American Journal of Physiology. Regulatory, Integrative and Comparative Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Sex differences in the purinergic 2 receptor mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00010.2024. Online ahead of print.ABSTRACTWe investigated the role played by ATP sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ~72 hours to induce simulated peripheral artery disease (PAD). We hypothesized that PPADS (P2 receptor antagonist, 10 mg i.v.) would reduce the pressor response to four minutes of treadmill exercise (15 m×min-1, 1° incline) and steady-state exercise plasma norepinephrine (NE) values in male and femal...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Alec L E Butenas Joseph S Flax Raimi J Carroll C Shane Chuwonganant Ashley M Baranczuk Steven W Copp Source Type: research

Stimulatory effect of methylglyoxal on capsaicin-sensitive lung vagal afferents in rats: role of TRPA1
In conclusion, these results suggest that MG exerts a stimulatory effect on CSLV afferents, inducing pulmonary chemoreflexes, and such stimulation is mediated through the TRPA1 activation.PMID:38497128 | DOI:10.1152/ajpregu.00297.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: You Shuei Lin Nai-Ju Chan Pei-Yu Xiao Ching Jung Lai Source Type: research

Nerve transfer for restoration of lower motor neuron-lesioned bladder, urethral and anal sphincter function. Part 4: Effectiveness of the motor reinnervation
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00248.2023. Online ahead of print.ABSTRACTIn pilot work we showed that somatic nerve transfers can restore motor function in long-term decentralized dogs. We continue to explore the effectiveness of motor reinnervation in 30 female dogs. After anesthesia, 12 underwent bilateral transection of coccygeal and sacral (S) spinal roots, dorsal roots of lumbar (L)7, and hypogastric nerves. Twelve months post-decentralization, 8 underwent transfer of obturator nerve branches to pelvic nerve vesical branches, and sciatic nerve branches to pudendal nerves, fol...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Ekta Tiwari Danielle S Porreca Alan S Braverman Lewis Holt-Bright Nagat A Frara Justin M Brown Benjamin R Johnston Stanley F Bazarek Brendan A Hilliard Michael Mazzei Michel A Pontari Daohai Yu Michael R Ruggieri Mary F Barbe Source Type: research

A modeling analysis of whole-body potassium regulation on a high potassium diet: Proximal tubule and tubuloglomerular feedback effects
In this study, we extend our mathematical model to incorporate recent experimental findings that showed decreased fractional proximal tubule reabsorption under a high K+ diet. We conducted model simulations and sensitivity analyses to investigate how these renal alterations impact whole-body K+ regulation. Model predictions quantify the sensitivity of K+ regulation to various levels of proximal tubule K+ reabsorption adaptation and tubuloglomerular feedback. Our results suggest that the reduced proximal tubule K+ reabsorption under a high K+ diet could achieve K+ balance in isolation, but the resulting tubuloglomerular fee...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 11, 2024 Category: Physiology Authors: Melissa M Stadt Anita T Layton Source Type: research

Obesity-Associated Inflammatory Macrophage Polarization Is Inhibited by Capsaicin and Phytolignans
In this study, we explored the potential for plant-derived dietary compounds to exert anti-inflammatory effects in macrophages that alleviate obesity-associated adipocyte dysfunction. Capsaicin (CAP), Schisandrin A (SA), Enterodiol (END), and Enterolactone (ENL) treatment polarized J774 macrophages to an "M2" or anti-inflammatory phenotype and inhibited responses to stimulation with lipopolysaccharide (LPS). Furthermore, these compounds blocked inflammasome activation when administered just before ATP-induced NLRP3 activation, as evidenced by the abrogation of IL-1b release in mouse macrophages and human peripheral blood m...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 4, 2024 Category: Physiology Authors: Matthew E Poynter Madeleine M Mank Jennifer L Ather Source Type: research

Activation of cardiac parasympathetic and sympathetic activity occur at different skin temperatures during face cooling
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 4. doi: 10.1152/ajpregu.00196.2023. Online ahead of print.ABSTRACTSufficiently cold-water temperatures (<7oC) are needed to elicit the sympathetic response to the cold pressor test using the hand. However, it is not known if stimulating the trigeminal nerve via face cooling, which increases both sympathetic and cardiac parasympathetic activity, also has a threshold temperature. We tested the hypothesis that peak autonomic activation during a progressive face cooling challenge would be achieved when the stimulus temperature is £ 7oC. Twelve healthy participants (age: 25 �...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 4, 2024 Category: Physiology Authors: Felipe Gorini Pereira Muhamed McBryde Morgan Reynolds James R Sackett Christopher L Chapman Elizabeth A Gideon Zachary J Schlader Blair D Johnson Source Type: research