Beyond the Barrier: Unraveling the Mechanisms of Immunotherapy Resistance
Annu Rev Immunol. 2024 Feb 21. doi: 10.1146/annurev-immunol-101819-024752. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB) induces a remarkable and durable response in a subset of cancer patients. However, most patients exhibit either primary or acquired resistance to ICB. This resistance arises from a complex interplay of diverse dynamic mechanisms within the tumor microenvironment (TME). These mechanisms include genetic, epigenetic, and metabolic alterations that prevent T cell trafficking to the tumor site, induce immune cell dysfunction, interfere with antigen presentation, drive heightened expression of...
Source: Annual Review of Immunology - February 21, 2024 Category: Allergy & Immunology Authors: Hannah N Bell Weiping Zou Source Type: research
The Immunobiology and Treatment of Food Allergy
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090122-043501. Online ahead of print.ABSTRACTIgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that leads to a detrimental type 2 helper T cell (TH2) adaptive immune response. While the processes governing this loss of tolerance are incompletely understood, several host-related and environmental factors impacting the risk of IgE-FA development have been identified. Mounting evidence supports the role of an impaired epithelial barrier in the development of IgE-FA, with exposure of allergens through damaged skin and gut epithelium lead...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Suzanne Barshow Jyothi Tirumalasetty Vanitha Sampath Xiaoying Zhou Hana Seastedt Jackson Schuetz Kari Nadeau Source Type: research
Priming and Maintenance of Adaptive Immunity in the Liver
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090122-041354. Online ahead of print.ABSTRACTThe liver's unique characteristics have a profound impact on the priming and maintenance of adaptive immunity. This review delves into the cellular circuits that regulate adaptive immune responses in the liver, with a specific focus on hepatitis B virus infection as an illustrative example. A key aspect highlighted is the liver's specialized role in priming CD8+ T cells, leading to a distinct state of immune hyporesponsiveness. Additionally, the influence of the liver's hemodynamics and anatomical features, particularly...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Keigo Kawashima Francesco Andreata Cristian Gabriel Beccaria Matteo Iannacone Source Type: research
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-080223-044610. Online ahead of print.ABSTRACTTen-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). All three epigenetic modifications are intermediates in DNA demethylation. TET proteins are recruited by transcription factors and by RNA polymerase II to modify 5mC at enhancers and gene bodies, thereby regulating gene expression during development, cell lineage ...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Isaac F L ópez-Moyado Myunggon Ko Patrick G Hogan Anjana Rao Source Type: research
Aire in Autoimmunity
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090222-101050. Online ahead of print.ABSTRACTThe role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-representation was first described more than 20 years ago, but fascinating new insights into its biology continue to emerge, particularly in the era of advanced single-cell genomics. We briefly describe the role of human genetics in the discovery of Aire, as well as insights into its function gained from genotype-phenotype correlations and the spectrum of Aire-associated autoimmunity-including insights from patients with Aire mutatio...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Corey N Miller Michael R Waterfield James M Gardner Mark S Anderson Source Type: research
The Immunobiology and Treatment of Food Allergy
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090122-043501. Online ahead of print.ABSTRACTIgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that leads to a detrimental type 2 helper T cell (TH2) adaptive immune response. While the processes governing this loss of tolerance are incompletely understood, several host-related and environmental factors impacting the risk of IgE-FA development have been identified. Mounting evidence supports the role of an impaired epithelial barrier in the development of IgE-FA, with exposure of allergens through damaged skin and gut epithelium lead...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Suzanne Barshow Jyothi Tirumalasetty Vanitha Sampath Xiaoying Zhou Hana Seastedt Jackson Schuetz Kari Nadeau Source Type: research
Priming and Maintenance of Adaptive Immunity in the Liver
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090122-041354. Online ahead of print.ABSTRACTThe liver's unique characteristics have a profound impact on the priming and maintenance of adaptive immunity. This review delves into the cellular circuits that regulate adaptive immune responses in the liver, with a specific focus on hepatitis B virus infection as an illustrative example. A key aspect highlighted is the liver's specialized role in priming CD8+ T cells, leading to a distinct state of immune hyporesponsiveness. Additionally, the influence of the liver's hemodynamics and anatomical features, particularly...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Keigo Kawashima Francesco Andreata Cristian Gabriel Beccaria Matteo Iannacone Source Type: research
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-080223-044610. Online ahead of print.ABSTRACTTen-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). All three epigenetic modifications are intermediates in DNA demethylation. TET proteins are recruited by transcription factors and by RNA polymerase II to modify 5mC at enhancers and gene bodies, thereby regulating gene expression during development, cell lineage ...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Isaac F L ópez-Moyado Myunggon Ko Patrick G Hogan Anjana Rao Source Type: research
Aire in Autoimmunity
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090222-101050. Online ahead of print.ABSTRACTThe role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-representation was first described more than 20 years ago, but fascinating new insights into its biology continue to emerge, particularly in the era of advanced single-cell genomics. We briefly describe the role of human genetics in the discovery of Aire, as well as insights into its function gained from genotype-phenotype correlations and the spectrum of Aire-associated autoimmunity-including insights from patients with Aire mutatio...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Corey N Miller Michael R Waterfield James M Gardner Mark S Anderson Source Type: research
The Immunobiology and Treatment of Food Allergy
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090122-043501. Online ahead of print.ABSTRACTIgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that leads to a detrimental type 2 helper T cell (TH2) adaptive immune response. While the processes governing this loss of tolerance are incompletely understood, several host-related and environmental factors impacting the risk of IgE-FA development have been identified. Mounting evidence supports the role of an impaired epithelial barrier in the development of IgE-FA, with exposure of allergens through damaged skin and gut epithelium lead...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Suzanne Barshow Jyothi Tirumalasetty Vanitha Sampath Xiaoying Zhou Hana Seastedt Jackson Schuetz Kari Nadeau Source Type: research
Priming and Maintenance of Adaptive Immunity in the Liver
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090122-041354. Online ahead of print.ABSTRACTThe liver's unique characteristics have a profound impact on the priming and maintenance of adaptive immunity. This review delves into the cellular circuits that regulate adaptive immune responses in the liver, with a specific focus on hepatitis B virus infection as an illustrative example. A key aspect highlighted is the liver's specialized role in priming CD8+ T cells, leading to a distinct state of immune hyporesponsiveness. Additionally, the influence of the liver's hemodynamics and anatomical features, particularly...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Keigo Kawashima Francesco Andreata Cristian Gabriel Beccaria Matteo Iannacone Source Type: research
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-080223-044610. Online ahead of print.ABSTRACTTen-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). All three epigenetic modifications are intermediates in DNA demethylation. TET proteins are recruited by transcription factors and by RNA polymerase II to modify 5mC at enhancers and gene bodies, thereby regulating gene expression during development, cell lineage ...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Isaac F L ópez-Moyado Myunggon Ko Patrick G Hogan Anjana Rao Source Type: research
Aire in Autoimmunity
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090222-101050. Online ahead of print.ABSTRACTThe role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-representation was first described more than 20 years ago, but fascinating new insights into its biology continue to emerge, particularly in the era of advanced single-cell genomics. We briefly describe the role of human genetics in the discovery of Aire, as well as insights into its function gained from genotype-phenotype correlations and the spectrum of Aire-associated autoimmunity-including insights from patients with Aire mutatio...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Corey N Miller Michael R Waterfield James M Gardner Mark S Anderson Source Type: research
The Immunobiology and Treatment of Food Allergy
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090122-043501. Online ahead of print.ABSTRACTIgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that leads to a detrimental type 2 helper T cell (TH2) adaptive immune response. While the processes governing this loss of tolerance are incompletely understood, several host-related and environmental factors impacting the risk of IgE-FA development have been identified. Mounting evidence supports the role of an impaired epithelial barrier in the development of IgE-FA, with exposure of allergens through damaged skin and gut epithelium lead...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Suzanne Barshow Jyothi Tirumalasetty Vanitha Sampath Xiaoying Zhou Hana Seastedt Jackson Schuetz Kari Nadeau Source Type: research
Priming and Maintenance of Adaptive Immunity in the Liver
Annu Rev Immunol. 2024 Feb 15. doi: 10.1146/annurev-immunol-090122-041354. Online ahead of print.ABSTRACTThe liver's unique characteristics have a profound impact on the priming and maintenance of adaptive immunity. This review delves into the cellular circuits that regulate adaptive immune responses in the liver, with a specific focus on hepatitis B virus infection as an illustrative example. A key aspect highlighted is the liver's specialized role in priming CD8+ T cells, leading to a distinct state of immune hyporesponsiveness. Additionally, the influence of the liver's hemodynamics and anatomical features, particularly...
Source: Annual Review of Immunology - February 15, 2024 Category: Allergy & Immunology Authors: Keigo Kawashima Francesco Andreata Cristian Gabriel Beccaria Matteo Iannacone Source Type: research
