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Sample preparation conditions for the real-time measurement of W/O emulsions by resonance-enhanced multiphoton ionization time-of-flight mass spectrometry
Anal Sci. 2024 Jan 9. doi: 10.1007/s44211-023-00486-3. Online ahead of print.ABSTRACTAnalysis of an emulsion in its original dispersed condition is quite important for quality assessment and quality control. In the present study, the practical experimental conditions of the real-time measurement of a water-in-oil (W/O) emulsion were examined via resonance-enhanced multiphoton ionization time-of-flight mass spectrometry (REMPI-TOFMS). A W/O emulsion was prepared using cyclohexane as the oil phase with toluene as an analyte species. A time profile of the peak area for toluene was constructed based on the mass spectra. Normal...
Source: Anal Sci - January 9, 2024 Category: Chemistry Authors: Minori Minami Shion Nakata Tomohiro Uchimura Source Type: research

Multidimensional Separations in Top-Down Proteomics
Anal Sci Adv. 2023 Jul;4(5-6):181-203. doi: 10.1002/ansa.202300016. Epub 2023 May 29.ABSTRACTTop-down proteomics (TDP) identifies, quantifies, and characterizes proteins at the intact proteoform level in complex biological samples to understand proteoform function and cellular mechanisms. However, analyzing complex biological samples using TDP is still challenging due to high sample complexity and wide dynamic range. High-resolution separation methods are often applied prior to mass spectrometry (MS) analysis to decrease sample complexity and increase proteomics throughput. These separation methods, however, may not be eff...
Source: Anal Sci - January 8, 2024 Category: Chemistry Authors: Yanting Guo Kellye A Cupp-Sutton Zhitao Zhao Samin Anjum Si Wu Source Type: research

An AuNPs-based electrochemical aptasensor for the detection of 25-hydroxy vitamin D 3 
In this study, we constructed an accurate, sensitive, simple, and cost-effective label-free biosensor based on an aptamer for the detection of 25(OH)D3. The aptamer-modified sulfhydryl adopted self-assembly as a way to stably immobilize at the glassy carbon electrode (GCE) surface modified by gold nanoparticles (AuNPs). Upon 25(OH)D3 binding to the aptamer, the complexes inhibit electron transfer at the electrode surface, leading to reduced [Fe(CN)6]3-/4- redox peak current. Consequently, the quantity of 25(OH)D3 that interacts with the electrode-bound aptamer correlates with the observed electric current response values. ...
Source: Anal Sci - January 8, 2024 Category: Chemistry Authors: Tongji Cai Meilun Chen Jie Yang Chunhua Tang Xiaoling Lu Zheng Wei Hanbing Jiang Yucui Hou Jia Zhao Peng Yu Source Type: research

Obesity Is Associated with Altered Rectal Sensitivity in Chronic Constipation
CONCLUSION: Obesity was independently associated with altered rectal sensitivity among patients with CC. Altered rectal sensation may play an important role in CC among patients with obesity. Anorectal physiology testing should be considered to understand the pathophysiology and guide management.PMID:38184499 | DOI:10.1007/s10620-023-08246-z (Source: Anal Sci)
Source: Anal Sci - January 6, 2024 Category: Chemistry Authors: Nayna A Lodhia Brent Hiramoto Laura Horton Alison H Goldin Christopher C Thompson Walter W Chan Source Type: research

Label-free fluorescence aptasensor for the detection of cadmium(II) ion based on the conformational switching of aptamer and thioflavine T
Anal Sci. 2024 Jan 5. doi: 10.1007/s44211-023-00488-1. Online ahead of print.ABSTRACTA simple label-free Cd2+ fluorescent aptasensor was proposed using aptamer as a recognition element and thioflavine T (ThT) as a signal reporter. The presence of Cd(II) can induce the conformational switching of the aptamer probe, accompanied by a change in fluorescence intensity. According to the difference in fluorescence signals before and after the addition of Cd2+, a fluorescence sensor for Cd2+ assay was established. Under the better experimental conditions, the sensor displayed a good linear range from 2 to 50 nM and the excellent d...
Source: Anal Sci - January 5, 2024 Category: Chemistry Authors: Ping Liu Yu He Xiaoqin Liu Xia Gao Source Type: research

Recent development of probes for radiotheranostics
Anal Sci. 2024 Jan;40(1):1-2. doi: 10.1007/s44211-023-00452-z.NO ABSTRACTPMID:38175493 | DOI:10.1007/s44211-023-00452-z (Source: Anal Sci)
Source: Anal Sci - January 4, 2024 Category: Chemistry Authors: Kazuma Ogawa Source Type: research

CF-LIBS based elemental analysis of Saussurea simpsoniana medicinal plant: a study on roots, seeds, and leaves
In this study, we present an elemental analysis of the chemical composition (wt%) of this medicinal plant using the laser-induced breakdown spectroscopy (LIBS) technique. In the air atmosphere, an Nd:YAG (Q-switched) laser operating at a wavelength of 532 nm is utilized to create plasma on the sample's surface. This laser has a maximum pulse energy of approximately 400 mJ and a pulse duration of 5 ns. A set of six miniature spectrometers, covering the wavelength range of 220-970 nm, was utilized to capture and record the optical emissions emitted by the plasma. The qualitative analysis of LIBS revealed the presence of 13 m...
Source: Anal Sci - January 3, 2024 Category: Chemistry Authors: Amir Fayyaz Najab Ali Z A Umar Haroon Asghar Muhammad Waqas Rizwan Ahmed Raheel Ali M A Baig Source Type: research

The rectum, anal sphincter and puborectalis muscle show different contraction wave forms during prolonged measurement with a simulated feces
In conclusion, the rectum, anal sphincter and puborectalis muscle showed different contraction waves during prolonged measurements. The data call for larger studies to better understand normal defecation, feces-withholding patterns, and the implications on anorectal disorders.PMID:38172283 | PMC:PMC10764324 | DOI:10.1038/s41598-023-50655-7 (Source: Anal Sci)
Source: Anal Sci - January 3, 2024 Category: Chemistry Authors: Daming Sun Kar Man Lo Ssu-Chi Chen Wing Wa Leung Cherry Wong Tony Mak Simon Ng Kaori Futaba Hans Gregersen Source Type: research

Quantification of peracetic acid (PAA) in the H 2 O 2 + acetic acid reaction by the wavelength shift analysis in near-UV/visible absorption region
Anal Sci. 2024 Jan 2. doi: 10.1007/s44211-023-00481-8. Online ahead of print.ABSTRACTIn our study, we present an innovative method for the analysis and real-time monitoring of peracetic acid (PAA) formation within the near-UV/Vis (visible) wavelength region. PAA's absorption spectrum, influenced by its presence in a complex quaternary equilibrium mixture with hydrogen peroxide (H2O2), acetic acid, and water, lacks discernible peaks. This inherent complexity challenges conventional analytical techniques like Beer's law, which rely on absorption intensity as a foundation. To address this challenge, we introduce a novel appro...
Source: Anal Sci - January 2, 2024 Category: Chemistry Authors: Guan-Yu Chen Yueh-Hsin Lin Cheng-Hsin Fu Cheng-Huang Lin Balaganesh Muthiah Wilfred V Espulgar Gil Nonato Santos Derrick Ethelbhert Yu Toshio Kasai Source Type: research

Fe-doped carbon dots: a novel fluorescent nanoprobe for cellular hypochlorous acid imaging
Anal Sci. 2023 Dec 27. doi: 10.1007/s44211-023-00484-5. Online ahead of print.ABSTRACTReal-time monitoring of hypochlorous acid (HClO) in biological systems is of great significance for exploring and regulating its pathological functions because abnormal production of HClO is closely related with many diseases, such as atherosclerosis, rheumatoid arthritis, and cancer. Herein, we developed a reliable fluorescent Fe-doped carbon dots (Fe-CDs) for the sensitive and selective detection of biological HClO using ferrocenecarboxylic acid and m-phenylenediamine as precursors through a one-step solvothermal procedure. The Fe-CDs e...
Source: Anal Sci - December 27, 2023 Category: Chemistry Authors: Yu Meng Yang Yuan Yan Jia Ying Zhou Cheng Zhi Huang Shu Jun Zhen Lei Zhan Source Type: research