T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
T Follicular Helper Cell Heterogeneity
Annu Rev Immunol. 2023 Dec 7. doi: 10.1146/annurev-immunol-090222-102834. Online ahead of print.ABSTRACTT follicular helper (Tfh) cells specialize in helping B cells and are therefore critical contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class-switch recombination and support the germinal center response, thereby promoting immunoglobulin affinity maturation and the generation of humoral immune memory. Although their primary function is to promote B cell responses, Tfh cells also display phenotypic and functional diversity determined by the immunological and spatial contexts from which th...
Source: Annual Review of Immunology - December 7, 2023 Category: Allergy & Immunology Authors: Wenzhi Song Joe Craft Source Type: research
B Cell-Directed Therapy in Autoimmunity
Annu Rev Immunol. 2023 Nov 27. doi: 10.1146/annurev-immunol-083122-044829. Online ahead of print.ABSTRACTAutoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines ...
Source: Annual Review of Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Ilana Abeles Chris Palma Nida Meednu Aimee S Payne R John Looney Jennifer H Anolik Source Type: research
B Cell-Directed Therapy in Autoimmunity
Annu Rev Immunol. 2023 Nov 27. doi: 10.1146/annurev-immunol-083122-044829. Online ahead of print.ABSTRACTAutoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines ...
Source: Annual Review of Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Ilana Abeles Chris Palma Nida Meednu Aimee S Payne R John Looney Jennifer H Anolik Source Type: research
B Cell-Directed Therapy in Autoimmunity
Annu Rev Immunol. 2023 Nov 27. doi: 10.1146/annurev-immunol-083122-044829. Online ahead of print.ABSTRACTAutoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines ...
Source: Annual Review of Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Ilana Abeles Chris Palma Nida Meednu Aimee S Payne R John Looney Jennifer H Anolik Source Type: research
B Cell-Directed Therapy in Autoimmunity
Annu Rev Immunol. 2023 Nov 27. doi: 10.1146/annurev-immunol-083122-044829. Online ahead of print.ABSTRACTAutoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines ...
Source: Annual Review of Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Ilana Abeles Chris Palma Nida Meednu Aimee S Payne R John Looney Jennifer H Anolik Source Type: research
B Cell-Directed Therapy in Autoimmunity
Annu Rev Immunol. 2023 Nov 27. doi: 10.1146/annurev-immunol-083122-044829. Online ahead of print.ABSTRACTAutoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines ...
Source: Annual Review of Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Ilana Abeles Chris Palma Nida Meednu Aimee S Payne R John Looney Jennifer H Anolik Source Type: research
B Cell-Directed Therapy in Autoimmunity
Annu Rev Immunol. 2023 Nov 27. doi: 10.1146/annurev-immunol-083122-044829. Online ahead of print.ABSTRACTAutoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines ...
Source: Annual Review of Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Ilana Abeles Chris Palma Nida Meednu Aimee S Payne R John Looney Jennifer H Anolik Source Type: research
B Cell-Directed Therapy in Autoimmunity
Annu Rev Immunol. 2023 Nov 27. doi: 10.1146/annurev-immunol-083122-044829. Online ahead of print.ABSTRACTAutoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines ...
Source: Annual Review of Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Ilana Abeles Chris Palma Nida Meednu Aimee S Payne R John Looney Jennifer H Anolik Source Type: research
B Cell-Directed Therapy in Autoimmunity
Annu Rev Immunol. 2023 Nov 27. doi: 10.1146/annurev-immunol-083122-044829. Online ahead of print.ABSTRACTAutoimmune diseases with B cell-directed therapeutics approved by the US Food and Drug Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this review, we focus on recent clinical and mechanistic insights into the efficacy of B cell depletion in these diverse autoimmune disorders, the rapidly expanding armamentarium of approved agents, and future approaches. The pathogenic roles for B cells include direct functions such as production of autoantibodies and proinflammatory cytokines ...
Source: Annual Review of Immunology - November 27, 2023 Category: Allergy & Immunology Authors: Ilana Abeles Chris Palma Nida Meednu Aimee S Payne R John Looney Jennifer H Anolik Source Type: research
Neuroimmune Interactions in the Lung
Annu Rev Immunol. 2023 Nov 21. doi: 10.1146/annurev-immunol-083122-042512. Online ahead of print.ABSTRACTBarrier tissues are highly innervated by sensory and autonomic nerves that are positioned in close proximity to both stromal and immune cell populations. Together with a growing awareness of the far-reaching consequences of neuroimmune interactions, recent studies have uncovered key mechanisms through which they contribute to organ homeostasis and immunity. It has also become clear that dysregulation of such interactions is implicated in the development of chronic lung diseases. This review describes the characteristics...
Source: Annual Review of Immunology - November 21, 2023 Category: Allergy & Immunology Authors: Rossana Azzoni Olaf Perdijk Nicola L Harris Benjamin J Marsland Source Type: research
