Frameworks for estimating causal effects in observational settings: comparing confounder adjustment and instrumental variables
To estimate causal effects, analysts performing observational studies in health settings utilize several strategies to mitigate bias due to confounding by indication. There are two broad classes of approaches ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 22, 2023 Category: Research Authors: Roy S. Zawadzki, Joshua D. Grill and Daniel L. Gillen Tags: Review Source Type: research
The estimation of long and short term survival time and associated factors of HIV patients using mixture cure rate models
HIV is one of the deadliest epidemics and one of the most critical global public health issues. Some are susceptible to die among people living with HIV and some survive longer. The aim of the present study is... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 22, 2023 Category: Research Authors: Khadijeh Najafi Ghobadi, Ghodratollah Roshanaei, Jalal Poorolajal, Ebrahim Shakiba, Kaivan KHassi and Hossein Mahjub Tags: Research Source Type: research
Neutral theory: applicability and neutrality of clinical study endpoints where a disease-specific instrument is available
There is a pressing need to improve the accuracy of rare disease clinical study endpoints. Neutral theory, first described here, can be used to assess the accuracy of endpoints and improve their selection in r... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 20, 2023 Category: Research Authors: Ravi Jandhyala Tags: Research Source Type: research
Goodness-of-fit two-phase sampling designs for time-to-event outcomes: a simulation study based on New York University Women ’s Health Study for breast cancer
Sub-cohort sampling designs such as a case-cohort study play a key role in studying biomarker-disease associations due to their cost effectiveness. Time-to-event outcome is often the focus in cohort studies, a... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 19, 2023 Category: Research Authors: Myeonggyun Lee, Jinbo Chen, Anne Zeleniuch-Jacquotte and Mengling Liu Tags: Research Source Type: research
Some examples of privacy-preserving sharing of COVID-19 pandemic data with statistical utility evaluation
A considerable amount of various types of data have been collected during the COVID-19 pandemic, the analysis and understanding of which have been indispensable for curbing the spread of the disease. As the pa... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 19, 2023 Category: Research Authors: Fang Liu, Dong Wang and Tian Yan Tags: Research Source Type: research
A one-size-fits-all approach to data-sharing will not suffice in lifecourse research: a grounded theory study of data-sharing from the perspective of participants in a 50-year-old lifecourse study about health and development
Data-sharing is increasingly encouraged or required by funders and journals. Data-sharing is more complicated for lifecourse studies that rely upon ongoing participation, but little is known about perspectives... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 16, 2023 Category: Research Authors: Jane Reeves, Gareth J. Treharne, Mihi Ratima, Reremoana Theodore, Will Edwards and Richie Poulton Tags: Research Source Type: research
TRIPLE C reporting principles for case study evaluations of the role of context in complex interventions
Guidance and reporting principles such as CONSORT (for randomised trials) and PRISMA (for systematic reviews) have greatly improved the reporting, discoverability, transparency and consistency of published res... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 13, 2023 Category: Research Authors: Sara E. Shaw, Sara Paparini, Jamie Murdoch, Judith Green, Trisha Greenhalgh, Benjamin Hanckel, Hannah M. James, Mark Petticrew, Gary W. Wood and Chrysanthi Papoutsi Tags: Research Source Type: research
The unrecognized role of fidelity in effectiveness-implementation hybrid trials: simulation study and guidance for implementation researchers
Effectiveness-implementation hybrid designs are a relatively new approach to evaluate efficacious interventions in real-world settings while concurrently gathering information on the implementation. Interventi... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 13, 2023 Category: Research Authors: Diana Trutschel, Catherine Blatter, Michael Simon, Daniela Holle, Sven Reuther and Thekla Brunkert Tags: Research Source Type: research
The Trial within Cohorts (TwiCs) study design in oncology: experience and methodological reflections
A Trial within Cohorts (TwiCs) study design is a trial design that uses the infrastructure of an observational cohort study to initiate a randomized trial. Upon cohort enrollment, the participants provide cons... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 13, 2023 Category: Research Authors: Rob Kessels, Anne M. May, Miriam Koopman and Kit C. B. Roes Tags: Research Source Type: research
Research recruitment and consent methods in a pandemic: a qualitative study of COVID-19 patients ’ perspectives
Virtual data collection methods and consent procedures adopted in response to the COVID-19 pandemic enabled continued research activities, but also introduced concerns about equity, inclusivity, representation... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 11, 2023 Category: Research Authors: Serena S Small, Erica Lau, Kassandra McFarlane, Patrick M Archambault, Holly Longstaff and Corinne M Hohl Tags: Research Source Type: research
Exploring flexible polynomial regression as a method to align routine clinical outcomes with daily data capture through remote technologies
Clinical outcomes are normally captured less frequently than data from remote technologies, leaving a disparity in volumes of data from these different sources. To align these data, flexible polynomial regress... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 11, 2023 Category: Research Authors: Nicole Filipow, Eleanor Main, Gizem Tanriver, Emma Raywood, Gwyneth Davies, Helen Douglas, Aidan Laverty and Sanja Stanojevic Tags: Research Source Type: research
Multiple imputation methods for missing multilevel ordinal outcomes
Multiple imputation (MI) is an established technique for handling missing data in observational studies. Joint modelling (JM) and fully conditional specification (FCS) are commonly used methods for imputing mu... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 9, 2023 Category: Research Authors: Mei Dong and Aya Mitani Tags: Research Source Type: research
Quantitative bias analysis in practice: review of software for regression with unmeasured confounding
Failure to appropriately account for unmeasured confounding may lead to erroneous conclusions. Quantitative bias analysis (QBA) can be used to quantify the potential impact of unmeasured confounding or how muc... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 4, 2023 Category: Research Authors: Emily Kawabata, Kate Tilling, Rolf H. H. Groenwold and Rachael A. Hughes Tags: Research Source Type: research
Interdisciplinary sport injury research and the integration of qualitative and quantitative data
To understand and prevent sport injuries, scholars have employed different scientific approaches and research methods. Traditionally, this research has been monodisciplinary, relying on one subdiscipline of sp... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 3, 2023 Category: Research Authors: S.E Hausken-Sutter, K Boije af Genn äs, A Schubring, S Grau, J Jungmalm and N Barker-Ruchti Tags: Research Source Type: research
Utilization of five data mining algorithms combined with simplified preprocessing to establish reference intervals of thyroid-related hormones for non-elderly adults
Despite the extensive research on data mining algorithms, there is still a lack of a standard protocol to evaluate the performance of the existing algorithms. Therefore, the study aims to provide a novel proce... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 2, 2023 Category: Research Authors: Jian Zhong, Chaochao Ma, Li ’an Hou, Yicong Yin, Fang Zhao, Yingying Hu, Ailing Song, Danchen Wang, Lei Li, Xinqi Cheng and Ling Qiu Tags: Research Source Type: research
