Immunohistochemical and ultrastructural characterization of the inner ear epithelial cells of splitnose rockfish ( < em > Sebastes diploproa < /em > )
This study provides a systematic characterization of the cell types in the inner ear of splitnose rockfish (Sebastes diploproa). Scanning electron microscopy revealed the apical morphologies of the six inner ear cell types. Additionally, immunostaining and confocal microscopy characterized the expression and subcellular localization of the proteins Na+/K+-ATPase, carbonic anhydrase, V-type H+-ATPase, Na+-K+-2Cl--Co-Transporter, Otolith Matrix Protein 1, and Otolin-1 in six inner ear cell types bordering the endolymph. This fundamental cytological characterization of the rockfish inner ear epithelium illustrates the intrica...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - January 8, 2024 Category: Physiology Authors: Garfield Tsz Kwan Leonardo R Andrade Kaelan J Prime Martin Tresguerres Source Type: research

Combined effects of mild hypothermia and nitrous-oxide-induced narcosis on manual and cognitive performance
Am J Physiol Regul Integr Comp Physiol. 2024 Jan 8. doi: 10.1152/ajpregu.00246.2023. Online ahead of print.ABSTRACTDivers are at enhanced risk of suffering from acute cognitive deteriorations, due to the low ambient temperatures, and the narcotic action of inert gases inspired at high pressures. Yet, the behavioral effects of cold and inert-gas narcosis have commonly been assessed in isolation, and during short-term provocations. We, therefore, evaluated the interactive influence of mild hypothermia and narcosis engendered by a subanaesthetic dose of nitrous oxide (N2O; a normobaric intervention analogue of hyperbaric nitr...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - January 8, 2024 Category: Physiology Authors: Maaike I Moes Antonis Elia Mikael Gennser Michail E Keramidas Source Type: research

Immunohistochemical and ultrastructural characterization of the inner ear epithelial cells of splitnose rockfish ( < em > Sebastes diploproa < /em > )
This study provides a systematic characterization of the cell types in the inner ear of splitnose rockfish (Sebastes diploproa). Scanning electron microscopy revealed the apical morphologies of the six inner ear cell types. Additionally, immunostaining and confocal microscopy characterized the expression and subcellular localization of the proteins Na+/K+-ATPase, carbonic anhydrase, V-type H+-ATPase, Na+-K+-2Cl--Co-Transporter, Otolith Matrix Protein 1, and Otolin-1 in six inner ear cell types bordering the endolymph. This fundamental cytological characterization of the rockfish inner ear epithelium illustrates the intrica...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - January 8, 2024 Category: Physiology Authors: Garfield Tsz Kwan Leonardo R Andrade Kaelan J Prime Martin Tresguerres Source Type: research

Editorial for Call for papers: "Cardiovascular regulation during exercise: role of biological sex and consequences of aging."
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00285.2023. Online ahead of print.NO ABSTRACTPMID:38145291 | DOI:10.1152/ajpregu.00285.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Audrey J Stone Ann-Katrin Grotle Nina S Stachenfeld Source Type: research

< em > Expression of Prolyl Hydroxylase Domains (PHDs), the < /em > upstream regulator of HIF, in < em > the Brain of the Anoxia-Tolerant Crucian Carp < /em > during Anoxia-Reoxygenation
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00211.2023. Online ahead of print.ABSTRACTThe hypoxia-inducible factor (HIF) is considered key in the transcriptional response to low oxygen. Yet, HIF's role in absence of oxygen (anoxia) and in preparation for reoxygenation remains unclear. Recent studies suggest that mounting a HIF response may be counterproductive for anoxia survival. We here studied the champion of anoxia survival, the crucian carp (Carassius carassius), and hypothesized that expression of prolyl hydroxylase domains, PHDs (the upstream regulators of HIF), are upregulated to circu...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Lucie Gerber Julien Resseguier Tellef Helle-Valle Elie Farhat G öran Erik Nilsson Sjannie Lefevre Source Type: research

Editorial for Call for papers: "Cardiovascular regulation during exercise: role of biological sex and consequences of aging."
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00285.2023. Online ahead of print.NO ABSTRACTPMID:38145291 | DOI:10.1152/ajpregu.00285.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Audrey J Stone Ann-Katrin Grotle Nina S Stachenfeld Source Type: research

< em > Expression of Prolyl Hydroxylase Domains (PHDs), the < /em > upstream regulator of HIF, in < em > the Brain of the Anoxia-Tolerant Crucian Carp < /em > during Anoxia-Reoxygenation
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00211.2023. Online ahead of print.ABSTRACTThe hypoxia-inducible factor (HIF) is considered key in the transcriptional response to low oxygen. Yet, HIF's role in absence of oxygen (anoxia) and in preparation for reoxygenation remains unclear. Recent studies suggest that mounting a HIF response may be counterproductive for anoxia survival. We here studied the champion of anoxia survival, the crucian carp (Carassius carassius), and hypothesized that expression of prolyl hydroxylase domains, PHDs (the upstream regulators of HIF), are upregulated to circu...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Lucie Gerber Julien Resseguier Tellef Helle-Valle Elie Farhat G öran Erik Nilsson Sjannie Lefevre Source Type: research

Editorial for Call for papers: "Cardiovascular regulation during exercise: role of biological sex and consequences of aging."
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00285.2023. Online ahead of print.NO ABSTRACTPMID:38145291 | DOI:10.1152/ajpregu.00285.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Audrey J Stone Ann-Katrin Grotle Nina S Stachenfeld Source Type: research

< em > Expression of Prolyl Hydroxylase Domains (PHDs), the < /em > upstream regulator of HIF, in < em > the Brain of the Anoxia-Tolerant Crucian Carp < /em > during Anoxia-Reoxygenation
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00211.2023. Online ahead of print.ABSTRACTThe hypoxia-inducible factor (HIF) is considered key in the transcriptional response to low oxygen. Yet, HIF's role in absence of oxygen (anoxia) and in preparation for reoxygenation remains unclear. Recent studies suggest that mounting a HIF response may be counterproductive for anoxia survival. We here studied the champion of anoxia survival, the crucian carp (Carassius carassius), and hypothesized that expression of prolyl hydroxylase domains, PHDs (the upstream regulators of HIF), are upregulated to circu...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Lucie Gerber Julien Resseguier Tellef Helle-Valle Elie Farhat G öran Erik Nilsson Sjannie Lefevre Source Type: research

Editorial for Call for papers: "Cardiovascular regulation during exercise: role of biological sex and consequences of aging."
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00285.2023. Online ahead of print.NO ABSTRACTPMID:38145291 | DOI:10.1152/ajpregu.00285.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Audrey J Stone Ann-Katrin Grotle Nina S Stachenfeld Source Type: research

< em > Expression of Prolyl Hydroxylase Domains (PHDs), the < /em > upstream regulator of HIF, in < em > the Brain of the Anoxia-Tolerant Crucian Carp < /em > during Anoxia-Reoxygenation
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00211.2023. Online ahead of print.ABSTRACTThe hypoxia-inducible factor (HIF) is considered key in the transcriptional response to low oxygen. Yet, HIF's role in absence of oxygen (anoxia) and in preparation for reoxygenation remains unclear. Recent studies suggest that mounting a HIF response may be counterproductive for anoxia survival. We here studied the champion of anoxia survival, the crucian carp (Carassius carassius), and hypothesized that expression of prolyl hydroxylase domains, PHDs (the upstream regulators of HIF), are upregulated to circu...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Lucie Gerber Julien Resseguier Tellef Helle-Valle Elie Farhat G öran Erik Nilsson Sjannie Lefevre Source Type: research

Editorial for Call for papers: "Cardiovascular regulation during exercise: role of biological sex and consequences of aging."
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00285.2023. Online ahead of print.NO ABSTRACTPMID:38145291 | DOI:10.1152/ajpregu.00285.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Audrey J Stone Ann-Katrin Grotle Nina S Stachenfeld Source Type: research

< em > Expression of Prolyl Hydroxylase Domains (PHDs), the < /em > upstream regulator of HIF, in < em > the Brain of the Anoxia-Tolerant Crucian Carp < /em > during Anoxia-Reoxygenation
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00211.2023. Online ahead of print.ABSTRACTThe hypoxia-inducible factor (HIF) is considered key in the transcriptional response to low oxygen. Yet, HIF's role in absence of oxygen (anoxia) and in preparation for reoxygenation remains unclear. Recent studies suggest that mounting a HIF response may be counterproductive for anoxia survival. We here studied the champion of anoxia survival, the crucian carp (Carassius carassius), and hypothesized that expression of prolyl hydroxylase domains, PHDs (the upstream regulators of HIF), are upregulated to circu...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Lucie Gerber Julien Resseguier Tellef Helle-Valle Elie Farhat G öran Erik Nilsson Sjannie Lefevre Source Type: research

Editorial for Call for papers: "Cardiovascular regulation during exercise: role of biological sex and consequences of aging."
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00285.2023. Online ahead of print.NO ABSTRACTPMID:38145291 | DOI:10.1152/ajpregu.00285.2023 (Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology)
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Audrey J Stone Ann-Katrin Grotle Nina S Stachenfeld Source Type: research

< em > Expression of Prolyl Hydroxylase Domains (PHDs), the < /em > upstream regulator of HIF, in < em > the Brain of the Anoxia-Tolerant Crucian Carp < /em > during Anoxia-Reoxygenation
Am J Physiol Regul Integr Comp Physiol. 2023 Dec 25. doi: 10.1152/ajpregu.00211.2023. Online ahead of print.ABSTRACTThe hypoxia-inducible factor (HIF) is considered key in the transcriptional response to low oxygen. Yet, HIF's role in absence of oxygen (anoxia) and in preparation for reoxygenation remains unclear. Recent studies suggest that mounting a HIF response may be counterproductive for anoxia survival. We here studied the champion of anoxia survival, the crucian carp (Carassius carassius), and hypothesized that expression of prolyl hydroxylase domains, PHDs (the upstream regulators of HIF), are upregulated to circu...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 25, 2023 Category: Physiology Authors: Lucie Gerber Julien Resseguier Tellef Helle-Valle Elie Farhat G öran Erik Nilsson Sjannie Lefevre Source Type: research