Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils
Annu Rev Immunol. 2023 Apr 26;41:375-404. doi: 10.1146/annurev-immunol-081022-113627.ABSTRACTMyeloid cells are a significant proportion of leukocytes within tissues, comprising granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various myeloid cells that perform separate but complementary functions during homeostasis and disease, our understanding of tissue myeloid cells has evolved significantly. Exciting findings from transcriptomics profiling and fate-mapping mouse models have facilitated the identification of their developmental origins, maturation, and tissue-specific specializations...
Source: Annual Review of Immunology - May 1, 2023 Category: Allergy & Immunology Authors: Lai Guan Ng Zhaoyuan Liu Immanuel Kwok Florent Ginhoux Source Type: research
RNA Modification in the Immune System
Annu Rev Immunol. 2023 Apr 26;41:73-98. doi: 10.1146/annurev-immunol-101921-045401.ABSTRACTCharacterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this review, we discuss the value of innovative RNA modification profiling technologies to uncover the function of these diverse, dynamic RNA modifications in various immune cells within healthy and diseased contexts. Further, we explore our current understanding of the mechanisms whereby aberrant RN...
Source: Annual Review of Immunology - May 1, 2023 Category: Allergy & Immunology Authors: Dali Han Meng Michelle Xu Source Type: research
Not Dead Yet
Annu Rev Immunol. 2023 Apr 26;41:1-15. doi: 10.1146/annurev-immunol-101721-065214.ABSTRACTI have been a scientific grasshopper throughout my career, moving from question to question within the domain of lupus. This has proven to be immensely gratifying. Scientific exploration is endlessly fascinating, and succeeding in studies you care about with colleagues and trainees leads to strong and lasting bonds. Science isn't easy; being a woman in science presents challenges, but the drive to understand a disease remains strong.PMID:37126416 | DOI:10.1146/annurev-immunol-101721-065214 (Source: Annual Review of Immunology)
Source: Annual Review of Immunology - May 1, 2023 Category: Allergy & Immunology Authors: Betty Diamond Source Type: research
Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging
Annu Rev Immunol. 2023 Apr 26;41:181-205. doi: 10.1146/annurev-immunol-101721-064501.ABSTRACTThere is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotype of terminally differentiated cells, lose the expression of costimulatory molecules, and acquire properties of senescent cells. In this review, we focus on the different subsets of age-associated T cells that accumulate during aging. These subsets include extremely cytotoxic T cells with natural...
Source: Annual Review of Immunology - May 1, 2023 Category: Allergy & Immunology Authors: Gonzalo Soto-Heredero Manuel M G ómez de Las Heras J Ignacio Escrig-Larena Mar ía Mittelbrunn Source Type: research
Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia
Annu Rev Immunol. 2023 Apr 26;41:561-585. doi: 10.1146/annurev-immunol-101921-050835.ABSTRACTInfection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign infection in most individuals to critical pneumonia and death in a few. Genetic studies in patients have established that critical cases can result from inborn errors of TLR3- or TLR7-dependent type I interferon immunity, or from preexisting autoantibodies neutralizing primarily IFN-α and/or IFN-ω. These findings are consistent with virological studies showing that multiple SARS-CoV-2 proteins interfere with pathways of induction of, or response ...
Source: Annual Review of Immunology - May 1, 2023 Category: Allergy & Immunology Authors: Helen C Su Huie Jing Yu Zhang Jean-Laurent Casanova Source Type: research
