Asymmetric cell division of mammary stem cells
Somatic stem cells are distinguished by their capacity to regenerate themselves and also to produce daughter cells that will differentiate. Self-renewal is achieved through the process of asymmetric cell divis... (Source: Cell Division)
Source: Cell Division - September 29, 2021 Category: Cytology Authors: Shaan N. Chhabra and Brian W. Booth Tags: Review Source Type: research
The budding yeast protein Chl1p is required for delaying progression through G1/S phase after DNA damage
The budding yeast protein Chl1p is a nuclear protein required for sister-chromatid cohesion, transcriptional silencing, rDNA recombination, ageing and plays an instrumental role in chromatin remodeling. This h... (Source: Cell Division)
Source: Cell Division - September 8, 2021 Category: Cytology Authors: Muhseena N. Katheeja, Shankar Prasad Das and Suparna Laha Tags: Research Source Type: research
Ral GTPase is essential for actin dynamics and Golgi apparatus distribution in mouse oocyte maturation
Ral family is a member of Ras-like GTPase superfamily, which includes RalA and RalB. RalA/B play important roles in many cell biological functions, including cytoskeleton dynamics, cell division, membrane tran... (Source: Cell Division)
Source: Cell Division - June 10, 2021 Category: Cytology Authors: Ming-Hong Sun, Lin-Lin Hu, Chao-Ying Zhao, Xiang Lu, Yan-Ping Ren, Jun-Li Wang, Xiang-Shun Cui and Shao-Chen Sun Tags: Research Source Type: research
Mitotic arrest affects clustering of tumor cells
Cancer cell aggregation is a key process involved in the formation of tumor cell clusters. It has recently been shown that clusters of circulating tumor cells (CTCs) have an increased metastatic potential comp... (Source: Cell Division)
Source: Cell Division - January 29, 2021 Category: Cytology Authors: Julia Bonnet, Lise Rigal, Odile Mondesert, Renaud Morin, Ga ëlle Corsaut, Mathieu Vigneau, Bernard Ducommun and Valérie Lobjois Tags: Research Source Type: research
Microarray expression profile of mRNAs and long noncoding RNAs and the potential role of PFK-1 in infantile hemangioma
Infantile hemangioma (IH) is the most common benign tumor in children. Long noncoding RNAs (lncRNAs) play a critical role in tumorigenesis. However, the expression levels and biological functions of lncRNAs in... (Source: Cell Division)
Source: Cell Division - January 11, 2021 Category: Cytology Authors: Kaiying Yang, Xuepeng Zhang, Linwen Chen, Siyuan Chen and Yi Ji Tags: Research Source Type: research
Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has opened new therapeutic possibilities. However, karyotypic abnormalities detected in iPSCs compromised their utility, especially chromos... (Source: Cell Division)
Source: Cell Division - November 3, 2020 Category: Cytology Authors: Xinyu Liu, Conghui Li, Kang Zheng, Xiaofeng Zhao, Xiaofeng Xu, Aifen Yang, Min Yi, Huaping Tao, Binghua Xie, Mengsheng Qiu and Junlin Yang Tags: Research Source Type: research
XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity
XMU-MP-1 is an inhibitor of the Hippo pathway kinases MST1/2 and has been shown to promote the downstream activation of the pro-proliferative, pro-regenerative and anti-apoptotic transcriptional regulator YAP1... (Source: Cell Division)
Source: Cell Division - September 17, 2020 Category: Cytology Authors: Ellen Mitchell, Charlotte E. L. Mellor and Talveen S. Purba Tags: Short Report Source Type: research
Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in Schizosaccharomyces pombe
The evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2. Together with the Wee1 kinase, a negative regulator of Cdc... (Source: Cell Division)
Source: Cell Division - June 29, 2020 Category: Cytology Authors: John P. Alao and Per Sunnerhagen Tags: Review Source Type: research
EZH2-inhibitor DZNep enhances apoptosis of renal tubular epithelial cells in presence and absence of cisplatin
The enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and induces the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter of many key genes; EZH2 acts as a transcriptional repress... (Source: Cell Division)
Source: Cell Division - May 25, 2020 Category: Cytology Authors: Si-qi Chen, Jia-qi Li, Xiao-qiao Wang, Wen-jing Lei, Hao Li, Jiao Wan, Zheng Hu, Yao-wei Zou, Xiao-yu Wu and Hong-xin Niu Tags: Research Source Type: research
The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division
Cell division is orchestrated by the phosphorylation and dephosphorylation of thousands of proteins. These post-translational modifications underlie the molecular cascades converging to the activation of the u... (Source: Cell Division)
Source: Cell Division - May 25, 2020 Category: Cytology Authors: Tom Lemonnier, Aude Dupr é and Catherine Jessus Tags: Review Source Type: research
Toll signaling promotes JNK-dependent apoptosis in Drosophila
Apoptosis plays pivotal roles in organ development and tissue homeostasis, with its major function to remove unhealthy cells that may compromise the fitness of the organism. Toll signaling, with the ancient ev... (Source: Cell Division)
Source: Cell Division - March 10, 2020 Category: Cytology Authors: Zhuojie Li, Chenxi Wu, Xiang Ding, Wenzhe Li and Lei Xue Tags: Research Source Type: research
Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes
Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation an... (Source: Cell Division)
Source: Cell Division - March 6, 2020 Category: Cytology Authors: Zhen-Yu She, Ning Zhong, Kai-Wei Yu, Yu Xiao, Ya-Lan Wei, Yang Lin, Yue-Ling Li and Ming-Hui Lu Tags: Research Source Type: research
IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells
Recurrence of Glioblastoma multiforme (GBM) seems to be the rule despite combination therapies. Cell invasion and cell proliferation are major reasons for recurrence of GBM. And insulin-like growth factor bind... (Source: Cell Division)
Source: Cell Division - February 27, 2020 Category: Cytology Authors: Chengyuan Dong, Junwen Zhang, Sheng Fang and Fusheng Liu Tags: Research Source Type: research
A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration
The senescence of nucleus pulposus (NP) cells plays a vital role in the pathogenesis of intervertebral disc (IVD) degeneration (IDD). NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce... (Source: Cell Division)
Source: Cell Division - February 1, 2020 Category: Cytology Authors: Chang Liu, Libangxi Liu, Minghui Yang, Bin Li, Jiarong Yi, Xuezheng Ai, Yang Zhang, Bo Huang, Changqing Li, Chencheng Feng and Yue Zhou Tags: Research Source Type: research
Coupled cycling and regulation of metazoan morphogenesis
Metazoan animals are characterized by restricted phenotypic heterogeneity (i.e. morphological disparity) of organisms within various species, a feature that contrasts sharply with intra-species morphological d... (Source: Cell Division)
Source: Cell Division - January 27, 2020 Category: Cytology Authors: Saba Rezaei-Lotfi and Ramin M. Farahani Tags: Commentary Source Type: research
