Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.A design of experiment based RP-HPLC method for the simultaneous estimation of antihypertensive drugs with greenness assessment
Anal Sci. 2024 Mar 11. doi: 10.1007/s44211-024-00538-2. Online ahead of print.ABSTRACTThe correlation between blood pressure (BP) and cardiovascular risk has a continuous, positive, and linear pattern. Lowering high BP decreases the risk associated with cardiovascular disease. Chlorthalidone (CHD) and Losartan potassium (LOS) combination is used to treat hypertension. The analytical community was concerned with minimizing or reducing the use of toxic chemicals and solvents. Therefore, the current study aimed to develop a rapid, sensitive, and cost-effective green RP-HPLC method to determine CHD and LOS simultaneously in a ...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 11, 2024 Category: Chemistry Authors: Naveenarani Dharuman Lakshmi Karunanidhi Santhana Manikandan Krishnan Source Type: research
A novel fluorescent sensor for selective rifampicin detection based on the bio-inspired molecularly imprinted polymer-AgInS < sub > 2 < /sub > /ZnS quantum dots
Anal Sci. 2024 Mar 10. doi: 10.1007/s44211-024-00512-y. Online ahead of print.ABSTRACTA fluorescent sensing material based on the ternary core-shell quantum dots with outstanding optical properties and a bio-inspired molecularly imprinted polymer (MIP) as a recognition element has been prepared for selective detection of rifampicin (RFP). Firstly, AgInS2/ZnS core/shell quantum dots (ZAIS QDs) were prepared by a hydrothermal process. Then, the fluorescent sensor was prepared by coating these QDs by a dopamine-based MIP layer. The fluorescence of MIP@ZAIS QDs was quenched by RFP probably due to the photoinduced electron tran...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 10, 2024 Category: Chemistry Authors: Farzaneh Rasoulzadeh Mohammad Amjadi Source Type: research
A novel fluorescent sensor for selective rifampicin detection based on the bio-inspired molecularly imprinted polymer-AgInS < sub > 2 < /sub > /ZnS quantum dots
Anal Sci. 2024 Mar 10. doi: 10.1007/s44211-024-00512-y. Online ahead of print.ABSTRACTA fluorescent sensing material based on the ternary core-shell quantum dots with outstanding optical properties and a bio-inspired molecularly imprinted polymer (MIP) as a recognition element has been prepared for selective detection of rifampicin (RFP). Firstly, AgInS2/ZnS core/shell quantum dots (ZAIS QDs) were prepared by a hydrothermal process. Then, the fluorescent sensor was prepared by coating these QDs by a dopamine-based MIP layer. The fluorescence of MIP@ZAIS QDs was quenched by RFP probably due to the photoinduced electron tran...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 10, 2024 Category: Chemistry Authors: Farzaneh Rasoulzadeh Mohammad Amjadi Source Type: research
Optimization of reverse NOE pumping experiments in the analysis of complex systems with densely crowded NMR spectra
We present an optimization of Reverse NOE-pumping (RNP) in order to observe the 1H signals of ligands bound to proteins. Although various ligand-based NMR screening methods have been proposed, the most frequently used method has been Saturation-Transfer Difference (STD), owing to the relatively easy setup of experiments. Yet the critical point of STD is the selective irradiation of protein without irradiating ligand, and thus the STD technique is unable to observe 1H ligand signals, which resonate across the entire 1H spectral width. In the present study, the RNP experiment has been improved to develop an effective NMR-bas...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 5, 2024 Category: Chemistry Authors: Kazuo Furihata Mitsuru Tashiro Source Type: research
Optimization of reverse NOE pumping experiments in the analysis of complex systems with densely crowded NMR spectra
We present an optimization of Reverse NOE-pumping (RNP) in order to observe the 1H signals of ligands bound to proteins. Although various ligand-based NMR screening methods have been proposed, the most frequently used method has been Saturation-Transfer Difference (STD), owing to the relatively easy setup of experiments. Yet the critical point of STD is the selective irradiation of protein without irradiating ligand, and thus the STD technique is unable to observe 1H ligand signals, which resonate across the entire 1H spectral width. In the present study, the RNP experiment has been improved to develop an effective NMR-bas...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 5, 2024 Category: Chemistry Authors: Kazuo Furihata Mitsuru Tashiro Source Type: research
Optimization of reverse NOE pumping experiments in the analysis of complex systems with densely crowded NMR spectra
We present an optimization of Reverse NOE-pumping (RNP) in order to observe the 1H signals of ligands bound to proteins. Although various ligand-based NMR screening methods have been proposed, the most frequently used method has been Saturation-Transfer Difference (STD), owing to the relatively easy setup of experiments. Yet the critical point of STD is the selective irradiation of protein without irradiating ligand, and thus the STD technique is unable to observe 1H ligand signals, which resonate across the entire 1H spectral width. In the present study, the RNP experiment has been improved to develop an effective NMR-bas...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 5, 2024 Category: Chemistry Authors: Kazuo Furihata Mitsuru Tashiro Source Type: research
Optimization of reverse NOE pumping experiments in the analysis of complex systems with densely crowded NMR spectra
We present an optimization of Reverse NOE-pumping (RNP) in order to observe the 1H signals of ligands bound to proteins. Although various ligand-based NMR screening methods have been proposed, the most frequently used method has been Saturation-Transfer Difference (STD), owing to the relatively easy setup of experiments. Yet the critical point of STD is the selective irradiation of protein without irradiating ligand, and thus the STD technique is unable to observe 1H ligand signals, which resonate across the entire 1H spectral width. In the present study, the RNP experiment has been improved to develop an effective NMR-bas...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 5, 2024 Category: Chemistry Authors: Kazuo Furihata Mitsuru Tashiro Source Type: research
Quantitative lipid composition characterization of intact liposomes via < sup > 31 < /sup > P nuclear magnetic resonance spectroscopy
Anal Sci. 2024 Mar 3. doi: 10.1007/s44211-024-00519-5. Online ahead of print.ABSTRACTDrug delivery systems (DDS) are important methods to maximize drug efficacy by enabling in vivo accumulation at the target site. Liposomes, which are nanoscale vesicles consisting of lipid bilayers, are widely used for clinical DDS. The lipid composition of an intact liposome is a significant factor that directly affects its characteristics and functions. Thus, it is important to develop quantitative or qualitative analytical methods to characterize the lipid composition. Nuclear magnetic resonance (NMR) of phosphorus (31P) is a particular...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 3, 2024 Category: Chemistry Authors: Nanako Endo Chisa Aoki Toshihiko Sugiki Kumiko Sakai-Kato Source Type: research
Quantitative lipid composition characterization of intact liposomes via < sup > 31 < /sup > P nuclear magnetic resonance spectroscopy
Anal Sci. 2024 Mar 3. doi: 10.1007/s44211-024-00519-5. Online ahead of print.ABSTRACTDrug delivery systems (DDS) are important methods to maximize drug efficacy by enabling in vivo accumulation at the target site. Liposomes, which are nanoscale vesicles consisting of lipid bilayers, are widely used for clinical DDS. The lipid composition of an intact liposome is a significant factor that directly affects its characteristics and functions. Thus, it is important to develop quantitative or qualitative analytical methods to characterize the lipid composition. Nuclear magnetic resonance (NMR) of phosphorus (31P) is a particular...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 3, 2024 Category: Chemistry Authors: Nanako Endo Chisa Aoki Toshihiko Sugiki Kumiko Sakai-Kato Source Type: research
Quantitative lipid composition characterization of intact liposomes via < sup > 31 < /sup > P nuclear magnetic resonance spectroscopy
Anal Sci. 2024 Mar 3. doi: 10.1007/s44211-024-00519-5. Online ahead of print.ABSTRACTDrug delivery systems (DDS) are important methods to maximize drug efficacy by enabling in vivo accumulation at the target site. Liposomes, which are nanoscale vesicles consisting of lipid bilayers, are widely used for clinical DDS. The lipid composition of an intact liposome is a significant factor that directly affects its characteristics and functions. Thus, it is important to develop quantitative or qualitative analytical methods to characterize the lipid composition. Nuclear magnetic resonance (NMR) of phosphorus (31P) is a particular...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 3, 2024 Category: Chemistry Authors: Nanako Endo Chisa Aoki Toshihiko Sugiki Kumiko Sakai-Kato Source Type: research
A simple and accurate ratiometric sensor for determination of dopamine based on dual-emission carbon dots
In this study, an economic and accurate DA ratiometric sensor was established using dual-emission carbon dots (DE-CDs). DE-CDs were first synthesized by the one-step solvothermal method and two separate fluorescence emission peaks at 340 and 500 nm were observed under the excitation of 310 nm. In the presence of Hg2+, the fluorescence signal at 340 nm was significantly quenched, while the signal at 500 nm keeps stable. Upon adding DA, the quenched signal at 340 nm was significantly recovered, whereas the signal at 500 nm remains stable. Therefore, a novel ratiometric sensor for DA analysis was established. This method show...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 2, 2024 Category: Chemistry Authors: Yuecheng Zhang Lingbo Sun Chengjia Li Jing Ma Shiyu Zhang QingQing Wang Hongyan Ma Source Type: research
Near-infrared-II fluorescence/magnetic resonance double modal imaging of transplanted stem cells using lanthanide co-doped gadolinium oxide nanoparticles
Anal Sci. 2024 Mar 2. doi: 10.1007/s44211-024-00507-9. Online ahead of print.ABSTRACTTo ensure maximum therapeutic safety and efficacy of stem cell transplantation, it is essential to observe the kinetics of behavior, accumulation, and engraftment of transplanted stem cells in vivo. However, it is difficult to detect transplanted stem cells with high sensitivity by conventional in vivo imaging technologies. To diagnose the kinetics of transplanted stem cells, we prepared multifunctional nanoparticles, Gd2O3 co-doped with Er3+ and Yb3+ (Gd2O3: Er, Yb-NPs), and developed an in vivo double modal imaging technique with near...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 2, 2024 Category: Chemistry Authors: Shota Yamada Kaori Yamada Ayae Sugawara-Narutaki Yoshinobu Baba Hiroshi Yukawa Source Type: research
A simple and accurate ratiometric sensor for determination of dopamine based on dual-emission carbon dots
In this study, an economic and accurate DA ratiometric sensor was established using dual-emission carbon dots (DE-CDs). DE-CDs were first synthesized by the one-step solvothermal method and two separate fluorescence emission peaks at 340 and 500 nm were observed under the excitation of 310 nm. In the presence of Hg2+, the fluorescence signal at 340 nm was significantly quenched, while the signal at 500 nm keeps stable. Upon adding DA, the quenched signal at 340 nm was significantly recovered, whereas the signal at 500 nm remains stable. Therefore, a novel ratiometric sensor for DA analysis was established. This method show...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 2, 2024 Category: Chemistry Authors: Yuecheng Zhang Lingbo Sun Chengjia Li Jing Ma Shiyu Zhang QingQing Wang Hongyan Ma Source Type: research
Near-infrared-II fluorescence/magnetic resonance double modal imaging of transplanted stem cells using lanthanide co-doped gadolinium oxide nanoparticles
Anal Sci. 2024 Mar 2. doi: 10.1007/s44211-024-00507-9. Online ahead of print.ABSTRACTTo ensure maximum therapeutic safety and efficacy of stem cell transplantation, it is essential to observe the kinetics of behavior, accumulation, and engraftment of transplanted stem cells in vivo. However, it is difficult to detect transplanted stem cells with high sensitivity by conventional in vivo imaging technologies. To diagnose the kinetics of transplanted stem cells, we prepared multifunctional nanoparticles, Gd2O3 co-doped with Er3+ and Yb3+ (Gd2O3: Er, Yb-NPs), and developed an in vivo double modal imaging technique with near...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - March 2, 2024 Category: Chemistry Authors: Shota Yamada Kaori Yamada Ayae Sugawara-Narutaki Yoshinobu Baba Hiroshi Yukawa Source Type: research
Detection of estradiol with a digital immunoassay using an anti-immunocomplex antibody and single-molecule observation of gold nanoparticles
In this study, with the aim of small molecule detection, we developed a digital immunoassay method using an anti-immunocomplex antibody that specifically recognizes immunocomplexes of small molecules with antibodies. The number of AuNPs modified with anti-immunocomplex antibody bound to immunocomplex of estradiol and anti-estradiol antibody was counted at a single nanoparticle level using DFM. We demonstrated for the first time that estradiol molecule can be detected by digital immunoassay using DFM and an anti-immunocomplex antibody with a detection sensitivity of 1 pg/mL.PMID:38424409 | DOI:10.1007/s44211-024-00518-6 (So...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - February 29, 2024 Category: Chemistry Authors: Yu Muto Gen Hirao Tamotsu Zako Source Type: research
