The emerging roles of CDK12 in tumorigenesis
Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested ext... (Source: Cell Division)
Source: Cell Division - October 27, 2017 Category: Cytology Authors: Hana Paculov á and Jiří Kohoutek Tags: Review Source Type: research
Proteins associated with the doubling time of the NCI-60 cancer cell lines
The varied nature of human cancers is recapitulated, at least to some extent, in the diverse NCI-60 panel of human cancer cell lines. Here, I used a basic, continuous variable of proliferating cells, their dou... (Source: Cell Division)
Source: Cell Division - August 29, 2017 Category: Cytology Authors: Michael Polymenis Tags: Hypothesis Source Type: research
Erratum to: Rpl22 is required for IME1 mRNA translation and meiotic induction in S. cerevisiae
(Source: Cell Division)
Source: Cell Division - July 18, 2017 Category: Cytology Authors: Stephen K. Kim and Randy Strich Source Type: research
Erratum to: Electrostatic forces drive poleward chromosome motions at kinetochores
(Source: Cell Division)
Source: Cell Division - July 3, 2017 Category: Cytology Authors: L. John Gagliardi and Daniel H. Shain Source Type: research
Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control
The G1-S phase transition is critical to maintaining proliferative control and preventing carcinogenesis. The retinoblastoma tumor suppressor is a key regulator of this step in the cell cycle. (Source: Cell Division)
Source: Cell Division - March 14, 2017 Category: Cytology Authors: Michael J. Thwaites, Matthew J. Cecchini, Srikanth Talluri, Daniel T. Passos, Jasmyne Carnevale and Frederick A. Dick Source Type: research
Systematic epistatic mapping of cellular processes
Genetic screens have identified many novel components of various biological processes, such as components required for cell cycle and cell division. While forward genetic screens typically generate unstructure... (Source: Cell Division)
Source: Cell Division - January 6, 2017 Category: Cytology Authors: Maximilian Billmann and Michael Boutros Source Type: research
The Irr1/Scc3 protein implicated in chromosome segregation in Saccharomyces cerevisiae has a dual nuclear-cytoplasmic localization
Correct chromosome segregation depends on the sister chromatid cohesion complex. The essential, evolutionarily conserved regulatory protein Irr1/Scc3, is responsible for the complex loading onto DNA and for it... (Source: Cell Division)
Source: Cell Division - January 3, 2017 Category: Cytology Authors: Piotr Kowalec, Jan Fronk and Anna Kurlandzka Source Type: research
Electrostatic forces drive poleward chromosome motions at kinetochores
Recent experiments regarding Ndc80/Hec1 in force generation at kinetochores for chromosome motions have prompted speculation about possible models for interactions between positively charged molecules at kinet... (Source: Cell Division)
Source: Cell Division - October 28, 2016 Category: Cytology Authors: L. John Gagliardi and Daniel H. Shain Source Type: research
Erratum to: The loop-less tmCdc34 E2 mutant defective polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2
(Source: Cell Division)
Source: Cell Division - October 6, 2016 Category: Cytology Authors: Agnieszka Lass, Ross Cocklin, Kenneth M. Scaglione, Michael Skowyra, Sergey Korolev, Mark Goebl and Dorota Skowyra Source Type: research
The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway
The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involve... (Source: Cell Division)
Source: Cell Division - September 27, 2016 Category: Cytology Authors: Humberto Contreras-Cornejo, Germ án Saucedo-Correa, Javier Oviedo-Boyso, Juan José Valdez-Alarcón, Víctor Manuel Baizabal-Aguirre, Marcos Cajero-Juárez and Alejandro Bravo-Patiño Source Type: research
