Immune Responses in Controllers of HIV Infection
Annu Rev Immunol. 2023 Oct 12. doi: 10.1146/annurev-immunol-083122-035233. Online ahead of print.ABSTRACTElite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent virus, thus they may serve as a model of a functional cure of HIV. The mechanisms responsible for virologic control have been actively studied. The most objective data support CD8+ T cell-based mechanisms of control, but other immune responses, mediated by antibodies and natural killer...
Source: Annual Review of Immunology - October 12, 2023 Category: Allergy & Immunology Authors: Abena K Kwaa Joel N Blankson Source Type: research
Immune Responses in Controllers of HIV Infection
Annu Rev Immunol. 2023 Oct 12. doi: 10.1146/annurev-immunol-083122-035233. Online ahead of print.ABSTRACTElite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent virus, thus they may serve as a model of a functional cure of HIV. The mechanisms responsible for virologic control have been actively studied. The most objective data support CD8+ T cell-based mechanisms of control, but other immune responses, mediated by antibodies and natural killer...
Source: Annual Review of Immunology - October 12, 2023 Category: Allergy & Immunology Authors: Abena K Kwaa Joel N Blankson Source Type: research
Immune Responses in Controllers of HIV Infection
Annu Rev Immunol. 2023 Oct 12. doi: 10.1146/annurev-immunol-083122-035233. Online ahead of print.ABSTRACTElite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent virus, thus they may serve as a model of a functional cure of HIV. The mechanisms responsible for virologic control have been actively studied. The most objective data support CD8+ T cell-based mechanisms of control, but other immune responses, mediated by antibodies and natural killer...
Source: Annual Review of Immunology - October 12, 2023 Category: Allergy & Immunology Authors: Abena K Kwaa Joel N Blankson Source Type: research
Peeking Into the Black Box of T Cell Receptor Signaling
Annu Rev Immunol. 2023 Oct 3. doi: 10.1146/annurev-immunol-090222-112028. Online ahead of print.ABSTRACTI have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation. Expected final onl...
Source: Annual Review of Immunology - October 3, 2023 Category: Allergy & Immunology Authors: Arthur Weiss Source Type: research
Peeking Into the Black Box of T Cell Receptor Signaling
Annu Rev Immunol. 2023 Oct 3. doi: 10.1146/annurev-immunol-090222-112028. Online ahead of print.ABSTRACTI have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation. Expected final onl...
Source: Annual Review of Immunology - October 3, 2023 Category: Allergy & Immunology Authors: Arthur Weiss Source Type: research
Peeking Into the Black Box of T Cell Receptor Signaling
Annu Rev Immunol. 2023 Oct 3. doi: 10.1146/annurev-immunol-090222-112028. Online ahead of print.ABSTRACTI have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation. Expected final onl...
Source: Annual Review of Immunology - October 3, 2023 Category: Allergy & Immunology Authors: Arthur Weiss Source Type: research
Peeking Into the Black Box of T Cell Receptor Signaling
Annu Rev Immunol. 2023 Oct 3. doi: 10.1146/annurev-immunol-090222-112028. Online ahead of print.ABSTRACTI have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation. Expected final onl...
Source: Annual Review of Immunology - October 3, 2023 Category: Allergy & Immunology Authors: Arthur Weiss Source Type: research
Peeking Into the Black Box of T Cell Receptor Signaling
Annu Rev Immunol. 2023 Oct 3. doi: 10.1146/annurev-immunol-090222-112028. Online ahead of print.ABSTRACTI have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation. Expected final onl...
Source: Annual Review of Immunology - October 3, 2023 Category: Allergy & Immunology Authors: Arthur Weiss Source Type: research
Peeking Into the Black Box of T Cell Receptor Signaling
Annu Rev Immunol. 2023 Oct 3. doi: 10.1146/annurev-immunol-090222-112028. Online ahead of print.ABSTRACTI have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation. Expected final onl...
Source: Annual Review of Immunology - October 3, 2023 Category: Allergy & Immunology Authors: Arthur Weiss Source Type: research
Peeking Into the Black Box of T Cell Receptor Signaling
Annu Rev Immunol. 2023 Oct 3. doi: 10.1146/annurev-immunol-090222-112028. Online ahead of print.ABSTRACTI have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation. Expected final onl...
Source: Annual Review of Immunology - October 3, 2023 Category: Allergy & Immunology Authors: Arthur Weiss Source Type: research
Peeking Into the Black Box of T Cell Receptor Signaling
Annu Rev Immunol. 2023 Oct 3. doi: 10.1146/annurev-immunol-090222-112028. Online ahead of print.ABSTRACTI have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful collaborators and colleagues during my journey who have enabled me to make significant contributions to our understanding of how the TCR initiates signaling. TCR signaling events contribute to T cell development as well as to mature T cell activation and differentiation. Expected final onl...
Source: Annual Review of Immunology - October 3, 2023 Category: Allergy & Immunology Authors: Arthur Weiss Source Type: research
Structural Racism and the Social Determinants of Health in Asthma
Adv Exp Med Biol. 2023;1426:101-115. doi: 10.1007/978-3-031-32259-4_5.ABSTRACTAsthma prevalence and morbidity are disproportionately higher among minoritized communities in the United States. Racial and ethnic disparities in asthma result from complex interactions across biological, environmental, and social factors. Asthma is considered a complex heterogeneous disease consisting of different phenotypes, some of which may be more common in individuals impacted by the downstream effects of structural racism and lack of access to the social determinants of health. Structural racism across generations has created and reinforc...
Source: Annual Review of Immunology - July 18, 2023 Category: Allergy & Immunology Authors: Adali Martinez Neeta Thakur Source Type: research
Structural Racism and the Social Determinants of Health in Asthma
Adv Exp Med Biol. 2023;1426:101-115. doi: 10.1007/978-3-031-32259-4_5.ABSTRACTAsthma prevalence and morbidity are disproportionately higher among minoritized communities in the United States. Racial and ethnic disparities in asthma result from complex interactions across biological, environmental, and social factors. Asthma is considered a complex heterogeneous disease consisting of different phenotypes, some of which may be more common in individuals impacted by the downstream effects of structural racism and lack of access to the social determinants of health. Structural racism across generations has created and reinforc...
Source: Annual Review of Immunology - July 18, 2023 Category: Allergy & Immunology Authors: Adali Martinez Neeta Thakur Source Type: research
Structural Racism and the Social Determinants of Health in Asthma
Adv Exp Med Biol. 2023;1426:101-115. doi: 10.1007/978-3-031-32259-4_5.ABSTRACTAsthma prevalence and morbidity are disproportionately higher among minoritized communities in the United States. Racial and ethnic disparities in asthma result from complex interactions across biological, environmental, and social factors. Asthma is considered a complex heterogeneous disease consisting of different phenotypes, some of which may be more common in individuals impacted by the downstream effects of structural racism and lack of access to the social determinants of health. Structural racism across generations has created and reinforc...
Source: Annual Review of Immunology - July 18, 2023 Category: Allergy & Immunology Authors: Adali Martinez Neeta Thakur Source Type: research
Structural Racism and the Social Determinants of Health in Asthma
Adv Exp Med Biol. 2023;1426:101-115. doi: 10.1007/978-3-031-32259-4_5.ABSTRACTAsthma prevalence and morbidity are disproportionately higher among minoritized communities in the United States. Racial and ethnic disparities in asthma result from complex interactions across biological, environmental, and social factors. Asthma is considered a complex heterogeneous disease consisting of different phenotypes, some of which may be more common in individuals impacted by the downstream effects of structural racism and lack of access to the social determinants of health. Structural racism across generations has created and reinforc...
Source: Annual Review of Immunology - July 18, 2023 Category: Allergy & Immunology Authors: Adali Martinez Neeta Thakur Source Type: research
