2024 Mar 6:S1355-8145(24)00053-1. doi: 10.1016/j.cstres.2024.03.001. Online ahead of print.ABSTRACTHeat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute to a vast variety of human pathologies, ranging from metabolic diseases to cancer and neurodegeneration. Despite their evident role in mitigating cellular perturbations, the functions of HSF1 and HSF2 in physiological proteostasis have remained inconclusive. Here, we analyzed a comprehensive selection of pa...
Source: Cell Stress and Chaperones - March 8, 2024 Category: Cytology Authors: Jenny Joutsen Jenny C Pessa Otto Jokelainen Reijo Sironen Jaana M Hartikainen Lea Sistonen Source Type: research
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2
Cell Stress Chaperones. 2024 Mar 6:S1355-8145(24)00053-1. doi: 10.1016/j.cstres.2024.03.001. Online ahead of print.ABSTRACTHeat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute to a vast variety of human pathologies, ranging from metabolic diseases to cancer and neurodegeneration. Despite their evident role in mitigating cellular perturbations, the functions of HSF1 and HSF2 in physiological proteostasis have remained inconclusive. Here, we analyzed a comprehensive selection of pa...
Source: Cell Stress and Chaperones - March 8, 2024 Category: Cytology Authors: Jenny Joutsen Jenny C Pessa Otto Jokelainen Reijo Sironen Jaana M Hartikainen Lea Sistonen Source Type: research
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2
Cell Stress Chaperones. 2024 Mar 6:S1355-8145(24)00053-1. doi: 10.1016/j.cstres.2024.03.001. Online ahead of print.ABSTRACTHeat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute to a vast variety of human pathologies, ranging from metabolic diseases to cancer and neurodegeneration. Despite their evident role in mitigating cellular perturbations, the functions of HSF1 and HSF2 in physiological proteostasis have remained inconclusive. Here, we analyzed a comprehensive selection of pa...
Source: Cell Stress and Chaperones - March 8, 2024 Category: Cytology Authors: Jenny Joutsen Jenny C Pessa Otto Jokelainen Reijo Sironen Jaana M Hartikainen Lea Sistonen Source Type: research
Comprehensive analysis of human tissues reveals unique expression and localization patterns of HSF1 and HSF2
Cell Stress Chaperones. 2024 Mar 6:S1355-8145(24)00053-1. doi: 10.1016/j.cstres.2024.03.001. Online ahead of print.ABSTRACTHeat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute to a vast variety of human pathologies, ranging from metabolic diseases to cancer and neurodegeneration. Despite their evident role in mitigating cellular perturbations, the functions of HSF1 and HSF2 in physiological proteostasis have remained inconclusive. Here, we analyzed a comprehensive selection of pa...
Source: Cell Stress and Chaperones - March 8, 2024 Category: Cytology Authors: Jenny Joutsen Jenny C Pessa Otto Jokelainen Reijo Sironen Jaana M Hartikainen Lea Sistonen Source Type: research
The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cells
In this study, we report that the S1 spike protein of SARS-CoV-2 induces the phosphorylation of ERKs in THP-1 cells, a DC-SIGN-expressing human monocytic leukemic cell line. On the other hand, the phosphorylation level of NF-κB remained unchanged under the same conditions. These data suggest that the major cell signaling pathway regulated by S1 spike protein is the ERK pathway, which is superior to the NF-κB pathway in these DC-SIGN-expressing THP-1 cells and may contribute to immune hyperactivation in SARS-CoV-2 infections. Additionally, several glycans such as mannans, mannosylated BSA, the serum amyloid beta protein, ...
Source: Cell Stress and Chaperones - March 7, 2024 Category: Cytology Authors: Emma Lee Johnson Yuki Ohkawa Noriko Kanto Reiko Fujinawa Taiki Kuribara Eiji Miyoshi Naoyuki Taniguchi Source Type: research
The S1 spike protein of SARS-CoV-2 upregulates the ERK/MAPK signaling pathway in DC-SIGN-expressing THP-1 cells
In this study, we report that the S1 spike protein of SARS-CoV-2 induces the phosphorylation of ERKs in THP-1 cells, a DC-SIGN-expressing human monocytic leukemic cell line. On the other hand, the phosphorylation level of NF-κB remained unchanged under the same conditions. These data suggest that the major cell signaling pathway regulated by S1 spike protein is the ERK pathway, which is superior to the NF-κB pathway in these DC-SIGN-expressing THP-1 cells and may contribute to immune hyperactivation in SARS-CoV-2 infections. Additionally, several glycans such as mannans, mannosylated BSA, the serum amyloid beta protein, ...
Source: Cell Stress and Chaperones - March 7, 2024 Category: Cytology Authors: Emma Lee Johnson Yuki Ohkawa Noriko Kanto Reiko Fujinawa Taiki Kuribara Eiji Miyoshi Naoyuki Taniguchi Source Type: research
