Improving access to community-based pulmonary rehabilitation: 3R protocol for real-world settings with cost-benefit analysis
Pulmonary rehabilitation (PR) has demonstrated patients ’ physiological and psychosocial improvements, symptoms reduction and health-economic benefits whilst enhances the ability of the whole family to adjust t... (Source: Cell Division)
Source: Cell Division - May 31, 2019 Category: Cytology Authors: Alda Marques, Cristina J ácome, Patrícia Rebelo, Cátia Paixão, Ana Oliveira, Joana Cruz, Célia Freitas, Marília Rua, Helena Loureiro, Cristina Peguinho, Fábio Marques, Adriana Simões, Madalena Santos, Paula Martins, Alexandra André, Sílvia De Fr Tags: Study protocol Source Type: research
HSP70 is required for the proper assembly of pericentriolar material and function of mitotic centrosomes
At the onset of mitosis, the centrosome expands and matures, acquiring enhanced activities for microtubule nucleation and assembly of a functional bipolar mitotic spindle. However, the mechanisms that regulate... (Source: Cell Division)
Source: Cell Division - May 10, 2019 Category: Cytology Authors: Chieh-Ting Fang, Hsiao-Hui Kuo, Shao-Chun Hsu and Ling-Huei Yih Tags: Research Source Type: research
A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin
Resveratrol and its natural stilbene-containing derivatives have been extensively investigated as potential chemotherapeutic agents. The synthetic manipulation of the stilbene scaffold has led to the generatio... (Source: Cell Division)
Source: Cell Division - April 10, 2019 Category: Cytology Authors: Gianandrea Traversi, David Sasah Staid, Mario Fiore, Zulema Percario, Daniela Trisciuoglio, Roberto Antonioletti, Veronica Morea, Francesca Degrassi and Renata Cozzi Tags: Research Source Type: research
p27kip1 at the crossroad between actin and microtubule dynamics
The p27kip1 protein, mainly known as a negative regulator of cell proliferation, has also been involved in the control of other cellular processes, including the regulation of cytoskeleton dynamics. Notably, thes... (Source: Cell Division)
Source: Cell Division - April 1, 2019 Category: Cytology Authors: Gian Luca Rampioni Vinciguerra, Francesca Citron, Ilenia Segatto, Barbara Belletti, Andrea Vecchione and Gustavo Baldassarre Tags: Commentary Source Type: research
Replication stress-induced Exo1 phosphorylation is mediated by Rad53/Pph3 and Exo1 nuclear localization is controlled by 14-3-3 proteins
Mechanisms controlling DNA resection at sites of damage and affecting genome stability have been the subject of deep investigation, though their complexity is not yet fully understood. Specifically, the regula... (Source: Cell Division)
Source: Cell Division - January 4, 2019 Category: Cytology Authors: Nagaraja Chappidi, Giuseppe De Gregorio and Stefano Ferrari Tags: Short Report Source Type: research
Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells
The p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor sup... (Source: Cell Division)
Source: Cell Division - December 26, 2018 Category: Cytology Authors: Alicja Sznarkowska, Anna Kostecka, Anna Kawiak, Pilar Acedo, Mattia Lion, Alberto Inga and Joanna Zawacka-Pankau Tags: Research Source Type: research
Kif18a regulates Sirt2-mediated tubulin acetylation for spindle organization during mouse oocyte meiosis
During oocyte meiosis, the cytoskeleton dynamics, especially spindle organization, are critical for chromosome congression and segregation. However, the roles of the kinesin superfamily in this process are sti... (Source: Cell Division)
Source: Cell Division - November 10, 2018 Category: Cytology Authors: Feng Tang, Meng-Hao Pan, Xiang Wan, Yujie Lu, Yu Zhang and Shao-Chen Sun Tags: Research Source Type: research
Triple A patient cells suffering from mitotic defects fail to localize PGRMC1 to mitotic kinetochore fibers
Membrane-associated progesterone receptors are restricted to the endoplasmic reticulum and are shown to regulate the activity of cytochrome P450 enzymes which are involved in steroidogenesis or drug detoxifica... (Source: Cell Division)
Source: Cell Division - November 10, 2018 Category: Cytology Authors: Ramona J ühlen, Dana Landgraf, Angela Huebner and Katrin Koehler Tags: Research Source Type: research
The functional diversity of Aurora kinases: a comprehensive review
Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellul... (Source: Cell Division)
Source: Cell Division - September 19, 2018 Category: Cytology Authors: Estelle Willems, Matthias Dedobbeleer, Marina Digregorio, Arnaud Lombard, Paul Noel Lumapat and Bernard Rogister Tags: Review Source Type: research
Measuring DNA content in live cells by fluorescence microscopy
Live-cell fluorescence microscopy (LCFM) is a powerful tool used to investigate cellular dynamics in real time. However, the capacity to simultaneously measure DNA content in cells being tracked over time rema... (Source: Cell Division)
Source: Cell Division - September 4, 2018 Category: Cytology Authors: Cecil J. Gomes, Michael W. Harman, Sara M. Centuori, Charles W. Wolgemuth and Jesse D. Martinez Tags: Methodology Source Type: research
IMP/GTP balance modulates cytoophidium assembly and IMPDH activity
Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregat... (Source: Cell Division)
Source: Cell Division - June 15, 2018 Category: Cytology Authors: Gerson Dierley Keppeke, Chia Chun Chang, Min Peng, Li-Yu Chen, Wei-Cheng Lin, Li-Mei Pai, Luis Eduardo Coelho Andrade, Li-Ying Sung and Ji-Long Liu Tags: Research Source Type: research
Eg5 orchestrates porcine oocyte maturational progression by maintaining meiotic organelle arrangement
Kinesin superfamily proteins are microtubule-based molecular motors essential for the intracellular transport of various cargos, including organelles, proteins, and RNAs. However, their exact roles during mamm... (Source: Cell Division)
Source: Cell Division - May 24, 2018 Category: Cytology Authors: Yan Xie, Minghui Cheng, Shan Lu, Qilong Yuan, Dongyu Yang, Ying Chen, Chen Pan, Yurong Qiu and Bo Xiong Tags: Research Source Type: research
Protein arginine methylation: an emerging regulator of the cell cycle
Protein arginine methylation is a common post-translational modification where a methyl group is added onto arginine residues of a protein to alter detection by its binding partners or regulate its activity. I... (Source: Cell Division)
Source: Cell Division - March 20, 2018 Category: Cytology Authors: Anita E. Raposo and Sabine C. Piller Tags: Review Source Type: research
Subunits of human condensins are potential therapeutic targets for cancers
The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits of condensin I and condensin II are invol... (Source: Cell Division)
Source: Cell Division - February 20, 2018 Category: Cytology Authors: Hong-Zhen Wang, Si-Han Yang, Gui-Ying Li and Xudong Cao Tags: Hypothesis Source Type: research
Phasing in on the cell cycle
Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate... (Source: Cell Division)
Source: Cell Division - January 25, 2018 Category: Cytology Authors: Steven Boeynaems, Peter Tompa and Ludo Van Den Bosch Tags: Commentary Source Type: research
