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Clinical Analysis and in Vitro Correlation of BCRP-Mediated Drug-Drug Interaction in the Gastrointestinal Tract
In this study, we performed a ROS uptake study using human colon cancer-derived Caco-2 cells and confirmed that BCRP inhibitors significantly increased the intracellular accumulation of ROS. The correlation between the cell to medium (C/M) ratio of ROS obtained by the in vitro study and the absorption rate constant (ka) ratio obtained by clinical analysis was examined, and a significant positive correlation was observed. Therefore, it is suggested that the in vitro study using Caco-2 cells could be used to quantitatively estimate BCRP-mediated DDI with ROS in the gastrointestinal tract.PMID:38556260 | DOI:10.1248/bpb.b23-0...
Source: Biological and Pharmaceutical Bulletin - March 31, 2024 Category: Drugs & Pharmacology Authors: Liyanage Manosika Buddhini Perera Kenzo Okazaki Yunje Woo Saori Takahashi Xieyi Zhang Kenta Mizoi Toshinari Takahashi Takuo Ogihara Source Type: research

Alteration of Sweet and Bitter Taste Sensitivity with Development of Glucose Intolerance in Non-insulin-Dependent Diabetes Mellitus Model OLETF Rats
Biol Pharm Bull. 2024;47(3):739-749. doi: 10.1248/bpb.b23-00756.ABSTRACTPatients with diabetes exhibit altered taste sensitivity, but its details have not been clarified yet. Here, we examined alteration of sweet taste sensitivity with development of glucose intolerance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats as a model of non-insulin-dependent diabetes mellitus. Compared to the cases of Long Evans Tokushima Otsuka (LETO) rats as a control, glucose tolerance of OLETF rats decreased with aging, resulting in development of diabetes at 36-weeks-old. In brief-access tests with a mixture of sucrose and quinine hydroch...
Source: Biological and Pharmaceutical Bulletin - March 31, 2024 Category: Drugs & Pharmacology Authors: Utano Tanaka Keisuke Mogi Natsumi Fujita Miho Moriwake Katsuya Morito Kentaro Takayama Hirotoshi Morimoto Takeshi Yasukawa Yoshinobu Uozumi Kazuki Nagasawa Source Type: research

Risk Factors of Cetuximab-Induced Hypomagnesemia and the Effect of Magnesium Prophylaxis in Patients with Head and Neck Cancer: A Retrospective Study
In conclusion, a low pre-treatment Mg level was the only risk factor that could be avoided by prophylactic Mg administration. This preventive intervention is recommended for managing cetuximab-induced hypomagnesemia.PMID:38556358 | DOI:10.1248/bpb.b23-00714 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - March 31, 2024 Category: Drugs & Pharmacology Authors: Ryosuke Matsukane Risa Isshiki Kimitaka Suetsugu Haruna Minami Kojiro Hata Mioko Matsuo Nobuaki Egashira Takeshi Hirota Takashi Nakagawa Ichiro Ieiri Source Type: research

Lymphatic Endothelial Cells Produce Chemokines in Response to the Lipid Nanoparticles Used in RNA Vaccines
In this study, SM-102, an ionizable lipid that is used in the approved RNA vaccine for the clinical usage of COVID-19 mRNA vaccine, was used. Immortalized mouse lymphatic endothelial cells (mLECs) or professional antigen presenting cells (APCs) such as RAW 264.7 monocyte/macrophage cells were incubated with LNPs that contained no mRNA. As a result, chemokines involved in the recruitment of monocytes/neutrophils were produced only by the mLECs following the LNP treatment. These findings indicate that LEC appear to serve as the cell that sends out initial signals to response LNPs.PMID:38538323 | DOI:10.1248/bpb.b23-00689 (So...
Source: Biological and Pharmaceutical Bulletin - March 27, 2024 Category: Drugs & Pharmacology Authors: Yi Liu Miho Suzuoki Hiroki Tanaka Yu Sakurai Hiroto Hatakeyama Hidetaka Akita Source Type: research

Changes in Pharmacy Students' Awareness of Hepatitis B Patients through Patient Lectures as Humanity Education: Findings from Questionnaire Surveys of Face-to-Face and Simultaneous Remote Classes
Biol Pharm Bull. 2024;47(3):708-712. doi: 10.1248/bpb.b23-00486.ABSTRACTIn 2020, the coronavirus disease 2019 (COVID-19) pandemic made social distancing compulsory. In patient lectures by hepatitis B patients (Patient Lectures)-a humanity education initiative that had traditionally been delivered face-to-face to assembled students-it was necessary to divide the students into two groups, one that attended the Patient Lectures in person (face-to-face group) and another that assembled in a separate room to view the delivered lecture simultaneously and remotely via a teleconferencing platform (remote group). To investigate pos...
Source: Biological and Pharmaceutical Bulletin - March 27, 2024 Category: Drugs & Pharmacology Authors: Ayano Iwazaki Tomomichi Sone Shuji Okumura Ryota Maki Takeyuki Kohno Source Type: research

Effect of chronic ethanol consumption on exogenous glucose metabolism in rats using [1- 13 C], [2- 13 C], and [3- 13 C]glucose breath tests
Biol Pharm Bull. 2024 Mar 26. doi: 10.1248/bpb.b23-00403. Online ahead of print.ABSTRACTThe C3 carbon of glucose molecules becomes the C1 carbon of pyruvate molecules during glycolysis, and the C1 and C2 carbons of glucose molecules are metabolized in the tricarboxylic acid (TCA) cycle. Utilizing this position-dependent metabolism of C atoms in glucose molecules, [1-13C], [2-13C], and [3-13C] glucose breath tests are used to evaluate glucose metabolism. However, the effects of chronic ethanol consumption remain incompletely understood. Therefore, we evaluated glucose metabolism in ethanol-fed rats using [1-13C], [2-13C], a...
Source: Biological and Pharmaceutical Bulletin - March 27, 2024 Category: Drugs & Pharmacology Authors: Naoyasu Kashima Yosuke Sasaki Naoyuki Kawagoe Tomoyuki Shigeta Fumiya Komatsu Yoshihisa Urita Source Type: research

Effect of Lipid Composition on the Interaction of Liposomes with THP-1-Derived Macrophages
Biol Pharm Bull. 2024;47(3):723-731. doi: 10.1248/bpb.b23-00755.ABSTRACTRecently, liposomal formulations that target macrophages have been used to treat lung diseases. However, the detailed mechanism of the cellular uptake must be elucidated to identify a formulation with excellent cellular uptake efficiency to treat non-tuberculous mycobacterial lung disease. We studied the effect of lipid composition on the cellular uptake of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)/cholesterol (Chol) liposomes with a size of approximately 200 nm into THP-1-derived macrophages. The amount of DPPC/Chol liposomes (80/20 mol%) was...
Source: Biological and Pharmaceutical Bulletin - March 27, 2024 Category: Drugs & Pharmacology Authors: Ryoya Ibuki Takashi Tokui Masaya Kuriyama Kanji Hosoda Hiroshi Tomoda Kumiko Sakai-Kato Source Type: research