Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways
Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFN γ) is one of the common cytokines coordinating tumor immune response and t... (Source: Cell Division)
Source: Cell Division - August 2, 2016 Category: Cytology Authors: Siraj M. El Jamal, Erin B. Taylor, Zakaria Y. Abd Elmageed, Abdulhadi A. Alamodi, Denis Selimovic, Abdulaziz Alkhateeb, Matthias Hannig, Sofie Y. Hassan, Simeon Santourlidis, Paul L. Friedlander, Youssef Haikel, Srinivasan Vijaykumar, Emad Kandil and Moha Source Type: research
Rpl22 is required for IME1 mRNA translation and meiotic induction in S. cerevisiae
The transition from mitotic cell division to meiotic development in S. cerevisiae requires induction of a transient transcription program that is initiated by Ime1-dependent destruction of the repressor Ume6. Alt... (Source: Cell Division)
Source: Cell Division - July 29, 2016 Category: Cytology Authors: Stephen J. Kim and Randy Strich Source Type: research
Insights into APC/C: from cellular function to diseases and therapeutics
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as c... (Source: Cell Division)
Source: Cell Division - July 13, 2016 Category: Cytology Authors: Zhuan Zhou, Mingjing He, Anil A. Shah and Yong Wan Source Type: research
Cullin-RING ligases in regulation of autophagy
Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological process... (Source: Cell Division)
Source: Cell Division - June 10, 2016 Category: Cytology Authors: Danrui Cui, Xiufang Xiong and Yongchao Zhao Source Type: research
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and... (Source: Cell Division)
Source: Cell Division - May 23, 2016 Category: Cytology Authors: Weijia Cai and Haifeng Yang Source Type: research
The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor
TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been s... (Source: Cell Division)
Source: Cell Division - April 22, 2016 Category: Cytology Authors: Tarryn Willmer, Shannagh Hare, Jade Peres and Sharon Prince Source Type: research
Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications
Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional module... (Source: Cell Division)
Source: Cell Division - April 1, 2016 Category: Cytology Authors: Hsin-Yi Chen, Chin-Chih Liu and Ruey-Hwa Chen Source Type: research
New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of ... (Source: Cell Division)
Source: Cell Division - March 31, 2016 Category: Cytology Authors: Mingjing He, Zhuan Zhou, Anil A. Shah, Yang Hong, Qianming Chen and Yong Wan Source Type: research
Mitochondria-cytoskeleton associations in mammalian cytokinesis
The role of the cytoskeleton in regulating mitochondrial distribution in dividing mammalian cells is poorly understood. We previously demonstrated that mitochondria are transported to the cleavage furrow durin... (Source: Cell Division)
Source: Cell Division - March 18, 2016 Category: Cytology Authors: E. J. Lawrence, E. Boucher and C. A. Mandato Source Type: research
C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response
Research on the involvement of C1D and its yeast homologues Rrp47 (S. cerevisiae) and Cti1 (S. pombe) in DNA damage repair and RNA processing has remained mutually exclusive, with most studies predominantly conce... (Source: Cell Division)
Source: Cell Division - March 9, 2016 Category: Cytology Authors: Rebecca A. Jackson, Jocelyn Shumei Wu and Ee Sin Chen Source Type: research
The role of cullin 5-containing ubiquitin ligases
The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase act... (Source: Cell Division)
Source: Cell Division - March 9, 2016 Category: Cytology Authors: Fumihiko Okumura, Akiko Joo-Okumura, Kunio Nakatsukasa and Takumi Kamura Source Type: research
Curcumin and tumor immune-editing: resurrecting the immune system
Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies ... (Source: Cell Division)
Source: Cell Division - October 12, 2015 Category: Cytology Authors: Sayantan Bose, Abir Kumar Panda, Shravanti Mukherjee and Gaurisankar Sa Source Type: research
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex
Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family proteins. Neddylation of Cul1 activates the ligase through some means of biochem... (Source: Cell Division)
Source: Cell Division - August 11, 2015 Category: Cytology Authors: Gil Bornstein and Chagai Grossman Source Type: research
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex
Conclusions:
We demonstrated that deneddylation of Cul1 is positively regulated through direct simultaneous neddylation and is not dependent upon autophosphorylation. Defining the mechanism that regulates neddylation and deneddylation of Cullin proteins is important due to their effect on highly conserved cellular processes. We showed that minor changes in the degree of Cul1 neddylation linearly control the degree of p27 conjugation to ubiquitin, which emphasizes the hypothetic physiologic significance of our findings. (Source: Cell Division)
Source: Cell Division - August 11, 2015 Category: Cytology Authors: Gil BornsteinChagai Grossman Source Type: research
Sumo and the cellular stress response
The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cel... (Source: Cell Division)
Source: Cell Division - June 20, 2015 Category: Cytology Authors: Jorrit M. Enserink Source Type: research
