Model-based standardization using multiple imputation
When studying the association between treatment and a clinical outcome, a parametric multivariable model of the conditional outcome expectation is often used to adjust for covariates. The treatment coefficient... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - February 10, 2024 Category: Research Authors: Antonio Remiro-Az ócar, Anna Heath and Gianluca Baio Tags: Research Source Type: research
An evaluation of the EASY instrument in a cross-sectional study
The purpose of this paper is to evaluate the impact of modifying the published scoring system to address identified potential weaknesses in the published scoring system for the Evaluation of Activity Surveys i... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - February 10, 2024 Category: Research Authors: Julie Agel, Umesh Ghimire, Nicholas M. Edwards, Bradley Nelson and Todd Rockwood Tags: Research Source Type: research
A data-adaptive method for investigating effect heterogeneity with high-dimensional covariates in Mendelian randomization
Mendelian randomization is a popular method for causal inference with observational data that uses genetic variants as instrumental variables. Similarly to a randomized trial, a standard Mendelian randomizatio... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - February 10, 2024 Category: Research Authors: Haodong Tian, Brian D. M. Tom and Stephen Burgess Tags: Research Source Type: research
Estimating cutoff values for diagnostic tests to achieve target specificity using extreme value theory
Rapidly developing tests for emerging diseases is critical for early disease monitoring. In the early stages of an epidemic, when low prevalences are expected, high specificity tests are desired to avoid numer... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - February 8, 2024 Category: Research Authors: Sierra Pugh, Bailey K. Fosdick, Mary Nehring, Emily N. Gallichotte, Sue VandeWoude and Ander Wilson Tags: Research Source Type: research
Designing tailored maintenance strategies for systematic reviews and clinical practice guidelines using the Portfolio Maintenance by Test-Treatment (POMBYTT) framework
Organizations face diverse contexts and requirements when updating and maintaining their portfolio, or pool, of systematic reviews or clinical practice guidelines they need to manage. We aimed to develop a com... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - February 2, 2024 Category: Research Authors: Michiel S. Oerbekke, Roy G. Elbers, Maarten J. van der Laan and Lotty Hooft Tags: Research Source Type: research
A modified Michaelis-Menten equation estimates growth from birth to 3 years in healthy babies in the USA
Standard pediatric growth curves cannot be used to impute missing height or weight measurements in individual children. The Michaelis –Menten equation, used for characterizing substrate-enzyme saturation curves... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - February 1, 2024 Category: Research Authors: William A. Walters, Catherine Ley, Trevor Hastie, Ruth E. Ley and Julie Parsonnet Tags: Research Source Type: research
An empirical comparison of statistical methods for multiple cut-off diagnostic test accuracy meta-analysis of the Edinburgh postnatal depression scale (EPDS) depression screening tool using published results vs individual participant data
Selective reporting of results from only well-performing cut-offs leads to biased estimates of accuracy in primary studies of questionnaire-based screening tools and in meta-analyses that synthesize results. I... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - February 1, 2024 Category: Research Authors: Zelalem F. Negeri, Brooke Levis, John P. A. Ioannidis, Brett D. Thombs and Andrea Benedetti Tags: Research Source Type: research
Health estimate differences between six independent web surveys: different web surveys, different results?
Most general population web surveys are based on online panels maintained by commercial survey agencies. Many of these panels are based on non-probability samples. However, survey agencies differ in their pane... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - January 27, 2024 Category: Research Authors: Rainer Schnell and Jonas Klingwort Tags: Research Source Type: research
Bayesian Mendelian randomization with an interval causal null hypothesis: ternary decision rules and loss function calibration
We enhance the Bayesian Mendelian Randomization (MR) framework of Berzuini et al. (Biostatistics 21(1):86 –101, 2018) by allowing for interval null causal hypotheses, where values of the causal effect parameter... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - January 27, 2024 Category: Research Authors: Linyi Zou, Teresa Fazia, Hui Guo and Carlo Berzuini Tags: Research Source Type: research
Gaussian process emulation to improve efficiency of computationally intensive multidisease models: a practical tutorial with adaptable R code
The rapidly growing burden of non-communicable diseases (NCDs) among people living with HIV in sub-Saharan Africa (SSA) has expanded the number of multidisease models predicting future care needs and health sy... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - January 27, 2024 Category: Research Authors: Sharon Jepkorir Sawe, Richard Mugo, Marta Wilson-Barthes, Brianna Osetinsky, Stavroula A. Chrysanthopoulou, Faith Yego, Ann Mwangi and Omar Gal árraga Tags: Research Source Type: research
Estimation of place-based vulnerability scores for HIV viral non-suppression: an application leveraging data from a cohort of people with histories of using drugs
The relationships between place (e.g., neighborhood) and HIV are commonly investigated. As measurements of place are multivariate, most studies apply some dimension reduction, resulting in one variable (or a s... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - January 25, 2024 Category: Research Authors: Trang Quynh Nguyen, Laken C. Roberts Lavigne, Carly Lupton Brantner, Gregory D. Kirk, Shruti H. Mehta and Sabriya L. Linton Tags: Research Source Type: research
Comparison of Pocock and Simon ’s covariate-adaptive randomization procedures in clinical trials
When multiple influential covariates need to be balanced during a clinical trial, stratified blocked randomization and covariate-adaptive randomization procedures are frequently used in trials to prevent bias ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - January 25, 2024 Category: Research Authors: Guogen Shan, Yulin Li, Xinlin Lu, Yahui Zhang and Samuel S. Wu Tags: Research Source Type: research
A time series driven model for early sepsis prediction based on transformer module
In this study, we have proposed pred... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - January 25, 2024 Category: Research Authors: Yan Tang, Yu Zhang and Jiaxi Li Tags: Research Source Type: research
Navigating PROSPERO4animals: 10 top tips for efficient pre-registration of your animal systematic review protocol
Systematic reviews are an essential tool in identifying knowledge gaps and synthesizing evidence from in vivo animal research to improve human health. The review process follows an explicit and systematic meth... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - January 24, 2024 Category: Research Authors: Alexandra Bannach-Brown, Torsten Rackoll, Nurcennet Kaynak, Natascha Drude, Ren é Aquarius, Sofija Vojvodić, Mariana Abreu, Julia M. L. Menon and Kimberley E. Wever Tags: Review Source Type: research
Exploring trial publication and research waste in COVID-19 randomised trials of hydroxychloroquine, corticosteroids, and vitamin D: a meta-epidemiological cohort study
The global research response to the COVID-19 pandemic was impressive, but also led to an infodemic and considerable research waste. Registered, but unpublished trials added to this noise. We aimed to determine... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - January 23, 2024 Category: Research Authors: Lisa Fincham, Ameer Hohlfeld, Mike Clarke, Tamara Kredo and Michael McCaul Tags: Research Source Type: research
