Biological and Pharmaceutical Bulletin 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Biosynthesis and Degradation of Free D-Amino Acids and Their Physiological Roles in the Periphery and Endocrine Glands
Biol Pharm Bull. 2024;47(3):562-579. doi: 10.1248/bpb.b23-00485.ABSTRACTIt was long believed that D-amino acids were either unnatural isomers or laboratory artifacts, and that the important functions of amino acids were exerted only by L-amino acids. However, recent investigations have revealed a variety of D-amino acids in mammals that play important roles in physiological functions, including free D-serine and D-aspartate that are crucial in the central nervous system. The functions of several D-amino acids in the periphery and endocrine glands are also receiving increasing attention. Here, we present an overview of rece...
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Authors: Masumi Katane Hiroshi Homma Source Type: research
Structural Perspective of NR4A Nuclear Receptor Family and Their Potential Endogenous Ligands
Biol Pharm Bull. 2024;47(3):580-590. doi: 10.1248/bpb.b23-00600.ABSTRACTThere are 48 nuclear receptors in the human genome, and many members of this superfamily have been implicated in human diseases. The NR4A nuclear receptor family consisting of three members, NR4A1, NR4A2, and NR4A3 (formerly annotated as Nur77, Nurr1, and NOR1, respectively), are still orphan receptors but exert pathological effects on immune-related and neurological diseases. We previously reported that prostaglandin A1 (PGA1) and prostaglandin A2 (PGA2) are potent activators of NR4A3, which bind directly to the ligand-binding domain (LBD) of the rece...
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Authors: Ryoichi Hashida Takeshi Kawabata Source Type: research
Errata for Biological and Pharmaceutical Bulletin
Biol Pharm Bull. 2024;47(2):547. doi: 10.1248/bpb.b24-e4702.NO ABSTRACTPMID:38432914 | DOI:10.1248/bpb.b24-e4702 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Source Type: research
Errata for Biological and Pharmaceutical Bulletin
Biol Pharm Bull. 2024;47(2):548. doi: 10.1248/bpb.b24-e4702b.NO ABSTRACTPMID:38432915 | DOI:10.1248/bpb.b24-e4702b (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Source Type: research
Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats
Biol Pharm Bull. 2024 Mar 1. doi: 10.1248/bpb.b23-00872. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) can cause visual impairment and blindness, and the increasing global prevalence of diabetes underscores the need for effective therapies to prevent and treat DR. Therefore, this study aimed to evaluate the protective effect of pemafibrate treatment against DR, using a Spontaneously Diabetic Torii (SDT) fatty rat model of obese type 2 diabetes. SDT fatty rats were fed either a diet supplemented with pemafibrate (0.3 mg/kg/day) for 16 weeks, starting at 8 weeks of age (Pf SDT fatty: study group), or normal chow (S...
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Authors: Yoshiaki Tanaka Rina Takagi Shingen Mitou Machiko Shimmura Tetsuya Hasegawa Jota Amarume Masami Shinohara Yasushi Kageyama Tomohiko Sasase Takeshi Ohta Shin-Ichi Muramatsu Akihiro Kakehashi Toshikatsu Kaburaki Source Type: research
Comparing the Efficacy of Fosnetupitant, an NK < sub > 1 < /sub > Receptor Antagonist in CDDP-Based Regimens, With that of Fosaprepitant and Aprepitant: A Retrospective Observational Study
This study compared the efficacy of fosnetupitant (F-NTP), a neurokinin 1 receptor antagonist, with that of fosaprepitant (F-APR) and aprepitant (APR) in the treatment of patients with cancer at high emetic risk due to chemotherapy. In this retrospective case-control study involving patients receiving cisplatin-containing regimens and neurokinin 1 receptor antagonists, patients were divided into three groups based on prophylactic antiemetic therapy: F-NTP, F-APR, and APR. The CR rate was evaluated for each period up to 168 h and further subdivided into acute (0-24 h), delayed (24-120 h), overall (0-120 h), and beyond-delay...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Hiroshi Inano Yoshihito Morimoto Kanata Kitagawa Akito Shibuya Kozue Nakagomi Tomohiro Ota Yuri Anzo Rika Miyauchi Aiko Shono Kazuhiro Watanabe Katsuya Otori Source Type: research
Emedastine Inhibits Th1 and Th2 Cell Differentiation Mediated by Mast Cells
Biol Pharm Bull. 2024;47(2):527-531. doi: 10.1248/bpb.b23-00765.ABSTRACTWe have previously clarified that emedastine, a second-generation antihistamine drug, inhibits T helper 1(Th1)/Th2 cell differentiation mediated by Langerhans cells (LCs). In addition, although we have recently found that mast cells also function as antigen-presenting cells (APCs) and induce Th1/Th2 cell differentiation, any influence of emedastine on this function remained unclear. Here we investigated the influence of emedastine on Th1/Th2 cell differentiation via mast cells. Mast cells were obtained by long-term culture of murine splenocytes in medi...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Katsuhiko Matsui Akari Kuroki Aya Morishima Source Type: research
The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured Lentinula edodes Mycelia Using Patient Derived Xenograft Model
In this study, we investigated the inhibitory effect of AHCC® on the growth of tumor PDX in Super SCID (severe combined immunodeficiency) mice. Effects of AHCC® and BCG administration on the growth of renal cancer PDX implanted in Super SCID mice were evaluated by PDX growth curve. Tendency for the effects on the growth of renal cancer PDX in Super SCID by administration of AHCC® and BCG before implanting the PDX were demonstrated. The effects of the oral administration of AHCC® on the growth of renal, invasive and non-invasive breast cancer PDX in Super SCID mice were studied. In Super SCID mice transplanted with rena...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Remi Yoshii Shigeki Adachi Haruko Ryo Eiko Hatanaka Koujun Yasuda Momoyo Kaji Kumiko Enomoto Jun Takanari Katsuhide Yoshidome Taisei Nomura Noriyuki Tomiyama Source Type: research
Metformin Attenuates Manganese-Induced Oxidative Stress in N27-A Dopaminergic Neuronal Cells
In this study, we investigated the protective effects of metformin against manganese (Mn)-induced cytotoxicity associated with Parkinson's disease-like symptoms in N27-A dopaminergic (DA) cells. Metformin (0.1-1 mM) suppressed Mn (0.4 mM)-induced cell death in a concentration-dependent manner. Metformin pretreatment effectively suppressed the Mn-mediated increase in the levels of oxidative stress markers, such as reactive oxygen species (ROS) and thiobarbituric acid reactive substances. Moreover, metformin restored the levels of the antioxidants, superoxide dismutase, intracellular glutathione, and glutathione peroxidase, ...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Jae-Sung Kim Jeong-Yeon Seo Kyeong-Rok Kang HyangI Lim Do Kyung Kim Hong Sung Chun Source Type: research
Comparing the Efficacy of Fosnetupitant, an NK < sub > 1 < /sub > Receptor Antagonist in CDDP-Based Regimens, With that of Fosaprepitant and Aprepitant: A Retrospective Observational Study
This study compared the efficacy of fosnetupitant (F-NTP), a neurokinin 1 receptor antagonist, with that of fosaprepitant (F-APR) and aprepitant (APR) in the treatment of patients with cancer at high emetic risk due to chemotherapy. In this retrospective case-control study involving patients receiving cisplatin-containing regimens and neurokinin 1 receptor antagonists, patients were divided into three groups based on prophylactic antiemetic therapy: F-NTP, F-APR, and APR. The CR rate was evaluated for each period up to 168 h and further subdivided into acute (0-24 h), delayed (24-120 h), overall (0-120 h), and beyond-delay...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Hiroshi Inano Yoshihito Morimoto Kanata Kitagawa Akito Shibuya Kozue Nakagomi Tomohiro Ota Yuri Anzo Rika Miyauchi Aiko Shono Kazuhiro Watanabe Katsuya Otori Source Type: research
Emedastine Inhibits Th1 and Th2 Cell Differentiation Mediated by Mast Cells
Biol Pharm Bull. 2024;47(2):527-531. doi: 10.1248/bpb.b23-00765.ABSTRACTWe have previously clarified that emedastine, a second-generation antihistamine drug, inhibits T helper 1(Th1)/Th2 cell differentiation mediated by Langerhans cells (LCs). In addition, although we have recently found that mast cells also function as antigen-presenting cells (APCs) and induce Th1/Th2 cell differentiation, any influence of emedastine on this function remained unclear. Here we investigated the influence of emedastine on Th1/Th2 cell differentiation via mast cells. Mast cells were obtained by long-term culture of murine splenocytes in medi...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Katsuhiko Matsui Akari Kuroki Aya Morishima Source Type: research
The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured Lentinula edodes Mycelia Using Patient Derived Xenograft Model
In this study, we investigated the inhibitory effect of AHCC® on the growth of tumor PDX in Super SCID (severe combined immunodeficiency) mice. Effects of AHCC® and BCG administration on the growth of renal cancer PDX implanted in Super SCID mice were evaluated by PDX growth curve. Tendency for the effects on the growth of renal cancer PDX in Super SCID by administration of AHCC® and BCG before implanting the PDX were demonstrated. The effects of the oral administration of AHCC® on the growth of renal, invasive and non-invasive breast cancer PDX in Super SCID mice were studied. In Super SCID mice transplanted with rena...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Remi Yoshii Shigeki Adachi Haruko Ryo Eiko Hatanaka Koujun Yasuda Momoyo Kaji Kumiko Enomoto Jun Takanari Katsuhide Yoshidome Taisei Nomura Noriyuki Tomiyama Source Type: research
Metformin Attenuates Manganese-Induced Oxidative Stress in N27-A Dopaminergic Neuronal Cells
In this study, we investigated the protective effects of metformin against manganese (Mn)-induced cytotoxicity associated with Parkinson's disease-like symptoms in N27-A dopaminergic (DA) cells. Metformin (0.1-1 mM) suppressed Mn (0.4 mM)-induced cell death in a concentration-dependent manner. Metformin pretreatment effectively suppressed the Mn-mediated increase in the levels of oxidative stress markers, such as reactive oxygen species (ROS) and thiobarbituric acid reactive substances. Moreover, metformin restored the levels of the antioxidants, superoxide dismutase, intracellular glutathione, and glutathione peroxidase, ...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Jae-Sung Kim Jeong-Yeon Seo Kyeong-Rok Kang HyangI Lim Do Kyung Kim Hong Sung Chun Source Type: research
Comparing the Efficacy of Fosnetupitant, an NK < sub > 1 < /sub > Receptor Antagonist in CDDP-Based Regimens, With that of Fosaprepitant and Aprepitant: A Retrospective Observational Study
This study compared the efficacy of fosnetupitant (F-NTP), a neurokinin 1 receptor antagonist, with that of fosaprepitant (F-APR) and aprepitant (APR) in the treatment of patients with cancer at high emetic risk due to chemotherapy. In this retrospective case-control study involving patients receiving cisplatin-containing regimens and neurokinin 1 receptor antagonists, patients were divided into three groups based on prophylactic antiemetic therapy: F-NTP, F-APR, and APR. The CR rate was evaluated for each period up to 168 h and further subdivided into acute (0-24 h), delayed (24-120 h), overall (0-120 h), and beyond-delay...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Hiroshi Inano Yoshihito Morimoto Kanata Kitagawa Akito Shibuya Kozue Nakagomi Tomohiro Ota Yuri Anzo Rika Miyauchi Aiko Shono Kazuhiro Watanabe Katsuya Otori Source Type: research
Emedastine Inhibits Th1 and Th2 Cell Differentiation Mediated by Mast Cells
Biol Pharm Bull. 2024;47(2):527-531. doi: 10.1248/bpb.b23-00765.ABSTRACTWe have previously clarified that emedastine, a second-generation antihistamine drug, inhibits T helper 1(Th1)/Th2 cell differentiation mediated by Langerhans cells (LCs). In addition, although we have recently found that mast cells also function as antigen-presenting cells (APCs) and induce Th1/Th2 cell differentiation, any influence of emedastine on this function remained unclear. Here we investigated the influence of emedastine on Th1/Th2 cell differentiation via mast cells. Mast cells were obtained by long-term culture of murine splenocytes in medi...
Source: Biological and Pharmaceutical Bulletin - February 28, 2024 Category: Drugs & Pharmacology Authors: Katsuhiko Matsui Akari Kuroki Aya Morishima Source Type: research
