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Peritoneal B Cells Play a Role in the Production of Anti-polyethylene Glycol (PEG) IgM against Intravenously Injected siRNA-PEGylated Liposome Complexes
In this study, it is interesting that splenectomy (removal of spleen) did not prevent anti-PEG IgM induction by IV injection of PLpx. This indicates that B cells other than the splenic version are involved in anti-PEG IgM production under these conditions. In vitro and in vivo studies have shown that peritoneal cells also secrete anti-PEG IgM in response to the administration of PLpx. Interleukin-6 (IL-6) is a glycoprotein that is secreted by peritoneal immune cells and has been detected in response to the in vivo administration of PLpx. These observations indicate that IV injection of PLpx stimulates the proliferation/dif...
Source: Biological and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Taro Shimizu Amr S Abu Lila Yuka Kitayama Ryo Abe Haruka Takata Hidenori Ando Yu Ishima Tatsuhiro Ishida Source Type: research

Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner
Biol Pharm Bull. 2024;47(2):478-485. doi: 10.1248/bpb.b23-00898.ABSTRACTThe medial prefrontal cortex (mPFC) is associated with various behavioral controls via diverse projections to cortical and subcortical areas of the brain. Dysfunctions and modulations of this circuitry are related to the pathophysiology of schizophrenia and its pharmacotherapy, respectively. Clozapine is an atypical antipsychotic drug used for treatment-resistant schizophrenia and is known to modulate neuronal activity in the mPFC. However, it remains unclear which prefrontal cortical projections are activated by clozapine among the various projection ...
Source: Biological and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Yumi Hirato Kaoru Seiriki Leo Kojima Shohei Yamada Hiroki Rokujo Tomoya Takemoto Takanobu Nakazawa Atsushi Kasai Hitoshi Hashimoto Source Type: research

Renal Metabolomics Study and Critical Pathway Validation of Shenkang Injection in the Treatment of Chronic Renal Failure
This study was the first to employ metabolomics to elucidate the underlying mechanisms of SKI in chronic renal failure. The results would provide some support for clinical application of traditional Chinese medicines in clinic.PMID:38382928 | DOI:10.1248/bpb.b23-00835 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Lin Zhou Xiaohui Wang Yi Zhang Yan Xie Rui Cui Jinlan Xia Zhi Sun Source Type: research

Immune Checkpoint Inhibitor Is Associated with Improved Survival in Advanced Non-small Cell Lung Cancer Occurring in Patients with Autoimmune Disease
In conclusion, our study showed comparable associations between ICI therapy and reduced mortality in AD and non-AD subgroups of patients with advanced NSCLC. However, therapy strategies tailored to each AD type and thorough discussions regarding the risk-benefit profile are crucial.PMID:38382998 | DOI:10.1248/bpb.b23-00713 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Yasutaka Ihara Kenji Sawa Takumi Imai Yuta Nonomiya Yuki Shimomura Asahi Ishihara Ayumi Shintani Source Type: research

Low Atmospheric Oxygen Attenuates Alpha Oscillations in the Primary Motor Cortex of Awake Rats
Biol Pharm Bull. 2024;47(2):462-468. doi: 10.1248/bpb.b23-00863.ABSTRACTOxygen is pivotal for survival of animals. Their cellular activity and cognitive behavior are impaired when atmospheric oxygen is insufficient, called hypoxia. However, concurrent effects of hypoxia on physiological signals are poorly understood. To address this question, we simultaneously recorded local field potentials in the primary motor cortex, primary somatosensory, and anterior cingulate cortex, electrocardiograms, electroolfactograms, and electromyograms of rats under acute hypoxic conditions (i.e., 5.0% O2). Exposure to acute hypoxia significa...
Source: Biological and Pharmaceutical Bulletin - February 21, 2024 Category: Drugs & Pharmacology Authors: Masashi Kawamura Airi Yoshimoto Yuji Ikegaya Nobuyoshi Matsumoto Source Type: research