Evidence for Policies and Practices to Address Global Food Insecurity
Annu Rev Immunol. 2024 Jan 2. doi: 10.1146/annurev-publhealth-060922-041451. Online ahead of print.ABSTRACTFood insecurity affects an estimated 691-783 million people globally and is disproportionately high in Africa and Asia and arising from poverty, armed conflict, and climate change, among other demographic and globalization forces. This review summarizes evidence for policies and practices across five elements of the agrifood system framework and identifies gaps that inform an agenda for future research. Under availability, imbalanced agriculture policies protect primarily staple food producers, and there is limited ev...
Source: Annual Review of Immunology - January 3, 2024 Category: Allergy & Immunology Authors: Lora Iannotti Eliza Kleban Patrizia Fracassi Stineke Oenema Chessa Lutter Source Type: research
T Cell Exhaustion
Annu Rev Immunol. 2024 Jan 2. doi: 10.1146/annurev-immunol-090222-110914. Online ahead of print.ABSTRACTT cell responses must be balanced to ensure adequate protection against malignant transformation and an array of pathogens while also limiting damage to healthy cells and preventing autoimmunity. T cell exhaustion serves as a regulatory mechanism to limit the activity and effector function of T cells undergoing chronic antigen stimulation. Exhausted T cells exhibit poor proliferative potential; high inhibitory receptor expression; altered transcriptome, epigenome, and metabolism; and, most importantly, reduced effector f...
Source: Annual Review of Immunology - January 2, 2024 Category: Allergy & Immunology Authors: Andrew Baessler Dario A A Vignali Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
