Estimating medication adherence from Electronic Health Records: comparing methods for mining and processing asthma treatment prescriptions
Medication adherence is usually defined as the extent of the agreement between the medication regimen agreed to by patients with their healthcare provider and the real-world implementation. Proactive identific... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 12, 2023 Category: Research Authors: Holly Tibble, Aziz Sheikh and Athanasios Tsanas Tags: Research Source Type: research
Technologies for frailty, comorbidity, and multimorbidity in older adults: a systematic review of research designs
Frailty, neurodegeneration and geriatric syndromes cause a significant impact at the clinical, social, and economic level, mainly in the context of the aging world. Recently, Information and Communication Tech... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 11, 2023 Category: Research Authors: Alessia Gallucci, Pietro D. Trimarchi, Cosimo Tuena, Silvia Cavedoni, Elisa Pedroli, Francesca Romana Greco, Antonio Greco, Carlo Abbate, Fabrizia Lattanzio, Marco Stramba-Badiale and Fabrizio Giunco Tags: Research Source Type: research
Performance metrics for models designed to predict treatment effect
Measuring the performance of models that predict individualized treatment effect is challenging because the outcomes of two alternative treatments are inherently unobservable in one patient. The C-for-benefit ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 8, 2023 Category: Research Authors: C. C. H. M. Maas, D. M. Kent, M. C. Hughes, R. Dekker, H. F. Lingsma and D. van Klaveren Tags: Research Source Type: research
A data-driven approach to categorizing early life adversity exposure in the ABCD Study
Adversity occurring during development is associated with detrimental health and quality of life outcomes, not just following exposure but throughout the lifespan. Despite increased research, there exists both... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 7, 2023 Category: Research Authors: Natalia Orendain, Ariana Anderson, Adriana Galv án, Susan Bookheimer and Paul J. Chung Tags: Research Source Type: research
Minimal important difference, patient acceptable symptom state and longitudinal validity of oxford elbow score and the quickDASH in patients with tennis elbow
The Oxford Elbow Score (OES) and the short version of Disabilities of Arms, Shoulder and Hand (QuickDASH) are common patient-reported outcomes for people with elbow problems. Our primary objective was to defin... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 6, 2023 Category: Research Authors: Teemu Karjalainen, Tuomas L ähdeoja, Mikko Salmela, Clare L Ardern, Joona Juurakko, Teppo LN Järvinen and Simo Taimela Tags: Research Source Type: research
Cross-cultural adaptation and psychometric properties of the Mainland Chinese version of the manchester orofacial pain disability scale (MOPDS) among college students
Orofacial pain (OFP) is a highly prevalent disorder in mainland China that predisposes to an associated physical and psychological disability. There is lack of a good properties mainland Chinese version of ins... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 6, 2023 Category: Research Authors: Yao Feng, Ze-Yue Ou-Yang, Jing-Jie Lu, Yi-Fan Yang, Qian Zhang, Meng-Mei Zhong, Ning-Xin Chen, Xiao-Lin Su, Jing Hu, Qin Ye, Jie Zhao, Ya-Qiong Zhao, Yun Chen, Li Tan, Qiong Liu, Yun-Zhi Feng & hellip; Tags: Research Source Type: research
The impact of iterative removal of low-information cluster-period cells from a stepped wedge design
Standard stepped wedge trials, where clusters switch from the control to the intervention condition in a staggered manner, can be costly and burdensome. Recent work has shown that the amount of information con... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 6, 2023 Category: Research Authors: Ehsan Rezaei-Darzi, Kelsey L. Grantham, Andrew B. Forbes and Jessica Kasza Tags: Research Source Type: research
Use of research electronic data capture (REDCap) in a sequential multiple assignment randomized trial (SMART): a practical example of automating double randomization
Adaptive interventions are often used in individualized health care to meet the unique needs of clients. Recently, more researchers have adopted the Sequential Multiple Assignment Randomized Trial (SMART), a t... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 6, 2023 Category: Research Authors: Carol A. Lee, Danilo Gamino, Michelle Lore, Curt Donelson and Liliane C. Windsor Tags: Research Source Type: research
Bayesian model averaging for predicting factors associated with length of COVID-19 hospitalization
The length of hospital stay (LOHS) caused by COVID-19 has imposed a financial burden, and cost on the healthcare service system and a high psychological burden on patients and health workers. The purpose of th... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 6, 2023 Category: Research Authors: Shabnam Bahrami, Karimollah Hajian-Tilaki, Masomeh Bayani, Mohammad Chehrazi, Zahra Mohamadi-Pirouz and Abazar Amoozadeh Tags: Research Source Type: research
Effect of alcohol consumption on breast cancer: probabilistic bias analysis for adjustment of exposure misclassification bias and confounders
This study was conducted to evaluate the effect of alcohol consumption on breast cancer, adjusting for alcohol consumption misclassification bias and confounders. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - July 4, 2023 Category: Research Authors: Reza Pakzad, Saharnaz Nedjat, Hamid Salehiniya, Nasrin Mansournia, Mahyar Etminan, Maryam Nazemipour, Iraj Pakzad and Mohammad Ali Mansournia Tags: Research Source Type: research
Quasi-rerandomization for observational studies
In the causal analysis of observational studies, covariates should be carefully balanced to approximate a randomized experiment. Numerous covariate balancing methods have been proposed for this purpose. Howeve... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - June 30, 2023 Category: Research Authors: Hengtao Zhang, Wen Su and Guosheng Yin Tags: Research article Source Type: research
Use of electronic health data to identify patients with moderate-to-severe osteoarthritis of the hip and/or knee and inadequate response to pain medications
No algorithms exist to identify important osteoarthritis (OA) patient subgroups (i.e., moderate-to-severe disease, inadequate response to pain treatments) in electronic healthcare data, possibly due to the com... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - June 30, 2023 Category: Research Authors: Yi Lu, Michael L. Ganz, Rebecca L. Robinson, Anthony J. Zagar, Sandra Okala, Craig T. Hartrick, Beth Johnston, Patricia Dorling, May Slim, Sheena Thakkar and Ariel Berger Tags: Research Source Type: research
Looking ahead in early-phase trial design to improve the drug development process: examples in oncology
Clinical trial design must consider the specific resource constraints and overall goals of the drug development process (DDP); for example, in designing a phase I trial to evaluate the safety of a drug and rec... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - June 29, 2023 Category: Research Authors: Alyssa M. Vanderbeek, Robert A. Redd, Steffen Ventz and Lorenzo Trippa Tags: Research Source Type: research
Evaluation of reporting quality of cohort studies using real-world data based on RECORD: systematic review
Real-world data (RWD) and real-world evidence (RWE) have been paid more and more attention in recent years. We aimed to evaluate the reporting quality of cohort studies using real-world data (RWD) published be... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - June 29, 2023 Category: Research Authors: Ran Zhao, Wen Zhang, ZeDan Zhang, Chang He, Rong Xu, XuDong Tang and Bin Wang Tags: Research Source Type: research
Increase in power by obtaining 10 or more controls per case when type-1 error is small in large-scale association studies
The rule of thumb that there is little gain in statistical power by obtaining more than 4 controls per case, is based on type-1 error α = 0.05. However, association studies that evaluate thousands or millions ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - June 29, 2023 Category: Research Authors: Hormuzd A. Katki, Sonja I. Berndt, Mitchell J. Machiela, Douglas R. Stewart, Montserrat Garcia-Closas, Jung Kim, Jianxin Shi, Kai Yu and Nathaniel Rothman Tags: Research Source Type: research
