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Combined Experiments with in Vivo Fiber Photometry and Behavior Tests Can Facilitate the Measurement of Neuronal Activity in the Primary Somatosensory Cortex and Hyperalgesia in an Inflammatory Pain Mice Model
In this study, to examine whether the interaction between change of neuronal activity in S1 and hyperalgesia in hind paw before and after causing inflammatory pain was detected from same animal, the combined experiment of in vivo fiber photometry system and von Frey hairs test was applied. This combined experiment detected that amplitude of calcium responses in S1 neurons increased and the mechanical threshold of hind paw decreased from same animals which have an inflammatory pain. Moreover, we found that the values between amplitude of calcium responses and mechanical thresholds were shifted to negative correlation after ...
Source: Biological and Pharmaceutical Bulletin - March 6, 2024 Category: Drugs & Pharmacology Authors: Tatsuya Ishikawa Daisuke Uta Hiroaki Okuda Ilia Potapenko Kiyomi Hori Toshiaki Kume Noriyuki Ozaki Source Type: research

Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2 α Kinases PERK and PKR through PI3K Activation
Biol Pharm Bull. 2024;47(3):600-605. doi: 10.1248/bpb.b23-00739.ABSTRACTTemperature-dependent translational control of the core clock gene Per2 plays an important role in establishing entrainment of the circadian clock to physiological body temperature cycles. Previously, we found an involvement of the phosphatidylinositol 3-kinase (PI3K) in causing Per2 protein expression in response to a warm temperature shift (WTS) within a physiological range (from 35 to 38.5 °C). However, signaling pathway mediating the Per2 protein expression in response to WTS is only sparsely understood. Additional factor(s) other than PI3K remain...
Source: Biological and Pharmaceutical Bulletin - March 6, 2024 Category: Drugs & Pharmacology Authors: Xinyan Shao Takahito Miyake Yuichi Inoue Emi Hasegawa Masao Doi Source Type: research

Potential Therapeutic Strategies and Drugs That Target Vascular Permeability in Severe Infectious Diseases
Biol Pharm Bull. 2024;47(3):549-555. doi: 10.1248/bpb.b24-00028.ABSTRACTSevere infection pathogenicity is induced by processes such as pathogen exposure, immune cell activation, inflammatory cytokine production, and vascular hyperpermeability. Highly effective drugs, such as antipathogenic agents, steroids, and antibodies that suppress cytokine function, have been developed to treat the first three processes. However, these drugs cannot completely suppress severe infectious diseases, such as coronavirus disease 2019 (COVID-19). Therefore, developing novel drugs that inhibit vascular hyperpermeability is crucial. This revie...
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Authors: Yoshiaki Okada Source Type: research

Integrative Research of Neuropharmacology and Informatics Pharmacology for Mental Disorder
Biol Pharm Bull. 2024;47(3):556-561. doi: 10.1248/bpb.b23-00926.ABSTRACTMental illness poses a huge social burden, accounting for approximately 14% of all deaths. Depression, a major component of mental illness, affects approximately 300 million people worldwide, mainly in developed countries, and is not only a major social burden but also a cause of suicide. The social burden of depression is estimated to increase further in developing countries, and overcoming it is a pressing issue for all countries, including Japan. Although clinical evidence has demonstrated the efficacy of serotonergic neurotransmission enhancers in ...
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Authors: Kazuki Nagayasu Source Type: research

Biosynthesis and Degradation of Free D-Amino Acids and Their Physiological Roles in the Periphery and Endocrine Glands
Biol Pharm Bull. 2024;47(3):562-579. doi: 10.1248/bpb.b23-00485.ABSTRACTIt was long believed that D-amino acids were either unnatural isomers or laboratory artifacts, and that the important functions of amino acids were exerted only by L-amino acids. However, recent investigations have revealed a variety of D-amino acids in mammals that play important roles in physiological functions, including free D-serine and D-aspartate that are crucial in the central nervous system. The functions of several D-amino acids in the periphery and endocrine glands are also receiving increasing attention. Here, we present an overview of rece...
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Authors: Masumi Katane Hiroshi Homma Source Type: research

Structural Perspective of NR4A Nuclear Receptor Family and Their Potential Endogenous Ligands
Biol Pharm Bull. 2024;47(3):580-590. doi: 10.1248/bpb.b23-00600.ABSTRACTThere are 48 nuclear receptors in the human genome, and many members of this superfamily have been implicated in human diseases. The NR4A nuclear receptor family consisting of three members, NR4A1, NR4A2, and NR4A3 (formerly annotated as Nur77, Nurr1, and NOR1, respectively), are still orphan receptors but exert pathological effects on immune-related and neurological diseases. We previously reported that prostaglandin A1 (PGA1) and prostaglandin A2 (PGA2) are potent activators of NR4A3, which bind directly to the ligand-binding domain (LBD) of the rece...
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Authors: Ryoichi Hashida Takeshi Kawabata Source Type: research

Errata for Biological and Pharmaceutical Bulletin
Biol Pharm Bull. 2024;47(2):547. doi: 10.1248/bpb.b24-e4702.NO ABSTRACTPMID:38432914 | DOI:10.1248/bpb.b24-e4702 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Source Type: research

Errata for Biological and Pharmaceutical Bulletin
Biol Pharm Bull. 2024;47(2):548. doi: 10.1248/bpb.b24-e4702b.NO ABSTRACTPMID:38432915 | DOI:10.1248/bpb.b24-e4702b (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Source Type: research

Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats
Biol Pharm Bull. 2024 Mar 1. doi: 10.1248/bpb.b23-00872. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) can cause visual impairment and blindness, and the increasing global prevalence of diabetes underscores the need for effective therapies to prevent and treat DR. Therefore, this study aimed to evaluate the protective effect of pemafibrate treatment against DR, using a Spontaneously Diabetic Torii (SDT) fatty rat model of obese type 2 diabetes. SDT fatty rats were fed either a diet supplemented with pemafibrate (0.3 mg/kg/day) for 16 weeks, starting at 8 weeks of age (Pf SDT fatty: study group), or normal chow (S...
Source: Biological and Pharmaceutical Bulletin - March 3, 2024 Category: Drugs & Pharmacology Authors: Yoshiaki Tanaka Rina Takagi Shingen Mitou Machiko Shimmura Tetsuya Hasegawa Jota Amarume Masami Shinohara Yasushi Kageyama Tomohiko Sasase Takeshi Ohta Shin-Ichi Muramatsu Akihiro Kakehashi Toshikatsu Kaburaki Source Type: research