Evaluation of Sustained-Release Steroid Hydrogels in a Guinea Pig Model for Noise-Induced Hearing Loss
The otoprotective effects of thermoreversible poloxamer 407 hydrogels containing dexamethasone or triamcinolone acetonide were evaluated in an animal model of noise-induced hearing loss. Seven days after noise exposure, hearing threshold shifts at 16 kHz were significantly reduced in the 6% dexamethasone group (p #x3c; 0.05). Even though no significant differences in hair cell counts were found, histological analysis revealed a significantly higher spiral ganglion cell density in the first turn of the cochlea in this group (p #x3c; 0.05). No otoprotective effects were observed after the application of the triamcinolone ace...
Source: Audiology and Neurotology - August 9, 2018 Category: Audiology Source Type: research

Cochlear Function in Adults with Epilepsy and Treated with Carbamazepine
Conclusions: Long-term CBZ treatment may result in cochlear dysfunction and auditory deficits.Audiol Neurotol 2018;23:63 –72 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - July 26, 2018 Category: Audiology Source Type: research

Contents Vol. 22, 2017
Audiol Neurotol 2017;22:I –VI (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - July 19, 2018 Category: Audiology Source Type: research

Trough-Shaped Audiograms Are Common in Patients with Acoustic Neuroma and Sudden Sensorineural Hearing Loss
This study suggests that a trough audiogram is a significant finding in patients with sudden-onset sensorineural hearing loss and indicates the presence of acoustic neuroma.Audiol Neurotol 2018;23:58 –62 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - July 18, 2018 Category: Audiology Source Type: research

Late Cochlear Implantation in Early-Deafened Adults: A Detailed Analysis of Auditory and Self-Perceived Benefits
Conclusions: Outcome measurement in this population should be adjusted to the patients ’ individual performance level and include self-perceived benefit. There is still a need for more knowledge regarding predictors of CI outcomes in this group, but the current study suggests the importance of the preoperative performance of the ear to be implanted.Audiol Neurotol 2017;22:364 –376 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 28, 2018 Category: Audiology Source Type: research

The Effect of Binaural Beamforming Technology on Speech Intelligibility in Bimodal Cochlear Implant Recipients
The objective of this study was to investigate the effect of a binaural beamformer for bimodal cochlear implant (CI) users. This prospective study measured speech reception thresholds (SRT) in noise in a repeated-measures design that varied in listening modality for static and dynamic listening conditions. A significant improvement in SRT of 4.7 dB was found with the binaural beamformer switched on in the bimodal static listening condition. No significant improvement was found in the dynamic listening condition. We conclude that there is a clear additional advantage of the binaural beamformer in bimodal CI users for predic...
Source: Audiology and Neurotology - June 22, 2018 Category: Audiology Source Type: research

Cochlear Nerve Aplasia with Detectable Olivocochlear Efferent Function: A Distinct Presentation of Auditory Neuropathy Spectrum Disorder
Conclusions: Children with unilateral ANSD can have normal efferent cochlear nerve function despite MRI evidence of ipsilateral CNA. The importance of these findings for newborn hearing screening and cochlear implantation is discussed.Audiol Neurotol 2018;23:39 –47 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 22, 2018 Category: Audiology Source Type: research

Abnormal Cochleovestibular Anatomy and Hearing Outcomes: Pediatric Patients with a Questionable Cochleovestibular Nerve Status May Benefit from Cochlear Implantation and/or Hearing Aids
Conclusions: Current imaging cannot accurately characterize the functional status of the CVN or predict an assistive device benefit. Children who would have otherwise been denied a CI exhibited auditory responses after implantation. A CI should be considered in children with abnormal CVN. Furthermore, imaging acquisition protocols need standardization for clear temporal bone imaging.Audiol Neurotol 2018;23:48 –57 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 22, 2018 Category: Audiology Source Type: research

One-Year Results for Patients with Unilateral Hearing Loss and Accompanying Severe Tinnitus and Hyperacusis Treated with a Cochlear Implant
Conclusion: A CI should be considered as a treatment option in patients with UHL and a concomitant severe tinnitus handicap. However, appropriate counselling of candidates on the anticipated risks, benefits, and limitations that are inherent to cochlear implantation is imperative.Audiol Neurotol 2018;23:8 –19 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 21, 2018 Category: Audiology Source Type: research

Methionine Sulfoxide Reductase A Knockout Mice Show Progressive Hearing Loss and Sensitivity to Acoustic Trauma
Methionine sulfoxide reductases (MsrA andMsrB) protect the biological activity of proteins from oxidative modifications to methionine residues and are important for protecting against the pathological effects of neurodegenerative diseases. In the current study, we characterized the auditory phenotype of theMsrA knockout mouse. YoungMsrA knockout mice showed small high-frequency threshold elevations for auditory brainstem response and distortion product otoacoustic emission compared to those of wild-type mice, which progressively worsened in olderMsrA knockout mice.MsrA knockout mice showed an increased sensitivity to noise...
Source: Audiology and Neurotology - June 21, 2018 Category: Audiology Source Type: research

Effect of Antioxidant Vitamins as Adjuvant Therapy for Sudden Sensorineural Hearing Loss: Systematic Review Study
Conclusions and Relevance: The success of the treatment is increased in patients who received antioxidant vitamins in combination with conventional therapy.Audiol Neurotol 2018;23:1-7 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - June 21, 2018 Category: Audiology Source Type: research

Predicting Sequential Cochlear Implantation Performance: A Systematic Review
This systematic review of the literature reveals which pre ­operative factors affect sequential cochlear implantation outcomes in adults. The findings can help health care prof­essionals provide evidence-based advice on the expected benefits from a second cochlear implant (CI). We searched PubMed, EMBASE, and the Cochrane database from November 1977 to Au gust 26, 2017, using the terms “sequential cochlear implantation”; the most frequently cited predictors for unilateral cochlear implantation performance and other potential predictors for sequential implantation outcome; and “speech perception,&r...
Source: Audiology and Neurotology - May 2, 2018 Category: Audiology Source Type: research

Long-Term Hearing Outcomes following Stapedotomy in Patients with Otosclerosis and Preoperative Small Air-Bone Gap
Conclusions: Even though long-term hearing levels will evolve similarly in patients with ≤20 and #x3e; 20 dB preoperative ABGs, the lack of clinical improvement found in the small ABG group is not in favor of an early surgery.Audiol Neurotol 2017;22:350 –355 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - April 26, 2018 Category: Audiology Source Type: research

Long-Term Effects of Middle Ear Tendon Resection on Middle Ear Myoclonic Tinnitus, Hearing, and Hyperacusis
Conclusions: METR seems to be an effective and safe treatment option for intractable MEMT, considering its high control rate of tinnitus and no long-term harmful effects on hearing and hyperacusis.Audiol Neurotol 2017;22:343 –349 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - April 12, 2018 Category: Audiology Source Type: research

Localization and Spatial Discrimination in Children and Adolescents with Moderate Sensorineural Hearing Loss Tested without Their Hearing Aids
The present study investigated two measures of spatial acoustic perception in children and adolescents with sensorineural hearing loss (SNHL) tested without their hearing aids and compared it to age-matched controls. Auditory localization was quantified by means of a sound source identification task and auditory spatial discrimination acuity by measuring minimum audible angles (MAA). Both low- and high-frequency noise bursts were employed in the tests to separately address spatial auditory processing based on interaural time and intensity differences. In SNHL children, localization (hit accuracy) was significantly reduced ...
Source: Audiology and Neurotology - March 1, 2018 Category: Audiology Source Type: research

Hearing Preservation with the Slim Modiolar Electrode Nucleus CI532 ® Cochlear Implant: A Preliminary Experience
As the indications for cochlear implant have expanded to include younger patients and individuals with greater degrees of residual hearing, increasing emphasis has been placed on atraumatic surgery and the preservation of the cochlear structure. Here, a descriptive prospective randomized study was performed. It was shown that residual hearing preservation is possible 12 months postoperatively with an atraumatic perimodiolar flexible electrode array CI532 ® (Cochlear Ltd, Sydney, Australia). Residual hearing preservation, considered as #x3c; 15 dB, was obtained in 70% of the cases. Better clinical outcomes and performan...
Source: Audiology and Neurotology - February 27, 2018 Category: Audiology Source Type: research

A Trend in Sudden Sensorineural Hearing Loss: Data from a Population-Based Study
In conclusion, this large-scale study indicates that unilateral SSNHL has a higher incidence among the elderly, women, and in autumn (i.e., along with colder w eather).Audiol Neurotol 2017;22:311 –316 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - February 20, 2018 Category: Audiology Source Type: research

Resveratrol Promotes Recovery of Hearing following Intense Noise Exposure by Enhancing Cochlear SIRT1 Activity
The sirtuin SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase known to have protective effects against a wide range of neurological disorders. In the present study, we discovered that C57BL/6 mice fed a long-term diet supplemented with high-dose resveratrol exhibited increased cochlear SIRT1 activity and presented a better recovery of hearing and less loss of hair cells after intense noise exposure compared with those fed a standard chew. Moreover, resveratrol attenuated cochlear SIRT1 decrease and reduced oxidative stress in the cochlea after noise exposure. These results su...
Source: Audiology and Neurotology - January 25, 2018 Category: Audiology Source Type: research

Role of the Frontal Sinus in Mediating Ocular Vestibular-Evoked Myogenic Potentials by Bone Vibration Stimuli Applied to the Forehead
In conclusion, the height of the frontal sinus plays a role in mediating the elicitation of oVEMPs. The oVEMPs could be easily elicited by the first-order bone vibration (Fpz/Fz tapping) coupled with the second-order r esonance effect (with a high extent of the frontal sinus). Thus, initial tapping at the Fpz site is suggested. If it fails, try the Fz site for screening the oVEMPs.Audiol Neurotol 2017;22:272-281 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - January 17, 2018 Category: Audiology Source Type: research

The Role of Preoperative Steroids for Hearing Preservation Cochlear Implantation: Results of a Randomized Controlled Trial
Objectives: To determine whether preoperative steroids can improve hearing outcomes in cochlear implantation (CI).Methods: This is a randomized controlled trial involving 30 postlingual deaf CI patients. Subjects had preoperative thresholds of better than or equal to 80 dB at 125 and 250 Hz, and better than or equal to 90 dB at 500 and 1,000 Hz. The subjects were randomized to a control group, an oral steroid group (receiving 1 mg/kg/day of prednisolone for 6 days prior to surgery), or a transtympanic steroid group (receiving a single dose of 0.5 mL of 10 mg/mL dexamethasone at 24 h prior to surgery).Results: The subjects ...
Source: Audiology and Neurotology - January 12, 2018 Category: Audiology Source Type: research

Toward Optimizing Vestibular Evoked Myogenic Potentials: Normalization Reduces the Need for Strong Neck Muscle Contraction
Conclusion: Muscle contraction amplitude strongly affects VEMPpp amplitude, but contractions 45-300 μV r.m.s. produce stable VEMPn and VEMPid values. Clinically, there may be no need for subjects to exert high contraction effort. This is especially beneficial in patients for whom maintaining high SCM contraction amplitudes is challenging.Audiol Neurotol 2017;22:282-291 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - January 11, 2018 Category: Audiology Source Type: research

Effect of Cochlear Implantation on Quality of Life in Adults with Unilateral Hearing Loss
Conclusions: Cochlear implantation in cases of substantial UHL may offer significant improvements in quality of life. Quality of life measures revealed a reduction in perceived tinnitus severity and subjective improvements in speech perception in noise, spatial hearing, and listening effort. While self-report of difficulties were lower for the UHL cohort than the conventional CI and EAS cohorts, subjects in all 3 groups reported an improvement in quality of life with CI use.Audiol Neurotol 2017;22:259-271 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - January 3, 2018 Category: Audiology Source Type: research

Quality of Life and Cost-Effectiveness of Cochlear Implants: A Narrative Review
Conclusions: Considerable work has been done on the QoL attainment and health economic implications of CI. Unilateral CI across all age groups leads to reported sustained benefits in the recipients' overall and disease-specific QoL. With increased cost associated with bilateral CI, further study is needed to characterize its costs and benefits with respect to the recipients' health, well-being, and contributions to society.Audiol Neurotol 2017;22:236-258 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - December 20, 2017 Category: Audiology Source Type: research

A Multicenter Clinical Evaluation of Data Logging in Cochlear Implant Recipients Using Automated Scene Classification Technologies
In this study, we report data logged for the different scenes and different loudness levels of 1,366 CI patients, as recorded by SCAN. Monitoring device use in cochlear implant recipients of all ages provides important information about the listening conditions encountered in recipients' daily lives that may support counseling and assist in the further management of their device settings. The findings for this large cohort of active CI users confirm differences between age groups concerning device use and exposure to various noise environments, especially between the youngest and oldest age groups, while similar levels of ...
Source: Audiology and Neurotology - December 12, 2017 Category: Audiology Source Type: research

Evidence of Osteoclastic Activity in the Human Temporal Bone
Bone remodeling within the otic capsule has been reported to be inhibited especially at or near the cochlea, except under some pathological conditions such as otosclerosis, Paget's disease, or mastoiditis, when bone remodeling can occur. Microcavitations found in periosteal and endosteal layers of human temporal bone specimens without otosclerosis, Paget's disease, or inflammation as reported in the current study are consistent with osteoclastic bone resorption. Thirty-three temporal bones from 33 patients were prepared for light microscopy and classified into 4 groups: histologically proven dehiscence of the superior semi...
Source: Audiology and Neurotology - December 8, 2017 Category: Audiology Source Type: research

The Protean Neuropsychiatric and Vestibuloauditory Manifestations of Neurosarcoidosis
Conclusions: Neurosarcoidosis is an elusive diagnosis and can cause hearing loss and psychiatric symptoms. Cochlear implantation for patients with severe hearing loss should be considered once the diagnosis is confirmed, as it is possible to achieve a successful level of hearing. Psychiatric symptoms can manifest with the onset of neurosarcoidosis, result from CN deficits, or develop as a side effect from long-term, high-dose corticosteroids, and should be monitored carefully in patients with neurosarcoidosis.Audiol Neurotol 2017;22:205-217 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - November 22, 2017 Category: Audiology Source Type: research

Tinnitus and Hearing Survey: A Polish Study of Validity and Reliability in a Clinical Population
In conclusion, the THS-POL is a valid and reliable screening tool to assist in deciding about the optimal management approach.Audiol Neurotol 2017;22:197-204 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - November 10, 2017 Category: Audiology Source Type: research

Electrophysiological Evidence of the Basilar-Membrane Travelling Wave and Frequency Place Coding of Sound in Cochlear Implant Recipients
Conclusions: Direct evidence for the travelling wave was observed. Electrocochleography from cochlear implant electrodes provides site-specific information on hair cell and neural function of the cochlea with potential diagnostic value.Audiol Neurotol 2017;22:180-189 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - October 30, 2017 Category: Audiology Source Type: research

Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease
Vogt-Koyanagi-Harada (VKH) disease is an idiopathic, multisystem autoimmune disorder characterized by bilateral, diffuse granulomatous uveitis associated with neurological, audiovestibular, and dermatological manifestations. The purpose of this study is to investigate vestibular functions in patients with VKH disease. A total of 43 patients with VKH disease in Hokkaido University Hospital were enrolled in this study. Subjective symptoms such as dizziness or vertigo and the results of various vestibular examinations including nystagmus testing, caloric testing, and vestibular-evoked myogenic potential (VEMP) testing were in...
Source: Audiology and Neurotology - October 27, 2017 Category: Audiology Source Type: research

Resistance of Gerbil Auditory Function to Reversible Decrease in Cochlear Blood Flow
The objective was to design in gerbils a model of reversible decrease in cochlear blood flow (CBF) and analyze its influence on cochlear function. In Mongolian gerbils injected with ferromagnetic microbeads, a magnet placed near the porus acusticus allowed CBF to be manipulated. The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. In 13 of the 20 successfully injected gerbils, stable CBF reduction was obtained for 11.5 min on average. The CM was affected only when CBF fell to less than 60% of its baseline, yet remained>40% of its initial level in about 2/3 of such cas...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss
Conclusion: Our results support a link between age-related apoptosis in auditory cortex neurons and miR-34a/Bcl-2 signaling, which may serve as a potential mechanism of the expression of AHL in the auditory cortex.Audiol Neurotol 2017;22:96-103 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Perception of Iterated Rippled Noise Periodicity in Cochlear Implant Users
Pitch perception is more challenging for individuals with cochlear implants (CIs) than normal-hearing subjects because the signal processing by CIs is restricted. Processing and perceiving the periodicity of signals may contribute to pitch perception. Whether individuals with CIs can discern pitch within an iterated rippled noise (IRN) signal is still unclear. In a prospective controlled psychoacoustic study with 34 CI users and 15 normal-hearing control subjects, the difference limen between IRN signals with different numbers of iterations was measured. In 7 CI users and 15 normal-hearing control listeners with single-sid...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation
The Cogan syndrome is a rare disorder characterized by nonsyphilitic interstitial keratitis and audiovestibular symptoms. Profound sensorineural hearing loss has been reported in approximately half of the patients with the Cogan syndrome resulting in candidacy for cochlear implantation in some patients. The current study is the first histopathologic report on the temporal bones of a patient with the Cogan syndrome who during life underwent bilateral cochlear implantation. Preoperative MRI revealed tissue with high density in the basal turns of both cochleae and both vestibular systems consistent with fibrous tissue due to ...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Brimonidine Protects Auditory Hair Cells from in vitro-Induced Toxicity of Gentamicin
This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined. Brimonidine had a protective effect on auditory HCs against gentamicin-induced toxicity that was blocked by yohimbine. This suggested that the protective effect of brimonidine on HCs was mediated by the α2-AR. None of the treatments altered α2-AR protein expression levels, and brimonidine d...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Expression Profiling of MicroRNAs in the Inner Ear of Elderly People by Real-Time PCR Quantification
In this study, we obtained 8 human temporal bones from 8 elderly subjects at brain autopsy in order to investigate the expression profile of miRNAs in the inner ear with miRNA arrays. A mean of 478 different miRNAs were expressed in the samples, of which 348 were commonly expressed in all 8 samples. Of these, levels of 16 miRNAs significantly differed between young elderly and old elderly subjects. miRNAs, which play important roles in inner ear development, were detected in all samples, i.e., in both young and old elderly subjects, whether with or without hearing loss. Our results suggest that these miRNAs play important ...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Impact of Lipid-Inflammatory-Oxidative Metabolism on Auditory Skills after Hearing Aid Fitting in the Elderly
This study aimed to assess whether lipid-inflammatory-oxidative metabolism influences auditory processing skills, and whether they function in changing auditory performance after hearing aid fitting in the elderly. Twelve subjects with bilateral hearing loss were submitted to blood tests (to check their lipid-inflammatory-oxidative metabolism) and auditory processing skill tests. After 3 months of using the hearing aids, their auditory skills were re-evaluated and the data were correlated statistically. Oxidative stress levels mainly showed some impact on auditory temporal processing; such a relation and others should best...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

A Subjective Rating Scale for Initial Assessment of Sudden Unilateral Sensorineural Hearing Loss
Objective: To examine the value of a subjective numerical rating scale (NRS) in the initial evaluation of patients suspected of suffering from unilateral sudden sensorineural hearing loss (SSNHL) until a formal audiogram is available.Study Design: Prospective noncontrolled clinical study.Methods: Thirty-one consecutive patients referred to the emergency department due to suspected unilateral SSNHL and with no other aural pathology by history or physical examination were enrolled. Patients were asked to characterize the severity of their hearing loss using an NRS of 1 (normal hearing) to 6 (complete deafness). SSNHL was def...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model
Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When ER stress occurs, the unfolded protein response (UPR) is subsequently activated to restore ER proteostasis. However, severe ER stress leads to apoptosis. Recent studies have suggested that cisplatin cytotoxicity may be related to ER stress. The purpose of this study was to determine whether ER stress participates in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model and to also determine the possible relationship between ER stress and hearing loss. Our results revealed that treatment with ci...
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Clinical investigation of the Nucleus Slim Modiolar Electrode
Conclusions: The new Nucleus CI532 cochlear implant with SME achieved the design goal of producing little or no trauma as indicated by consistent scala tympani placement. Surgeons should be carefully trained to use the new deployment method such that tip fold-overs and over insertion may be avoided.Audiol Neurotol 2017;22:169-179 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - October 25, 2017 Category: Audiology Source Type: research

Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model
Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When ER stress occurs, the unfolded protein response (UPR) is subsequently activated to restore ER proteostasis. However, severe ER stress leads to apoptosis. Recent studies have suggested that cisplatin cytotoxicity may be related to ER stress. The purpose of this study was to determine whether ER stress participates in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model and to also determine the possible relationship between ER stress and hearing loss. Our results revealed that treatment with ci...
Source: Audiology and Neurotology - October 19, 2017 Category: Audiology Source Type: research

A Subjective Rating Scale for Initial Assessment of Sudden Unilateral Sensorineural Hearing Loss
Objective: To examine the value of a subjective numerical rating scale (NRS) in the initial evaluation of patients suspected of suffering from unilateral sudden sensorineural hearing loss (SSNHL) until a formal audiogram is available.Study Design: Prospective noncontrolled clinical study.Methods: Thirty-one consecutive patients referred to the emergency department due to suspected unilateral SSNHL and with no other aural pathology by history or physical examination were enrolled. Patients were asked to characterize the severity of their hearing loss using an NRS of 1 (normal hearing) to 6 (complete deafness). SSNHL was def...
Source: Audiology and Neurotology - October 10, 2017 Category: Audiology Source Type: research

Impact of Lipid-Inflammatory-Oxidative Metabolism on Auditory Skills after Hearing Aid Fitting in the Elderly
This study aimed to assess whether lipid-inflammatory-oxidative metabolism influences auditory processing skills, and whether they function in changing auditory performance after hearing aid fitting in the elderly. Twelve subjects with bilateral hearing loss were submitted to blood tests (to check their lipid-inflammatory-oxidative metabolism) and auditory processing skill tests. After 3 months of using the hearing aids, their auditory skills were re-evaluated and the data were correlated statistically. Oxidative stress levels mainly showed some impact on auditory temporal processing; such a relation and others should best...
Source: Audiology and Neurotology - October 5, 2017 Category: Audiology Source Type: research

Expression Profiling of MicroRNAs in the Inner Ear of Elderly People by Real-Time PCR Quantification
In this study, we obtained 8 human temporal bones from 8 elderly subjects at brain autopsy in order to investigate the expression profile of miRNAs in the inner ear with miRNA arrays. A mean of 478 different miRNAs were expressed in the samples, of which 348 were commonly expressed in all 8 samples. Of these, levels of 16 miRNAs significantly differed between young elderly and old elderly subjects. miRNAs, which play important roles in inner ear development, were detected in all samples, i.e., in both young and old elderly subjects, whether with or without hearing loss. Our results suggest that these miRNAs play important ...
Source: Audiology and Neurotology - October 2, 2017 Category: Audiology Source Type: research

Brimonidine Protects Auditory Hair Cells from in vitro-Induced Toxicity of Gentamicin
This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined. Brimonidine had a protective effect on auditory HCs against gentamicin-induced toxicity that was blocked by yohimbine. This suggested that the protective effect of brimonidine on HCs was mediated by the α2-AR. None of the treatments altered α2-AR protein expression levels, and brimonidine d...
Source: Audiology and Neurotology - September 8, 2017 Category: Audiology Source Type: research

Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation
The Cogan syndrome is a rare disorder characterized by nonsyphilitic interstitial keratitis and audiovestibular symptoms. Profound sensorineural hearing loss has been reported in approximately half of the patients with the Cogan syndrome resulting in candidacy for cochlear implantation in some patients. The current study is the first histopathologic report on the temporal bones of a patient with the Cogan syndrome who during life underwent bilateral cochlear implantation. Preoperative MRI revealed tissue with high density in the basal turns of both cochleae and both vestibular systems consistent with fibrous tissue due to ...
Source: Audiology and Neurotology - August 23, 2017 Category: Audiology Source Type: research

Perception of Iterated Rippled Noise Periodicity in Cochlear Implant Users
Pitch perception is more challenging for individuals with cochlear implants (CIs) than normal-hearing subjects because the signal processing by CIs is restricted. Processing and perceiving the periodicity of signals may contribute to pitch perception. Whether individuals with CIs can discern pitch within an iterated rippled noise (IRN) signal is still unclear. In a prospective controlled psychoacoustic study with 34 CI users and 15 normal-hearing control subjects, the difference limen between IRN signals with different numbers of iterations was measured. In 7 CI users and 15 normal-hearing control listeners with single-sid...
Source: Audiology and Neurotology - August 18, 2017 Category: Audiology Source Type: research

The miR-34a/Bcl-2 Pathway Contributes to Auditory Cortex Neuron Apoptosis in Age-Related Hearing Loss
Conclusion: Our results support a link between age-related apoptosis in auditory cortex neurons and miR-34a/Bcl-2 signaling, which may serve as a potential mechanism of the expression of AHL in the auditory cortex.Audiol Neurotol 2017;22:96-103 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - August 17, 2017 Category: Audiology Source Type: research

Resistance of Gerbil Auditory Function to Reversible Decrease in Cochlear Blood Flow
The objective was to design in gerbils a model of reversible decrease in cochlear blood flow (CBF) and analyze its influence on cochlear function. In Mongolian gerbils injected with ferromagnetic microbeads, a magnet placed near the porus acusticus allowed CBF to be manipulated. The cochlear microphonic potential (CM) from the basal cochlea was monitored by a round-window electrode. In 13 of the 20 successfully injected gerbils, stable CBF reduction was obtained for 11.5 min on average. The CM was affected only when CBF fell to less than 60% of its baseline, yet remained>40% of its initial level in about 2/3 of such cas...
Source: Audiology and Neurotology - August 9, 2017 Category: Audiology Source Type: research

Unilateral Sensorineural Hearing Loss: Medical Context and Etiology
Conclusion: Long-term hearing follow-up remains useful in USNHL as it can become bilateral. Looking to etiology, MRI should be the gold standard, as CND is frequently observed and screening for CMV infection should be systematic. Genetic etiologies appear to be different compared to bilateral HL. Further genetic research in this domain is needed.Audiol Neurotol 2017;22:83-88 (Source: Audiology and Neurotology)
Source: Audiology and Neurotology - July 21, 2017 Category: Audiology Source Type: research