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A Multicenter Clinical Evaluation of Data Logging in Cochlear Implant Recipients Using Automated Scene Classification Technologies
In this study, we report data logged for the different scenes and different loudness levels of 1,366 CI patients, as recorded by SCAN. Monitoring device use in cochlear implant recipients of all ages provides important information about the listening conditions encountered in recipients' daily lives that may support counseling and assist in the further management of their device settings. The findings for this large cohort of active CI users confirm differences between age groups concerning device use and exposure to various noise environments, especially between the youngest and oldest age groups, while similar levels of ...
Source: Audiology and Neurotology - December 12, 2017 Category: Audiology Source Type: research

Evidence of Osteoclastic Activity in the Human Temporal Bone
Bone remodeling within the otic capsule has been reported to be inhibited especially at or near the cochlea, except under some pathological conditions such as otosclerosis, Paget's disease, or mastoiditis, when bone remodeling can occur. Microcavitations found in periosteal and endosteal layers of human temporal bone specimens without otosclerosis, Paget's disease, or inflammation as reported in the current study are consistent with osteoclastic bone resorption. Thirty-three temporal bones from 33 patients were prepared for light microscopy and classified into 4 groups: histologically proven dehiscence of the superior semi...
Source: Audiology and Neurotology - December 8, 2017 Category: Audiology Source Type: research

The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis
Conclusions: Neurosarcoidosis is an elusive diagnosis and can cause hearing loss and psychiatric symptoms. Cochlear implantation for patients with severe hearing loss should be considered once the diagnosis is confirmed, as it is possible to achieve a successful level of hearing. Psychiatric symptoms can manifest with the onset of neurosarcoidosis, result from CN deficits, or develop as a side effect from long-term, high-dose corticosteroids, and should be monitored carefully in patients with neurosarcoidosis.Audiol Neurotol 2017;22:205-217 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - November 22, 2017 Category: Audiology Source Type: research

Tinnitus and Hearing Survey: A Polish Study of Validity and Reliability in a Clinical Population
In conclusion, the THS-POL is a valid and reliable screening tool to assist in deciding about the optimal management approach.Audiol Neurotol 2017;22:197-204 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - November 10, 2017 Category: Audiology Source Type: research

Electrophysiological Evidence of the Basilar-Membrane Travelling Wave and Frequency Place Coding of Sound in Cochlear Implant Recipients
Conclusions: Direct evidence for the travelling wave was observed. Electrocochleography from cochlear implant electrodes provides site-specific information on hair cell and neural function of the cochlea with potential diagnostic value.Audiol Neurotol 2017;22:180-189 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - October 30, 2017 Category: Audiology Source Type: research

Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease
Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Subjective symptoms such as dizziness or vertigo and the results of various vestibular examinations including nystagmus testing, caloric testing, and vestibular-evoked myogenic potential (VEMP) testing were in...
Source: Audiology and Neurotology - October 27, 2017 Category: Audiology Source Type: research

Resistance of Gerbil Auditory Function to Reversible Decrease in Cochlear Blood Flow
The objective was to design in gerbils a model of reversible decrease in cochlear blood flow (CBF) and analyze its influence on cochlear function. In Mongolian gerbils injected with ferromagnetic microbeads, a magnet placed near the porus acusticus allowed CBF to be manipulated. The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. In 13 of the 20 successfully injected gerbils, stable CBF reduction was obtained for 11.5 min on average. The CM was affected only when CBF fell to less than 60% of its baseline, yet remained>40% of its initial level in about 2/3 of such cas...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss
Conclusion: Our results support a link between age-related apoptosis in auditory cortex neurons and miR-34a/Bcl-2 signaling, which may serve as a potential mechanism of the expression of AHL in the auditory cortex.Audiol Neurotol 2017;22:96-103 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Perception of Iterated Rippled Noise Periodicity in Cochlear Implant Users
Pitch perception is more challenging for individuals with cochlear implants (CIs) than normal-hearing subjects because the signal processing by CIs is restricted. Processing and perceiving the periodicity of signals may contribute to pitch perception. Whether individuals with CIs can discern pitch within an iterated rippled noise (IRN) signal is still unclear. In a prospective controlled psychoacoustic study with 34 CI users and 15 normal-hearing control subjects, the difference limen between IRN signals with different numbers of iterations was measured. In 7 CI users and 15 normal-hearing control listeners with single-sid...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation
The Cogan syndrome is a rare disorder characterized by nonsyphilitic interstitial keratitis and audiovestibular symptoms. Profound sensorineural hearing loss has been reported in approximately half of the patients with the Cogan syndrome resulting in candidacy for cochlear implantation in some patients. The current study is the first histopathologic report on the temporal bones of a patient with the Cogan syndrome who during life underwent bilateral cochlear implantation. Preoperative MRI revealed tissue with high density in the basal turns of both cochleae and both vestibular systems consistent with fibrous tissue due to ...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Brimonidine Protects Auditory Hair Cells from in vitro-Induced Toxicity of Gentamicin
This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined. Brimonidine had a protective effect on auditory HCs against gentamicin-induced toxicity that was blocked by yohimbine. This suggested that the protective effect of brimonidine on HCs was mediated by the α2-AR. None of the treatments altered α2-AR protein expression levels, and brimonidine d...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Expression Profiling of MicroRNAs in the Inner Ear of Elderly People by Real-Time PCR Quantification
In this study, we obtained 8 human temporal bones from 8 elderly subjects at brain autopsy in order to investigate the expression profile of miRNAs in the inner ear with miRNA arrays. A mean of 478 different miRNAs were expressed in the samples, of which 348 were commonly expressed in all 8 samples. Of these, levels of 16 miRNAs significantly differed between young elderly and old elderly subjects. miRNAs, which play important roles in inner ear development, were detected in all samples, i.e., in both young and old elderly subjects, whether with or without hearing loss. Our results suggest that these miRNAs play important ...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Impact of Lipid-Inflammatory-Oxidative Metabolism on Auditory Skills after Hearing Aid Fitting in the Elderly
This study aimed to assess whether lipid-inflammatory-oxidative metabolism influences auditory processing skills, and whether they function in changing auditory performance after hearing aid fitting in the elderly. Twelve subjects with bilateral hearing loss were submitted to blood tests (to check their lipid-inflammatory-oxidative metabolism) and auditory processing skill tests. After 3 months of using the hearing aids, their auditory skills were re-evaluated and the data were correlated statistically. Oxidative stress levels mainly showed some impact on auditory temporal processing; such a relation and others should best...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

A Subjective Rating Scale for Initial Assessment of Sudden Unilateral Sensorineural Hearing Loss
Objective: To examine the value of a subjective numerical rating scale (NRS) in the initial evaluation of patients suspected of suffering from unilateral sudden sensorineural hearing loss (SSNHL) until a formal audiogram is available.Study Design: Prospective noncontrolled clinical study.Methods: Thirty-one consecutive patients referred to the emergency department due to suspected unilateral SSNHL and with no other aural pathology by history or physical examination were enrolled. Patients were asked to characterize the severity of their hearing loss using an NRS of 1 (normal hearing) to 6 (complete deafness). SSNHL was def...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model
Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When ER stress occurs, the unfolded protein response (UPR) is subsequently activated to restore ER proteostasis. However, severe ER stress leads to apoptosis. Recent studies have suggested that cisplatin cytotoxicity may be related to ER stress. The purpose of this study was to determine whether ER stress participates in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model and to also determine the possible relationship between ER stress and hearing loss. Our results revealed that treatment with ci...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Clinical investigation of the Nucleus Slim Modiolar Electrode
Conclusions: The new Nucleus CI532 cochlear implant with SME achieved the design goal of producing little or no trauma as indicated by consistent scala tympani placement. Surgeons should be carefully trained to use the new deployment method such that tip fold-overs and over insertion may be avoided.Audiol Neurotol 2017;22:169-179 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model
Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When ER stress occurs, the unfolded protein response (UPR) is subsequently activated to restore ER proteostasis. However, severe ER stress leads to apoptosis. Recent studies have suggested that cisplatin cytotoxicity may be related to ER stress. The purpose of this study was to determine whether ER stress participates in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model and to also determine the possible relationship between ER stress and hearing loss. Our results revealed that treatment with ci...
Source: Audiology and Neurotology - October 19, 2017 Category: Audiology Source Type: research

A Subjective Rating Scale for Initial Assessment of Sudden Unilateral Sensorineural Hearing Loss
Objective: To examine the value of a subjective numerical rating scale (NRS) in the initial evaluation of patients suspected of suffering from unilateral sudden sensorineural hearing loss (SSNHL) until a formal audiogram is available.Study Design: Prospective noncontrolled clinical study.Methods: Thirty-one consecutive patients referred to the emergency department due to suspected unilateral SSNHL and with no other aural pathology by history or physical examination were enrolled. Patients were asked to characterize the severity of their hearing loss using an NRS of 1 (normal hearing) to 6 (complete deafness). SSNHL was def...
Source: Audiology and Neurotology - October 10, 2017 Category: Audiology Source Type: research

Impact of Lipid-Inflammatory-Oxidative Metabolism on Auditory Skills after Hearing Aid Fitting in the Elderly
This study aimed to assess whether lipid-inflammatory-oxidative metabolism influences auditory processing skills, and whether they function in changing auditory performance after hearing aid fitting in the elderly. Twelve subjects with bilateral hearing loss were submitted to blood tests (to check their lipid-inflammatory-oxidative metabolism) and auditory processing skill tests. After 3 months of using the hearing aids, their auditory skills were re-evaluated and the data were correlated statistically. Oxidative stress levels mainly showed some impact on auditory temporal processing; such a relation and others should best...
Source: Audiology and Neurotology - October 5, 2017 Category: Audiology Source Type: research

Expression Profiling of MicroRNAs in the Inner Ear of Elderly People by Real-Time PCR Quantification
In this study, we obtained 8 human temporal bones from 8 elderly subjects at brain autopsy in order to investigate the expression profile of miRNAs in the inner ear with miRNA arrays. A mean of 478 different miRNAs were expressed in the samples, of which 348 were commonly expressed in all 8 samples. Of these, levels of 16 miRNAs significantly differed between young elderly and old elderly subjects. miRNAs, which play important roles in inner ear development, were detected in all samples, i.e., in both young and old elderly subjects, whether with or without hearing loss. Our results suggest that these miRNAs play important ...
Source: Audiology and Neurotology - October 2, 2017 Category: Audiology Source Type: research

Brimonidine Protects Auditory Hair Cells from in vitro-Induced Toxicity of Gentamicin
This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined. Brimonidine had a protective effect on auditory HCs against gentamicin-induced toxicity that was blocked by yohimbine. This suggested that the protective effect of brimonidine on HCs was mediated by the α2-AR. None of the treatments altered α2-AR protein expression levels, and brimonidine d...
Source: Audiology and Neurotology - September 8, 2017 Category: Audiology Source Type: research

Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation
The Cogan syndrome is a rare disorder characterized by nonsyphilitic interstitial keratitis and audiovestibular symptoms. Profound sensorineural hearing loss has been reported in approximately half of the patients with the Cogan syndrome resulting in candidacy for cochlear implantation in some patients. The current study is the first histopathologic report on the temporal bones of a patient with the Cogan syndrome who during life underwent bilateral cochlear implantation. Preoperative MRI revealed tissue with high density in the basal turns of both cochleae and both vestibular systems consistent with fibrous tissue due to ...
Source: Audiology and Neurotology - August 23, 2017 Category: Audiology Source Type: research

Perception of Iterated Rippled Noise Periodicity in Cochlear Implant Users
Pitch perception is more challenging for individuals with cochlear implants (CIs) than normal-hearing subjects because the signal processing by CIs is restricted. Processing and perceiving the periodicity of signals may contribute to pitch perception. Whether individuals with CIs can discern pitch within an iterated rippled noise (IRN) signal is still unclear. In a prospective controlled psychoacoustic study with 34 CI users and 15 normal-hearing control subjects, the difference limen between IRN signals with different numbers of iterations was measured. In 7 CI users and 15 normal-hearing control listeners with single-sid...
Source: Audiology and Neurotology - August 18, 2017 Category: Audiology Source Type: research

The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss
Conclusion: Our results support a link between age-related apoptosis in auditory cortex neurons and miR-34a/Bcl-2 signaling, which may serve as a potential mechanism of the expression of AHL in the auditory cortex.Audiol Neurotol 2017;22:96-103 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - August 17, 2017 Category: Audiology Source Type: research

Resistance of Gerbil Auditory Function to Reversible Decrease in Cochlear Blood Flow
The objective was to design in gerbils a model of reversible decrease in cochlear blood flow (CBF) and analyze its influence on cochlear function. In Mongolian gerbils injected with ferromagnetic microbeads, a magnet placed near the porus acusticus allowed CBF to be manipulated. The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. In 13 of the 20 successfully injected gerbils, stable CBF reduction was obtained for 11.5 min on average. The CM was affected only when CBF fell to less than 60% of its baseline, yet remained>40% of its initial level in about 2/3 of such cas...
Source: Audiology and Neurotology - August 9, 2017 Category: Audiology Source Type: research

Unilateral Sensorineural Hearing Loss: Medical Context and Etiology
Conclusion: Long-term hearing follow-up remains useful in USNHL as it can become bilateral. Looking to etiology, MRI should be the gold standard, as CND is frequently observed and screening for CMV infection should be systematic. Genetic etiologies appear to be different compared to bilateral HL. Further genetic research in this domain is needed.Audiol Neurotol 2017;22:83-88 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - July 21, 2017 Category: Audiology Source Type: research

Population-Based Study on the Epidemiology of M énière's Disease
Conclusions: MD is uncommon in primary care in the UK with a preponderance among females.Audiol Neurotol 2017;22:74-82 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - July 19, 2017 Category: Audiology Source Type: research

Patient-Related Benefits for Adults with Cochlear Implantation: A Multicultural Longitudinal Observational Study
Objectives: To assess subjectively perceived, real-world benefits longitudinally for unilateral cochlear implant (CI) recipients in a multinational population treated routinely. To identify possible predictors of self-reported benefits.Design: This was a prospective, multicenter, repeated-measures study. Self-assessment of performance at preimplantation and postimplantation at 1, 2, and 3 years using standardized, validated, local language versions of the Speech, Spatial, and Qualities of Hearing Scale (SSQ), and the Health Utilities Index Mark 3 (HUI3) was performed. Outcomes were analyzed using a longitudinal mixed-effec...
Source: Audiology and Neurotology - July 18, 2017 Category: Audiology Source Type: research

Influence of Sex and Age on Posterior Semicircular Canal Thickness
Conclusions: PSC thickness did not significantly evolve with age in young males ( ≤45 years) but it decreased from age 45 years onwards. On the other hand, PCS thickness increased with age in women until the age of 45 years and it did not significantly change in older females.Audiol Neurotol 2017;22:56-59 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 30, 2017 Category: Audiology Source Type: research

The Crista Fenestra and Its Impact on the Surgical Approach to the Scala Tympani during Cochlear Implantation
Conclusion: The crista fenestra occupies a variable but expressive area within the bony round window niche. Narrower round window niches tended to house smaller crests. The presence of the crista fenestra is an important obstacle to adequate access to the scala tympani. Nevertheless, a high-resolution CT scan provides no additional preoperative information with regard to its presence for the purpose of surgical access to the scala tympani via the round window niche.Audiol Neurotol 2017;22:50-55 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 22, 2017 Category: Audiology Source Type: research

Anatomical Characteristics of Facial Nerve and Cochlea Interaction
Conclusion: Micro-CT with 3D rendering offers new possibilities to study the topographic anatomy of the human temporal bone. The varied shape of the cross-section of the LP could often be explained by an “intruding” cochlea.Audiol Neurotol 2017;22:41-49 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 19, 2017 Category: Audiology Source Type: research

AUNA2: A Novel Type of Non-Syndromic Slowly Progressive Auditory Synaptopathy/Auditory Neuropathy with Autosomal-Dominant Inheritance
Conclusion: We identified a large family with autosomal-dominant AS/AN. By means of linkage analyses, the AUNA1 locus was excluded, and putatively linked regions on chromosomal bands 12q24 and 13q34 were identified as likely carrying the second locus for autosomal-dominant AS/AN (AUNA2). AUNA2 is associated with a slowly progressive postlingual hearing loss without any evidence for additional symptoms in other organ systems.Audiol Neurotol 2017;22:30-40 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 9, 2017 Category: Audiology Source Type: research

Delayed Effect of Active Pressure Treatment on Endolymphatic Hydrops
Objective: To identify eventual correlations between the effect of low-pressure treatment and endolymphatic hydrops in M énière patients.Material and Methods: The study group consisted of subjects affected by definite M énière disease (2015) and a severe degree of disability, who received a ventilation tube with or without a low-pressure treatment before undergoing a surgical procedure (vestibular neurectomy). After the placement of the ventilation tube, the subjects were either left alone with the tube or receiv ed 1 month of self-administered low-pressure therapy with a portable device. In all...
Source: Audiology and Neurotology - May 17, 2017 Category: Audiology Source Type: research

Erratum
Audiol Neurotol 2016;21:406 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - May 2, 2017 Category: Audiology Source Type: research

Contents Vol. 21, 2016
Audiol Neurotol 2016;21:I-VI (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - May 2, 2017 Category: Audiology Source Type: research

In situ Hearing Tests for the Purpose of a Self-Fit Hearing Aid
This study investigated the potential and limitations of a self-fit hearing aid. This can be used in the “developing” world or in countries with large distances between the hearing-impaired subjects and the professional. It contains an on-board tone generator for in situ user-controlled, automated audiometry, and other tests for hearing aid fitting. Twenty subjects with mild hearing losses were inv olved. In situ audiometry showed a test-retest reliability (SD (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - April 21, 2017 Category: Audiology Source Type: research

Hyperbaric Oxygen Therapy as Adjuvant Treatment for Idiopathic Sudden Sensorineural Hearing Loss after Failure of Systemic Steroids
We evaluated the outcomes of and prognostic factors for idiopathic sudden sensorineural hearing loss (ISSNHL) treated with adjuvant hyperbaric oxygen therapy (HBOT). A retrospective review of clinical data was performed for 167 patients with ISSNHL who failed to respond to systemic steroids and were treated by adjuvant HBOT at Shizuoka Saiseikai General Hospital. We analysed the clinical outcomes, the averaged 5-frequency hearing level after systemic steroids, patient age, the interval between post-steroids and pre-HBOT, vertigo as a complication, the presence of diabetes mellitus, smoking history, and hypertension. Overal...
Source: Audiology and Neurotology - April 19, 2017 Category: Audiology Source Type: research

Self-Administered Tinnitus Pitch Matching versus a Conventional Audiometric Procedure
Objective: Obtaining an accurate tinnitus pitch match is an initial and critical requirement for tinnitus evaluation and treatment, particularly for applying tailor-made notched music training. We investigated whether computer-based self-administered tinnitus pitch matching (CSTPM) is comparable with a conventional audiometric procedure (CAP).Methods: In total, 82 patients (mean age 45.52 years; 42 females) with tonal tinnitus participated. The CAP was performed by the same audiologist using a 2-alternative forced choice method with a frequency range of 0.25-16 kHz. In the CSTPM, the subjects used personal computer softwar...
Source: Audiology and Neurotology - April 19, 2017 Category: Audiology Source Type: research

Simultaneous versus Sequential Intratympanic Steroid Treatment for Severe-to-Profound Sudden Sensorineural Hearing Loss
Conclusions: Simultaneous oral/intratympanic steroid treatment yielded a recovery similar to that produced by sequential treatment. Because the addition of intratympanic steroids can be decided upon based on the improvement after an oral steroid, the sequential regimen can be recommended to avoid unnecessary intratympanic injections.Audiol Neurotol 2016;21:399-405 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - April 11, 2017 Category: Audiology Source Type: research

Towards a Unified Testing Framework for Single-Sided Deafness Studies: A Consensus Paper
Conclusion: A protocol for the assessment of treatment options and outcomes in recipients with SSD and AHL is presented. The proposed set of minimum outcome measures aims at harmonizing assessment methods across centers and thus at generating a growing body of high-level evidence for those treatment options.Audiol Neurotol 2016;21:391-398 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - March 20, 2017 Category: Audiology Source Type: research

Assessment and Outcome in Non-Traditional Cochlear Implant Candidates
The objectives of this study were to assess: (i) patient expectations met as a measure of outcome in early-deafened, late-implanted (non-traditional) cochlear implant recipients and (ii) pre-implantation predictive factors for postoperative speech perception. The notes of 13 recipients were retrospectively reviewed. The mean age at onset of profound deafness was 1.5 years (range 0-6). The mean age at implantation was 37 years (range 22-51 years). Patient expectations were assessed pre-operatively and 1 year after implantation. They were met or exceeded in 129/140 (92%) domains overall. A higher Speech Intelligibility Ratin...
Source: Audiology and Neurotology - February 21, 2017 Category: Audiology Source Type: research

Somatosensory Tinnitus: Correlation between Cranio-Cervico-Mandibular Disorder History and Somatic Modulation
In this study, we included 310 tinnitus patients with normal hearing, no psychiatric comorbidities, and a positive history of TMJ and/or NECK dysfunction and/or a positive modulation of tinnitus to evaluate the characteristics of somatic modulation, investigate the relationship between positive history and positive modulation, and identify factors most strongly associated with somatic modulation. Tinnitus modulation was present in 79.67% of the patients. We found a significant association within the same subjects between a positive history and a positive tinnitus modulation for the same region, mainly for TMJ in unilateral...
Source: Audiology and Neurotology - January 18, 2017 Category: Audiology Source Type: research

Enhanced Auditory Sensitivity to Body Vibrations in Superior Canal Dehiscence Syndrome
A key feature of superior canal dehiscence (SCD) syndrome is supranormal hearing of body sounds. The aim of the present study was to quantify this phenomenon and to ascertain whether auditory sensitivity to body vibrations can distinguish SCD patients. Hearing thresholds in response to vibration at the vertex, at the spinous process of the 7th cervical vertebra, and at the medial malleolus were tested in 10 SCD patients and 10 controls. Both patients and controls had insert earphones in both ears. The insert in the test ear was blocked while masking was presented to the other ear. Vibration in the frequency range of 125-1,...
Source: Audiology and Neurotology - January 12, 2017 Category: Audiology Source Type: research

Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion
Conclusion: MEE is highly correlated with hearing loss in mice undergoing RW surgery. Otoscopy is an important adjunct to consider after ear surgery in mice, as MEE may contribute to postsurgical hearing loss.Audiol Neurotol 2016;21:356-364 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - January 9, 2017 Category: Audiology Source Type: research

Comparison of Alternative Coupling Methods of the Vibrant Soundbridge Floating Mass Transducer
The active middle ear implant Vibrant Soundbridge © provides a variety of coupling modalities of the floating mass transducer (FMT) to various structures of the ossicular chain and the round window. A retrospective analysis was performed on 125 subjects (n = 137 ears) (1) to compare the efficacy of the different FMT coupling modalities with increasing degree of hearing loss, (2) to compare the performance in speech outcome and the effective gain between the coupling types, and (3) to evaluate the risk of additional hearing loss of each coupling procedure. The patients were grouped according to their type of FMT coupli...
Source: Audiology and Neurotology - January 9, 2017 Category: Audiology Source Type: research

A Retrospective Multicentre Cohort Review of Patient Characteristics and Surgical Aspects versus the Long-Term Outcomes for Recipients of a Fully Implantable Active Middle Ear Implant
Objective: To summarise treatment outcomes compared to surgical and patient variables for a multicentre recipient cohort using a fully implantable active middle ear implant for hearing impairment. To describe the authors' preferred surgical technique to determine microphone placement.Study Design: Multicentre retrospective, observational survey.Setting: Five tertiary referral centres.Patients: Carina recipients (66 ears, 62 subjects) using the current Cochlear ® Carina® System or the legacy device, the Otologics® Fully Implantable Middle Ear, with a T2 transducer.Methods: Patient file review and routine clinica...
Source: Audiology and Neurotology - January 4, 2017 Category: Audiology Source Type: research

Differential Expression of Bcl-2 in the Cochlea and Auditory Cortex of a Mouse Model of Age-Related Hearing Loss
Bcl-2, the first gene shown to be involved in apoptosis, is a potent regulator of cell survival and known to have protective effects against a variety of age-related diseases. However, the possible relationship between hearing and Bcl-2 expression in the cochlea or auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss, is still unknown. Using RT-PCR, immunohistochemistry, and Western blot analysis, our results show that Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the...
Source: Audiology and Neurotology - December 7, 2016 Category: Audiology Source Type: research

Comparison of the HiFocus Mid-Scala and HiFocus 1J Electrode Array: Angular Insertion Depths and Speech Perception Outcomes
In this study we prospectively examined the angular insertion depth achieved and speech perception outcomes resulting from the HiFocus MS electrode array for 6 months after implantation, and retrospectively compared these with the HiFocus 1J lateral wall electrode array. The mean angular insertion depth within the MS population (n = 96) was found at 470 °. This was 50° shallower but more consistent than the 1J electrode array (n = 110). Audiological evaluation within a subgroup, including only postlingual, unilaterally implanted, adult cochlear implant recipients who were matched on preoperative speech perception s...
Source: Audiology and Neurotology - November 21, 2016 Category: Audiology Source Type: research

Consequences of Stimulus Type on Higher-Order Processing in Single-Sided Deaf Cochlear Implant Users
Single-sided deaf subjects with a cochlear implant (CI) provide the unique opportunity to compare central auditory processing of the electrical input (CI ear) and the acoustic input (normal-hearing, NH, ear) within the same individual. In these individuals, sensory processing differs between their two ears, while cognitive abilities are the same irrespectively of the sensory input. To better understand perceptual-cognitive factors modulating speech intelligibility with a CI, this electroencephalography study examined the central-auditory processing of words, the cognitive abilities, and the speech intelligibility in 10 pos...
Source: Audiology and Neurotology - November 18, 2016 Category: Audiology Source Type: research