Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8+ T lymphocyte exhaustion
Lymphocyte-activation gene (LAG)3 is a 498 aa transmembrane type I protein acting as an immune inhibitory receptor. It is expressed on activated lymphocytes, natural killer cells and plasmacytoid dendritic cel... (Source: BMC Biotechnology)
Source: BMC Biotechnology - October 17, 2019 Category: Biotechnology Authors: Alessandro Ascione, Claudia Arenaccio, Alessandra Mallano, Michela Flego, Mara Gellini, Mauro Andreotti, Craig Fenwick, Giuseppe Pantaleo, Stefano Vella and Maurizio Federico Tags: Research article Source Type: research
Soybean plants expressing the Bacillus thuringiensis cry8-like gene show resistance to Holotrichia parallela
Cry8-like from Bacillus thuringiensis (Bt) encodes an insecticidal crystal (Cry) protein. Holotrichia parallela (Coleoptera: Scarabaeoidae), commonly known as the dark black chafer, is a troublesome pest of soybe... (Source: BMC Biotechnology)
Source: BMC Biotechnology - October 15, 2019 Category: Biotechnology Authors: Di Qin, Xiao-Yi Liu, Cristina Miceli, Qi Zhang and Pi-wu Wang Tags: Research article Source Type: research
Rejuvenation of chicory and lettuce plants following phase change in tissue culture
A frequent problem associated with the tissue culture of Compositae species such as chicory (Cichorium intybus L.) and lettuce (Lactuca sativa L.) is the premature bolting to in vitro flowering of regenerated pla... (Source: BMC Biotechnology)
Source: BMC Biotechnology - September 11, 2019 Category: Biotechnology Authors: Anthony J. Conner, Helen Searle and Jeanne M. E. Jacobs Tags: Research article Source Type: research
Intracellular human antibody fragments recognizing the VP35 protein of Zaire Ebola filovirus inhibit the protein activity
Ebola hemorrhagic fever is caused by the Ebola filovirus (EBOV), which is one of the most aggressive infectious agents known worldwide. The EBOV pathogenesis starts with uncontrolled viral replication and subv... (Source: BMC Biotechnology)
Source: BMC Biotechnology - September 5, 2019 Category: Biotechnology Authors: Michela Flego, Aldo Frau, Luisa Accardi, Alessandra Mallano, Alessandro Ascione, Mara Gellini, Elisa Fanunza, Stefano Vella, Paola Di Bonito and Enzo Tramontano Tags: Research article Source Type: research
Identification and characterization of an Endo-glucanase secreted from cellulolytic Escherichia coli ZH-4
In the previous study, the cellulolytic Escherichia coli ZH-4 isolated from bovine rumen was found to show extracellular cellulase activity and could degrade cellulose in the culture. The goal of this work was to... (Source: BMC Biotechnology)
Source: BMC Biotechnology - August 27, 2019 Category: Biotechnology Authors: Jian Pang, Junshu Wang, Zhanying Liu, Qiancheng Zhang and Qingsheng Qi Tags: Research article Source Type: research
