Disease progression model anchored around clinical diagnosis in longitudinal cohorts: example of Alzheimer ’s disease and related dementia
Alzheimer ’s disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including accumulation of abnormal proteins in the brain, brain atrophy and severe cogniti... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 5, 2023 Category: Research Authors: J érémie Lespinasse, Carole Dufouil and Cécile Proust-Lima Tags: Research Source Type: research
The heterogeneity of symptom reporting across study sites: a secondary analysis of a randomised placebo-controlled multicentre antimalarial trial
Symptoms reported following the administration of investigational drugs play an important role in decisions for registration and treatment guidelines. However, symptoms are subjective, and interview methods to... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 4, 2023 Category: Research Authors: Kamala Thriemer, Robert James Commons, Megha Rajasekhar, Tamiru Shibiru Degaga, Krisin Chand, Nguyen Hoang Chau, Ashenafi Assefa, Mohammad Nader Naddim, Ayodhia Pitaloka Pasaribu, Awab Ghulam Rahim, Inge Sutanto, Tran Tinh Hien, Asrat Hailu, Mohammad Anwa Tags: Research Source Type: research
Target trial emulation with multi-state model analysis to assess treatment effectiveness using clinical COVID-19 data
Real-world observational data are an important source of evidence on the treatment effectiveness for patients hospitalized with coronavirus disease 2019 (COVID-19). However, observational studies evaluating tr... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - September 2, 2023 Category: Research Authors: Oksana Martinuka, Derek Hazard, Hamid Reza Marateb, Camille Maringe, Marjan Mansourian, Manuel Rubio-Rivas and Martin Wolkewitz Tags: Research Source Type: research
Designs used in published therapeutic studies of rare superficial vascular anomalies: a systematic literature search
Rare superficial vascular anomalies represent a wide range of diseases. Their management is difficult given the broad spectrum and the lack of clinical trials assessing treatment efficacy. A randomized clinica... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 30, 2023 Category: Research Authors: Aude Allemang-Trivalle, Sophie Leducq, Annabel Maruani and Bruno Giraudeau Tags: Research Source Type: research
An innovative sequential mixed-methods approach to evaluating clinician acceptability during implementation of a standardized labor induction protocol
Implementation outcomes, including acceptability, are of critical importance in both implementation research and practice. The gold standard measure of acceptability, Acceptability of Intervention Measure (AIM... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 29, 2023 Category: Research Authors: Rebecca Feldman Hamm, Lisa D. Levine, Julia E. Szymczak, Samuel Parry, Sindhu K. Srinivas and Rinad S. Beidas Tags: Research Source Type: research
Correction: Design and analysis of outcomes following SARS-CoV-2 infection in veterans
(Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 25, 2023 Category: Research Authors: Valerie A. Smith, Theodore S. Z. Berkowitz, Paul Hebert, Edwin S. Wong, Meike Niederhausen, John A. Pura, Kristin Berry, Pamela Green, Anna Korpak, Alexandra Fox, Aaron Baraff, Alex Hickok, Troy A Shahoumian, Amy S.B. Bohnert, Denise M. Hynes, Edward J. B Tags: Correction Source Type: research
Considerations for pooling real-world data as a comparator cohort to a single arm trial: a simulation study on assessment of heterogeneity
Novel precision medicine therapeutics target increasingly granular, genomically-defined populations. Rare sub-groups make it challenging to study within a clinical trial or single real-world data (RWD) source;... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 24, 2023 Category: Research Authors: Daniel Backenroth, Trevor Royce, Jose Pinheiro, Meghna Samant and Olivier Humblet Tags: Research article Source Type: research
Application of the multiple dependent state sampling strategy to late adolescent suicide rates
A multiple dependent state sampling plan (MDSSP) is designed when the lifetimes of the variables follow New Lomax Rayleigh Distribution (NLRD). The decision to accept or reject a lot in the proposed methodolog... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 22, 2023 Category: Research Authors: Nagasaritha Kolli, Kanaparthi Rosaiah, Gadde Srinivasa Rao and Peter Josephat Kirigiti Tags: Research Source Type: research
A study on fractional tumor-immune interaction model related to lung cancer via generalized Laguerre polynomials
Cancer, a complex and deadly health concern today, is characterized by forming potentially malignant tumors or cancer cells. The dynamic interaction between these cells and their environment is crucial to the ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 21, 2023 Category: Research Authors: Hossein Hassani, Zakieh Avazzadeh, Praveen Agarwal, Samrad Mehrabi, M. J. Ebadi, Mohammad Shafi Dahaghin and Eskandar Naraghirad Tags: Research Source Type: research
A Bayesian latent class extension of naive Bayesian classifier and its application to the classification of gastric cancer patients
The Naive Bayes (NB) classifier is a powerful supervised algorithm widely used in Machine Learning (ML). However, its effectiveness relies on a strict assumption of conditional independence, which is often vio... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 21, 2023 Category: Research Authors: Kimiya Gohari, Anoshirvan Kazemnejad, Marjan Mohammadi, Farzad Eskandari, Samaneh Saberi, Maryam Esmaieli and Ali Sheidaei Tags: Research Source Type: research
Comparison of Bayesian Networks, G-estimation and linear models to estimate causal treatment effects in aggregated N-of-1 trials with carry-over effects
The aggregation of a series of N-of-1 trials presents an innovative and efficient study design, as an alternative to traditional randomized clinical trials. Challenges for the statistical analysis arise when t... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 21, 2023 Category: Research Authors: Thomas G ärtner, Juliana Schneider, Bert Arnrich and Stefan Konigorski Tags: Research Source Type: research
Assessing the transportability of clinical prediction models for cognitive impairment using causal models
Machine learning models promise to support diagnostic predictions, but may not perform well in new settings. Selecting the best model for a new setting without available data is challenging. We aimed to invest... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 19, 2023 Category: Research Authors: Jana Fehr, Marco Piccininni, Tobias Kurth and Stefan Konigorski Tags: Research Source Type: research
Sample size requirements are not being considered in studies developing prediction models for binary outcomes: a systematic review
Having an appropriate sample size is important when developing a clinical prediction model. We aimed to review how sample size is considered in studies developing a prediction model for a binary outcome. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 19, 2023 Category: Research Authors: Paula Dhiman, Jie Ma, Cathy Qi, Garrett Bullock, Jamie C Sergeant, Richard D Riley and Gary S Collins Tags: Research Source Type: research
Implementation of the trial emulation approach in medical research: a scoping review
When conducting randomised controlled trials is impractical, an alternative is to carry out an observational study. However, making valid causal inferences from observational data is challenging because of the... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 16, 2023 Category: Research Authors: Giulio Scola, Anca Chis Ster, Daniel Bean, Nilesh Pareek, Richard Emsley and Sabine Landau Tags: Research Source Type: research
Do animation videos increase participation in national health surveys? A randomised controlled trial
Declining response proportions in surveys have been observed internationally. Improving response proportions is important for the generalizability of the outcome. The aim of this study was to examine the poten... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - August 14, 2023 Category: Research Authors: Anne Illemann Christensen, Cathrine Juel Lau, Hanne Stald Poulsen and Ola Ekholm Tags: Research Source Type: research
