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Impact of Polypharmacy and Risk Factors for Exacerbation of Lower Urinary Tract Symptoms in Patients with Urological Conditions: A Retrospective Study in a Japanese Municipal Hospital
In conclusion, this study revealed that "polypharmacy" and "taking multiple anticholinergic medications" were risk factors for LUTS. Particularly, "polypharmacy" is associated with storage symptom exacerbation. Therefore, eliminating "polypharmacy" and "taking multiple anticholinergic medications" is expected to improve LUTS.PMID:38599882 | DOI:10.1248/bpb.b23-00762 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 10, 2024 Category: Drugs & Pharmacology Authors: Shunsuke Yoshizawa Tomoya Tachi Yuta Takahashi Satoshi Aoyama Yoshihiro Noguchi Kazuhide Tanaka Masahiro Yasuda Takashi Mizui Hisao Komeda Tomoaki Yoshimura Hitomi Teramachi Source Type: research

Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells
This study examined the association of GBA L444P mutation with Taiwanese PD in 1016 cases and 539 controls. In addition, the protective effects of C. chinensis rhizome extract and its active constituents (berberine, coptisine, and palmatine) against PD were assayed using GBA reporter cells, LC3 reporter cells, and cells expressing mutated (A53T) α-synuclein. Case-control study revealed that GBA L444P carriers had a 3.93-fold increased risk of PD (95% confidence interval (CI): 1.37-11.24, p = 0.006) compared to normal controls. Both C. chinensis rhizome extract and its constituents exhibited chemical chaperone activity to ...
Source: Biological and Pharmaceutical Bulletin - April 10, 2024 Category: Drugs & Pharmacology Authors: Chih-Hsin Lin Yih-Ru Wu Chih-Ying Chao Kuo-Hsuan Chang Chiung-Mei Chen Wan-Ling Chen Pei-Ning Yang Guey-Jen Lee-Chen Source Type: research

Development of a Remote Health Support Program by Pharmacists and Elucidation of Its Effectiveness: A Randomized Controlled Study
In this study, we developed a remote health support program by pharmacists for community residents and conducted a randomized controlled study on its effectiveness in proper self-medication through pharmacists. People over the age of 20 years who lived in the vicinity of Gifu City, Japan were eligible to participate in this study. Participants were recruited using posters and brochures. This program comprised a lecture, based on the health belief model and behavioral economics, and access to remote health support. The participants were randomly assigned to two groups: the medicine/health class only (control) and the medici...
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Tomoya Tachi Yoshihiro Noguchi Hitomi Teramachi Source Type: research

Pharmacological Investigation of Hypoalbuminemia on the Prolonged and Potentiated Action of Midazolam in Rats
Biol Pharm Bull. 2024;47(4):785-790. doi: 10.1248/bpb.b23-00906.ABSTRACTMidazolam (MDZ) is clinically used for its sedative and anticonvulsant properties. However, its prolonged or potentiated effects are sometimes concerning. The main binding protein of MDZ is albumin, and reduced serum albumin levels could lead to MDZ accumulation, thereby potentiating or prolonging its effects. Previous investigations have not thoroughly examined these phenomena from a behavioral pharmacology standpoint. Consequently, this study aimed to evaluate both the prolonged and potentiated effects of MDZ, as well as the effects of serum albumin ...
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Takaaki Yano Shinichi Watanabe Yukiro Kurokawa Yuya Sakamoto Noriaki Hidaka Mamoru Tanaka Source Type: research

Interactions between Age-Related Type 2 Diabetes and the Small Intestine
Biol Pharm Bull. 2024;47(4):791-795. doi: 10.1248/bpb.b24-00065.ABSTRACTThe number of patients with type 2 diabetes is increasing worldwide. The mechanisms leading to type 2 diabetes and its complications is being researched; however, the pathological mechanisms of diabetes in the small intestine remain unclear. Therefore, we examined these pathological mechanisms in the small intestine using a mouse model of type 2 diabetes (KK-Ay/TaJcl) aged 10 and 50 weeks. The results showed that diabetes worsened with age in the mice with type 2 diabetes. In these mice, advanced glycation end products (AGEs) in the small intestine and...
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Masashi Imai Keiichi Hiramoto Shota Tanaka Kazuya Ooi Source Type: research

Zinc Deficiency Decreases Neurite Extension via CRMP2 Signal Pathway
In conclusion, this study is the first to demonstrate that CRMP signaling is involved in the suppression of neurite outgrowth by low zinc.PMID:38583951 | DOI:10.1248/bpb.b24-00019 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Hisaka Kurita Misa Ueda Miyu Kimura Ayu Okuda Kazuki Ohuchi Isao Hozumi Masatoshi Inden Source Type: research

Probing the Deoxyflavonoid Biosynthesis: Naringenin Chalcone Is a Substrate for the Reductase Synthesizing Isoliquiritigenin
This study is the first to identify a substrate for CHR, reveals that deoxyflavonoid biosynthesis diverges from naringenin chalcone, endorses the term "chalcone reductase," and answers the long-standing questions about doubly-labeled acetic acid uptake pattern in deoxyflavonoid biosynthesis.PMID:38583953 | DOI:10.1248/bpb.b24-00132 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Masaaki Shibuya Source Type: research

Angiotensin II Is Involved in MLKL Activation During the Development of Heart Failure Following Myocardial Infarction in Rats
Biol Pharm Bull. 2024;47(4):809-817. doi: 10.1248/bpb.b23-00741.ABSTRACTSeveral reports assume that myocardial necroptotic cell death is induced during the development of chronic heart failure. Although it is well accepted that angiotensin II induces apoptotic cell death of cardiac myocytes, the involvement of angiotensin II in the induction of myocardial necroptosis during the development of heart failure is still unknown. Therefore, we examined the role of angiotensin II in myocardial necroptosis using rat failing hearts following myocardial infarction and cultured cardiomyocytes. We found that administration of azilsart...
Source: Biological and Pharmaceutical Bulletin - April 7, 2024 Category: Drugs & Pharmacology Authors: Tetsuro Marunouchi Sumika Onda Minami Kurasawa Kouichi Tanonaka Source Type: research