Competition, cooperation, and parental effects in larval aggregations formed on carrion by communally breeding beetles Necrodes littoralis (Staphylinidae: Silphinae)
Insect Sci. 2024 Mar 13. doi: 10.1111/1744-7917.13353. Online ahead of print.ABSTRACTAggregations of juveniles are dominant forms of social life in some insect groups. Larval societies are shaped by competitive and cooperative interactions of the larvae, in parallel with parental effects. Colonies of necrophagous larvae are excellent systems to study these relationships. Necrodes littoralis (Staphylinidae: Silphinae), a carrion beetle that colonizes cadavers of large vertebrates, forms massive juvenile aggregations. By spreading over carrion anal and oral exudates, the beetles form the feeding matrix, in which the heat is ...
Source: Anal Sci - March 14, 2024 Category: Chemistry Authors: Natalia Lis Anna M ądra-Bielewicz J ędrzej Wydra Szymon Matuszewski Source Type: research
Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis
Adv Sci (Weinh). 2024 Mar 14:e2306378. doi: 10.1002/advs.202306378. Online ahead of print.ABSTRACTAspirin, also named acetylsalicylate, can directly acetylate the side-chain of lysine in protein, which leads to the possibility of unexplained drug effects. Here, the study used isotopic-labeling aspirin-d3 with mass spectrometry analysis to discover that aspirin directly acetylates 10 HDACs proteins, including SIRT1, the most studied NAD+ -dependent deacetylase. SIRT1 is also acetylated by aspirin in vitro. It is also identified that aspirin directly acetylates lysine 408 of SIRT1, which abolishes SIRT1 deacetylation activit...
Source: Anal Sci - March 14, 2024 Category: Chemistry Authors: Liangguo Xie Chaoqun Li Chao Wang Zhen Wu Changchun Wang Chunyu Chen Xiaojian Chen Dejian Zhou Qiang Zhou Ping Lu Chen Ding Chen-Ying Liu Jinzhong Lin Xumin Zhang Xiaofei Yu Wei Yu Source Type: research
Itemized determination of As, Sb, Bi, Se, and Ge in graphite sample by HG-AFS with high-temperature microwave digestion
Anal Sci. 2024 Mar 14. doi: 10.1007/s44211-024-00526-6. Online ahead of print.ABSTRACTIn this paper, we optimized a method for fast and accurate determination of five impurity elements (As, Sb, Bi, Se, and Ge) in graphite samples to overcome the shortcomings of existing methods, such as complicated equipment, cumbersome process, multiple-time preparation, separate determination, and large error in results. Graphite samples were digested with HNO3-H2SO4-HClO4-HF in a high-temperature and high-pressure microwave digestion apparatus, and the elements were extracted and determined separately by AFS (atomic fluorescence spectro...
Source: Anal Sci - March 14, 2024 Category: Chemistry Authors: Jian-Wei Meng Li-Ping Wang Ai-Qin Liu Yan-Qiao Hu Li Wei Chao Chen Xue-Mei Zhang Liang-Cheng Zhao Hua-Jie Liu Meng-Hua Sun Source Type: research
Competition, cooperation, and parental effects in larval aggregations formed on carrion by communally breeding beetles Necrodes littoralis (Staphylinidae: Silphinae)
Insect Sci. 2024 Mar 13. doi: 10.1111/1744-7917.13353. Online ahead of print.ABSTRACTAggregations of juveniles are dominant forms of social life in some insect groups. Larval societies are shaped by competitive and cooperative interactions of the larvae, in parallel with parental effects. Colonies of necrophagous larvae are excellent systems to study these relationships. Necrodes littoralis (Staphylinidae: Silphinae), a carrion beetle that colonizes cadavers of large vertebrates, forms massive juvenile aggregations. By spreading over carrion anal and oral exudates, the beetles form the feeding matrix, in which the heat is ...
Source: Anal Sci - March 14, 2024 Category: Chemistry Authors: Natalia Lis Anna M ądra-Bielewicz J ędrzej Wydra Szymon Matuszewski Source Type: research
Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis
Adv Sci (Weinh). 2024 Mar 14:e2306378. doi: 10.1002/advs.202306378. Online ahead of print.ABSTRACTAspirin, also named acetylsalicylate, can directly acetylate the side-chain of lysine in protein, which leads to the possibility of unexplained drug effects. Here, the study used isotopic-labeling aspirin-d3 with mass spectrometry analysis to discover that aspirin directly acetylates 10 HDACs proteins, including SIRT1, the most studied NAD+ -dependent deacetylase. SIRT1 is also acetylated by aspirin in vitro. It is also identified that aspirin directly acetylates lysine 408 of SIRT1, which abolishes SIRT1 deacetylation activit...
Source: Anal Sci - March 14, 2024 Category: Chemistry Authors: Liangguo Xie Chaoqun Li Chao Wang Zhen Wu Changchun Wang Chunyu Chen Xiaojian Chen Dejian Zhou Qiang Zhou Ping Lu Chen Ding Chen-Ying Liu Jinzhong Lin Xumin Zhang Xiaofei Yu Wei Yu Source Type: research
LC-MS/MS determination of pyocyanin-N-acetyl cysteine adduct: application for understanding Pseudomonas aeruginosa virulence factor neutralization
This study investigates the neutralization reaction between PCN and N-acetyl cysteine (NAC) for bacterial inhibition and explores its mechanism of action. The neutralization adduct (PCN-NAC) was synthesized by reacting the purified PCN and NAC. The adduct was analyzed and its structure was elucidated. LC-MS/MS method was developed for the determination of PCN-NAC in P. aeruginosa cultures post-treatment with NAC (0-5 mg/mL). The corresponding anti-bacterial potential was estimated and compared to nanoparticles (NPs) alone and under stress conditions. In silico studies were performed to support explaining the mechanism of a...
Source: Anal Sci - March 13, 2024 Category: Chemistry Authors: Faten Farouk Rania Ibrahim Shebl Source Type: research
Pimonidazole-alkyne conjugate for sensitive detection of hypoxia by Cu-catalyzed click reaction
Anal Sci. 2024 Mar 13. doi: 10.1007/s44211-024-00520-y. Online ahead of print.ABSTRACTHypoxia is involved in various diseases, such as cancers. Pimonidazole has often been used as the gold-standard marker to visualize hypoxic regions. Pimonidazole labels hypoxic regions by forming a covalent bond with a neighboring protein under hypoxic conditions in the body, which is detected by immunohistochemistry performed on tissue sections. To date, some pimonidazole-fluorophore conjugates have been reported as fluorescent probes for hypoxia imaging that do not require immunostaining. They are superior to pimonidazole because immuno...
Source: Anal Sci - March 13, 2024 Category: Chemistry Authors: Iori Tamura Daichi M Sakamoto Bo Yi Yutaro Saito Naoki Yamada Yoichi Takakusagi Shinsuke Sando Source Type: research
Correction for the calculated XANES spectra of 1,4,7,10-alkyltetracenes considering the total electron yield (TEY) efficiency of sp < sup > 2 < /sup > - and sp < sup > 3 < /sup > -carbon atoms
Anal Sci. 2024 Mar 11. doi: 10.1007/s44211-024-00532-8. Online ahead of print.ABSTRACTThe calculated X-ray-absorption-near-edge-structure (XANES) spectra in the CK region of 1,4,7,10-alkyltetracenes, which are composed of both sp2-C atoms in the tetracene ring and sp3-C atoms in the alkyl-chains, can be corrected by considering the total electron yield (TEY) efficiency of sp3-C relative to sp2-C. In the correction, the previously measured TEY efficiency of k = 0.51 is applied to the calculated transition probabilities for sp3-C atoms. Then the calculated CK-XANES obtained from density functional theory (DFT) calculations c...
Source: Anal Sci - March 12, 2024 Category: Chemistry Authors: Yasuji Muramatsu Source Type: research
Micro/nanofluidic device for tamsulosin therapeutic drug monitoring in patients with benign prostatic hyperplasia at point of care
Anal Sci. 2024 Mar 11. doi: 10.1007/s44211-024-00533-7. Online ahead of print.ABSTRACTDiscovering the balance between toxicity and efficacy for many drugs requires therapeutic drug monitoring (TDM) of their concentrations in the blood. Here, a hot-embossed microfluidic device with a new design integrated to a nanofracture is presented for purification of blood samples from numerous proteins and cells, allowing to the separation of small molecules from blood matrix. The device was used to separate and quantitatively detect tamsulosin drug after derivatization with fluorescamine reagent, allowing converting it from a neutral...
Source: Anal Sci - March 12, 2024 Category: Chemistry Authors: Zaidon T Al-Aqbi Hassan T Abdulsahib Faris A J Al-Doghachi Source Type: research
A design of experiment based RP-HPLC method for the simultaneous estimation of antihypertensive drugs with greenness assessment
Anal Sci. 2024 Mar 11. doi: 10.1007/s44211-024-00538-2. Online ahead of print.ABSTRACTThe correlation between blood pressure (BP) and cardiovascular risk has a continuous, positive, and linear pattern. Lowering high BP decreases the risk associated with cardiovascular disease. Chlorthalidone (CHD) and Losartan potassium (LOS) combination is used to treat hypertension. The analytical community was concerned with minimizing or reducing the use of toxic chemicals and solvents. Therefore, the current study aimed to develop a rapid, sensitive, and cost-effective green RP-HPLC method to determine CHD and LOS simultaneously in a ...
Source: Anal Sci - March 11, 2024 Category: Chemistry Authors: Naveenarani Dharuman Lakshmi Karunanidhi Santhana Manikandan Krishnan Source Type: research
A novel fluorescent sensor for selective rifampicin detection based on the bio-inspired molecularly imprinted polymer-AgInS < sub > 2 < /sub > /ZnS quantum dots
Anal Sci. 2024 Mar 10. doi: 10.1007/s44211-024-00512-y. Online ahead of print.ABSTRACTA fluorescent sensing material based on the ternary core-shell quantum dots with outstanding optical properties and a bio-inspired molecularly imprinted polymer (MIP) as a recognition element has been prepared for selective detection of rifampicin (RFP). Firstly, AgInS2/ZnS core/shell quantum dots (ZAIS QDs) were prepared by a hydrothermal process. Then, the fluorescent sensor was prepared by coating these QDs by a dopamine-based MIP layer. The fluorescence of MIP@ZAIS QDs was quenched by RFP probably due to the photoinduced electron tran...
Source: Anal Sci - March 10, 2024 Category: Chemistry Authors: Farzaneh Rasoulzadeh Mohammad Amjadi Source Type: research
A novel fluorescent sensor for selective rifampicin detection based on the bio-inspired molecularly imprinted polymer-AgInS < sub > 2 < /sub > /ZnS quantum dots
Anal Sci. 2024 Mar 10. doi: 10.1007/s44211-024-00512-y. Online ahead of print.ABSTRACTA fluorescent sensing material based on the ternary core-shell quantum dots with outstanding optical properties and a bio-inspired molecularly imprinted polymer (MIP) as a recognition element has been prepared for selective detection of rifampicin (RFP). Firstly, AgInS2/ZnS core/shell quantum dots (ZAIS QDs) were prepared by a hydrothermal process. Then, the fluorescent sensor was prepared by coating these QDs by a dopamine-based MIP layer. The fluorescence of MIP@ZAIS QDs was quenched by RFP probably due to the photoinduced electron tran...
Source: Anal Sci - March 10, 2024 Category: Chemistry Authors: Farzaneh Rasoulzadeh Mohammad Amjadi Source Type: research
Ligation of the Intersphincteric Fistula Tract as an Emergency Treatment for Cryptoglandular Anal Fistula
CONCLUSION: EM-LIFT is a feasible and safe primary procedure for active cryptoglandular-type anal fistulas.PMID:38456116 | PMC:PMC10917591 | DOI:10.21315/mjms2024.31.1.5 (Source: Anal Sci)
Source: Anal Sci - March 8, 2024 Category: Chemistry Authors: Diana Melissa Dualim Michael Pak-Kai Wong Siti Mayuha Rusli Abdel Latif Khalifa Elnaim Ali Ismail Sagap Source Type: research
Genetic correlations and causal relationships between cardio-metabolic traits and sepsis
Sci Rep. 2024 Mar 8;14(1):5718. doi: 10.1038/s41598-024-56467-7.ABSTRACTCardio-metabolic traits have been reported to be associated with the development of sepsis. It is, however, unclear whether these co-morbidities reflect causal associations, shared genetic heritability, or are confounded by environmental factors. We performed three analyses to explore the relationships between cardio-metabolic traits and sepsis. Mendelian randomization (MR) study to evaluate the causal effects of multiple cardio-metabolic traits on sepsis. Global genetic correlation analysis to explore the correlations between cardio-metabolic traits a...
Source: Anal Sci - March 8, 2024 Category: Chemistry Authors: Zhongheng Zhang Lin Chen Haoyang Zhang Wei Xiao Jie Yang Jiajie Huang Qichao Hu Ketao Jin Yucai Hong Source Type: research
Ligation of the Intersphincteric Fistula Tract as an Emergency Treatment for Cryptoglandular Anal Fistula
CONCLUSION: EM-LIFT is a feasible and safe primary procedure for active cryptoglandular-type anal fistulas.PMID:38456116 | PMC:PMC10917591 | DOI:10.21315/mjms2024.31.1.5 (Source: Anal Sci)
Source: Anal Sci - March 8, 2024 Category: Chemistry Authors: Diana Melissa Dualim Michael Pak-Kai Wong Siti Mayuha Rusli Abdel Latif Khalifa Elnaim Ali Ismail Sagap Source Type: research
