Sustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancer
Triple-negative breast cancer (TBNC) is an aggressive breast cancer subtype with a poor prognosis. Shugoshin-1 (SGO1) protects chromatids from early separation. Previous studies from our group have demonstrate... (Source: Cell Division)
Source: Cell Division - April 30, 2023 Category: Cytology Authors: Shirley Jusino, Yainyrette Rivera-Rivera, Camille Chard ón-Colón, Patricia C. Rodríguez-Rodríguez, Janeishly Román-González, Valeria S. Juliá-Hernández, Angel Isidro, Qianxing Mo and Harold I. Saavedra Tags: Brief Report Source Type: research
Update of cellular responses to the efferocytosis of necroptosis and pyroptosis
Cell death is a basic physiological process that occurs in all living organisms. A few key players in these mechanisms, as well as various forms of cell death programming, have been identified. Apoptotic cell ... (Source: Cell Division)
Source: Cell Division - April 9, 2023 Category: Cytology Authors: Chandra Agung Purnama, Anna Meiliana, Melisa Intan Barliana and Keri Lestari Tags: Review Source Type: research
MiR-146b-5p/SEMA3G regulates epithelial-mesenchymal transition in clear cell renal cell carcinoma
The primary purpose was to unveil how the miR-146b-5p/SEMA3G axis works in clear cell renal cell carcinoma (ccRCC). (Source: Cell Division)
Source: Cell Division - March 7, 2023 Category: Cytology Authors: Mengxi Tang and Tao Xiong Tags: Research Source Type: research
Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis
Non-coding RNA (ncRNA) is a type of non-protein-coding RNA molecule transcribed from the genome which performs broad regulation of a variety of biological functions in human cells. The Wnt signaling pathway is... (Source: Cell Division)
Source: Cell Division - March 7, 2023 Category: Cytology Authors: Fangyu An, Xiangrui Meng, Lingqing Yuan, Yanqiang Niu, Jie Deng, Zhaohui Li, Yongqi Liu, Ruoliu Xia, Shiqing Liu and Chunlu Yan Tags: Review Source Type: research
Commentary: locating the restriction point
Attempts to map the Restriction Point in the mammalian cell cycle typically involve stimulating quiescent cells with mitogens for increasing intervals, removing the stimulus and then determining the proportion... (Source: Cell Division)
Source: Cell Division - February 10, 2023 Category: Cytology Authors: Robert F. Brooks Tags: Comment Source Type: research
Circular RNA hsa_circ_0075323 promotes glioblastoma cells proliferation and invasion via regulation of autophagy
Protein p62 (sequestosome 1) encoded by gene SQSTM1 plays a vital role in mediating protectively selective autophagy in tumor cells under stressed conditions. CircSQSTM1 (hsa_circ_0075323) is a circular transc... (Source: Cell Division)
Source: Cell Division - January 17, 2023 Category: Cytology Authors: Wenrui Zhang, Zhonggang Shi, Shouren Chen, Shaoshan Shen, Songjie Tu, Jian Yang, Yongming Qiu, Yingying Lin and Xuejun Dai Tags: Research Source Type: research
Ethnic and racial-specific differences in levels of centrosome-associated mitotic kinases, proliferative and epithelial-to-mesenchymal markers in breast cancers
Molecular epidemiology evidence indicates racial and ethnic differences in the aggressiveness and survival of breast cancer. Hispanics/Latinas (H/Ls) and non-Hispanic Black women (NHB) are at higher risk of br... (Source: Cell Division)
Source: Cell Division - December 9, 2022 Category: Cytology Authors: Yainyrette Rivera-Rivera, Geraldine Vargas, Neha Jaiswal, Angel N úñez-Marrero, Jiannong Li, Dung-Tsa Chen, Steven Eschrich, Marilin Rosa, Joseph O. Johnson, Julie Dutil, Srikumar P. Chellappan and Harold I. Saavedra Tags: Research Source Type: research
The genomic stability regulator PTIP is required for proper chromosome segregation in mitosis
The Pax transcription activation domain-interacting protein (PTIP) is a nuclear protein that is an essential component of H3K4 methylation for gene activation in vascular, kidney, B cell, and adipocyte develop... (Source: Cell Division)
Source: Cell Division - September 24, 2022 Category: Cytology Authors: Fengxia Zhang, Mingxuan Wei, Haoran Chen, Liting Ji, Yan Nie and Jungseog Kang Tags: Brief Report Source Type: research
dGLYAT modulates Gadd45-mediated JNK activation and cell invasion
Cell invasion is a crucial step of tumor metastasis, finding new regulators of which offers potential drug targets for cancer therapy. Aberrant GLYAT expression is associated with human cancers, yet its role in c... (Source: Cell Division)
Source: Cell Division - August 6, 2022 Category: Cytology Authors: Meng Xu, Pu Ren, Juhui Tian, Lisha Xiao, Ping Hu, Ping Chen, Wenzhe Li and Lei Xue Tags: Research Source Type: research
Proteolysis dependent cell cycle regulation in Caulobacter crescentus
Caulobacter crescentus, a Gram-negative alpha-proteobacterium, has surfaced as a powerful model system for unraveling molecular networks that control the bacterial cell cycle. A straightforward synchronization pr... (Source: Cell Division)
Source: Cell Division - April 1, 2022 Category: Cytology Authors: Nida I Fatima, Khalid Majid Fazili and Nowsheen Hamid Bhat Tags: Review Source Type: research
Principles of dormancy evident in high-grade serous ovarian cancer
In cancer, dormancy refers to a clinical state in which microscopic residual disease becomes non-proliferative and is largely refractory to chemotherapy. Dormancy was first described in breast cancer where dis... (Source: Cell Division)
Source: Cell Division - March 23, 2022 Category: Cytology Authors: Trevor G. Shepherd and Frederick A. Dick Tags: Review Source Type: research
An updated view on the centrosome as a cell cycle regulator
The centrosome is a multifunctional organelle that is known primarily for its microtubule organising function. Centrosomal defects caused by changes in centrosomal structure or number have been associated with... (Source: Cell Division)
Source: Cell Division - February 14, 2022 Category: Cytology Authors: Muyang Lin, Shuang Shuang Xie and Kuan Yoow Chan Tags: Review Source Type: research
Heat shock factor 1 suppression induces spindle abnormalities and sensitizes cells to antimitotic drugs
Heat shock factor 1 (HSF1) is the master regulator of the heat shock response and supports malignant cell transformation. Recent work has shown that HSF1 can access the promoters of heat shock proteins (HSPs) ... (Source: Cell Division)
Source: Cell Division - December 18, 2021 Category: Cytology Authors: Hsiao-Hui Kuo, Zhi-Rou Su, Jing-Yuan Chuang and Ling-Huei Yih Tags: Research Source Type: research
ROMO1 is required for mitochondrial metabolism during preimplantation embryo development in pigs
Reactive oxygen species (ROS) modulator 1 (ROMO1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial ROS production and redox sensing. ROMO1 regulates ROS generation with... (Source: Cell Division)
Source: Cell Division - December 16, 2021 Category: Cytology Authors: Dongjie Zhou, Ming-Hong Sun, Song-Hee Lee and Xiang-Shun Cui Tags: Research Source Type: research
MPS1 is involved in the HPV16-E7-mediated centrosomes amplification
It has been reported that the oncoprotein E7 from human papillomavirus type 16 (HPV16-E7) can induce the excessive synthesis of centrosomes through the increase in the expression of PLK4, which is a transcript... (Source: Cell Division)
Source: Cell Division - November 4, 2021 Category: Cytology Authors: Yair Alfaro-Mora, Guadalupe Dom ínguez-Gómez, Rodrigo E. Cáceres-Gutiérrez, Laura Tolentino-García, Luis A. Herrera, Clementina Castro-Hernández, Rosa María Bermúdez-Cruz and José Díaz-Chávez Tags: Research Source Type: research
